Topamax

Tonic - clonic seizures, BMI >27 kg/m2, Epilepsy + 15 more

Treatment

20 Active Studies for Topamax

Treatment for

Tonic - clonic seizures

What is Topamax

TopiramateThe Generic name of this drug

Treatment SummaryTopiramate is a medication used to control seizures and prevent migraines in adults. It was approved by the FDA in 1996 and is made up of oxygen and a monosaccharide chemical structure with a sulfamate. It was originally created as an experimental diabetes drug but was found to also be effective in controlling seizures and preventing migraines. In 2012, an extended-release formula was approved for weight management in adults, when combined with phentermine.

Topamaxis the brand name

Topamax Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Topamax

Topiramate

1997

524

Effectiveness

How Topamax Affects PatientsTopiramate is an effective anti-seizure and migraine prevention drug, but it can have serious side effects. It can cause metabolic acidosis, changes in mood, suicidal thoughts and behaviors, as well as kidney stones. Taking it with valproic acid can lead to hypothermia.

How Topamax works in the bodySeizures and migraines are caused by an abnormal electrical discharge in the brain. Topiramate works by blocking this discharge. It does this by increasing the activity of GABA-A receptors, which are inhibitory to neuronal activity, and reducing the activity of glutamate receptors, which are stimulatory. Furthermore, it blocks voltage-dependent sodium channels, further blocking seizure activity. It also inhibits certain carbonic anhydrase isozymes, though the clinical significance of this is unknown.

When to interrupt dosage

The proposed measure of Topamax is contingent upon the diagnosed illness, including Seizures, Weight Reduction and Tonic - clonic seizures. The measure of dosage is dependent on the technique of delivery (e.g. Tablet, coated or Tablet) featured in the table underneath.

Condition

Dosage

Administration

Weight Reduction

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

Seizures

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

Tonic - clonic seizures

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

BMI >27 kg/m2

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

Epilepsy

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

Mood Disorders

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

at least one weight-related comorbid condition

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

Alcoholism

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

Lennox Gastaut Syndrome (LGS)

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

Obesity

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

prophylaxis of migraine headaches

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

High cholesterol

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

Hypertensive disease

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

Weight

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

Type 2 Diabetes

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

Calorie Restriction

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

Migraine

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

Exercise

25.0 mg/mL, , 50.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 25.0 mg, 69.0 mg, 92.0 mg, 23.0 mg, 46.0 mg, 15.0 mg, 25.0 meq

Tablet, coated, Tablet, Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets - Oral, Tablet - Oral, Capsule, Tablet, coated - Oral, , Tablet, film coated - Oral, Capsule, coated pellets, Tablet, film coated, Solution - Oral, Capsule - Oral, Solution

Warnings

Topamax Contraindications

Condition

Risk Level

Notes

Metabolic Acidosis

Do Not Combine

There are 20 known major drug interactions with Topamax.

Common Topamax Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Topiramate.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Topiramate.

Acenocoumarol

Major

The metabolism of Acenocoumarol can be increased when combined with Topiramate.

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Topiramate.

Alpelisib

Major

The metabolism of Alpelisib can be increased when combined with Topiramate.

Topamax Toxicity & Overdose RiskThe highest amount of topiramate that is non-toxic to rats is 1500mg/kg. A study of 4 women taking topiramate found that overdose symptoms could range from mild to severe, with no reported deaths. Possible effects of an overdose include low blood pressure, severe acidosis, dizziness, coma, convulsions, confusion, and depression. If someone recently ingested topiramate, a doctor may recommend inducing vomiting, using activated charcoal, and undergoing hemodialysis.

Topamax Novel Uses: Which Conditions Have a Clinical Trial Featuring Topamax?

313 active trials are currently being conducted to explore the potential of Topamax in treating Type 2 Diabetes, Migraine and Exercise-induced symptoms.

Condition

Clinical Trials

Trial Phases

Exercise

57 Actively Recruiting

Phase 1, Not Applicable, Early Phase 1, Phase 3

Type 2 Diabetes

174 Actively Recruiting

Phase 2, Not Applicable, Phase 4, Early Phase 1, Phase 1, Phase 3

Weight

0 Actively Recruiting

Migraine

61 Actively Recruiting

Not Applicable, Phase 1, Phase 4, Phase 2, Phase 3

Mood Disorders

1 Actively Recruiting

Not Applicable

Hypertensive disease

20 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4

Alcoholism

8 Actively Recruiting

Phase 3, Not Applicable, Phase 2

Weight Reduction

0 Actively Recruiting

High cholesterol

5 Actively Recruiting

Phase 2, Not Applicable, Phase 3, Phase 1

at least one weight-related comorbid condition

0 Actively Recruiting

Obesity

0 Actively Recruiting

BMI >27 kg/m2

0 Actively Recruiting

Calorie Restriction

0 Actively Recruiting

Seizures

3 Actively Recruiting

Phase 2, Phase 3

Lennox Gastaut Syndrome (LGS)

4 Actively Recruiting

Phase 2, Phase 3

prophylaxis of migraine headaches

0 Actively Recruiting

Epilepsy

0 Actively Recruiting

Tonic - clonic seizures

0 Actively Recruiting

Topamax Reviews: What are patients saying about Topamax?

