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What is Trilipix
Fenofibric acidThe Generic name of this drug
Treatment SummaryFenofibric acid is a medication used to lower dangerous levels of cholesterol and triglycerides. It helps to lower bad cholesterol (low-density lipoprotein cholesterol) while raising good cholesterol (high-density lipoprotein cholesterol). Fenofibric acid is not well absorbed by the body, so it is usually given as a prodrug or a conjugated compound to help it be more easily absorbed and more effective.
Fenofibric Acidis the brand name
Trilipix Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Fenofibric Acid
Fenofibric acid
2008
66
Effectiveness
How Trilipix Affects PatientsStudies have linked high levels of total cholesterol, LDL (low-density-lipoprotein), and apolipoprotein B (a type of LDL) to atherosclerosis. Low levels of HDL (high-density-lipoprotein) and its transport complex (apolipoproteins apo AI and apo AII) have also been linked to atherosclerosis. Additionally, research suggests that cardiovascular problems and death risk increase with higher levels of total cholesterol, LDL, and triglycerides, but decrease with higher levels of HDL.Fenofibric acid, a metabolite of fenofibrate,
How Trilipix works in the bodyFenofibric acid helps reduce triglycerides and increase good cholesterol in the body. It does this by activating a receptor in the body called PPAR-alpha. This leads to an increase in lipolysis, which is the breakdown of fat. It also causes low-density-lipoprotein particles to become larger and more easily broken down by the body. Fenofibric acid also increases production of apoproteins A-I and A-II, which are proteins that help transport fats in the blood. Lastly, it can help reduce uric acid levels in the body by increasing the amount of uric acid excret
When to interrupt dosage
The advised dosage of Trilipix is contingent upon the diagnosed disorder, including Hypertriglyceridemias, Primary Hypercholesterolemia and Diet. The amount of dosage is contingent on the delivery approach (e.g. Capsule, delayed release - Oral or Oral) as depicted in the following table.Condition
Dosage
Administration
Primary Hypercholesterolemia
, 45.0 mg, 135.0 mg, 35.0 mg, 105.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral
Hypertriglyceridemias
, 45.0 mg, 135.0 mg, 35.0 mg, 105.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral
Diet
, 45.0 mg, 135.0 mg, 35.0 mg, 105.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral
Triglycerides
, 45.0 mg, 135.0 mg, 35.0 mg, 105.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral
Dyslipidemias
, 45.0 mg, 135.0 mg, 35.0 mg, 105.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral
Warnings
Trilipix has five contraindications. It should not be employed in combination with the conditions specified in the following table.Trilipix ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Fenofibric Acid may interact with Pulse Frequency
active liver disease
Do Not Combine
severe renal dysfunction
Do Not Combine
Disease
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Fenofibric Acid may interact with Pulse Frequency
Common Trilipix Drug Interactions
Drug Name
Risk Level
Description
Albutrepenonacog alfa
Minor
Fenofibric acid may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Bismuth subgallate
Minor
Fenofibric acid may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level.
Choline salicylate
Minor
Fenofibric acid may decrease the excretion rate of Choline salicylate which could result in a higher serum level.
Chromic citrate
Minor
Fenofibric acid may decrease the excretion rate of Chromic citrate which could result in a higher serum level.
Chromic nitrate
Minor
Fenofibric acid may decrease the excretion rate of Chromic nitrate which could result in a higher serum level.
Trilipix Novel Uses: Which Conditions Have a Clinical Trial Featuring Trilipix?
14 active clinical trials are currently assessing the potential of Trilipix in ameliorating Dyslipidemias, Triglycerides and Dietary-related issues.Condition
Clinical Trials
Trial Phases
Dyslipidemias
1 Actively Recruiting
Phase 2
Diet
5 Actively Recruiting
Not Applicable
Primary Hypercholesterolemia
16 Actively Recruiting
Early Phase 1, Not Applicable, Phase 3, Phase 2
Triglycerides
0 Actively Recruiting
Hypertriglyceridemias
0 Actively Recruiting
Trilipix Reviews: What are patients saying about Trilipix?
5Patient Review
6/12/2012 I developed a dry mouth and tongue around the same time. Wearing dentures becomes painful when my mouth gets too dry.
5Patient Review
4/18/2013 I've been using this treatment for two years and have seen a significant drop in my cholesterol levels. My HDL is down to 30, LDL 61, and TRIGLYCERIDES have gone from over 300 to 82. I take it with breakfast every day and don't notice any negative side effects.
