Terazosin Hydrochloride

Enlarged Prostate, Hypertensive disease, Ureteral Calculi

Treatment

2 FDA approvals

20 Active Studies for Terazosin Hydrochloride

What is Terazosin Hydrochloride

Terazosin

The Generic name of this drug

Treatment Summary

Terazosin is a medication used to treat benign prostatic hyperplasia and high blood pressure. It works by blocking the action of adrenaline on the alpha-1 adrenergic receptors, which helps relax the muscles in the blood vessels and prostate.

Hytrin

is the brand name

image of different drug pills on a surface

Terazosin Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Hytrin

Terazosin

1987

173

Approved as Treatment by the FDA

Terazosin, otherwise known as Hytrin, is approved by the FDA for 2 uses including Enlarged Prostate and Hypertensive disease .

Enlarged Prostate

Hypertensive disease

Helps manage High Blood Pressure (Hypertension)

Effectiveness

How Terazosin Hydrochloride Affects Patients

Terazosin is a type of drug that helps block the actions of certain hormones in the body (alpha-1 adrenergic hormones) to help treat certain conditions.

How Terazosin Hydrochloride works in the body

Terazosin targets certain receptors found in the blood vessels and prostate. When those receptors are blocked, the smooth muscles in those areas relax, reducing blood pressure and improving urine flow. Terazosin has also been shown to stop cell growth and cause some prostate cells to die, a process called apoptosis. This is done by increasing the expression of certain factors like TGF-beta1, p27kip1, and caspase.

When to interrupt dosage

The proposed dosage of Terazosin Hydrochloride is contingent upon the ascertained condition, for example Ureteral Calculus, Hypertensive disease and Enlarged Prostate. The measure of dosage relies upon the technique of administration (e.g. Capsule, liquid filled or Capsule - Oral) as indicated in the table below.

Condition

Dosage

Administration

Enlarged Prostate

10.0 mg, , 1.0 mg, 2.0 mg, 5.0 mg

, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule, liquid filled, Capsule, liquid filled - Oral

Hypertensive disease

10.0 mg, , 1.0 mg, 2.0 mg, 5.0 mg

, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule, liquid filled, Capsule, liquid filled - Oral

Ureteral Calculi

10.0 mg, , 1.0 mg, 2.0 mg, 5.0 mg

, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule, liquid filled, Capsule, liquid filled - Oral

Warnings

Terazosin Hydrochloride Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Terazosin may interact with Pulse Frequency

There are 20 known major drug interactions with Terazosin Hydrochloride.

Common Terazosin Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

Acepromazine

Major

Terazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.

Alfuzosin

Major

Terazosin may increase the hypotensive activities of Alfuzosin.

Amifostine

Major

Terazosin may increase the hypotensive activities of Amifostine.

Aripiprazole

Major

Terazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.

Aripiprazole lauroxil

Major

Terazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole lauroxil.

Terazosin Hydrochloride Toxicity & Overdose Risk

If someone takes too much terazosin, they may have low blood pressure. To help control their heart rate and blood pressure, they should lie down and may need extra fluids or medicine to increase their blood pressure. It is important to monitor their kidney function. Since terazosin is strongly bound to proteins, dialysis is not likely to be very effective in removing the drug from the body. The lowest toxic dose of terazosin in mice is 5500mg/kg.

image of a doctor in a lab doing drug, clinical research

Terazosin Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Terazosin Hydrochloride?

39 active clinical trials are currently being conducted to assess the potential of Terazosin Hydrochloride to treat Enlarged Prostate, Ureteral Calculus and Hypertensive Disease.

Condition

Clinical Trials

Trial Phases

Hypertensive disease

27 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Enlarged Prostate

16 Actively Recruiting

Not Applicable, Phase 2

Ureteral Calculi

0 Actively Recruiting

Terazosin Hydrochloride Reviews: What are patients saying about Terazosin Hydrochloride?

5

Patient Review

8/8/2016

Terazosin Hydrochloride for Enlarged Prostate with Urination Problems

I experienced really great results while taking this medication for a year. However, I recently had to stop because it started causing an irregular heartbeat. Thankfully, my heart is back to normal now.

