Tioconazole

Onychomycosis, Inflammation, Cellulitis + 5 more
Treatment
20 Active Studies for Tioconazole

What is Tioconazole

TioconazoleThe Generic name of this drug
Treatment SummaryTioconazole is a medication used to treat fungal and yeast infections. It can be applied topically to the skin to treat ringworm, jock itch, athlete's foot, and tinea versicolor, which is also known as “sun fungus”. Tioconazole blocks the activity of an enzyme called 14-alpha demethylase, which is responsible for producing ergosterol in yeast cells. By disrupting this enzyme, the medication causes the cell membranes to become more permeable, which stops the growth of the infection.
Vagistat-1is the brand name
Tioconazole Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Vagistat-1
Tioconazole
1997
32

Effectiveness

How Tioconazole Affects PatientsTioconazole is a medicine used to fight fungal infections. It is effective against certain species of Candida and Torulopsis, which are types of yeast. Tioconazole works by blocking the production of substances that keep the cell membrane of the fungal organism healthy. This drug should not be used to treat bacterial or viral infections.
How Tioconazole works in the bodyTioconazole works by blocking an essential enzyme that helps yeast cells make a key element of their cell membrane. Without this element, the cell membrane becomes more permeable and it's harder for the yeast cell to survive. Tioconazole also interferes with other processes, like respiration, cell transformation, and ion transport. This makes it harder for yeast cells to survive and grow.

When to interrupt dosage

The quantity of Tioconazole is contingent upon the diagnosed affliction, including Vulvovaginal Candidiasis, cutaneous dermatophyte corruption and Infection, Mixed. The amount of dosage also relies upon the method of delivery (e.g. Ointment - Vaginal or Topical) as outlined in the table beneath.
Condition
Dosage
Administration
Onychomycosis
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
, Ointment, Ointment - Vaginal, Vaginal, Topical, Ointment - Topical, Suppository, Cream, Suppository - Vaginal, Cream - Topical, Topical; Vaginal, Cream; Ointment, Cream; Ointment - Topical; Vaginal, Cream; Suppository, Cream; Suppository - Topical; Vaginal
Coinfection
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
, Ointment, Ointment - Vaginal, Vaginal, Topical, Ointment - Topical, Suppository, Cream, Suppository - Vaginal, Cream - Topical, Topical; Vaginal, Cream; Ointment, Cream; Ointment - Topical; Vaginal, Cream; Suppository, Cream; Suppository - Topical; Vaginal
Cellulitis
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
, Ointment, Ointment - Vaginal, Vaginal, Topical, Ointment - Topical, Suppository, Cream, Suppository - Vaginal, Cream - Topical, Topical; Vaginal, Cream; Ointment, Cream; Ointment - Topical; Vaginal, Cream; Suppository, Cream; Suppository - Topical; Vaginal
Candidiasis, Vulvovaginal
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
, Ointment, Ointment - Vaginal, Vaginal, Topical, Ointment - Topical, Suppository, Cream, Suppository - Vaginal, Cream - Topical, Topical; Vaginal, Cream; Ointment, Cream; Ointment - Topical; Vaginal, Cream; Suppository, Cream; Suppository - Topical; Vaginal
Tinea Pedis
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
, Ointment, Ointment - Vaginal, Vaginal, Topical, Ointment - Topical, Suppository, Cream, Suppository - Vaginal, Cream - Topical, Topical; Vaginal, Cream; Ointment, Cream; Ointment - Topical; Vaginal, Cream; Suppository, Cream; Suppository - Topical; Vaginal
cutaneous dermatophyte infection
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
, Ointment, Ointment - Vaginal, Vaginal, Topical, Ointment - Topical, Suppository, Cream, Suppository - Vaginal, Cream - Topical, Topical; Vaginal, Cream; Ointment, Cream; Ointment - Topical; Vaginal, Cream; Suppository, Cream; Suppository - Topical; Vaginal
Candidiasis, Vulvovaginal
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
, Ointment, Ointment - Vaginal, Vaginal, Topical, Ointment - Topical, Suppository, Cream, Suppository - Vaginal, Cream - Topical, Topical; Vaginal, Cream; Ointment, Cream; Ointment - Topical; Vaginal, Cream; Suppository, Cream; Suppository - Topical; Vaginal
Inflammation
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
, Ointment, Ointment - Vaginal, Vaginal, Topical, Ointment - Topical, Suppository, Cream, Suppository - Vaginal, Cream - Topical, Topical; Vaginal, Cream; Ointment, Cream; Ointment - Topical; Vaginal, Cream; Suppository, Cream; Suppository - Topical; Vaginal