5Patient Review

7/15/2022

Topamax for Migraine Prevention

My doctor prescribed Topamax to me in order to prevent migraines and it works great! Not only does it lower my appetite, but it has a few other benefits for people with bipolar disorder.

5Patient Review

3/31/2022

Topamax for Migraine Prevention

I was pretty naive about the potential side effects of this medication until I started reading reviews. After six days, I'm quitting completely. So far, the headaches it's helped with have been worth it but I don't want to risk anything getting worse.

4.7Patient Review

10/21/2022

Topamax for Migraine Prevention

The only notable side effects I experience are slight weight loss and an inability to taste carbonation. However, these are more than worth it because my migraines have been reduced significantly. I take 25-50 mg at night depending on how I'm feeling.

3Patient Review

10/24/2021

Topamax for Migraine Prevention

My wife takes this medication and I'm not thrilled about it. She has a lot of the side effects, like incessant talking, and it's really wearing on me.

3Patient Review

9/17/2022

Topamax for Tonic-Clonic Epilepsy

I had serious problems with this medication, including cognitive impairment and visual hallucinations. It took changing doctors to finally get off of it.

2.3Patient Review

2/18/2022

Topamax for Migraine Prevention

Though this drug did help with my migraines, I found the cognitive side effects to be really detrimental. I was struggling in school and having a lot of trouble with basic tasks. I would definitely not recommend this medication.

2Patient Review

10/30/2021

Topamax for Migraine Prevention

I didn't find this medication very effective. I felt weak and exhausted all the time, to the point where doing simple chores was a struggle. My migraines were still there, too. Overall, not worth it in my opinion.

1.7Patient Review

3/24/2022

Topamax for Migraine Prevention

I saw no benefits for headaches, unfortunately. And the dosage I was supposed to take just made me feel worse and more suicidal.

1.7Patient Review

5/31/2022

Topamax for Migraine Prevention

I started taking this medication for migraines with aura, but it unfortunately had the opposite effect. I found that I got them more frequently and with a greater intensity of aura.

1Patient Review

5/31/2022

Topamax for Migraine Prevention

Unfortunately, this medication made my migraines with aura worse. I experienced three times as many episodes and felt foggy most of the time I was on the drug. Additionally, I gained 20lbs while taking it.

1Patient Review

3/17/2022

Topamax for Migraine Prevention

I would highly advise against taking this medication. It had detrimental effects on my mental state and caused me to become forgetful and crazy. I've seen it have similar effects on other people as well.

Patient Q&A Section about topamax

How does Topamax make you feel?

"While taking Topamax, some people may experience changes in their personality that affect the way they behave, react, feel, or interact with others. These changes can include agitation, aggression, or other behavior problems. Additionally, Topamax may cause mood changes, such as anxiety, mood swings, and depression." - Anonymous Online Contributor

Unverified Answer

What is Topamax used to treat?

"Topiramate is a medication used to treat various types of seizures, including primary generalized tonic-clonic seizures and partial onset seizures. It can be used alone or in combination with other medications." - Anonymous Online Contributor

Unverified Answer

What are Topamax side effects?

"Common symptoms of ocular myasthenia include blurred vision, burning/prickling/tingling sensations, clumsiness or unsteadiness, drowsiness, redness or pain in the eyes, and increased eye pressure." - Anonymous Online Contributor

Unverified Answer

Is Topamax used for weight loss?

"Topamax is a prescription drug approved by the FDA to treat epilepsy and migraine. It is also sometimes used off-label as a weight-loss medication. The generic name of Topamax is topiramate. Topamax causes weight loss by reducing the appetite. It may also speed up metabolism, causing you to burn more calories." - Anonymous Online Contributor

Unverified Answer

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Topamax

Image of Research Site in Brooklyn, United States.

Phase-Based Progress Estimates

Treatment Sequence A-Bfor High Cholesterol

This trial studies how a new drug (AZD0780) interacts with an existing drug (rosuvastatin) and how safe it is when taken alone or together.

