Tri-Luma

Hyperpigmentation, Melanosis, Chloasma + 7 more

Treatment

5 FDA approvals

20 Active Studies for Tri-Luma

What is Tri-Luma

Hydroquinone

The Generic name of this drug

Treatment Summary

Hydroquinone is a skin-lightening product found in some over-the-counter products. It is used to treat discoloration on the skin caused by melasma, freckles, sunspots, and other conditions. It is often combined with other agents such as alpha-hydroxy acids, corticosteroids, retinoids, or sunscreen. However, due to possible side effects such as irritation, discoloration, and carcinogenicity, hydroquinone has been banned in the EU and UK.

Ultra Glow Fade with Aloe Vera

is the brand name

image of different drug pills on a surface

Tri-Luma Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Ultra Glow Fade with Aloe Vera

Hydroquinone

1964

1

Approved as Treatment by the FDA

Hydroquinone, commonly known as Ultra Glow Fade with Aloe Vera, is approved by the FDA for 5 uses including severe Melasma and moderate Melasma .

severe Melasma

Used to treat severe Melasma in combination with Fluocinolone acetonide

moderate Melasma

Used to treat moderate Melasma in combination with Fluocinolone acetonide

Chloasma

Used to treat severe Melasma in combination with Fluocinolone acetonide

Chloasma

Used to treat moderate Melasma in combination with Fluocinolone acetonide

Melanosis

Effectiveness

How Tri-Luma works in the body

Hydroquinone lightens skin by blocking the enzyme that produces melanin pigment. This process takes several months to take effect.

When to interrupt dosage

The prescribed measure of Tri-Luma is reliant upon the designated malady, such as Chloasma, Chloasma and Melasma. The amount likewise fluctuates in relation to the mode of delivery, featured in the table beneath.

Condition

Dosage

Administration

Sunburn

0.02 mg/mg, , 0.04 mg/mg, 0.02 mg/mL, 20.0 mg/mL, 0.02 mL/mL, 0.12 mL/mL, 0.0946 mg/mL, 0.1 mg/mg, 0.2 mg/mg, 30.0 mg/mL, 40.0 mg/mL, 0.01695 mg/mg, 0.06 mg/mg, 0.1 mL/mL, 0.104 mL/mL, 0.04 mL/mL, 0.05 mL/mL, 0.019 mg/mg, 40000.0 mg/mL, 0.12 mg/mg, 2.0 %, 4.0 %, 0.114 mg/mg, 1.8 %, 1.5 %, 200.0 mg/mL, 0.00002 mg/mg, 100.0 mg/mL, 0.08 mg/mg, 0.05 mg/mg, 0.05 mg/mL, 0.015 mg/mg, 100.0 mg/mg, 0.03 mg/mg, 0.075 mg/mg, 0.04 mg/mL, 0.004 mg/mg, 2.0 mg/mg, 0.08 mg/mL, 20.0 mg, 20000.0 mg/mL, 80.0 mg/mL, 0.0002 mg/mL, 57.0 mg/mL, 76.0 mg/mL, 50.0 mg/mL, 95.0 mg/mL, 0.0012 mg/mg, 0.0006 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Liquid, Liquid - Topical, Kit, Gel, Gel - Topical, Emulsion, Cutaneous, Lotion - Cutaneous, Solution - Topical, Kit - Topical, Emulsion - Topical, Cream - Cutaneous, Cloth, Cloth - Topical, Solution

Melanosis

0.02 mg/mg, , 0.04 mg/mg, 0.02 mg/mL, 20.0 mg/mL, 0.02 mL/mL, 0.12 mL/mL, 0.0946 mg/mL, 0.1 mg/mg, 0.2 mg/mg, 30.0 mg/mL, 40.0 mg/mL, 0.01695 mg/mg, 0.06 mg/mg, 0.1 mL/mL, 0.104 mL/mL, 0.04 mL/mL, 0.05 mL/mL, 0.019 mg/mg, 40000.0 mg/mL, 0.12 mg/mg, 2.0 %, 4.0 %, 0.114 mg/mg, 1.8 %, 1.5 %, 200.0 mg/mL, 0.00002 mg/mg, 100.0 mg/mL, 0.08 mg/mg, 0.05 mg/mg, 0.05 mg/mL, 0.015 mg/mg, 100.0 mg/mg, 0.03 mg/mg, 0.075 mg/mg, 0.04 mg/mL, 0.004 mg/mg, 2.0 mg/mg, 0.08 mg/mL, 20.0 mg, 20000.0 mg/mL, 80.0 mg/mL, 0.0002 mg/mL, 57.0 mg/mL, 76.0 mg/mL, 50.0 mg/mL, 95.0 mg/mL, 0.0012 mg/mg, 0.0006 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Liquid, Liquid - Topical, Kit, Gel, Gel - Topical, Emulsion, Cutaneous, Lotion - Cutaneous, Solution - Topical, Kit - Topical, Emulsion - Topical, Cream - Cutaneous, Cloth, Cloth - Topical, Solution

