Tioconazole

Onychomycosis, Inflammation, Cellulitis + 5 more
Treatment
20 Active Studies for Tioconazole

What is Tioconazole

TioconazoleThe Generic name of this drug
Treatment SummaryTioconazole is a medication used to treat fungal and yeast infections. It can be applied topically to the skin to treat ringworm, jock itch, athlete's foot, and tinea versicolor, which is also known as “sun fungus”. Tioconazole blocks the activity of an enzyme called 14-alpha demethylase, which is responsible for producing ergosterol in yeast cells. By disrupting this enzyme, the medication causes the cell membranes to become more permeable, which stops the growth of the infection.
Vagistat-1is the brand name
Tioconazole Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Vagistat-1
Tioconazole
1997
32

Effectiveness

How Tioconazole Affects PatientsTioconazole is a medicine used to fight fungal infections. It is effective against certain species of Candida and Torulopsis, which are types of yeast. Tioconazole works by blocking the production of substances that keep the cell membrane of the fungal organism healthy. This drug should not be used to treat bacterial or viral infections.
How Tioconazole works in the bodyTioconazole works by blocking an essential enzyme that helps yeast cells make a key element of their cell membrane. Without this element, the cell membrane becomes more permeable and it's harder for the yeast cell to survive. Tioconazole also interferes with other processes, like respiration, cell transformation, and ion transport. This makes it harder for yeast cells to survive and grow.

When to interrupt dosage

The quantity of Tioconazole is contingent upon the diagnosed affliction, including Vulvovaginal Candidiasis, cutaneous dermatophyte corruption and Infection, Mixed. The amount of dosage also relies upon the method of delivery (e.g. Ointment - Vaginal or Topical) as outlined in the table beneath.
Condition
Dosage
Administration
Onychomycosis
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
Vaginal, Ointment - Vaginal, Ointment, , Topical, Ointment - Topical, Suppository, Suppository - Vaginal, Cream, Cream - Topical, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Cream; Ointment - Topical; Vaginal, Topical; Vaginal, Cream; Ointment
Coinfection
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
Vaginal, Ointment - Vaginal, Ointment, , Topical, Ointment - Topical, Suppository, Suppository - Vaginal, Cream, Cream - Topical, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Cream; Ointment - Topical; Vaginal, Topical; Vaginal, Cream; Ointment
Cellulitis
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
Vaginal, Ointment - Vaginal, Ointment, , Topical, Ointment - Topical, Suppository, Suppository - Vaginal, Cream, Cream - Topical, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Cream; Ointment - Topical; Vaginal, Topical; Vaginal, Cream; Ointment
Candidiasis, Vulvovaginal
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
Vaginal, Ointment - Vaginal, Ointment, , Topical, Ointment - Topical, Suppository, Suppository - Vaginal, Cream, Cream - Topical, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Cream; Ointment - Topical; Vaginal, Topical; Vaginal, Cream; Ointment
Tinea Pedis
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
Vaginal, Ointment - Vaginal, Ointment, , Topical, Ointment - Topical, Suppository, Suppository - Vaginal, Cream, Cream - Topical, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Cream; Ointment - Topical; Vaginal, Topical; Vaginal, Cream; Ointment
cutaneous dermatophyte infection
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
Vaginal, Ointment - Vaginal, Ointment, , Topical, Ointment - Topical, Suppository, Suppository - Vaginal, Cream, Cream - Topical, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Cream; Ointment - Topical; Vaginal, Topical; Vaginal, Cream; Ointment
Candidiasis, Vulvovaginal
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
Vaginal, Ointment - Vaginal, Ointment, , Topical, Ointment - Topical, Suppository, Suppository - Vaginal, Cream, Cream - Topical, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Cream; Ointment - Topical; Vaginal, Topical; Vaginal, Cream; Ointment
Inflammation
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
Vaginal, Ointment - Vaginal, Ointment, , Topical, Ointment - Topical, Suppository, Suppository - Vaginal, Cream, Cream - Topical, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Cream; Ointment - Topical; Vaginal, Topical; Vaginal, Cream; Ointment

Warnings

There are 20 known major drug interactions with Tioconazole.
Common Tioconazole Drug Interactions
Drug Name
Risk Level
Description
Cariprazine
Major
The metabolism of Cariprazine can be decreased when combined with Tioconazole.
Eliglustat
Major
The metabolism of Eliglustat can be decreased when combined with Tioconazole.
Entrectinib
Major
The metabolism of Entrectinib can be decreased when combined with Tioconazole.
Fentanyl
Major
The metabolism of Fentanyl can be decreased when combined with Tioconazole.
Infigratinib
Major
The metabolism of Infigratinib can be decreased when combined with Tioconazole.
Tioconazole Toxicity & Overdose RiskOverdosing on this drug may cause redness, stinging, blisters, swelling, itching, hives, burning sensation, and skin irritation. It may also lead to muscle cramps.
image of a doctor in a lab doing drug, clinical research

Tioconazole Novel Uses: Which Conditions Have a Clinical Trial Featuring Tioconazole?

