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2-HOBA for High Cholesterol
Study Summary
This trial will test whether 2-HOBA can reduce modification of HDL and LDL, and improve HDL function, in people with a genetic condition that causes high cholesterol.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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- Your blood has high levels of triglycerides when you haven't eaten for a while.I have been diagnosed with systemic lupus erythematosus.I have Type 2 Diabetes and my BMI is over 30.I have had a heart attack or severe chest pain before.I have an underactive thyroid.I have nephrotic syndrome.I have a genetic condition that causes high cholesterol.My liver enzymes are not more than twice the upper limit.I have AIDS or HIV.My kidney function is reduced with a creatinine level over 1.8.My heart's pumping ability is severely reduced.I have not had a heart attack or stroke in the last 6 months.I have not had chest pain or angina in the last 3 months.You currently smoke cigarettes.I have rheumatoid arthritis.I have had cancer in any part of my body in the last 5 years.My blood pressure is not higher than 180/110 mm Hg.I have a genetic condition that causes high cholesterol.
- Group 1: Placebo
- Group 2: 2-Hydroxybenzylamine (2-HOBA)
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
If a patient is 35 years old or younger, could they qualify for this research?
"This study is seeking participants that fall within the age range of 18 to 69 years old."
Has 2-Hydroxybenzylamine (2-HOBA) been cleared by the FDA?
"There is some evidence to support 2-Hydroxybenzylamine's (2-HOBA) safety, but none for efficacy. This received a score of 2."
Are patients being actively sought for this research project?
"Clinicaltrials.gov indicates that this study is no longer looking for participants. The trial was originally posted on January 15th, 2023 but the most recent edit was November 4th, 2022. Although this research is not ongoing, there are 77 other studies that are still recruiting patients."
Is 2-Hydroxybenzylamine (2-HOBA) a new or novel medication?
"There are 2 ongoing studies involving 2-Hydroxybenzylamine (2-HOBA), and neither of them have progressed to Phase 3 yet. Most of the trials related to this treatment are based in Nashville, but there are also active research sites in 2 other locations."
How many total participants will be used for this clinical research?
"Unfortunately, this particular study is no longer looking for participants. The last time it was updated was on November 4th, 2022 and it was originally posted on January 15th, 2023. However, there are currently 75 other trials recruiting patients with primary hypercholesterolemia and 2 studies involving 2-Hydroxybenzylamine (2-HOBA) that are still enrolling patients."
How does one qualify for this particular medical study?
"The current study is investigating a possible treatment for primary hypercholesterolemia and thus requires participants that have this condition. In addition, all potential patients must be between 18-69 years old. Right now, the plan is to enroll 72 individuals in total."
Who else is applying?
What state do they live in?
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What portion of applicants met pre-screening criteria?
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