Chloasma

0.02 mg/mg, , 0.04 mg/mg, 0.02 mg/mL, 20.0 mg/mL, 0.02 mL/mL, 0.12 mL/mL, 0.0946 mg/mL, 0.1 mg/mg, 0.2 mg/mg, 30.0 mg/mL, 40.0 mg/mL, 0.01695 mg/mg, 0.06 mg/mg, 0.1 mL/mL, 0.104 mL/mL, 0.04 mL/mL, 0.05 mL/mL, 0.019 mg/mg, 40000.0 mg/mL, 0.12 mg/mg, 2.0 %, 4.0 %, 0.114 mg/mg, 1.8 %, 1.5 %, 200.0 mg/mL, 0.00002 mg/mg, 100.0 mg/mL, 0.08 mg/mg, 0.05 mg/mg, 0.05 mg/mL, 0.015 mg/mg, 100.0 mg/mg, 0.03 mg/mg, 0.075 mg/mg, 0.04 mg/mL, 0.004 mg/mg, 2.0 mg/mg, 0.08 mg/mL, 20.0 mg, 20000.0 mg/mL, 80.0 mg/mL, 0.0002 mg/mL, 57.0 mg/mL, 76.0 mg/mL, 50.0 mg/mL, 95.0 mg/mL, 0.0012 mg/mg, 0.0006 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Liquid, Liquid - Topical, Kit, Gel, Gel - Topical, Emulsion, Cutaneous, Lotion - Cutaneous, Solution - Topical, Kit - Topical, Emulsion - Topical, Cream - Cutaneous, Cloth, Cloth - Topical, Solution

Hyperpigmentation

0.02 mg/mg, , 0.04 mg/mg, 0.02 mg/mL, 20.0 mg/mL, 0.02 mL/mL, 0.12 mL/mL, 0.0946 mg/mL, 0.1 mg/mg, 0.2 mg/mg, 30.0 mg/mL, 40.0 mg/mL, 0.01695 mg/mg, 0.06 mg/mg, 0.1 mL/mL, 0.104 mL/mL, 0.04 mL/mL, 0.05 mL/mL, 0.019 mg/mg, 40000.0 mg/mL, 0.12 mg/mg, 2.0 %, 4.0 %, 0.114 mg/mg, 1.8 %, 1.5 %, 200.0 mg/mL, 0.00002 mg/mg, 100.0 mg/mL, 0.08 mg/mg, 0.05 mg/mg, 0.05 mg/mL, 0.015 mg/mg, 100.0 mg/mg, 0.03 mg/mg, 0.075 mg/mg, 0.04 mg/mL, 0.004 mg/mg, 2.0 mg/mg, 0.08 mg/mL, 20.0 mg, 20000.0 mg/mL, 80.0 mg/mL, 0.0002 mg/mL, 57.0 mg/mL, 76.0 mg/mL, 50.0 mg/mL, 95.0 mg/mL, 0.0012 mg/mg, 0.0006 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Liquid, Liquid - Topical, Kit, Gel, Gel - Topical, Emulsion, Cutaneous, Lotion - Cutaneous, Solution - Topical, Kit - Topical, Emulsion - Topical, Cream - Cutaneous, Cloth, Cloth - Topical, Solution