191 active studies are assessing the potential of Tioconazole to provide a therapeutic intervention for cutaneous dermatophyte infection, superficial Fungal skin infection and Communicable Diseases.
Condition
Clinical Trials
Trial Phases
Candidiasis, Vulvovaginal
2 Actively Recruiting
Not Applicable, Phase 3
Inflammation
58 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1, Phase 2, Phase 3, Phase 4
cutaneous dermatophyte infection
0 Actively Recruiting
Cellulitis
0 Actively Recruiting
Tinea Pedis
0 Actively Recruiting
Onychomycosis
0 Actively Recruiting
Coinfection
0 Actively Recruiting
Candidiasis, Vulvovaginal
0 Actively Recruiting

Tioconazole Reviews: What are patients saying about Tioconazole?

4Patient Review
2/20/2021
Tioconazole for Yeast Infection of Vagina and Vulva
After trying several prescription medicines that didn’t work, I was given another prescription but Walmart didn’t have medicine and told me it would be Monday. I therefore went to look for OTC cream to try!!! I’m glad I did bc this gave me instant relief!!!
3.3Patient Review
5/25/2021
Tioconazole for Yeast Infection of Vagina and Vulva
I've had 5 yeast infections in my lifetime, and this product made me hurt more than any of those previous times. The first two days were the worst, with constant itching that was only relieved by cold yogurt. I'm on day three now and feeling better, but still itch occasionally. I hope this medicine will work, but next time I'll buy Monostat just in case."
3.3Patient Review
6/15/2020
Tioconazole for Yeast Infection of Vagina and Vulva
I've used this medication in the past to great success; however, the last couple of times I've bought it, I've experienced some pretty unpleasant side effects.
3Patient Review
8/20/2019
Tioconazole for Yeast Infection of Vagina and Vulva
In retrospect, I wish I had read the reviews before buying this product. The itchiness increased for the first hour after application (it wasn't very bad to start). There is no pain or swelling but still discomfort and significantly more leakage than I thought. It's only day 1, so I'll give it a few more days before I can tell if it really worked.
3Patient Review
5/21/2022
Tioconazole for Yeast Infection of Vagina and Vulva
After using this treatment, I felt bloated and had an aftertaste in my mouth. Is this normal?
1.7Patient Review
2/5/2019
Tioconazole for Yeast Infection of Vagina and Vulva
I was really hoping this would help with my yeast infection but it made things worse. I woke up in the middle of the night with throbbing pain and swelling. If you're considering this treatment, don't bother.
1Patient Review
7/24/2019
Tioconazole for Yeast Infection of Vagina and Vulva
Do not buy this product! I inserted it as directed and experienced severe burning and redness. This never happened to me with the three-day treatment.
1Patient Review
1/5/2020
Tioconazole for Yeast Infection of Vagina and Vulva
This is not a good product. It feels like there's someone inside my vagina burning it and sticking it with needles. I'm so irritated that I can't sleep, and I've been tossing and turning all night. My husband has to work in the morning, and this product has made my already bad situation worse. I'm literally in tears right now!
1Patient Review
11/2/2019
Tioconazole for Yeast Infection of Vagina and Vulva
I wish I had read the reviews before buying this product. It's still on the market, but it shouldn't be. A few people were happy with the results, but most people (including myself) have had a horrible experience.
1Patient Review
7/10/2021
Tioconazole for Yeast Infection of Vagina and Vulva
About an hour after a painful insertion with the applicator, the itching and burning woke me from a deep sleep. It was HORRIBLE!. I'm still in pain after 3weeks, and I've seen a gynecologist about it. The exam was too painful for him to finish. Another appointment on Tuesday. Prayers appreciated..
1Patient Review
5/8/2021
Tioconazole for Yeast Infection of Vagina and Vulva
I should have read the reviews before using this product. I'm still swollen, itchy, and in pain two days after application. The burning and tingling I felt immediately after use was actually a reaction to the medication, not the sign of it working. Overall, a very unpleasant experience that I wouldn't wish on anyone.
1Patient Review
5/15/2021
Tioconazole for Yeast Infection of Vagina and Vulva
Do not use this product! I got a mild infection and used this as a temporary measure until I could see my OB, but it just made everything worse. I'm in more pain now than when I started, and it's honestly the worst decision ever.
1Patient Review
9/2/2022
Tioconazole for Yeast Infection of Vagina and Vulva
The burning sensation is really bad and it doesn't go away even if you washed off. I even took Tylenol and nothing worked.
1Patient Review
2/8/2021
Tioconazole for Yeast Infection of Vagina and Vulva
DO NOT TAKE THIS MEDICATION. It's incredibly painful and made my vagina swell up. Not to mention, the applicator is very uncomfortable to insert. Save yourself the trouble and don't take this medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tioconazole

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What happens after using tioconazole?