5Patient Review
1/18/2014 I take this medicine in conjunction with Lipitor. While Lipitor lowered my triglyceride and LDL levels, it didn't increase my HDL levels. However, the combination of the two medications did the trick. I'm 5'8" and 142lbs, I exercise regularly and watch what I eat--but these lifestyle choices alone weren't enough. The only side effect I experienced was some muscle problems, but they were tolerable.
5Patient Review
10/14/2013 I had zero of the bad reactions that other people have described. In fact, my LDL (low-density lipoprotein) went down and HDL (high-density lipoprotein) up. The only issue I had was with the cost, but I've since switched to the generic version and it's working just as well.
4Patient Review
1/6/20123.7Patient Review
5/2/2012 The medication is easy to take, which is great. However, the muscle pain and cramping it causes is really tough to deal with. I often have to cut back on how many days I take them because of this.
3Patient Review
12/30/2016 I've been taking this drug for three weeks now and have experienced terrible back pain, nausea, and constipation. I'm also constantly tired. I can't take it anymore.
2.7Patient Review
11/15/2012 Since starting this medication, I have developed cysts on my thyroid, kidney and liver. Additionally, I have been experiencing a lot of pain and dizziness. This drug has also not prevented me from having a heart attack or stroke like it is supposed to!
2.7Patient Review
6/16/2012 I've experienced most of the listed side effects, with the exception of itching and scaly skin - which I unfortunately have been dealing with.
2.3Patient Review
9/8/2012 I took this drug for over a year, but I developed severe itching all over my body. Once I stopped taking the medicine, the itching went away within a week. I'm hesitant to start taking it again because it only had moderate results on my triglycerides and cholesterol.
2.3Patient Review
2/4/2013 I took trilipix for 12 days. On the last day, I started vomiting and had severe diarrhea for two days. I haven't taken it since.
2.3Patient Review
7/4/2013 I unfortunately didn't get to use this treatment for very long before some really unpleasant side effects set it. After just eight days I started developing indigestion, heartburn, headaches and a sore throat. My mouth also started swelling!
2Patient Review
9/28/2013 I developed terrible pain after only a week of taking this medication. I was in so much agony that my primary care doctor sent me to the ER via ambulance. The MRI showed that this medication had nearly destroyed the Infraspinatus and both the Teres Minor and Teres Major muscles. I'm still in pain almost a year later and receiving treatment at a center
2Patient Review
11/18/2012 I was worried that it was just me getting old, but after reading these reviews I see that other people are experiencing similar problems. The muscle pains and itching are a real bother, and my doctor says to give my body a little while to get used to the medication. I'm not sure if I want to do that after reading all of these reviews though.
1.7Patient Review
4/17/2012 I was on a very low dosage of Trilipix for the first month. I had no symptoms of any kind, so my physician increased the dosage last week. I have been on the increased dosage for 6 days now and the muscle pain in my legs and lower back is intolerable. I threw the medicine away.
1.7Patient Review
1/3/2013 After four months of treatment, I was almost constantly dealing with pain in my lower back, legs, hips, and muscles. In addition to that, I developed colon problems and GERD. To be clear: I would not recommend this medication to anyone, but I am aware of the dangers of high cholesterol and triglycerides. Right now, I'm trying red yeast rice as an alternative treatment option.
1.7Patient Review
7/12/2014 After taking this medication for a while, I started having issues with coughing and choking. I would literally cough up the little round beads that the medicine comes in.
1.7Patient Review
4/8/2013 I've been taking this medication for about a week now, and I'm not seeing any improvement. In fact, I seem to be experiencing more back pain, as well as dizziness and fogginess in my eyes.
1.3Patient Review
4/3/2013 I've been taking this med for a few years now and haven't seen any real change. I'll be looking into other options for my cholesterol treatment.
Patient Q&A Section about trilipix
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of TRILIPIX?
"The possible side effects of the medication are nausea, an upset stomach, headaches, dizziness, back pain, joint pain, or cold symptoms such as a stuffy nose, sneezing, or a sore throat."
Answered by AI
What is TRILIPIX used for?
"TRILIPIX is a prescription medicine used to lower the total amount of triglycerides and LDL (bad) cholesterol in the blood, and increase the HDL (good) cholesterol. You should be on a low fat and low cholesterol diet while you take TRILIPIX."
Answered by AI
Is there a generic for TRILIPIX?
"If you are taking Tricor, Trilipix, or the generic fenofibrate, you should be aware of what has happened. Abbott Laboratories used this strategy to avoid generic competition for its branded formulations of fenofibrate."
Answered by AI
Is TRILIPIX a statin drug?
"Zocor is a statin drug, while Trilipix is a lipid regulating agent."
Answered by AI