Skin

0.02 mg/mg, , 0.04 mg/mg, 0.02 mg/mL, 20.0 mg/mL, 0.02 mL/mL, 0.12 mL/mL, 0.0946 mg/mL, 0.1 mg/mg, 0.2 mg/mg, 30.0 mg/mL, 40.0 mg/mL, 0.01695 mg/mg, 0.06 mg/mg, 0.1 mL/mL, 0.104 mL/mL, 0.04 mL/mL, 0.05 mL/mL, 0.019 mg/mg, 40000.0 mg/mL, 0.12 mg/mg, 2.0 %, 4.0 %, 0.114 mg/mg, 1.8 %, 1.5 %, 200.0 mg/mL, 0.00002 mg/mg, 100.0 mg/mL, 0.08 mg/mg, 0.05 mg/mg, 0.05 mg/mL, 0.015 mg/mg, 100.0 mg/mg, 0.03 mg/mg, 0.075 mg/mg, 0.04 mg/mL, 0.004 mg/mg, 2.0 mg/mg, 0.08 mg/mL, 20.0 mg, 20000.0 mg/mL, 80.0 mg/mL, 0.0002 mg/mL, 57.0 mg/mL, 76.0 mg/mL, 50.0 mg/mL, 95.0 mg/mL, 0.0012 mg/mg, 0.0006 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Liquid, Liquid - Topical, Kit, Gel, Gel - Topical, Emulsion, Cutaneous, Lotion - Cutaneous, Solution - Topical, Kit - Topical, Emulsion - Topical, Cream - Cutaneous, Cloth, Cloth - Topical, Solution

Chloasma

0.02 mg/mg, , 0.04 mg/mg, 0.02 mg/mL, 20.0 mg/mL, 0.02 mL/mL, 0.12 mL/mL, 0.0946 mg/mL, 0.1 mg/mg, 0.2 mg/mg, 30.0 mg/mL, 40.0 mg/mL, 0.01695 mg/mg, 0.06 mg/mg, 0.1 mL/mL, 0.104 mL/mL, 0.04 mL/mL, 0.05 mL/mL, 0.019 mg/mg, 40000.0 mg/mL, 0.12 mg/mg, 2.0 %, 4.0 %, 0.114 mg/mg, 1.8 %, 1.5 %, 200.0 mg/mL, 0.00002 mg/mg, 100.0 mg/mL, 0.08 mg/mg, 0.05 mg/mg, 0.05 mg/mL, 0.015 mg/mg, 100.0 mg/mg, 0.03 mg/mg, 0.075 mg/mg, 0.04 mg/mL, 0.004 mg/mg, 2.0 mg/mg, 0.08 mg/mL, 20.0 mg, 20000.0 mg/mL, 80.0 mg/mL, 0.0002 mg/mL, 57.0 mg/mL, 76.0 mg/mL, 50.0 mg/mL, 95.0 mg/mL, 0.0012 mg/mg, 0.0006 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Liquid, Liquid - Topical, Kit, Gel, Gel - Topical, Emulsion, Cutaneous, Lotion - Cutaneous, Solution - Topical, Kit - Topical, Emulsion - Topical, Cream - Cutaneous, Cloth, Cloth - Topical, Solution

Aging

0.02 mg/mg, , 0.04 mg/mg, 0.02 mg/mL, 20.0 mg/mL, 0.02 mL/mL, 0.12 mL/mL, 0.0946 mg/mL, 0.1 mg/mg, 0.2 mg/mg, 30.0 mg/mL, 40.0 mg/mL, 0.01695 mg/mg, 0.06 mg/mg, 0.1 mL/mL, 0.104 mL/mL, 0.04 mL/mL, 0.05 mL/mL, 0.019 mg/mg, 40000.0 mg/mL, 0.12 mg/mg, 2.0 %, 4.0 %, 0.114 mg/mg, 1.8 %, 1.5 %, 200.0 mg/mL, 0.00002 mg/mg, 100.0 mg/mL, 0.08 mg/mg, 0.05 mg/mg, 0.05 mg/mL, 0.015 mg/mg, 100.0 mg/mg, 0.03 mg/mg, 0.075 mg/mg, 0.04 mg/mL, 0.004 mg/mg, 2.0 mg/mg, 0.08 mg/mL, 20.0 mg, 20000.0 mg/mL, 80.0 mg/mL, 0.0002 mg/mL, 57.0 mg/mL, 76.0 mg/mL, 50.0 mg/mL, 95.0 mg/mL, 0.0012 mg/mg, 0.0006 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Liquid, Liquid - Topical, Kit, Gel, Gel - Topical, Emulsion, Cutaneous, Lotion - Cutaneous, Solution - Topical, Kit - Topical, Emulsion - Topical, Cream - Cutaneous, Cloth, Cloth - Topical, Solution