"The most common side effects of tioconazole vaginal are mild stomach pain, pain or burning when urinating, headache, runny or stuffy nose, or mild vaginal burning, itching or irritation after use."

Answered by AI

How long does it take tioconazole to work?

"Your symptoms should start to improve after using the 1-day treatment, but it might take up to 7 days for them to go away completely. If your symptoms haven't improved after 3 days or if they last for more than 7 days, give your doctor a call."

Answered by AI

Is Monistat or tioconazole better?

"Monistat's 1-Day yeast infection treatment is the best overall pick because it contains 6.5% tioconazole ointment, which is an effective ingredient in treating yeast infections and other types of bacteria."

Answered by AI

Does tioconazole cure yeast infection?

"This ointment is used to treat vaginal yeast infections. It helps by reducing the burning, itching and discharge that come with the infection. The ointment does this by killing the fungus that causes the infection."

Answered by AI

Clinical Trials for Tioconazole

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Cognitive Remediation for Memory and Thinking Difficulties

18+
All Sexes
Farmington, CT
The goal of this clinical trial is to determine if a neuroscience-based computerized cognitive remediation ("brain training") program can treat neurocognitive dysfunction (i.e., memory or thinking difficulties) that emerges in some older adults following a viral infection. The main questions it aims to answer are: * Does computerized cognitive remediation improve cognitive performance and day-to-day functioning in older adults with postviral neurocognitive dysfunction? * Will treatment effects be maintained over time, leading to better long term cognitive outcomes? * Does the treatment lead to reductions in blood-based markers of inflammation as a potential mechanism of cognitive symptom improvement? * Can the treatment be optimized and refined based on feedback from participants to improve user (patient) experience? Researchers will compare the computerized cognitive remediation program to an active computer-based control condition (alternative computer activities) to see if the computerized cognitive remediation program works to treat postviral neurocognitive dysfunction. Participation takes approximately 43-48 hours over 7 months, with most activities (40-46 hours) completed within the first 7-8 weeks, including: * Initial intake visit: Eligibility confirmation (\~2-3 hours) * Computer activities: About 5 hours per week for \~6 weeks (total \~30 hours) completed on a computer tablet provided by the study and loaned to participants for use during the treatment phase * Weekly remote check-in meetings: \~30 minutes each during treatment * Blood draws: Two sessions (before and after treatment), \~20-30 minutes each * Three research visits: Pre-treatment, post-treatment, and 6-month follow-up (\~2-3 hours each, including assessments of cognitive, emotional, and daily functioning)
Waitlist Available
Has No Placebo
UConn HealthCutter Lindbergh, Ph.D.
Have you considered Tioconazole clinical trials? We made a collection of clinical trials featuring Tioconazole, we think they might fit your search criteria.Go to Trials
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Orticumab for Heart Attack

18+
All Sexes
Los Angeles, CA
The goal of this clinical trial is to determine the clinical effect of orticumab treatment on inflammation in study participants with prior myocardial infarction who have elevated coronary inflammation based on CCTA. The main question it aims to answer is: Clinical effects of orticumab treatment on inflammation of the coronary artery parameters measured with CCTA Researchers will compare the effects with placebo group after 6 months of treatment Participants will Keep the planned study visit appointments Provide complete information about medical and medical history Speak to the study doctor before changing any of non-study treatments, including starting new medications, receiving any vaccinations, or setting out to join any other clinical studies
Phase 2
Recruiting
Abcentra Investigational Site (+6 Sites)Abcentra
Image of School of Public Health in Bloomington, United States.

