Ultram Er

Premature Ejaculation, Pain, Pain + 2 more
Treatment
2 FDA approvals
2 Active Studies for Ultram Er

What is Ultram Er

TramadolThe Generic name of this drug
Treatment SummaryTramadol is a prescription drug used to treat moderate to severe pain. It is a synthetic opioid that works by activating the μ-opioid receptor, as well as affecting neurotransmitters involved in pain modulation like serotonin and norepinephrine. Tramadol is often considered a safer alternative to other opioid medications due to its lower potency and good tolerability. However, it still carries the risk of developing tolerance, dependence, and abuse, and can also cause overdose, respiratory depression, seizures, and serotonin syndrome if used in higher doses or with other opioid medications.
Ultramis the brand name
image of different drug pills on a surface
Ultram Er Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ultram
Tramadol
1995
475

Approved as Treatment by the FDA

Tramadol, otherwise called Ultram, is approved by the FDA for 2 uses including Pain, Acute and Acute Pain .
Pain, Acute
Used to treat Pain, Acute in combination with Acetaminophen
Acute Pain
Used to treat Pain, Acute in combination with Acetaminophen

Effectiveness

How Ultram Er Affects PatientsTramadol is a painkiller that works by changing how pain is processed in the central nervous system. It can cause side effects like dizziness, drowsiness, nausea, constipation, sweating and itching. It is less likely to cause a histamine release compared to morphine, and will not have a major effect on heart rate. It can cause respiratory depression, meaning slower breathing, and can reduce the ability to cough. It can also cause miosis (small pupils) and seizures in some cases. Tramadol can also cause a rare but potentially life-threatening reaction if taken with certain drugs, like antidepressants or migraine
How Ultram Er works in the bodyTramadol is a drug that helps reduce pain. It works by interacting with the body's opioid receptors, which are responsible for pain perception. It also helps to block or reduce the reuptake of serotonin and norepinephrine, two neurotransmitters involved in pain. Tramadol's primary metabolite, M1, is 6 times more potent in reducing pain than tramadol itself. Tramadol can also affect other pain modulators, such as alpha2-adrenoreceptors, neurokinin 1 receptors, voltage-gated sodium channels, transient receptor potential cation channels, muscar

When to interrupt dosage

The advised dosage of Ultram Er is contingent upon the identified condition, including Pain, Pain and Acute Pain. The measure of dosage differs, according to the method of delivery (e.g. Capsule or Tablet) featured in the table beneath.
Condition
Dosage
Administration
Pain
, 50.0 mg, 200.0 mg, 300.0 mg, 100.0 mg, 37.5 mg, 150.0 mg, 0.5 mg, 5.0 mg/mg, 400.0 mg, 75.0 mg, 1.0 mg/mL, 1.0 mg/mg, 5.8 mg/mg, 5.0 mg/mL, 44.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Kit - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Topical, Cream - Topical, Cream, Tablet, delayed release, Tablet, delayed release - Oral, Solution, Solution - Oral
Pain
, 50.0 mg, 200.0 mg, 300.0 mg, 100.0 mg, 37.5 mg, 150.0 mg, 0.5 mg, 5.0 mg/mg, 400.0 mg, 75.0 mg, 1.0 mg/mL, 1.0 mg/mg, 5.8 mg/mg, 5.0 mg/mL, 44.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Kit - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Topical, Cream - Topical, Cream, Tablet, delayed release, Tablet, delayed release - Oral, Solution, Solution - Oral
Pain
, 50.0 mg, 200.0 mg, 300.0 mg, 100.0 mg, 37.5 mg, 150.0 mg, 0.5 mg, 5.0 mg/mg, 400.0 mg, 75.0 mg, 1.0 mg/mL, 1.0 mg/mg, 5.8 mg/mg, 5.0 mg/mL, 44.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Kit - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Topical, Cream - Topical, Cream, Tablet, delayed release, Tablet, delayed release - Oral, Solution, Solution - Oral
Premature Ejaculation
, 50.0 mg, 200.0 mg, 300.0 mg, 100.0 mg, 37.5 mg, 150.0 mg, 0.5 mg, 5.0 mg/mg, 400.0 mg, 75.0 mg, 1.0 mg/mL, 1.0 mg/mg, 5.8 mg/mg, 5.0 mg/mL, 44.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Kit - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Topical, Cream - Topical, Cream, Tablet, delayed release, Tablet, delayed release - Oral, Solution, Solution - Oral
Acute Pain
, 50.0 mg, 200.0 mg, 300.0 mg, 100.0 mg, 37.5 mg, 150.0 mg, 0.5 mg, 5.0 mg/mg, 400.0 mg, 75.0 mg, 1.0 mg/mL, 1.0 mg/mg, 5.8 mg/mg, 5.0 mg/mL, 44.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Kit - Oral, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Topical, Cream - Topical, Cream, Tablet, delayed release, Tablet, delayed release - Oral, Solution, Solution - Oral