Acne Vulgaris

0.02 mg/mg, , 0.04 mg/mg, 0.02 mg/mL, 20.0 mg/mL, 0.02 mL/mL, 0.12 mL/mL, 0.0946 mg/mL, 0.1 mg/mg, 0.2 mg/mg, 30.0 mg/mL, 40.0 mg/mL, 0.01695 mg/mg, 0.06 mg/mg, 0.1 mL/mL, 0.104 mL/mL, 0.04 mL/mL, 0.05 mL/mL, 0.019 mg/mg, 40000.0 mg/mL, 0.12 mg/mg, 2.0 %, 4.0 %, 0.114 mg/mg, 1.8 %, 1.5 %, 200.0 mg/mL, 0.00002 mg/mg, 100.0 mg/mL, 0.08 mg/mg, 0.05 mg/mg, 0.05 mg/mL, 0.015 mg/mg, 100.0 mg/mg, 0.03 mg/mg, 0.075 mg/mg, 0.04 mg/mL, 0.004 mg/mg, 2.0 mg/mg, 0.08 mg/mL, 20.0 mg, 20000.0 mg/mL, 80.0 mg/mL, 0.0002 mg/mL, 57.0 mg/mL, 76.0 mg/mL, 50.0 mg/mL, 95.0 mg/mL, 0.0012 mg/mg, 0.0006 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Liquid, Liquid - Topical, Kit, Gel, Gel - Topical, Emulsion, Cutaneous, Lotion - Cutaneous, Solution - Topical, Kit - Topical, Emulsion - Topical, Cream - Cutaneous, Cloth, Cloth - Topical, Solution

Hormone Disturbance

0.02 mg/mg, , 0.04 mg/mg, 0.02 mg/mL, 20.0 mg/mL, 0.02 mL/mL, 0.12 mL/mL, 0.0946 mg/mL, 0.1 mg/mg, 0.2 mg/mg, 30.0 mg/mL, 40.0 mg/mL, 0.01695 mg/mg, 0.06 mg/mg, 0.1 mL/mL, 0.104 mL/mL, 0.04 mL/mL, 0.05 mL/mL, 0.019 mg/mg, 40000.0 mg/mL, 0.12 mg/mg, 2.0 %, 4.0 %, 0.114 mg/mg, 1.8 %, 1.5 %, 200.0 mg/mL, 0.00002 mg/mg, 100.0 mg/mL, 0.08 mg/mg, 0.05 mg/mg, 0.05 mg/mL, 0.015 mg/mg, 100.0 mg/mg, 0.03 mg/mg, 0.075 mg/mg, 0.04 mg/mL, 0.004 mg/mg, 2.0 mg/mg, 0.08 mg/mL, 20.0 mg, 20000.0 mg/mL, 80.0 mg/mL, 0.0002 mg/mL, 57.0 mg/mL, 76.0 mg/mL, 50.0 mg/mL, 95.0 mg/mL, 0.0012 mg/mg, 0.0006 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Liquid, Liquid - Topical, Kit, Gel, Gel - Topical, Emulsion, Cutaneous, Lotion - Cutaneous, Solution - Topical, Kit - Topical, Emulsion - Topical, Cream - Cutaneous, Cloth, Cloth - Topical, Solution

Solar Elastosis

0.02 mg/mg, , 0.04 mg/mg, 0.02 mg/mL, 20.0 mg/mL, 0.02 mL/mL, 0.12 mL/mL, 0.0946 mg/mL, 0.1 mg/mg, 0.2 mg/mg, 30.0 mg/mL, 40.0 mg/mL, 0.01695 mg/mg, 0.06 mg/mg, 0.1 mL/mL, 0.104 mL/mL, 0.04 mL/mL, 0.05 mL/mL, 0.019 mg/mg, 40000.0 mg/mL, 0.12 mg/mg, 2.0 %, 4.0 %, 0.114 mg/mg, 1.8 %, 1.5 %, 200.0 mg/mL, 0.00002 mg/mg, 100.0 mg/mL, 0.08 mg/mg, 0.05 mg/mg, 0.05 mg/mL, 0.015 mg/mg, 100.0 mg/mg, 0.03 mg/mg, 0.075 mg/mg, 0.04 mg/mL, 0.004 mg/mg, 2.0 mg/mg, 0.08 mg/mL, 20.0 mg, 20000.0 mg/mL, 80.0 mg/mL, 0.0002 mg/mL, 57.0 mg/mL, 76.0 mg/mL, 50.0 mg/mL, 95.0 mg/mL, 0.0012 mg/mg, 0.0006 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Liquid, Liquid - Topical, Kit, Gel, Gel - Topical, Emulsion, Cutaneous, Lotion - Cutaneous, Solution - Topical, Kit - Topical, Emulsion - Topical, Cream - Cutaneous, Cloth, Cloth - Topical, Solution

Warnings

Tri-Luma Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Common Tri-Luma Drug Interactions

Drug Name

Risk Level

Description

image of a doctor in a lab doing drug, clinical research

Tri-Luma Novel Uses: Which Conditions Have a Clinical Trial Featuring Tri-Luma?