Research SiteAstraZeneca

Image of St Michael's Hospital Academic Family Health Team in Toronto, Canada.

Phase-Based Progress Estimates

Food Voucherfor Type 2 Diabetes

Toronto, Canada

This trial tests if giving low-income people with diabetes/high blood sugar access to healthy food can lower their blood sugar. #diabetes

Waitlist Available

St Michael's Hospital Academic Family Health Team

Image of University of Colorado Department of Family Medicine in Aurora, United States.

Phase-Based Progress Estimates

Glucose Excursion Minimization (GEM)for Type 2 Diabetes

This trial tests if self-managed diabetes treatment can be more effective and cost less than traditional meds for newly-diagnosed Type 2 Diabetes.

Waitlist Available

University of Colorado Department of Family Medicine (+1 Sites)Daniel J. Cox, PhD, AHPPDexCom, Inc.

Image of Charles R. Drew University in Los Angeles, United States.

Phase-Based Progress Estimates

Intervention Group (IG)for Colorectal Cancer

Los Angeles, CA

This trial observes the impact of a tailored education program on colorectal cancer screening & dietary habits in minority patients w/ type 2 diabetes.

Waitlist Available

Charles R. Drew University

Have you considered Topamax clinical trials? We made a collection of clinical trials featuring Topamax, we think they might fit your search criteria.

Explore trials for Topamax

Image of Clinical Trial Site in Montréal, Canada.

Phase-Based Progress Estimates

Part A: ALN-KHKfor Type 2 Diabetes

Montréal, Canada

This trial tests how safe and effective a drug is and how it works in the body when given in single or multiple doses.

Clinical Trial SiteMedical DirectorAlnylam Pharmaceuticals

Image of Mayo Clinic Minnesota in Rochester, United States.

Phase-Based Progress Estimates

Custom Phone EHealth Applicationfor Migraine

This trial seeks to use smart devices to track and predict headaches, allowing for earlier and more effective treatment.

Waitlist Available

Mayo Clinic MinnesotaNaraya Kissoon, MD

Image of Vancouver Island Health Authority /ID# 247733 in Victoria, Canada.

Phase-Based Progress Estimates

Atogepantfor Migraine

Victoria, Canada

This trial will study whether a medicine (atogepant) is safe and effective for preventing migraine symptoms compared to another medicine (topiramate). 520 participants will be enrolled worldwide. Both medicines are taken by mouth.

Waitlist Available

Vancouver Island Health Authority /ID# 247733 (+2 Sites)ABBVIE INC.AbbVie

Image of Rachel W. Goode in Kannapolis, United States.

Phase-Based Progress Estimates

DSMES + ASE Intervention Appetite Self-Regulation (Centering Appetite)for Type 2 Diabetes

This trial will test if an app & Fitbit can help African Americans with type 2 diabetes lower glucose and binge eating. They'll receive online lessons and be monitored for 6 months.

Waitlist Available

Rachel W. GoodeRachel Goode, PhD, MPH, LCSW

Have you considered Topamax clinical trials? We made a collection of clinical trials featuring Topamax, we think they might fit your search criteria.

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Image of Southwest General Healthcare Center in Fort Myers, United States.

Phase-Based Progress Estimates

Phase 1 (SAD Cohorts)for Type 2 Diabetes

This trial tests safety, tolerability & effects of BMF-219, an oral drug for adults with Type 2 Diabetes Mellitus.

Southwest General Healthcare Center (+5 Sites)Stephen Morris, MDBiomea Fusion Inc.

Image of University of Alabama at Birmingham in Birmingham, United States.

Phase-Based Progress Estimates

Obese, Receives Access To Exercise Phone Applicationfor Type 2 Diabetes

This trial will study how an exercise app & glucose monitor can help teens w/obesity, prediabetes & Type 2 diabetes reach their health goals.

Waitlist Available

University of Alabama at Birmingham

Image of Kaiser Permanente in Berkeley, United States.

Phase-Based Progress Estimates

CGA-rich Coffee (Speciality Coffee)for Type 2 Diabetes

This trial explores the effects of specialty coffee on cognitive function & blood sugar control in people with diabetes, to reduce risk of cognitive decline & diabetes.

Kaiser PermanenteDaniel Lamport, PhD

Image of Fiel Family and Sports Medicine PC in Tempe, United States.

Phase-Based Progress Estimates

Tirzepatidefor Type 2 Diabetes

This trial studies effects of switching T2D meds to see if they help manage blood sugar better.

Fiel Family and Sports Medicine PC (+34 Sites)Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)Eli Lilly and Company

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Explore trials for Topamax

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