5

Patient Review

4/28/2019

Terazosin Hydrochloride for Enlarged Prostate with Urination Problems

I began with a low dose of 1mg, and have since increased to 5mg in the morning and 5mg at night. I haven't experienced any negative side effects, save for feeling lightheaded if I stand up too quickly. The medication has been effective in controlling my urination symptoms, which is something I'm grateful for. Although I would prefer not to be taking medication at all, this treatment seems to be working well for me.

4.3

Patient Review

12/25/2020

Terazosin Hydrochloride for Enlarged Prostate with Urination Problems

I find that this treatment is effective when I avoid bladder irritants. If I stick to one cup of green tea in the morning and no Diet Coke during the day, I can usually make it through the night without having to urinate. Without terasozin, I would get up 2-3 times a night to urinate.

4.3

Patient Review

11/10/2015

Terazosin Hydrochloride for Enlarged Prostate with Urination Problems

The capsules are supposed to be 5 mg, but they're only half the size of the former capsules.

4

Patient Review

2/8/2020

Terazosin Hydrochloride for Enlarged Prostate with Urination Problems

This medication has helped me to sleep through the night when I previously had to wake up multiple times due to nocturia.

4

Patient Review

1/8/2014

Terazosin Hydrochloride for Enlarged Prostate

3.7

Patient Review

6/21/2016

Terazosin Hydrochloride for Enlarged Prostate with Urination Problems

I found the sexual side effects quite distressing. I lost the ability to ejaculate, and as a result, also lost the orgasm associated with it. I stopped taking it for that reason - then all the old urinary problems returned. So I'm back on it and have had to accept that lack of sexual fulfillment is now a part of my life.

3.7

Patient Review

5/13/2014

Terazosin Hydrochloride for Enlarged Prostate

This treatment is good. It helped me a lot.

3.7

Patient Review

11/7/2013

Terazosin Hydrochloride for Enlarged Prostate

3

Patient Review

8/6/2016

Terazosin Hydrochloride for Enlarged Prostate with Urination Problems

I had to play around with the dosage a bit before finding one that didn't make me too dizzy and fatigued. I'm urinating much better now, but it is still a bit of a trade-off.

3

Patient Review

3/20/2017

Terazosin Hydrochloride for Enlarged Prostate with Urination Problems

The doctor prescribed this for me to help with high blood pressure caused by pain. Unfortunately, it made it difficult to concentrate and my vision got worse. I stopped taking it once the pain subsided, but my eyes are still blurry. Make sure you stay hydrated if you go on this medication.

3

Patient Review

7/16/2014

Terazosin Hydrochloride for Enlarged Prostate

Flomax gave me some really unpleasant side effects, so I had to switch to Terazosin. So far it's been working well for my BPH with only minor headaches. It's also a lot cheaper than Flomax, so that's a bonus.

2.7

Patient Review

9/12/2016

Terazosin Hydrochloride for High Blood Pressure

I'm a 64 year old woman who has been taking this once per day, and it's helped me a lot without any noticeable side effects. It's also very affordable, which is great.

2.3

Patient Review

5/6/2016

Terazosin Hydrochloride for Enlarged Prostate with Urination Problems

Honestly, this was the worst headache I have ever experienced. I couldn't sleep at all, and felt nauseous and dizzy the entire time. My teeth even started hurting really badly. This drug is absolutely intolerable, and I still feel its effects 11 days later. So scary.

2

Patient Review

8/29/2018

Terazosin Hydrochloride for Enlarged Prostate with Urination Problems

I had to stop taking this after just a few days because the side effects were so bad. My heart rate would skyrocket and I felt really sick all the time.

1

Patient Review

3/24/2017

Terazosin Hydrochloride for Enlarged Prostate with Urination Problems

Though my issues weren't major, this treatment still helped me a lot. I don't have any severe side effects, which is great. My erections aren't perfect but they work well enough, and my blood pressure is as low as it can be without causing problems.