176 active clinical trials are currently exploring the potential of Tri-Luma to alleviate Melasma, Solar Elastosis and Acne.

Condition

Clinical Trials

Trial Phases

Skin

0 Actively Recruiting

Hyperpigmentation

0 Actively Recruiting

Chloasma

0 Actively Recruiting

Melanosis

0 Actively Recruiting

Chloasma

0 Actively Recruiting

Solar Elastosis

1 Actively Recruiting

Not Applicable

Sunburn

0 Actively Recruiting

Hormone Disturbance

0 Actively Recruiting

Acne Vulgaris

2 Actively Recruiting

Phase 1, Phase 2, Early Phase 1

Aging

147 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Early Phase 1, Phase 1, Phase 4

Tri-Luma Reviews: What are patients saying about Tri-Luma?

5

Patient Review

9/6/2013

Tri-Luma for Yellow-Brown Patches on Skin

This cream was on the pricey side, but it delivered great results. I started peeling a little and my face felt a little sensitive like there was a mild burning sensation but nothing too drastic.

5

Patient Review

4/28/2015

Tri-Luma for Yellow-Brown Patches on Skin

I'm so happy I decided to go to the dermatologist and figure out what was going on with my face. In just four weeks, this product has given me back my confidence. I can't believe how well it works! Thank you so much for developing this amazing treatment.

5

Patient Review

11/5/2015

Tri-Luma for Yellow-Brown Patches on Skin

Tri Luma was able to effectively clear up my melasma in just two months. I'm now confident enough to go without makeup entirely.

5

Patient Review

7/7/2014

Tri-Luma for Yellow-Brown Patches on Skin

This stuff is amazing and works exactly as advertised. In a few weeks, my sunspots were totally gone. I highly recommend this to anyone with facial discoloration issues.

5

Patient Review

8/1/2015

Tri-Luma for Yellow-Brown Patches on Skin

Tri-Luma has been a total lifesaver for me. I had gotten to the point where I was really self-conscious about the melasma on my upper lip, but this cream has made such a difference in just a couple of weeks. I can almost go makeup-free now, and there's no irritation or side effects that I've noticed.

3

Patient Review

9/25/2013

Tri-Luma for Yellow-Brown Patches on Skin

I used this cream on and off for a year. While it did help with my melasma, it also made my skin very red and thin. I stopped using it and the melasma came back immediately. This is not a permanent cure; don't use it long term because of the bad side effects.

3

Patient Review

4/21/2018

Tri-Luma for Yellow-Brown Patches on Skin

I'm an older woman with melasma on my forehead. I had given up hope that anything could improve the condition, but this treatment has shown some promise in just a week of use. There's still more progress to be made, but I'm cautiously optimistic.

2.3

Patient Review

12/30/2013

Tri-Luma for Yellow-Brown Patches on Skin

I am a medium complexion African American female. I started using this product six months ago to target brown spots, but they have actually gotten larger since then. Needless to say, I'll be discontinuing use and consulting my dermatologist for other options.

2

Patient Review

12/13/2015

Tri-Luma for Yellow-Brown Patches on Skin

Triluma was effective for my melasma in the short term, but unfortunately it came back even darker once I stopped using the treatment.

1.7

Patient Review

12/30/2017

Tri-Luma for Yellow-Brown Patches on Skin

I would not recommend this treatment to anyone. Not only is it expensive, but it also made my skin red and irritated. I followed the instructions to a T, and after two months of use, I can say with certainty that this cream does nothing but burn your skin. Folic acid is a much cheaper and more effective alternative.

1.3

Patient Review

9/22/2016

Tri-Luma for Yellow-Brown Patches on Skin

I used this product for seven weeks as directed, and saw no change in the skin above my upper lip. very disappointed, especially given the high cost of the treatment.

