Tofranil

Nocturnal Enuresis (bedwetting), Bulimia Nervosa, Panic Disorder + 3 more
Treatment
20 Active Studies for Tofranil

What is Tofranil

ImipramineThe Generic name of this drug
Treatment SummaryImipramine is an antidepressant medication from the tricyclic antidepressant (TCA) family. It has a positive effect on mood for people with depression, but has little effect on those who are not depressed. Imipramine works by blocking serotonin and norepinephrine reuptake and by blocking certain receptors in the body. It has fewer sedative and anticholinergic effects than other TCAs, such as amitriptyline and clomipramine. Common uses of imipramine include treating depression and bedwetting in children, but it may also be used to treat chronic pain, panic
Tofranilis the brand name
image of different drug pills on a surface
Tofranil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tofranil
Imipramine
1959
103

Effectiveness

How Tofranil Affects PatientsImipramine is an antidepressant medication that works by blocking the reuptake of serotonin and norepinephrine in the brain. This increases the levels of these neurotransmitters, which helps to improve depressive symptoms. Imipramine has also been shown to increase neurogenesis in the hippocampus, and reduce the downregulation of this neurogenesis caused by stress. It is also thought to cause a decrease in the number of beta-adrenergic receptors in the brain.
How Tofranil works in the bodyImipramine helps to treat depression by stopping the brain from taking back two important chemicals, norepinephrine and serotonin. These chemicals are responsible for stimulating the post-synaptic neuron and when they are slowed down, they stay in the brain longer and produce changes that help relieve the symptoms of depression.

When to interrupt dosage

The recommended dosage of Tofranil is contingent upon the diagnosed affliction, including Bedwetting, Bulimia Nervosa and Depression. The measure of dosage is also influenced by the mode of delivery (e.g. Tablet, sugar coated or Tablet, sugar coated - Oral) depicted in the following table.
Condition
Dosage
Administration
Nocturnal Enuresis (bedwetting)
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular
Panic Disorder
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular
Bulimia Nervosa
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular
Attention Deficit Hyperactivity Disorder
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular
Depression
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular
Neuropathic Pain
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular

Warnings

Tofranil Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Myocardial Infarction
Do Not Combine
There are 20 known major drug interactions with Tofranil.
Common Tofranil Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Major
Imipramine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Imipramine is combined with Aclidinium.
Alfuzosin
Major
Imipramine may increase the hypotensive activities of Alfuzosin.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Imipramine.
Amoxapine
Major
Imipramine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amoxapine.
Tofranil Toxicity & Overdose RiskImipramine can cause dry mouth, blurry vision, high body temperature, constipation, difficulty urinating, and drowsiness. It can also cause anorexia, nausea, vomiting, stomach discomfort, strange taste in the mouth, and a black tongue. Rarely, it can cause a decrease in white blood cells, platelets, and red blood cells. When taken by pregnant women, it may cause heart problems, restlessness, muscle spasms, seizures, and difficulty urinating in the baby. Taking imipramine with other drugs that increase serotonin levels can cause serotonin syndrome. The toxic dosage of imipram
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Tofranil Novel Uses: Which Conditions Have a Clinical Trial Featuring Tofranil?

At present, 779 active trials are evaluating the potential of Tofranil to mitigate Attention Deficit Hyperactivity Disorder, Bulimia Nervosa and Depression.
Condition
Clinical Trials
Trial Phases
Attention Deficit Hyperactivity Disorder
75 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1
Depression
693 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4
Nocturnal Enuresis (bedwetting)
0 Actively Recruiting
Panic Disorder
17 Actively Recruiting
Not Applicable, Phase 2
Bulimia Nervosa
16 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Early Phase 1
Neuropathic Pain
27 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4

Tofranil Reviews: What are patients saying about Tofranil?

5Patient Review
6/13/2016
Tofranil for Bedwetting
I gave this to my 8 year old grandson who wet the bed every night, and it worked perfectly. His dad was 5 years old when I used this on him, and it cleared up his problem in just three days.
5Patient Review
11/18/2013
Tofranil for Problems with Bladder Control
I've been using this medication for a while now to treat my incontinence, and it's worked great! I haven't had any accidents since starting the Tofranil, and bedwetting is no longer an issue. I highly recommend this product.
5Patient Review
11/6/2015
Tofranil for Panic Disorder
I've taken this medication for over 30 years now to prevent night terrors. My doctor and I have attempted to wean me off of it several times, but each time the night terrors come back. So, as long as it keeps working, I'll keep taking it. It's been a true blessing with no negative side effects.
4.7Patient Review
2/9/2013
Tofranil for Attention Deficit Disorder with Hyperactivity
My grandson started this treatment for enuresis and ADHD when he was five years old. It worked great at first, but after six months we had to increase the dose to keep the same results. He's doing well now, but I wonder if a child can build up a tolerance to this medication over time.
4.3Patient Review
3/6/2014
Tofranil for Depression
Tofranil saved my life. After trying and failing to take Zoloft and Lexapro, I started on Tofranil at a low dose of 10mg. Every two days, I increased the dosage by 10mg until I reached 150mg--all taken at night. At first, I experienced dry mouth and blurred vision; however, after just a few weeks, I felt so much better. My depression had lifted, my panic was manageable, and my anxiety was back to normal.
3.7Patient Review
5/22/2012
Tofranil for Anxious
1Patient Review
10/10/2016
Tofranil for Bedwetting
I would not recommend this medication to anyone. My son began taking it for bedwetting and very quickly started exhibiting signs of severe emotional distress, including self-harm and outbursts of violence. I contacted his doctor right away and had him taken off the medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tofranil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of drug is Tofranil?

"In chemistry, generally speaking, organic compounds are any chemical compounds that contain either carbon-hydrogen or carbon-carbon bonds. The reason for this is that carbon has the ability to catenate, or form chains with other carbon atoms. This results in there being millions of known organic compounds."

Answered by AI

What is Tofranil used to treat?

"This medication is typically used to treat depression, but it can also be used in conjunction with other therapies to treat nighttime bed-wetting in children. This medication may improve your mood, sleep, appetite, and energy level, and restore your interest in daily living."

Answered by AI

What does Tofranil do to the brain?

"It is believed that Tofranil elevates mood by increasing the levels of neurotransmitters in the brain."

Answered by AI

Does Tofranil help with anxiety?

"When other stimulants are not effective, Tofranil, a tricyclic antidepressant, may be prescribed. Tofranil can be effective in treating symptoms of ADHD in adults, as well as depression and anxiety that often accompany ADHD."

Answered by AI

Clinical Trials for Tofranil

Have you considered Tofranil clinical trials? We made a collection of clinical trials featuring Tofranil, we think they might fit your search criteria.
Have you considered Tofranil clinical trials? We made a collection of clinical trials featuring Tofranil, we think they might fit your search criteria.
Have you considered Tofranil clinical trials? We made a collection of clinical trials featuring Tofranil, we think they might fit your search criteria.