1

Patient Review

1/16/2016

Terazosin Hydrochloride for Enlarged Prostate with Urination Problems

This medication definitely helped me with my urinary frequency.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about terazosin hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why do you take terazosin at night?

"Take terazosin at night to avoid problems with dizziness or fainting. The doctor will start with a small dose and gradually increase it."

Answered by AI

What is terazosin hydrochloride used for?

"Terazosin relaxes blood vessels and helps to lower blood pressure. Terazosin is also used to treat benign prostatic hyperplasia (BPH)."

Answered by AI

What is an important side effect of terazosin?

"You may feel dizzy, lightheaded, or faint if you stand up too quickly after lying down. This is more common when you first start or increase your dose of terazosin, or if you stop taking it for a few days and then start again."

Answered by AI

Does terazosin make you pee?

"Terazosin helps to relax the muscles in the prostate and around the bladder opening. This may help to increase the flow of urine, and/or reduce symptoms."

Answered by AI

Clinical Trials for Terazosin Hydrochloride

Image of UCSF Medical Center at Parnassus in San Francisco, United States.

Treatment for Atrial Fibrillation

18+
All Sexes
San Francisco, CA

The goal of this clinical trial is to learn if screening for atrial fibrillation (AFib), a common irregular heart rhythm, through daily home blood pressure monitoring will decrease the time to atrial fibrillation diagnosis in older adults with hypertension. The main question it aims to answer is: \-- Does introducing screening for AFib using a blood pressure monitor with AFib detection technology decrease time to AFib diagnosis in patients with high blood pressure, compared to usual care using a conventional home blood pressure monitor with no AFib detection? Participants will participate in two phases of the study: (1) clinical trial and (2) the registry. During the 6-month clinical trial period, participants will be asked to: * Take blood pressure measurements twice daily * Answer short weekly mobile app-based surveys * If assigned, complete continuous heart monitoring for 2 weeks and complete 1 blood test During the 12-month registry period, participants will be asked to: * Take blood pressure measurements twice daily * Answer monthly mobile app-based surveys Researchers will compare standard blood pressure measurements and AFib screening blood pressure measurements to see if there is a difference in the time to AFib diagnosis and other cardiovascular events. Participants will participate in two phases of the study: (1) trial and (2) the registry. During the 6-month trial period, participants will be asked to: * Take daily blood pressure measurements * Answer short weekly mobile app-based surveys * If assigned, complete continuous heart monitoring for 2 weeks and complete 1 blood test During the 12-month registry period, participants will be asked to: * Take daily blood pressure measurements * Answer monthly mobile app-based surveys

Waitlist Available
Has No Placebo

UCSF Medical Center at Parnassus

Gregory M Marcus, MD, MAS

Omron Healthcare Co., Ltd.

Image of Southern Alberta Institute of Urology in Calgary, Canada.

Prehabilitation Program for Enlarged Prostate

18+
Male
Calgary, Canada

Benign prostatic hyperplasia (BPH) is a debilitating condition which is highly prevalent in older males, up to 45% of those over the age of 45 are affected and 80% of those over the age of 70 are affected. While not all men with BPH experience problematic symptoms, many will experience lower urinary tract symptoms (LUTS) including difficulty passing urine, recurrent urinary tract infections, bladder stones, and hematuria. Holmium Laser Enucleation of the Prostate (HoLEP) is the gold standard in terms of surgical BPH management and is associated with a low risk for requiring repeat interventions. However, in the weeks following HoLEP procedures many men will experience transient urinary incontinence which can be distressing to patients. In the setting of prostate cancer, exercise and mental health supports prior to surgery has been shown to improve incontinence and post-surgical recovery. This is often termed prehabilitation and consists of programming done in the months before surgery. The objective of this study is to assess the safety and feasibility of prehabilitation programming prior to HoLEP procedures for men with BPH. The investigators will be randomizing 40 patients into 2 groups, one receiving standard of care interventions prior to their HoLEP surgery and one receiving at least 12 weeks of comprehensive prehabilitation programming including: pelvic floor physiotherapy, access to additional informational resources, and access to mental health supports including individual and couples counselling. In both groups the investigators will be collecting key demographics and clinical information from patients as well as assessing their urinary function through several questionnaires before prehabilitation, immediately before surgery, and up to 1 year after surgery. The investigators hope to establish that prehabilitation is a safe and feasible option for these patients. Secondarily investigators hope to provide evidence that prehabilitation improves incontinence faster following HoLEP procedures and improves post-surgical recovery.