1

Patient Review

11/23/2014

Tri-Luma for Yellow-Brown Patches on Skin

At first, this product lightened my dark spots significantly. However, as soon as I stopped using it, the brown spots not only returned but were darker than before.

1

Patient Review

4/24/2022

Tri-Luma for Yellow-Brown Patches on Skin

I was very disappointed with this treatment. I followed the doctor's orders perfectly, but instead of getting better, my condition got much worse. Now I have to wear makeup to cover up the dark patches on my forehead that this treatment caused.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tri-luma

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of Tri-Luma?

"You may experience a mild burning, stinging, redness, dryness, tingling, itching, swelling, or peeling of your skin. You may also develop a rash, acne, or skin bumps or blisters."

Answered by AI

Is Tri-Luma the same as hydroquinone?

"The medication Fluocinolone/Tretinoin/Hydroquinone is sold under the brand name Tri-Luma."

Answered by AI

How long does it take for Tri-Luma to work?

"Although you may not see significant improvement for up to 4 weeks, this medication is not recommended for long-term use without taking breaks. If your condition does not improve after 4 weeks of treatment, inform your doctor."

Answered by AI

What is TRI-LUMA Cream good for?

"Hydroquinone 4% is a skin-lightening agent that inhibits melanin production. Tretinoin 0.05% is a retinoid that promotes skin cell turnover and clears plugged hair follicles.

Tri-Luma® Cream is a unique triple-combination topical therapy that is used for the short-term treatment of dark spots that are associated with moderate to severe facial melasma. Fluocinolone acetonide 0.01% is a mild corticosteroid that helps to reduce inflammation. Hydroquinone 4% is a skin-lightening agent that inhibits melanin production. Tretinoin 0.05% is a retinoid that promotes skin cell turnover and clears plugged hair follicles."

Answered by AI

Clinical Trials for Tri-Luma

Image of AIM for Wellbeing in Cincinnati, United States.

Rapamycin + Prolon Diet for Aging

18+
All Sexes
Cincinnati, OH

Aging can be defined as a time-dependent functional decline in physiological function, which may increase the vulnerability to diseases and eventually death. The question is whether aging is a normal process, or exists as an "uber-illness?" Work done by Dr Sinclair at Harvard suggests the latter. Dr. Sinclair feels people should be able to age-in-place, or even reverse age. Aging is arguably the single biggest risk factor for all acquired and chronic diseases. Delaying the aging rate by 7 years would cut the incidence of chronic disease in half! Up until know the effects of anti-aging would need longitudinal studies until death. Now, with the advent of a 3rd generation OMIC Age clock, there is a way to assess if an intervention is changing the rate of aging and other methylation patterns associated with aging.

Phase < 1
Waitlist Available

AIM for Wellbeing

Image of Potocsnak Human Longevity Lab in Chicago, United States.

Positive Emotion Skills for Healthy Aging

40 - 70
All Sexes
Chicago, IL

This randomized control study is designed to understand the role of a positive psychology intervention (PARK: Positive Affect Regulation sKills) in biological aging and well-being. PARK provides a series of positive emotion skills in a self-guided online format, making the program accessible and convenient. Our main aims are: Aim 1: To explore the effects of PARK on psychological well-being (e.g., depression, anxiety, positive affect). Aim 2: To explore the effects of PARK on biological age as defined by DNA methylation (DNAm) GrimAge and electrocardiogram-age (ECG-age), as well as physiological well-being in adults (e.g., cardiovascular, endocrine, musculoskeletal functioning, etc.).

Recruiting
Has No Placebo

Potocsnak Human Longevity Lab

Image of University of Texas Medical Branch, Galveston in Galveston, United States.

Smartphone App for Cognitive Impairment

50 - 100
All Sexes
Galveston, TX

The objective of this project is to test the feasibility of using a smartphone app in a community setting through collaborating with community-based organizations. The app is called utmbHealthyBrain and it has three activities: (1) drawing, (2) Tai-Chi and meditation, and (3) prayer reading. It also has a "share" function to enable users to interact with their family and friend. These activities can be translated to humans' well-beings such as a more stable emotion, more muscle movement, and better social engagement. This app does not collect any personal data and users are not required to register an account either. The overall study period is 6 weeks including one introduction session (week 1), four weeks of intervention (week 2 to 5), and final feedback session (week 6).

Waitlist Available
Has No Placebo

University of Texas Medical Branch, Galveston

Wei-Chen Lee, PhD

Image of The University of Alabama at Birmingham in Birmingham, United States.

