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What is Topamax
TopiramateThe Generic name of this drug
Treatment SummaryTopiramate is a medication used to control seizures and prevent migraines in adults. It was approved by the FDA in 1996 and is made up of oxygen and a monosaccharide chemical structure with a sulfamate. It was originally created as an experimental diabetes drug but was found to also be effective in controlling seizures and preventing migraines. In 2012, an extended-release formula was approved for weight management in adults, when combined with phentermine.
Topamaxis the brand name
Topamax Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Topamax
Topiramate
1997
526
Effectiveness
How Topamax Affects PatientsTopiramate is an effective anti-seizure and migraine prevention drug, but it can have serious side effects. It can cause metabolic acidosis, changes in mood, suicidal thoughts and behaviors, as well as kidney stones. Taking it with valproic acid can lead to hypothermia.
How Topamax works in the bodySeizures and migraines are caused by an abnormal electrical discharge in the brain. Topiramate works by blocking this discharge. It does this by increasing the activity of GABA-A receptors, which are inhibitory to neuronal activity, and reducing the activity of glutamate receptors, which are stimulatory. Furthermore, it blocks voltage-dependent sodium channels, further blocking seizure activity. It also inhibits certain carbonic anhydrase isozymes, though the clinical significance of this is unknown.
When to interrupt dosage
The proposed measure of Topamax is contingent upon the diagnosed illness, including Seizures, Weight Reduction and Tonic - clonic seizures. The measure of dosage is dependent on the technique of delivery (e.g. Tablet, coated or Tablet) featured in the table underneath.Condition
Dosage
Administration
Migraine
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Caloric Restriction
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
High cholesterol
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
BMI >27 kg/m2
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
at least one weight-related comorbid condition
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
prophylaxis of migraine headaches
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Weight
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Seizures
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Type 2 Diabetes
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Hypertensive disease
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Epilepsy
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Weight Reduction
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
increase in physical activity
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Mood Disorders
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Alcoholism
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Obesity
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Chronic Weight Management therapy
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Exercise
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Lennox Gastaut Syndrome (LGS)
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Warnings
Topamax ContraindicationsCondition
Risk Level
Notes
Metabolic Acidosis
Do Not Combine
Common Topamax Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Topiramate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Topiramate.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be increased when combined with Topiramate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Topiramate.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Topiramate.
Topamax Toxicity & Overdose RiskThe highest amount of topiramate that is non-toxic to rats is 1500mg/kg. A study of 4 women taking topiramate found that overdose symptoms could range from mild to severe, with no reported deaths. Possible effects of an overdose include low blood pressure, severe acidosis, dizziness, coma, convulsions, confusion, and depression. If someone recently ingested topiramate, a doctor may recommend inducing vomiting, using activated charcoal, and undergoing hemodialysis.
Topamax Novel Uses: Which Conditions Have a Clinical Trial Featuring Topamax?
313 active trials are currently being conducted to explore the potential of Topamax in treating Type 2 Diabetes, Migraine and Exercise-induced symptoms.Condition
Clinical Trials
Trial Phases
Exercise
47 Actively Recruiting
Phase 1, Not Applicable, Phase 2, Phase 3
Weight
1 Actively Recruiting
Not Applicable
Chronic Weight Management therapy
0 Actively Recruiting
prophylaxis of migraine headaches
1 Actively Recruiting
Phase 3
Hypertensive disease
21 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Weight Reduction
0 Actively Recruiting
Mood Disorders
1 Actively Recruiting
Not Applicable
Seizures
3 Actively Recruiting
Phase 3, Phase 2
High cholesterol
5 Actively Recruiting
Phase 2, Phase 1, Not Applicable
Obesity
0 Actively Recruiting
at least one weight-related comorbid condition
0 Actively Recruiting
Lennox Gastaut Syndrome (LGS)
2 Actively Recruiting
Phase 2, Phase 3
BMI >27 kg/m2
0 Actively Recruiting
Caloric Restriction
0 Actively Recruiting
Epilepsy
0 Actively Recruiting
Migraine
53 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1
Alcoholism
7 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Type 2 Diabetes
183 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
increase in physical activity
0 Actively Recruiting
Topamax Reviews: What are patients saying about Topamax?
5Patient Review
7/15/2022 My doctor prescribed Topamax to me in order to prevent migraines and it works great! Not only does it lower my appetite, but it has a few other benefits for people with bipolar disorder.
5Patient Review
3/31/2022 I was pretty naive about the potential side effects of this medication until I started reading reviews. After six days, I'm quitting completely. So far, the headaches it's helped with have been worth it but I don't want to risk anything getting worse.
4.7Patient Review
10/21/2022 The only notable side effects I experience are slight weight loss and an inability to taste carbonation. However, these are more than worth it because my migraines have been reduced significantly. I take 25-50 mg at night depending on how I'm feeling.
3Patient Review
10/24/2021 My wife takes this medication and I'm not thrilled about it. She has a lot of the side effects, like incessant talking, and it's really wearing on me.
3Patient Review
9/17/2022 I had serious problems with this medication, including cognitive impairment and visual hallucinations. It took changing doctors to finally get off of it.
2.3Patient Review
2/18/2022 Though this drug did help with my migraines, I found the cognitive side effects to be really detrimental. I was struggling in school and having a lot of trouble with basic tasks. I would definitely not recommend this medication.
2Patient Review
10/30/2021 I didn't find this medication very effective. I felt weak and exhausted all the time, to the point where doing simple chores was a struggle. My migraines were still there, too. Overall, not worth it in my opinion.
1.7Patient Review
3/24/2022 I saw no benefits for headaches, unfortunately. And the dosage I was supposed to take just made me feel worse and more suicidal.
1.7Patient Review
5/31/2022 I started taking this medication for migraines with aura, but it unfortunately had the opposite effect. I found that I got them more frequently and with a greater intensity of aura.
1Patient Review
5/31/2022 Unfortunately, this medication made my migraines with aura worse. I experienced three times as many episodes and felt foggy most of the time I was on the drug. Additionally, I gained 20lbs while taking it.
1Patient Review
3/17/2022 I would highly advise against taking this medication. It had detrimental effects on my mental state and caused me to become forgetful and crazy. I've seen it have similar effects on other people as well.
Patient Q&A Section about topamax
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How does Topamax make you feel?
"While taking Topamax, some people may experience changes in their personality that affect the way they behave, react, feel, or interact with others. These changes can include agitation, aggression, or other behavior problems. Additionally, Topamax may cause mood changes, such as anxiety, mood swings, and depression."
Answered by AI
What is Topamax used to treat?
"Topiramate is a medication used to treat various types of seizures, including primary generalized tonic-clonic seizures and partial onset seizures. It can be used alone or in combination with other medications."
Answered by AI
What are Topamax side effects?
"Common symptoms of ocular myasthenia include blurred vision, burning/prickling/tingling sensations, clumsiness or unsteadiness, drowsiness, redness or pain in the eyes, and increased eye pressure."
Answered by AI
Is Topamax used for weight loss?
"Topamax is a prescription drug approved by the FDA to treat epilepsy and migraine. It is also sometimes used off-label as a weight-loss medication. The generic name of Topamax is topiramate. Topamax causes weight loss by reducing the appetite. It may also speed up metabolism, causing you to burn more calories."
Answered by AI