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What is Treanda
BendamustineThe Generic name of this drug
Treatment SummaryBendamustine is a medication used in treating chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) when the cancer has not responded to treatment with rituximab or a rituximab-containing regimen. Bendamustine works by forming bonds between molecules that lead to cell death. Its exact mechanism of action is not known, but it is effective against both active and inactive cells.
Treandais the brand name
Treanda Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Treanda
Bendamustine
2008
16
Effectiveness
How Treanda Affects PatientsThe study found that there were no significant changes in the QTc interval (a measure of the time between the start of the heart's electrical activity and the end of it) up to an hour after administration.
How Treanda works in the bodyBendamustine is a drug that can form strong chemical bonds to molecules. It uses this ability to create links between DNA bases, which leads to the death of cells. Bendamustine works on both active and inactive cells, but exactly how it causes cell death is unknown.
When to interrupt dosage
The proposed measure of Treanda is reliant upon the recognized illness, including B-Cell Lymphomas, Multiple Myeloma and Lymphoma, Follicular. The amount likewise changes in accordance with the technique of delivery (e.g. Injection or Injection, solution) specified in the table beneath.Condition
Dosage
Administration
Chronic Lymphocytic Leukemia
, 25.0 mg, 100.0 mg, 25.0 mg/mL, 10.0 mg/mL, 450.0 mg/mL, 180.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
Refractory Mantle Cell Lymphoma
, 25.0 mg, 100.0 mg, 25.0 mg/mL, 10.0 mg/mL, 450.0 mg/mL, 180.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
Multiple Myeloma
, 25.0 mg, 100.0 mg, 25.0 mg/mL, 10.0 mg/mL, 450.0 mg/mL, 180.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
Waldenstrom Macroglobulinemia
, 25.0 mg, 100.0 mg, 25.0 mg/mL, 10.0 mg/mL, 450.0 mg/mL, 180.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
Lymphoma, Follicular
, 25.0 mg, 100.0 mg, 25.0 mg/mL, 10.0 mg/mL, 450.0 mg/mL, 180.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
B-Cell Lymphomas
, 25.0 mg, 100.0 mg, 25.0 mg/mL, 10.0 mg/mL, 450.0 mg/mL, 180.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
Hodgkin Disease
, 25.0 mg, 100.0 mg, 25.0 mg/mL, 10.0 mg/mL, 450.0 mg/mL, 180.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous
Warnings
Treanda ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Treanda Drug Interactions
Drug Name
Risk Level
Description
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Bendamustine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Acteoside
Major
The risk or severity of adverse effects can be increased when Bendamustine is combined with Acteoside.
Antilymphocyte immunoglobulin (horse)
Major
The risk or severity of adverse effects can be increased when Bendamustine is combined with Antilymphocyte immunoglobulin (horse).
Bacillus calmette-guerin substrain russian BCG-I live antigen
Major
The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Bendamustine.
Baricitinib
Major
The risk or severity of adverse effects can be increased when Bendamustine is combined with Baricitinib.
Treanda Toxicity & Overdose RiskPeople taking this drug may develop tumor-lysis syndrome. Skin reactions, infections, or allergic reactions may occur. It is not recommended for those with kidney or liver problems, and pregnant women should avoid use. In rare cases, severe allergic reactions or infusion reactions may occur.
Treanda Novel Uses: Which Conditions Have a Clinical Trial Featuring Treanda?
214 active clinical trials are presently assessing the potential of Treanda to aid in the management of Multiple Myeloma, Waldenstrom Macroglobulinemia and Chronic Lymphocytic Leukemia.Condition
Clinical Trials
Trial Phases
Lymphoma, Follicular
0 Actively Recruiting
B-Cell Lymphomas
0 Actively Recruiting
Multiple Myeloma
0 Actively Recruiting
Chronic Lymphocytic Leukemia
164 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3
Waldenstrom Macroglobulinemia
8 Actively Recruiting
Phase 2, Phase 1
Hodgkin Disease
17 Actively Recruiting
Phase 1, Phase 2, Early Phase 1
Refractory Mantle Cell Lymphoma
26 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Treanda Reviews: What are patients saying about Treanda?
