Treatment for Healthy Aging

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Kansas Alzheimer's Disease Center, Fairway, KS
Healthy Aging
Eligibility
65+
All Sexes
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Study Summary

Combined Exercise Trial

See full description

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Healthy Aging

Study Objectives

This trial is evaluating whether Treatment will improve 1 primary outcome and 3 secondary outcomes in patients with Healthy Aging. Measurement will happen over the course of Baseline, 12 months.

Baseline, 12 months
1-repetition maximum
Hippocampal volume
Peak oxygen consumption
Month 12
Global Cognition

Trial Safety

Safety Progress

1 of 3

Other trials for Healthy Aging

Trial Design

4 Treatment Groups

Weight Training
1 of 4
Core and Fusion Training
1 of 4
Combined Endurance and Weight Training
1 of 4
Endurance Training
1 of 4
Active Control

This trial requires 280 total participants across 4 different treatment groups

This trial involves 4 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Weight Training
Behavioral
Progressive resistance training 2 days/week, non-consecutive, of 2 sets (10 - 15 repetitions) of 10 exercises (~75 minutes/week). Progression based on repetition completion and 1-repetition maximum. In addition 3 days of Core and Fusion control exercise will also be recommended.
Core and Fusion Training
Behavioral
150 minutes/week of Core and Fusion exercise, a mix of low impact toning, strengthening, flexibility and balance exercises.
Combined Endurance and Weight Training
Behavioral
Moderate-intensity endurance training such as brisk walking, 150 minutes/week over 3-5 days. Progression based on a set schedule. Progressive resistance training 2 days/week, non-consecutive, of 2 sets (10 - 15 repetitions) of 10 exercises (~75 minutes/week). Progression based on repetition completion and 1-repetition maximum.
Endurance Training
Behavioral
Moderate-intensity endurance training such as brisk walking, 150 minutes/week over 3-5 days. Progression based on a set schedule. In addition 0-2 days of Core and Fusion control exercise will also be recommended.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, 6 months, 12 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline, 6 months, 12 months for reporting.

Closest Location

University of Kansas Alzheimer's Disease Center - Fairway, KS

Eligibility Criteria

This trial is for patients born any sex aged 65 and older. There are 5 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Age 65-80 yrs (inclusive at time of consent).
Conversant English speaking and reading ability.
Medical clearance by a health care provider.
Reliable means of transportation.
Telephone Interview of Cognitive Status score > 25 and adjudication of normal cognition based on cognitive test data by a study medical monitor.

Patient Q&A Section

Can healthy aging be cured?

"Aging individuals in the midst of successful aging (i.e., aging in its normal trajectory) have a similar rate of mortality as the general population. Furthermore, the rate of successful aging is not increased with age. Aging is merely a product of living a long time; and successful aging can be measured by not falling below a set age of mortality. Age per se does not accelerate successful aging." - Anonymous Online Contributor

Unverified Answer

What causes healthy aging?

"The prevalence of some chronic conditions increases with age with the highest rates occurring in those over 80 or 90 years-old. The occurrence of some chronic conditions has been proposed to be affected by aging cells accumulating damage in their genomes. Thus, the association of chronic conditions with aging reflects a complex interplay between genetic, environmental, and aging-associated factors leading to disease. Future research should examine whether and how genomic changes contribute to age-related processes such as insulin resistance and chronic inflammation." - Anonymous Online Contributor

Unverified Answer

How many people get healthy aging a year in the United States?

"The number of Americans aged 55 and older who are in fair or good health increased from 1 million in 1997 to 2.9 million in 2012, but the health of those 55 and older has not improved. In 2012, health problems were an increasing proportion of total disability, and the number of years of life lost by disability has risen continually." - Anonymous Online Contributor

Unverified Answer

What is healthy aging?

"Healthy aging refers to the maintenance of a good physical, mental, and social competence in old age. Healthy aging is a concept with wide-ranging interests for scientists from diverse backgrounds because it is linked to the prevention of disorders associated with disease, injuries and mortality. Healthy aging is not as simple as the sum of its parts; it is a complex interplay between genetic, behavioural, environmental, cognitive, physical, and social aspects of health. Healthy aging is a theoretical model of ageing in which all the changes in a population are described in terms of interrelated biological, behavioural, and social changes, and in which the goal is the maintenance of functional health." - Anonymous Online Contributor

Unverified Answer

What are common treatments for healthy aging?

"In a recent study, findings demonstrates the difficulty in delineating treatment for a wide variety of conditions. While patients experience some degree of improvement following treatment, many often find this improvement too slight to be of obvious diagnostic or therapeutic value. The extent to which different treatment options improve the health and well-being of patients and caregivers remains an area of ongoing research and investigation." - Anonymous Online Contributor

Unverified Answer

What are the signs of healthy aging?

"Healthy aging is associated with many symptoms, including headache, loss of appetite, malaise and fatigue. Older adults often complain about memory problems, low energy and difficulty sleeping. The majority of symptoms are non-specific and do not provide additional diagnostic information to a physical examination. These symptoms are commonly attributed to the physiological changes of healthy aging and do not necessarily indicate a physical or mental health disorder." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of treatment?

"A comprehensive search of reports of side effects from all published clinical trials may be a useful strategy for identifying commonly encountered adverse events that are more likely to be relevant in a given patient population. Most common adverse reactions include fever (> 30%), fatigue (> 10%), dizziness (> 6%) and diarrhea (< 6%)." - Anonymous Online Contributor

Unverified Answer

What is treatment?

"Clinical practice in the U.K. in the last 5 years has mirrored that of North America; a focus on symptomatic management, as evidenced by the low rates of PN use over the last decade, has been largely unchanged. The use of a broad range of non-operative treatments also increased, for patients with advanced disease at presentation. This supports further research into alternatives to surgery as first-line management of advanced and refractory disease." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets healthy aging?

"Age is an important factor in health, and should be part of the discussion for the average health-related goal for older people. There is a need for specific, evidence-based, and standardized health-related goals for different populations, ages, and health condition groups." - Anonymous Online Contributor

Unverified Answer

What is the latest research for healthy aging?

"Research for healthy aging is growing and advancing in all levels, and health providers can reap the benefits of this development by being well-informed and engaging in informed, competent, and appropriate practices." - Anonymous Online Contributor

Unverified Answer

How serious can healthy aging be?

"Given the high prevalence of this condition and the fact that it is a major public health problem that leads to substantial mortality and morbidity, it is important to understand the nature and scope of the problem. More research is urgently needed to evaluate and modify treatment options for those most at risk of these problems." - Anonymous Online Contributor

Unverified Answer

What does treatment usually treat?

"The majority of the treatments used to maintain, improve, and prevent HRQOL in older adults with HRQOL impairment do not meet the definition of being "usual treatments." In a recent study, findings, a greater percentage of participants received no treatment than received usual treatment." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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