Behavioral vs Mindfulness Treatments for Insomnia in HIV

50 - 99
All Sexes
Birmingham, AL

The goal of this clinical trial is to examine the effects of a telephone-delivered Brief Behavioral Treatment Insomnia (BBTI) versus a Brief Mindfulness Treatment (BMT) on cognitive and sleep outcomes in older adults with HIV. The main questions it aims to answer are: What are the effects of BBTI vs BMT on self-reported and observed sleep outcomes in older adults with HIV and insomnia up to 1-year post-intervention? What are the effects of BBTI vs BMT on self-reported and observed cognitive comes in older adults with HIV and insomnia up to 1-year post-intervention? What is the association between Alzheimer's Disease biomarkers and sleep and cognitive outcomes in older adults with HIV receiving BBTI vs BMT? Participants will: * Complete 4 weeks of telephone-delivered BBTI or BMT * Attend baseline, post-intervention, and 1-year post in-person visits for sleep and cognitive assessments * Have blood collected at all three time points

Waitlist Available
Has No Placebo

The University of Alabama at Birmingham (+1 Sites)

Dr. Shameka L Cody, PhD, AGNP-C, PMHNP-BC, FAAN

Have you considered Tri-Luma clinical trials?

We made a collection of clinical trials featuring Tri-Luma, we think they might fit your search criteria.
Go to Trials

Have you considered Tri-Luma clinical trials?

We made a collection of clinical trials featuring Tri-Luma, we think they might fit your search criteria.
Go to Trials
Image of UConn Health in Farmington, United States.

Cognitive Remediation for Memory and Thinking Difficulties

18+
All Sexes
Farmington, CT

The goal of this clinical trial is to determine if a neuroscience-based computerized cognitive remediation ("brain training") program can treat neurocognitive dysfunction (i.e., memory or thinking difficulties) that emerges in some older adults following a viral infection. The main questions it aims to answer are: * Does computerized cognitive remediation improve cognitive performance and day-to-day functioning in older adults with postviral neurocognitive dysfunction? * Will treatment effects be maintained over time, leading to better long term cognitive outcomes? * Does the treatment lead to reductions in blood-based markers of inflammation as a potential mechanism of cognitive symptom improvement? * Can the treatment be optimized and refined based on feedback from participants to improve user (patient) experience? Researchers will compare the computerized cognitive remediation program to an active computer-based control condition (alternative computer activities) to see if the computerized cognitive remediation program works to treat postviral neurocognitive dysfunction. Participation takes approximately 43-48 hours over 7 months, with most activities (40-46 hours) completed within the first 7-8 weeks, including: * Initial intake visit: Eligibility confirmation (\~2-3 hours) * Computer activities: About 5 hours per week for \~6 weeks (total \~30 hours) completed on a computer tablet provided by the study and loaned to participants for use during the treatment phase * Weekly remote check-in meetings: \~30 minutes each during treatment * Blood draws: Two sessions (before and after treatment), \~20-30 minutes each * Three research visits: Pre-treatment, post-treatment, and 6-month follow-up (\~2-3 hours each, including assessments of cognitive, emotional, and daily functioning)

Waitlist Available
Has No Placebo

UConn Health

Cutter Lindbergh, Ph.D.

Image of University of Illinois at Chicago in Chicago, United States.

Cognitive-Motor Training for Mild Cognitive Impairment

55 - 95
All Sexes
Chicago, IL

Alzheimer's disease and related dementias (AD/ADRD) greatly affect memory and daily activities in older adults. Mild Cognitive Impairment (MCI) is an early stage of dementia, affecting about 17% of older adults. People with MCI often show problems with gait and balance, which doubles their risk of falling compared to cognitively healthy peers. Falls can cause injuries, increase sedentary behavior, and reduce physical activity. This decline in activity can also speed up the progression from MCI to dementia. Exercise can help older adults make healthy lifestyle changes; however, most of the existing exercise programs focus mainly on physical movement rather than cognitive function. Therefore, we developed a new program that uses computer vision and a cloud-based system to provide more scalable, engaging, and personalized cognitive-motor training for OAwMCI. The purpose of this study is to investigate the short- and long-term effects of a novel CogXergaming training (CXT) paradigm for improving the cognitive-motor function, physical activity, falls efficacy, and quality of life.

Waitlist Available
Has No Placebo

University of Illinois at Chicago

Shuaijie Wang, PhD

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