High Salt Intake for High Blood Pressure

60 - 85
All Sexes
Bloomington, IN
Most Americans consume excess dietary salt based on the recommendations set by the American Heart Association and Dietary Guidelines for Americans. High dietary salt impairs blood pressure control by affecting systemic blood vessels and the kidneys. These changes contribute to excess salt consumption being associated with increased risk for chronic kidney disease and cardiovascular disease, the leading cause of death in America. Salt is particularly deleterious in older adults who are more likely to exhibit salt-sensitive hypertension. However, salt consumption remains high in the United States. Thus, there is a critical need for strategies to counteract the effects of high dietary salt as consumption is likely not going to decrease. One promising option is ketones, metabolites that are produced in the liver during prolonged exercise and very low-calorie diets. While exercise and low-calorie diets are beneficial, not many people engage in these activities. Limited evidence indicates that ketone supplements improve cardiovascular health in humans. Additionally, published rodent data indicates that ketone supplements prevent high salt-induced increases in blood pressure, blood vessel dysfunction, and kidney injury. Our human pilot data also indicates that high dietary salt reduces intrinsic ketone production, but it is unclear whether ketone supplementation confers humans' protection against high salt similar to rodents. Therefore, the investigators seek to conduct a short-term high-dietary salt study to determine whether ketone supplementation prevents high dietary salt from eliciting increased blood pressure, blood vessel dysfunction, and kidney injury/impaired blood flow. The investigators will also measure inflammatory markers in blood samples and isolate immune cells that control inflammation. Lastly, the investigators will also measure blood ketone concentration and other circulating metabolites that may be altered by high salt, which could facilitate novel therapeutic targets to combat high salt.
Recruiting
Has No Placebo
School of Public Health
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Biophoton Therapy for Stem Cell Proliferation

18 - 70
All Sexes
Tampa, FL
Study Objective The purpose of this clinical study is to evaluate if biophoton therapy, delivered by Tesla BioHealing® Biophoton Generators (Biophotonizer), can increase self-grown stem cells naturally. Study Design This is a randomized, double-blinded, placebo-controlled intervention clinical study to assess the effectiveness of biophoton therapy in impacting stem cells. Approximately 46 volunteers who want to increase self-grown stem cells will participate in the study. Study Randomization The biostatistician will prepare a randomization schedule including a serial of subject numbers. A subject number will be randomly assigned to each study participant, which will assign them to either the control group or the treatment group. Other than the Informed Consent Form (ICF), all study information will be recorded by using the subject number. The Principal Investigator, study physicians, study nurse, data-entry specialists, and biostatisticians, as well as the participants, will be blinded about who received which product during the first two weeks of study participation.
Recruiting
Online Trial
Tesla MedBed at Tampa-FL (+1 Sites)James Z Liu, MD, PhD
Have you considered Tioconazole clinical trials? We made a collection of clinical trials featuring Tioconazole, we think they might fit your search criteria.Go to Trials
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Physical Activity for Delayed Onset Muscle Soreness

18 - 35
All Sexes
Toronto, Canada
After completing novel activity or exercise we may experience exercise-induced muscle damage (EIMD), resulting in a period of reduced muscle function and delayed onset muscle soreness (DOMS). DOMS is characterized by muscle pain and tenderness that typically resolves within a week. While the precise cause of DOMS is unknown, there is growing evidence implicating damage to the connective tissue that surrounds our muscle fibers and is related to a small amount of inflammation. This inflammation is a normal part of our body's ability to recovery from injuries and may be visualized through the use of ultrasound technology. A variety of recovery techniques have been proposed that may help with the recovery of DOMS such as massage and electrical muscle stimulation, but these are not always accessible. Therefore, we are interested in investigating whether the number of daily steps can affect how you experience DOMS.
Waitlist Available
Has No Placebo
Goldring Center for High Performance Sport
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Moisturizers for Aging

65+
All Sexes
San Francisco, CA
This is a randomized, investigator-blinded, self-controlled pilot study of the physiologic response to topical moisturizers among older adults with dry skin. The overarching hypothesis is that skin barrier decline is an important source of chronic inflammation, and that skin barrier restoration with moisturizers can reduce serum biomarkers of inflammation. The primary objective is to determine the feasibility for a larger trial, and the secondary objectives are to determine the extent to which measures of serum inflammation, skin barrier function, and the skin microbiome change in response to moisturizers. Participants will be asked to apply one of two topical moisturizers that are widely available over the counter in the US (Vaseline® 100% pure petroleum jelly or CeraVe® moisturizing cream) once daily for 4 weeks to the front of the torso, buttocks, arms, and legs. Subjects will act as their own control (i.e. they will be asked to apply the study moisturizer they are randomized to for one intervention period (4 weeks) and not to apply topical moisturizers for the other 4- week intervention period). Participants will be randomized in a 1:1:1:1 ratio to one of 4 treatment groups: i. no intervention then CeraVe; ii. CeraVe then no intervention; iii. no intervention then Vaseline; iv. Vaseline then no intervention. At each visit (baseline, week 4, and week 8), participants will undergo skin barrier testing, skin microbiome sampling, and phlebotomy to measure serum inflammatory markers.
Phase 4
Recruiting
UCSFKatrina Abuabara, MD
Have you considered Tioconazole clinical trials? We made a collection of clinical trials featuring Tioconazole, we think they might fit your search criteria.Go to Trials
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