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What is Tigecycline
TigecyclineThe Generic name of this drug
Treatment SummaryTigecycline is an antibiotic used to treat bacterial infections like Staphylococcus aureus. It was developed in response to the increasing number of antibiotic-resistant bacteria and was approved by the FDA in 2005. It is marketed under the brand name Tygacil.
Tygacilis the brand name
Tigecycline Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tygacil
Tigecycline
2008
10
Approved as Treatment by the FDA
Tigecycline, also known as Tygacil, is approved by the FDA for 4 uses including Urinary Tract Infection (UTI) and Community Acquired Pneumonia (CAP) .Urinary Tract Infection (UTI)
Community Acquired Pneumonia (CAP)
Abdominal Infection
Communicable Diseases
Effectiveness
How Tigecycline Affects PatientsTigecycline is an antibiotic from a new class called glycylcyclines. These are similar to the tetracycline antibiotics, but are designed to be more effective against bacteria that have become resistant to tetracycline. Like tetracyclines, glycylcyclines work by stopping the growth of bacteria by blocking the binding of amino-acyl tRNA to the A site of the ribosome. This makes them more effective than tetracyclines.
How Tigecycline works in the bodyTigecycline is an antibiotic that works by stopping bacteria from making proteins. It binds to the ribosome and prevents amino-acyl tRNA molecules from entering the ribosome. This stops bacteria from making proteins and stops them from multiplying. Tigecycline is not affected by resistance mechanisms like other antibiotics and it does not cause any drug interactions. In general, it works by keeping bacteria from reproducing and is considered a bacteriostatic drug.
When to interrupt dosage
The suggested dosage of Tigecycline is contingent upon the specified condition, such as Abdominal Infection, Community Acquired Pneumonia (CAP) and Communicable Diseases. The degree of dosage is to be found in the table beneath, in accordance with the technique of delivery (e.g. Intravenous or Powder, for solution).Condition
Dosage
Administration
Urinary Tract Infection (UTI)
, 50.0 mg, 50.0 mg/mL, 5.0 mg/mL
Intravenous, Powder, for solution, Powder, for solution - Intravenous, , Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Community Acquired Pneumonia (CAP)
, 50.0 mg, 50.0 mg/mL, 5.0 mg/mL
Intravenous, Powder, for solution, Powder, for solution - Intravenous, , Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Communicable Diseases
, 50.0 mg, 50.0 mg/mL, 5.0 mg/mL
Intravenous, Powder, for solution, Powder, for solution - Intravenous, , Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Abdominal Infection
, 50.0 mg, 50.0 mg/mL, 5.0 mg/mL
Intravenous, Powder, for solution, Powder, for solution - Intravenous, , Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Warnings
There are 20 known major drug interactions with Tigecycline.Common Tigecycline Drug Interactions
Drug Name
Risk Level
Description
Amdinocillin
Major
The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Tigecycline.
Amoxicillin
Major
The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Tigecycline.
Ampicillin
Major
The therapeutic efficacy of Ampicillin can be decreased when used in combination with Tigecycline.
Aspoxicillin
Major
The therapeutic efficacy of Aspoxicillin can be decreased when used in combination with Tigecycline.
Azidocillin
Major
The therapeutic efficacy of Azidocillin can be decreased when used in combination with Tigecycline.
Tigecycline Toxicity & Overdose RiskGlycylcyclines are similar to tetracyclines, so they can cause the same side effects, such as nausea, headaches, sensitivity to light, discoloration of developing teeth, and harm to unborn babies.
Tigecycline Novel Uses: Which Conditions Have a Clinical Trial Featuring Tigecycline?
28 active trials are presently examining the potential of Tigecycline to treat Community Acquired Pneumonia (CAP), Urinary Tract Infection (UTI) and Abdominal Infections.Condition
Clinical Trials
Trial Phases
Abdominal Infection
0 Actively Recruiting
Urinary Tract Infection (UTI)
24 Actively Recruiting
Phase 2, Phase 1, Phase 4, Phase 3, Not Applicable
Communicable Diseases
0 Actively Recruiting
Community Acquired Pneumonia (CAP)
1 Actively Recruiting
Not Applicable
Tigecycline Reviews: What are patients saying about Tigecycline?
5Patient Review
3/21/2009Patient Q&A Section about tigecycline
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why is tigecycline not an ideal antibiotic?
"The low plasma concentrations of tigecycline suggest that it is not ideal for treating bacteremia or other endovascular infections."
Answered by AI
What class of antibiotics is tigecycline?
"Tigecycline is the first drug in a class of antibiotics called glycylcyclines. It is similar to minocycline, but it works against a wider range of bacteria and is less likely to cause resistance."
Answered by AI
What is tigecycline used to treat?
"Tigecycline is an antibiotic that is used to treat bacterial infections. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections."
Answered by AI
Is tigecycline a strong antibiotic?
"Although clinicians and microbiologists may feel that tetracyclines are not as strong as antibiotics like β-lactams, aminoglycosides, and quinolones, tigecycline has been shown to be just as effective as imipenem in treating intra-abdominal infections and vancomycin plus aztreonam in treating skin and skin structure infections."
Answered by AI