Topamax

Migraine, Caloric Restriction, High cholesterol + 16 more
Treatment
20 Active Studies for Topamax

What is Topamax

TopiramateThe Generic name of this drug
Treatment SummaryTopiramate is a medication used to control seizures and prevent migraines in adults. It was approved by the FDA in 1996 and is made up of oxygen and a monosaccharide chemical structure with a sulfamate. It was originally created as an experimental diabetes drug but was found to also be effective in controlling seizures and preventing migraines. In 2012, an extended-release formula was approved for weight management in adults, when combined with phentermine.
Topamaxis the brand name
image of different drug pills on a surface
Topamax Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Topamax
Topiramate
1997
526

Effectiveness

How Topamax Affects PatientsTopiramate is an effective anti-seizure and migraine prevention drug, but it can have serious side effects. It can cause metabolic acidosis, changes in mood, suicidal thoughts and behaviors, as well as kidney stones. Taking it with valproic acid can lead to hypothermia.
How Topamax works in the bodySeizures and migraines are caused by an abnormal electrical discharge in the brain. Topiramate works by blocking this discharge. It does this by increasing the activity of GABA-A receptors, which are inhibitory to neuronal activity, and reducing the activity of glutamate receptors, which are stimulatory. Furthermore, it blocks voltage-dependent sodium channels, further blocking seizure activity. It also inhibits certain carbonic anhydrase isozymes, though the clinical significance of this is unknown.

When to interrupt dosage

The proposed measure of Topamax is contingent upon the diagnosed illness, including Seizures, Weight Reduction and Tonic - clonic seizures. The measure of dosage is dependent on the technique of delivery (e.g. Tablet, coated or Tablet) featured in the table underneath.
Condition
Dosage
Administration
Obesity
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Exercise
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Lennox Gastaut Syndrome
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Alcoholism
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Migraine
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Caloric Restriction
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
High cholesterol
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Obesity
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
at least one weight-related comorbid condition
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Migraine Disorders
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Obesity
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Seizures
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Type 2 Diabetes
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Hypertensive disease
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Epilepsy
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Weight Loss
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
increase in physical activity
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Mood Disorders
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Chronic Weight Management therapy
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Warnings

Topamax Contraindications
Condition
Risk Level
Notes
Acidosis
Do Not Combine
There are 20 known major drug interactions with Topamax.
Common Topamax Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Topiramate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Topiramate.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be increased when combined with Topiramate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Topiramate.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Topiramate.
Topamax Toxicity & Overdose RiskThe highest amount of topiramate that is non-toxic to rats is 1500mg/kg. A study of 4 women taking topiramate found that overdose symptoms could range from mild to severe, with no reported deaths. Possible effects of an overdose include low blood pressure, severe acidosis, dizziness, coma, convulsions, confusion, and depression. If someone recently ingested topiramate, a doctor may recommend inducing vomiting, using activated charcoal, and undergoing hemodialysis.
image of a doctor in a lab doing drug, clinical research

Topamax Novel Uses: Which Conditions Have a Clinical Trial Featuring Topamax?

313 active trials are currently being conducted to explore the potential of Topamax in treating Type 2 Diabetes, Migraine and Exercise-induced symptoms.
Condition
Clinical Trials
Trial Phases
Exercise
59 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1
Weight Loss
0 Actively Recruiting
Mood Disorders
0 Actively Recruiting
Migraine
52 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1
Obesity
0 Actively Recruiting
Chronic Weight Management therapy
0 Actively Recruiting
Migraine Disorders
1 Actively Recruiting
Phase 3
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Seizures
4 Actively Recruiting
Phase 3, Phase 2
High cholesterol
0 Actively Recruiting
Obesity
0 Actively Recruiting
at least one weight-related comorbid condition
0 Actively Recruiting
Lennox Gastaut Syndrome
3 Actively Recruiting
Phase 2, Phase 1, Phase 4
Obesity
0 Actively Recruiting
Caloric Restriction
0 Actively Recruiting
Epilepsy
0 Actively Recruiting
Alcoholism
6 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Type 2 Diabetes
174 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
increase in physical activity
0 Actively Recruiting

Topamax Reviews: What are patients saying about Topamax?

5Patient Review
7/15/2022
Topamax for Migraine Prevention
My doctor prescribed Topamax to me in order to prevent migraines and it works great! Not only does it lower my appetite, but it has a few other benefits for people with bipolar disorder.
5Patient Review
3/31/2022
Topamax for Migraine Prevention
I was pretty naive about the potential side effects of this medication until I started reading reviews. After six days, I'm quitting completely. So far, the headaches it's helped with have been worth it but I don't want to risk anything getting worse.
4.7Patient Review
10/21/2022
Topamax for Migraine Prevention
The only notable side effects I experience are slight weight loss and an inability to taste carbonation. However, these are more than worth it because my migraines have been reduced significantly. I take 25-50 mg at night depending on how I'm feeling.
3Patient Review
10/24/2021
Topamax for Migraine Prevention
My wife takes this medication and I'm not thrilled about it. She has a lot of the side effects, like incessant talking, and it's really wearing on me.
3Patient Review
9/17/2022
Topamax for Tonic-Clonic Epilepsy
I had serious problems with this medication, including cognitive impairment and visual hallucinations. It took changing doctors to finally get off of it.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about topamax

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How does Topamax make you feel?

"While taking Topamax, some people may experience changes in their personality that affect the way they behave, react, feel, or interact with others. These changes can include agitation, aggression, or other behavior problems. Additionally, Topamax may cause mood changes, such as anxiety, mood swings, and depression."

Answered by AI

What is Topamax used to treat?

"Topiramate is a medication used to treat various types of seizures, including primary generalized tonic-clonic seizures and partial onset seizures. It can be used alone or in combination with other medications."

Answered by AI

What are Topamax side effects?

"Common symptoms of ocular myasthenia include blurred vision, burning/prickling/tingling sensations, clumsiness or unsteadiness, drowsiness, redness or pain in the eyes, and increased eye pressure."

Answered by AI

Is Topamax used for weight loss?

"Topamax is a prescription drug approved by the FDA to treat epilepsy and migraine. It is also sometimes used off-label as a weight-loss medication. The generic name of Topamax is topiramate. Topamax causes weight loss by reducing the appetite. It may also speed up metabolism, causing you to burn more calories."

Answered by AI

Clinical Trials for Topamax

Have you considered Topamax clinical trials? We made a collection of clinical trials featuring Topamax, we think they might fit your search criteria.
Have you considered Topamax clinical trials? We made a collection of clinical trials featuring Topamax, we think they might fit your search criteria.
Have you considered Topamax clinical trials? We made a collection of clinical trials featuring Topamax, we think they might fit your search criteria.
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