Treanda

Multiple Myeloma, B-Cell Lymphomas, Chronic Lymphocytic Leukemia + 4 more
Treatment
20 Active Studies for Treanda

What is Treanda

BendamustineThe Generic name of this drug
Treatment SummaryBendamustine is a medication used in treating chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) when the cancer has not responded to treatment with rituximab or a rituximab-containing regimen. Bendamustine works by forming bonds between molecules that lead to cell death. Its exact mechanism of action is not known, but it is effective against both active and inactive cells.
Treandais the brand name
image of different drug pills on a surface
Treanda Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Treanda
Bendamustine
2008
16

Effectiveness

How Treanda Affects PatientsThe study found that there were no significant changes in the QTc interval (a measure of the time between the start of the heart's electrical activity and the end of it) up to an hour after administration.
How Treanda works in the bodyBendamustine is a drug that can form strong chemical bonds to molecules. It uses this ability to create links between DNA bases, which leads to the death of cells. Bendamustine works on both active and inactive cells, but exactly how it causes cell death is unknown.

When to interrupt dosage

The proposed measure of Treanda is reliant upon the recognized illness, including B-Cell Lymphomas, Multiple Myeloma and Lymphoma, Follicular. The amount likewise changes in accordance with the technique of delivery (e.g. Injection or Injection, solution) specified in the table beneath.
Condition
Dosage
Administration
B-Cell Lymphomas
, 25.0 mg, 100.0 mg, 25.0 mg/mL, 10.0 mg/mL, 450.0 mg/mL, 180.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
Hodgkin Disease
, 25.0 mg, 100.0 mg, 25.0 mg/mL, 10.0 mg/mL, 450.0 mg/mL, 180.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
Lymphoma, Follicular
, 25.0 mg, 100.0 mg, 25.0 mg/mL, 10.0 mg/mL, 450.0 mg/mL, 180.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
Lymphoma, Mantle-Cell
, 25.0 mg, 100.0 mg, 25.0 mg/mL, 10.0 mg/mL, 450.0 mg/mL, 180.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
Waldenstrom Macroglobulinemia
, 25.0 mg, 100.0 mg, 25.0 mg/mL, 10.0 mg/mL, 450.0 mg/mL, 180.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
Multiple Myeloma
, 25.0 mg, 100.0 mg, 25.0 mg/mL, 10.0 mg/mL, 450.0 mg/mL, 180.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
Chronic Lymphocytic Leukemia
, 25.0 mg, 100.0 mg, 25.0 mg/mL, 10.0 mg/mL, 450.0 mg/mL, 180.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous

Warnings

Treanda Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Treanda.
Common Treanda Drug Interactions
Drug Name
Risk Level
Description
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Bendamustine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Acteoside
Major
The risk or severity of adverse effects can be increased when Bendamustine is combined with Acteoside.
Antilymphocyte immunoglobulin (horse)
Major
The risk or severity of adverse effects can be increased when Bendamustine is combined with Antilymphocyte immunoglobulin (horse).
Bacillus calmette-guerin substrain russian BCG-I live antigen
Major
The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Bendamustine.
Baricitinib
Major
The risk or severity of adverse effects can be increased when Bendamustine is combined with Baricitinib.
Treanda Toxicity & Overdose RiskPeople taking this drug may develop tumor-lysis syndrome. Skin reactions, infections, or allergic reactions may occur. It is not recommended for those with kidney or liver problems, and pregnant women should avoid use. In rare cases, severe allergic reactions or infusion reactions may occur.
image of a doctor in a lab doing drug, clinical research

Treanda Novel Uses: Which Conditions Have a Clinical Trial Featuring Treanda?

214 active clinical trials are presently assessing the potential of Treanda to aid in the management of Multiple Myeloma, Waldenstrom Macroglobulinemia and Chronic Lymphocytic Leukemia.
Condition
Clinical Trials
Trial Phases
Chronic Lymphocytic Leukemia
143 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Lymphoma, Mantle-Cell
0 Actively Recruiting
Multiple Myeloma
0 Actively Recruiting
Waldenstrom Macroglobulinemia
7 Actively Recruiting
Phase 2, Phase 1
B-Cell Lymphomas
0 Actively Recruiting
Lymphoma, Follicular
0 Actively Recruiting
Hodgkin Disease
2 Actively Recruiting
Phase 2, Phase 1

Treanda Reviews: What are patients saying about Treanda?

5Patient Review
10/26/2012
Treanda for Chronic Lymphoid Leukemia
I started my CLL treatment with Treanda and Rituxan. My WBC count was 383. After four rounds of Treanda with Rituxan, I'm down to WBC of 5. Minimal side effects. It's been good!
4.7Patient Review
2/25/2010
Treanda for Indolent B-Cell Non-Hodgkin Lymphoma
I've had three two-day treatments thus far and my white blood cell counts have been low. I'm waiting for them to come back up, but other than that, this drug hasn't caused me much trouble other than some fatigue. It really helps to drink lots of water though- six to ten bottles a day.
4.7Patient Review
4/6/2010
Treanda for Indolent B-Cell Non-Hodgkin Lymphoma
The first three treatments weren't too bad. I only experienced nausea for a day and a half, and fatigue for five to seven days afterward. However, after my fourth treatment I needed the neulasta shot because my counts weren't recovering. Also, the fatigue held on for almost three weeks after that fourth treatment. Even though it was tough, I still functioned fine-- just not as enthusiastically. So far no mouth sores or hair loss, but I have two more treatments to go. We did a scan before my third treatment and there was no sign of disease, so it seems to be working well.
4Patient Review
7/16/2009
Treanda for Chronic Lymphoid Leukemia
Please be cautious and do not take this medication if you are also taking allopurinol. Unfortunately, there has been at least one reported death from Stephens Johnson Syndrome as a result of taking the two together.
3.7Patient Review
10/4/2013
Treanda for Follicular Lymphoma
The first treatment helped a lot by reducing the size of my lymph node. However, after the fourth treatment I started to experience a rash that spread from my legs to my torso and arms. The steroid cream and benedryl help somewhat, but I'm worried about the fifth and sixth treatments.
View All Reviews
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Patient Q&A Section about treanda

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Treanda used for?

"This medication is used to treat certain types of cancer, such as lymphoma and chronic lymphocytic leukemia (CLL). Bendamustine belongs to a class of cancer chemotherapy drugs known as alkylating agents. These drugs work by killing cancer cells or slowing their growth."

Answered by AI

Is Treanda a chemo drug?

"Chemotherapy drugs work by destroying rapidly growing cells in the body. Treanda is a kind of chemotherapy known as an alkylating agent."

Answered by AI

What is the difference between Bendeka and Treanda?

"Teva replaced Treanda with Bendeka in 2016 because Bendeka is compatible with polycarbonate or acrylonitrile-butadiene-styrene (ABS)-containing infusion equipment, and Treanda was not. Bendeka also has a shorter infusion time. Bendeka has the same indications for use and side effects as Treanda."

Answered by AI

How is Treanda administered?

"The recommended dosage for CLL is 100 mg/m2 given intravenously over 30 minutes on Days 1 and 2 of a 28-day cycle, for up to 6 cycles."

Answered by AI

Clinical Trials for Treanda

Have you considered Treanda clinical trials? We made a collection of clinical trials featuring Treanda, we think they might fit your search criteria.
Have you considered Treanda clinical trials? We made a collection of clinical trials featuring Treanda, we think they might fit your search criteria.
Have you considered Treanda clinical trials? We made a collection of clinical trials featuring Treanda, we think they might fit your search criteria.