Warnings

There are 20 known major drug interactions with Tioconazole.
Common Tioconazole Drug Interactions
Drug Name
Risk Level
Description
Cariprazine
Major
The metabolism of Cariprazine can be decreased when combined with Tioconazole.
Eliglustat
Major
The metabolism of Eliglustat can be decreased when combined with Tioconazole.
Entrectinib
Major
The metabolism of Entrectinib can be decreased when combined with Tioconazole.
Fentanyl
Major
The metabolism of Fentanyl can be decreased when combined with Tioconazole.
Infigratinib
Major
The metabolism of Infigratinib can be decreased when combined with Tioconazole.
Tioconazole Toxicity & Overdose RiskOverdosing on this drug may cause redness, stinging, blisters, swelling, itching, hives, burning sensation, and skin irritation. It may also lead to muscle cramps.
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Tioconazole Novel Uses: Which Conditions Have a Clinical Trial Featuring Tioconazole?

191 active studies are assessing the potential of Tioconazole to provide a therapeutic intervention for cutaneous dermatophyte infection, superficial Fungal skin infection and Communicable Diseases.
Condition
Clinical Trials
Trial Phases
Candidiasis, Vulvovaginal
2 Actively Recruiting
Early Phase 1
Inflammation
64 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1, Phase 2, Phase 3, Phase 4
cutaneous dermatophyte infection
0 Actively Recruiting
Cellulitis
0 Actively Recruiting
Tinea Pedis
0 Actively Recruiting
Onychomycosis
0 Actively Recruiting
Coinfection
0 Actively Recruiting
Candidiasis, Vulvovaginal
0 Actively Recruiting

Tioconazole Reviews: What are patients saying about Tioconazole?

4Patient Review
2/20/2021
Tioconazole for Yeast Infection of Vagina and Vulva
After trying several prescription medicines that didn’t work, I was given another prescription but Walmart didn’t have medicine and told me it would be Monday. I therefore went to look for OTC cream to try!!! I’m glad I did bc this gave me instant relief!!!
3.3Patient Review
5/25/2021
Tioconazole for Yeast Infection of Vagina and Vulva
I've had 5 yeast infections in my lifetime, and this product made me hurt more than any of those previous times. The first two days were the worst, with constant itching that was only relieved by cold yogurt. I'm on day three now and feeling better, but still itch occasionally. I hope this medicine will work, but next time I'll buy Monostat just in case."
3.3Patient Review
6/15/2020
Tioconazole for Yeast Infection of Vagina and Vulva
I've used this medication in the past to great success; however, the last couple of times I've bought it, I've experienced some pretty unpleasant side effects.
3Patient Review
8/20/2019
Tioconazole for Yeast Infection of Vagina and Vulva
In retrospect, I wish I had read the reviews before buying this product. The itchiness increased for the first hour after application (it wasn't very bad to start). There is no pain or swelling but still discomfort and significantly more leakage than I thought. It's only day 1, so I'll give it a few more days before I can tell if it really worked.
3Patient Review
5/21/2022
Tioconazole for Yeast Infection of Vagina and Vulva
After using this treatment, I felt bloated and had an aftertaste in my mouth. Is this normal?
View All Reviews
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Patient Q&A Section about tioconazole

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What happens after using tioconazole?

"The most common side effects of tioconazole vaginal are mild stomach pain, pain or burning when urinating, headache, runny or stuffy nose, or mild vaginal burning, itching or irritation after use."

Answered by AI

How long does it take tioconazole to work?

"Your symptoms should start to improve after using the 1-day treatment, but it might take up to 7 days for them to go away completely. If your symptoms haven't improved after 3 days or if they last for more than 7 days, give your doctor a call."

Answered by AI

Is Monistat or tioconazole better?

"Monistat's 1-Day yeast infection treatment is the best overall pick because it contains 6.5% tioconazole ointment, which is an effective ingredient in treating yeast infections and other types of bacteria."

Answered by AI

Does tioconazole cure yeast infection?

"This ointment is used to treat vaginal yeast infections. It helps by reducing the burning, itching and discharge that come with the infection. The ointment does this by killing the fungus that causes the infection."

Answered by AI

Clinical Trials for Tioconazole

Have you considered Tioconazole clinical trials? We made a collection of clinical trials featuring Tioconazole, we think they might fit your search criteria.
Have you considered Tioconazole clinical trials? We made a collection of clinical trials featuring Tioconazole, we think they might fit your search criteria.
Have you considered Tioconazole clinical trials? We made a collection of clinical trials featuring Tioconazole, we think they might fit your search criteria.
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