5Patient Review
10/26/2012 I started my CLL treatment with Treanda and Rituxan. My WBC count was 383. After four rounds of Treanda with Rituxan, I'm down to WBC of 5. Minimal side effects. It's been good!
4.7Patient Review
2/25/2010 I've had three two-day treatments thus far and my white blood cell counts have been low. I'm waiting for them to come back up, but other than that, this drug hasn't caused me much trouble other than some fatigue. It really helps to drink lots of water though- six to ten bottles a day.
4.7Patient Review
4/6/2010 The first three treatments weren't too bad. I only experienced nausea for a day and a half, and fatigue for five to seven days afterward. However, after my fourth treatment I needed the neulasta shot because my counts weren't recovering. Also, the fatigue held on for almost three weeks after that fourth treatment. Even though it was tough, I still functioned fine-- just not as enthusiastically. So far no mouth sores or hair loss, but I have two more treatments to go. We did a scan before my third treatment and there was no sign of disease, so it seems to be working well.
4Patient Review
7/16/2009 Please be cautious and do not take this medication if you are also taking allopurinol. Unfortunately, there has been at least one reported death from Stephens Johnson Syndrome as a result of taking the two together.
3.7Patient Review
10/4/2013 The first treatment helped a lot by reducing the size of my lymph node. However, after the fourth treatment I started to experience a rash that spread from my legs to my torso and arms. The steroid cream and benedryl help somewhat, but I'm worried about the fifth and sixth treatments.
3.7Patient Review
4/30/2014 This medication is effective, but I am experiencing significant side effects involving my gastrointestinal system. These include severe GERD and bowel issues.
3.3Patient Review
4/30/2009 The only issue I had with this was increased urination at night, which led to some sleepless nights.
3.3Patient Review
6/14/2010 After each of the first two treatments, I felt incredibly exhausted to the point where I would fall asleep sitting up. It was hard to manage since I didn't know this was going to be a common side effect. Thankfully, treatments are only every three weeks and only last for an hour.
3.3Patient Review
7/18/2013 My platelets were the issue and after two treatments they're up 52 from 10. My white blood cell count is down to 5 from 13. I had some burning in my arm during the IV, but this week my arm has just been sore to the touch. Hoping for the best.
3.3Patient Review
8/25/2015 After four treatments (out of the six required), I experienced diarrhea. Has anyone else had this side effect?
3Patient Review
5/14/2009 The biggest side effect I have experienced is extreme fatigue. The first treatment took about one week to recover; the second treatment has taken almost two weeks. I will find out next week if I will have a 3rd. The first Neulasta shot gave me spasms of pain controlled by Tylenol. The second was insignificant as far as side effects go but kept my counts up. I have had slight nausea, loss of appetite with the Treanda and hope the scans next week prove it is working.
3Patient Review
7/9/2011 I've only been on this medication for a few days, but I can already tell it's working better than the chemo I was on in 2005.
2.7Patient Review
8/13/2008 I experienced a lot of mouth sores which made it hard to do everyday activities or even get a good night's sleep.
Patient Q&A Section about treanda
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Treanda used for?
"This medication is used to treat certain types of cancer, such as lymphoma and chronic lymphocytic leukemia (CLL). Bendamustine belongs to a class of cancer chemotherapy drugs known as alkylating agents. These drugs work by killing cancer cells or slowing their growth."
Answered by AI
Is Treanda a chemo drug?
"Chemotherapy drugs work by destroying rapidly growing cells in the body. Treanda is a kind of chemotherapy known as an alkylating agent."
Answered by AI
What is the difference between Bendeka and Treanda?
"Teva replaced Treanda with Bendeka in 2016 because Bendeka is compatible with polycarbonate or acrylonitrile-butadiene-styrene (ABS)-containing infusion equipment, and Treanda was not. Bendeka also has a shorter infusion time. Bendeka has the same indications for use and side effects as Treanda."
Answered by AI
How is Treanda administered?
"The recommended dosage for CLL is 100 mg/m2 given intravenously over 30 minutes on Days 1 and 2 of a 28-day cycle, for up to 6 cycles."
Answered by AI