Ultram Er

Premature Ejaculation, Pain, Pain + 2 more

Treatment

2 FDA approvals

2 Active Studies for Ultram Er

Treatment for

Premature Ejaculation

What is Ultram Er

Tramadol

The Generic name of this drug

Treatment Summary

Tramadol is a prescription drug used to treat moderate to severe pain. It is a synthetic opioid that works by activating the μ-opioid receptor, as well as affecting neurotransmitters involved in pain modulation like serotonin and norepinephrine. Tramadol is often considered a safer alternative to other opioid medications due to its lower potency and good tolerability. However, it still carries the risk of developing tolerance, dependence, and abuse, and can also cause overdose, respiratory depression, seizures, and serotonin syndrome if used in higher doses or with other opioid medications.

Ultram

is the brand name

image of different drug pills on a surface

Ultram Er Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Ultram

Tramadol

1995

475

Approved as Treatment by the FDA

Tramadol, otherwise called Ultram, is approved by the FDA for 2 uses including Pain, Acute and Acute Pain .

Pain, Acute

Used to treat Pain, Acute in combination with Acetaminophen

Acute Pain

Used to treat Pain, Acute in combination with Acetaminophen

Effectiveness

How Ultram Er Affects Patients

Tramadol is a painkiller that works by changing how pain is processed in the central nervous system. It can cause side effects like dizziness, drowsiness, nausea, constipation, sweating and itching. It is less likely to cause a histamine release compared to morphine, and will not have a major effect on heart rate. It can cause respiratory depression, meaning slower breathing, and can reduce the ability to cough. It can also cause miosis (small pupils) and seizures in some cases. Tramadol can also cause a rare but potentially life-threatening reaction if taken with certain drugs, like antidepressants or migraine

How Ultram Er works in the body

Tramadol is a drug that helps reduce pain. It works by interacting with the body's opioid receptors, which are responsible for pain perception. It also helps to block or reduce the reuptake of serotonin and norepinephrine, two neurotransmitters involved in pain. Tramadol's primary metabolite, M1, is 6 times more potent in reducing pain than tramadol itself. Tramadol can also affect other pain modulators, such as alpha2-adrenoreceptors, neurokinin 1 receptors, voltage-gated sodium channels, transient receptor potential cation channels, muscar

When to interrupt dosage

The advised dosage of Ultram Er is contingent upon the identified condition, including Pain, Pain and Acute Pain. The measure of dosage differs, according to the method of delivery (e.g. Capsule or Tablet) featured in the table beneath.

Condition

Dosage

Administration

Premature Ejaculation

, 50.0 mg, 200.0 mg, 300.0 mg, 100.0 mg, 37.5 mg, 150.0 mg, 0.5 mg, 5.0 mg/mg, 400.0 mg, 75.0 mg, 1.0 mg/mL, 1.0 mg/mg, 5.8 mg/mg, 5.0 mg/mL, 44.0 mg

, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, coated - Oral, Tablet, coated, Capsule, extended release, Capsule, extended release - Oral, Kit, Kit - Oral, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Topical, Cream, Cream - Topical, Tablet, delayed release, Tablet, delayed release - Oral, Solution - Oral, Solution

Pain

, 50.0 mg, 200.0 mg, 300.0 mg, 100.0 mg, 37.5 mg, 150.0 mg, 0.5 mg, 5.0 mg/mg, 400.0 mg, 75.0 mg, 1.0 mg/mL, 1.0 mg/mg, 5.8 mg/mg, 5.0 mg/mL, 44.0 mg

, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, coated - Oral, Tablet, coated, Capsule, extended release, Capsule, extended release - Oral, Kit, Kit - Oral, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Topical, Cream, Cream - Topical, Tablet, delayed release, Tablet, delayed release - Oral, Solution - Oral, Solution

Pain

, 50.0 mg, 200.0 mg, 300.0 mg, 100.0 mg, 37.5 mg, 150.0 mg, 0.5 mg, 5.0 mg/mg, 400.0 mg, 75.0 mg, 1.0 mg/mL, 1.0 mg/mg, 5.8 mg/mg, 5.0 mg/mL, 44.0 mg

, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, coated - Oral, Tablet, coated, Capsule, extended release, Capsule, extended release - Oral, Kit, Kit - Oral, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Topical, Cream, Cream - Topical, Tablet, delayed release, Tablet, delayed release - Oral, Solution - Oral, Solution

Pain

, 50.0 mg, 200.0 mg, 300.0 mg, 100.0 mg, 37.5 mg, 150.0 mg, 0.5 mg, 5.0 mg/mg, 400.0 mg, 75.0 mg, 1.0 mg/mL, 1.0 mg/mg, 5.8 mg/mg, 5.0 mg/mL, 44.0 mg

, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, coated - Oral, Tablet, coated, Capsule, extended release, Capsule, extended release - Oral, Kit, Kit - Oral, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Topical, Cream, Cream - Topical, Tablet, delayed release, Tablet, delayed release - Oral, Solution - Oral, Solution

Acute Pain

, 50.0 mg, 200.0 mg, 300.0 mg, 100.0 mg, 37.5 mg, 150.0 mg, 0.5 mg, 5.0 mg/mg, 400.0 mg, 75.0 mg, 1.0 mg/mL, 1.0 mg/mg, 5.8 mg/mg, 5.0 mg/mL, 44.0 mg

, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, coated - Oral, Tablet, coated, Capsule, extended release, Capsule, extended release - Oral, Kit, Kit - Oral, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Topical, Cream, Cream - Topical, Tablet, delayed release, Tablet, delayed release - Oral, Solution - Oral, Solution

Warnings

Ultram Er Contraindications

Condition

Risk Level

Notes

Mental Depression

Do Not Combine

Asthma

Do Not Combine

Abdomen

Do Not Combine

Alcohol Withdrawal Delirium

Do Not Combine

ethanol

Do Not Combine

Ileus

Do Not Combine

Pulmonary Heart Disease

Do Not Combine

Head

Do Not Combine

Pulse Frequency

Do Not Combine

Pulmonary Disease, Chronic Obstructive

Do Not Combine

Intoxication

Do Not Combine

Epilepsy

Do Not Combine

Severe Hepatic Impairment

Do Not Combine

Respiratory Insufficiency

Do Not Combine

Status Asthmaticus

Do Not Combine

Intestinal Obstruction

Do Not Combine

Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Tramadol may interact with Pulse Frequency

There are 20 known major drug interactions with Ultram Er.

Common Ultram Er Drug Interactions

Drug Name

Risk Level

Description

Aclidinium

Major

The risk or severity of adverse effects can be increased when Tramadol is combined with Aclidinium.

Azelastine

Major

Tramadol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Carbamazepine

Major

The therapeutic efficacy of Carbamazepine can be decreased when used in combination with Tramadol.

Cimetropium

Major

The risk or severity of adverse effects can be increased when Tramadol is combined with Cimetropium.

Eluxadoline

Major

The risk or severity of constipation can be increased when Tramadol is combined with Eluxadoline.

Ultram Er Toxicity & Overdose Risk

The toxic dose of tramadol in mice is 350mg/kg. There has been evidence of tumors in mice, but no proof of it being carcinogenic in humans. Tramadol has not been linked to mutations or fertility problems, but there have been reports of harm to embryos and fetuses.

image of a doctor in a lab doing drug, clinical research

Ultram Er Novel Uses: Which Conditions Have a Clinical Trial Featuring Ultram Er?

18 active studies are investigating the utility of Ultram ER for alleviating Acute Pain, Pain and Painful sensations.

Condition

Clinical Trials

Trial Phases

Acute Pain

1 Actively Recruiting

Not Applicable

Pain

0 Actively Recruiting

Premature Ejaculation

0 Actively Recruiting

Pain

0 Actively Recruiting

Pain

0 Actively Recruiting

Ultram Er Reviews: What are patients saying about Ultram Er?

5

Patient Review

7/18/2010

Ultram Er for Joint Damage causing Pain and Loss of Function

Ultram Er has been a total godsend. It's alleviated my pain to the point where I can still work, which is amazing given how bad things were before. The only downside is that if I miss a dose, I start to feel jittery.