Warnings

Ultram Er Contraindications
Condition
Risk Level
Notes
Mental Depression
Do Not Combine
Asthma
Do Not Combine
Abdomen
Do Not Combine
Alcohol Withdrawal Delirium
Do Not Combine
ethanol
Do Not Combine
Ileus
Do Not Combine
Pulmonary Heart Disease
Do Not Combine
Head
Do Not Combine
Pulse Frequency
Do Not Combine
Pulmonary Disease, Chronic Obstructive
Do Not Combine
Intoxication
Do Not Combine
Epilepsy
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Respiratory Insufficiency
Do Not Combine
Status Asthmaticus
Do Not Combine
Intestinal Obstruction
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Tramadol may interact with Pulse Frequency
There are 20 known major drug interactions with Ultram Er.
Common Ultram Er Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Tramadol is combined with Aclidinium.
Azelastine
Major
Tramadol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Carbamazepine
Major
The therapeutic efficacy of Carbamazepine can be decreased when used in combination with Tramadol.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Tramadol is combined with Cimetropium.
Eluxadoline
Major
The risk or severity of constipation can be increased when Tramadol is combined with Eluxadoline.
Ultram Er Toxicity & Overdose RiskThe toxic dose of tramadol in mice is 350mg/kg. There has been evidence of tumors in mice, but no proof of it being carcinogenic in humans. Tramadol has not been linked to mutations or fertility problems, but there have been reports of harm to embryos and fetuses.
image of a doctor in a lab doing drug, clinical research

Ultram Er Novel Uses: Which Conditions Have a Clinical Trial Featuring Ultram Er?

18 active studies are investigating the utility of Ultram ER for alleviating Acute Pain, Pain and Painful sensations.
Condition
Clinical Trials
Trial Phases
Acute Pain
2 Actively Recruiting
Early Phase 1, Not Applicable
Pain
0 Actively Recruiting
Premature Ejaculation
0 Actively Recruiting
Pain
0 Actively Recruiting
Pain
0 Actively Recruiting

Ultram Er Reviews: What are patients saying about Ultram Er?

5Patient Review
7/18/2010
Ultram Er for Joint Damage causing Pain and Loss of Function
Ultram Er has been a total godsend. It's alleviated my pain to the point where I can still work, which is amazing given how bad things were before. The only downside is that if I miss a dose, I start to feel jittery.
5Patient Review
10/26/2013
Ultram Er for Neuropathic Pain
Ultram er helps with sleep and pain management so I can do daily activities, just like cleaning. It does lose it's effect after a while and needs to be reevaluated for dosage. Over all this works great.
4.7Patient Review
11/14/2015
Ultram Er for Disorder characterized by Stiff, Tender & Painful Muscles
Ultram ER was prescribed to me by a pain specialist, and it has been an incredible help. Not only does it manage my pain, but it also got rid of my restless legs syndrome entirely! The generic doesn't work as well, unfortunately, so I have to get the brand name which is way more expensive. But relief from this much suffering is worth any cost.
4.3Patient Review
6/29/2011
Ultram Er for Neuropathic Pain
This medication works well for me. On days when the pain is bad, I take 200mg and it helps a lot. On good days, I only need 100mg. It's much better than taking narcotics.
3.7Patient Review
3/17/2010
Ultram Er for Chronic Pain
I found that the side effects were less manageable at night, so I switched to taking it in the morning. This seemed to help quite a bit. Additionally, while it doesn't completely erase my pain, it does allow me to be more active throughout the day which is great. Although, I have noticed that my heart rate seems to increase at times.
View All Reviews
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Patient Q&A Section about ultram er

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the difference between tramadol and tramadol ER?

"Tramadol extended-release (Durotram XR) provides a steadier stream of medication over 24 hours than the traditional tramadol formulation."

Answered by AI

What is Ultram ER used for?

"Ultram ER is a prescription medication used to manage moderate to severe pain. It may be used on its own or alongside other medications. Ultram ER falls under a category of drugs known as Opioid Analgesics. The safety and efficacy of Ultram ER has not been established in children younger than 17."

Answered by AI

How long does it take for Ultram ER to start working?

"How long does it take for this medication to work? You should notice some pain relief within 1-2 hours of taking this medication (depending on the brand) although it may take about 4-12 hours to reach full effectiveness."

Answered by AI

What is the difference between Ultram and Ultram ER?

"Ultram is the brand name for the generic drug tramadol. Tramadol is also available in brand names including Ultram ER, which is an extended release version of Ultram; ConZip; and Enova RX."

Answered by AI

Clinical Trials for Ultram Er

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