Waitlist Available
Has No Placebo

Southern Alberta Institute of Urology

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Image of National Association of Pasifika Organizations in Fayetteville, United States.

PILI Pasifika Program for Cardiometabolic Conditions

18+
All Sexes
Fayetteville, AR

In this study, the investigators are conducting a Type 3 hybrid effectiveness-implementation trial to evaluate the implementation of the Community Health Workers (CHW)-delivered PILI Pasifika Program (PPP) across 3 regions, the U.S. Affiliated Pacific Islands (USAPI), the continental U.S., and Hawai'i, among 400 Native Hawaiian and Pacific Islander (NHPI) participants in two settings, (clinical and non-clinical) over a 3-year period. The PPP is a 3-month lifestyle intervention that includes a Social Determinants of Health (SDOH) component and was NHPI-adapted from the Diabetes Prevention Program's Lifestyle Program, renamed to the PILI Lifestyle Program (PLP), which demonstrated effectiveness in improving weight, blood pressure, physical activity, and diet among NHPIs. The PPP consists of 8 lifestyle lessons and 4 SDOH activities delivered over a 3-month period. The aims of this study are threefold: 1. To evaluate the implementation of the PPP across multiple community sites using a Type 3 hybrid effectiveness-implementation design guided by established frameworks such as RE-AIM and PRISM. 2. To examine participant-level outcomes associated with PPP implementation, including changes in cardiometabolic risk factors, health behaviors, and SDOH factors from baseline to 3 and 9-month follow-up. 3. To evaluate the cost and cost-effectiveness of implementing the PPP across community settings.

Waitlist Available
Has No Placebo

National Association of Pasifika Organizations (+1 Sites)

Joseph K Kaholokula, PhD

Image of Rush University Medical Center in Chicago, United States.

Food is Medicine for High Blood Pressure

18+
All Sexes
Chicago, IL

The goal of this clinical trial is to assess nutrition incentives and produce vouchers to measure the impacts of food insecurity-related chronic health conditions in adults with hypertension and/or diabetes. The main questions it aims to answer are: * Does participation increase fruit and vegetable consumption for participants? * Does participation reduce individual and household food insecurity? * Does participation reduce healthcare utilization and associated costs? * Does participation lead to improvements in diet-related health outcomes (e.g., hypertension, diabetes)? * Does participation support the local economy by increasing participant spending at local food vendors? Participants will: * Receive 6 months home delivered produce prescription boxes * Receive 6 months match of produce vouchers * Receive nutrition education and participate in Chronic Disease Self-Management classes

Waitlist Available
Has No Placebo

Rush University Medical Center

Traci Simmons, DrPHc, MPH

Image of Miles Square Health Center Chicago in Chicago, United States.

Food is Medicine for High Blood Pressure and Obesity

Any Age
All Sexes
Chicago, IL

The goal of this clinical trial is to treat both hypertension and obesity in adults using a food is medicine framework. Participants will be randomized 1:1 to FIM+DASH or usual-care control. The 24-week trial includes a 12-week FIM+DASH intervention followed by a 12-week maintenance period and leverages existing partnerships with community-based organizations for home food delivery and culinary skill-skill building. The main questions it aims to answer are: (1) What is the effect of FIM+DASH vs. usual care control on blood pressure? (2) What is the effect of FIM+DASH vs. usual care control on DASH diet adherence (diet quality), body weight, and waist circumference? (3) How to identify factors associated with the sustainability and scalability of FIM+DASH in real-world settings?

Phase 2
Waitlist Available

Miles Square Health Center Chicago (+3 Sites)

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