5

Patient Review

10/26/2013

Ultram Er for Neuropathic Pain

Ultram er helps with sleep and pain management so I can do daily activities, just like cleaning. It does lose it's effect after a while and needs to be reevaluated for dosage. Over all this works great.

4.7

Patient Review

11/14/2015

Ultram Er for Disorder characterized by Stiff, Tender & Painful Muscles

Ultram ER was prescribed to me by a pain specialist, and it has been an incredible help. Not only does it manage my pain, but it also got rid of my restless legs syndrome entirely! The generic doesn't work as well, unfortunately, so I have to get the brand name which is way more expensive. But relief from this much suffering is worth any cost.

4.3

Patient Review

6/29/2011

Ultram Er for Neuropathic Pain

This medication works well for me. On days when the pain is bad, I take 200mg and it helps a lot. On good days, I only need 100mg. It's much better than taking narcotics.

3.7

Patient Review

3/17/2010

Ultram Er for Chronic Pain

I found that the side effects were less manageable at night, so I switched to taking it in the morning. This seemed to help quite a bit. Additionally, while it doesn't completely erase my pain, it does allow me to be more active throughout the day which is great. Although, I have noticed that my heart rate seems to increase at times.

3.7

Patient Review

3/25/2010

Ultram Er for Chronic Pain

I was taking this medication for some major pain I have been in for some time now.

3.3

Patient Review

8/9/2011

Ultram Er for Chronic Pain

This medication helps me sleep and lowers my blood pressure.

3

Patient Review

2/26/2010

Ultram Er for Disorder characterized by Stiff, Tender & Painful Muscles

Tramadol has been a godsend for chronic pain relief. It's much easier on my body than traditional painkillers, and I haven't experienced any major negative side effects besides occasionally having to pee and feeling drowsy.

2.7

Patient Review

5/21/2011

Ultram Er for Chronic Pain

I've been dealing with chronic back pain for two years now, and I switched to Ultram ER about eight months ago. At first it was effective, but now it's losing its potency.

2.3

Patient Review

4/17/2010

Ultram Er for Chronic Pain

I've been taking this medication for three years to manage my fibromyalgia pain. At first, it was very effective; however, now it has all but stopped working for me.

2.3

Patient Review

3/9/2011

Ultram Er for Chronic Pain

I've been using regular ultram, but the extended release does nothing.

2

Patient Review

6/30/2011

Ultram Er for Chronic Pain

I didn't finish the course of this medication because I got sick to my stomach after just two doses. It's a shame, because it did help with my back pain. Additionally, it made me very drowsy.

2

Patient Review

11/12/2015

Ultram Er for Chronic Pain

I experienced slight relief from PAD after taking the maximum dose of Tylenol.

1

Patient Review

5/14/2014

Ultram Er for Chronic Pain

I'm an ex-athlete who has had five knee surgeries, three of which were total knee replacements. Tramadol has helped me immensely and I've even been able to go back to coaching soccer. I take a maximum of 150 per day and have found it to be extremely effective.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ultram er

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the difference between tramadol and tramadol ER?

"Tramadol extended-release (Durotram XR) provides a steadier stream of medication over 24 hours than the traditional tramadol formulation."

Answered by AI

What is Ultram ER used for?

"Ultram ER is a prescription medication used to manage moderate to severe pain. It may be used on its own or alongside other medications. Ultram ER falls under a category of drugs known as Opioid Analgesics. The safety and efficacy of Ultram ER has not been established in children younger than 17."

Answered by AI

How long does it take for Ultram ER to start working?

"How long does it take for this medication to work? You should notice some pain relief within 1-2 hours of taking this medication (depending on the brand) although it may take about 4-12 hours to reach full effectiveness."

Answered by AI

What is the difference between Ultram and Ultram ER?

"Ultram is the brand name for the generic drug tramadol. Tramadol is also available in brand names including Ultram ER, which is an extended release version of Ultram; ConZip; and Enova RX."

Answered by AI

Clinical Trials for Ultram Er