Terazosin Hydrochloride

Enlarged Prostate, Hypertensive disease, Ureteral Calculi
Treatment
2 FDA approvals
20 Active Studies for Terazosin Hydrochloride

What is Terazosin Hydrochloride

TerazosinThe Generic name of this drug
Treatment SummaryTerazosin is a medication used to treat benign prostatic hyperplasia and high blood pressure. It works by blocking the action of adrenaline on the alpha-1 adrenergic receptors, which helps relax the muscles in the blood vessels and prostate.
Hytrinis the brand name
image of different drug pills on a surface
Terazosin Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Hytrin
Terazosin
1987
173

Approved as Treatment by the FDA

Terazosin, otherwise known as Hytrin, is approved by the FDA for 2 uses including Enlarged Prostate and Hypertensive disease .
Enlarged Prostate
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)

Effectiveness

How Terazosin Hydrochloride Affects PatientsTerazosin is a type of drug that helps block the actions of certain hormones in the body (alpha-1 adrenergic hormones) to help treat certain conditions.
How Terazosin Hydrochloride works in the bodyTerazosin targets certain receptors found in the blood vessels and prostate. When those receptors are blocked, the smooth muscles in those areas relax, reducing blood pressure and improving urine flow. Terazosin has also been shown to stop cell growth and cause some prostate cells to die, a process called apoptosis. This is done by increasing the expression of certain factors like TGF-beta1, p27kip1, and caspase.

When to interrupt dosage

The proposed dosage of Terazosin Hydrochloride is contingent upon the ascertained condition, for example Ureteral Calculus, Hypertensive disease and Enlarged Prostate. The measure of dosage relies upon the technique of administration (e.g. Capsule, liquid filled or Capsule - Oral) as indicated in the table below.
Condition
Dosage
Administration
Enlarged Prostate
10.0 mg, , 1.0 mg, 2.0 mg, 5.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule, liquid filled, Capsule, liquid filled - Oral
Hypertensive disease
10.0 mg, , 1.0 mg, 2.0 mg, 5.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule, liquid filled, Capsule, liquid filled - Oral
Ureteral Calculi
10.0 mg, , 1.0 mg, 2.0 mg, 5.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule, liquid filled, Capsule, liquid filled - Oral

Warnings

Terazosin Hydrochloride Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Terazosin may interact with Pulse Frequency
There are 20 known major drug interactions with Terazosin Hydrochloride.
Common Terazosin Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Major
Terazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Alfuzosin
Major
Terazosin may increase the hypotensive activities of Alfuzosin.
Amifostine
Major
Terazosin may increase the hypotensive activities of Amifostine.
Aripiprazole
Major
Terazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.
Aripiprazole lauroxil
Major
Terazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole lauroxil.
Terazosin Hydrochloride Toxicity & Overdose RiskIf someone takes too much terazosin, they may have low blood pressure. To help control their heart rate and blood pressure, they should lie down and may need extra fluids or medicine to increase their blood pressure. It is important to monitor their kidney function. Since terazosin is strongly bound to proteins, dialysis is not likely to be very effective in removing the drug from the body. The lowest toxic dose of terazosin in mice is 5500mg/kg.
image of a doctor in a lab doing drug, clinical research

Terazosin Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Terazosin Hydrochloride?

39 active clinical trials are currently being conducted to assess the potential of Terazosin Hydrochloride to treat Enlarged Prostate, Ureteral Calculus and Hypertensive Disease.
Condition
Clinical Trials
Trial Phases
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Enlarged Prostate
16 Actively Recruiting
Not Applicable, Phase 2
Ureteral Calculi
0 Actively Recruiting

Terazosin Hydrochloride Reviews: What are patients saying about Terazosin Hydrochloride?

5Patient Review
8/8/2016
Terazosin Hydrochloride for Enlarged Prostate with Urination Problems
I experienced really great results while taking this medication for a year. However, I recently had to stop because it started causing an irregular heartbeat. Thankfully, my heart is back to normal now.
5Patient Review
4/28/2019
Terazosin Hydrochloride for Enlarged Prostate with Urination Problems
I began with a low dose of 1mg, and have since increased to 5mg in the morning and 5mg at night. I haven't experienced any negative side effects, save for feeling lightheaded if I stand up too quickly. The medication has been effective in controlling my urination symptoms, which is something I'm grateful for. Although I would prefer not to be taking medication at all, this treatment seems to be working well for me.
4.3Patient Review
12/25/2020
Terazosin Hydrochloride for Enlarged Prostate with Urination Problems
I find that this treatment is effective when I avoid bladder irritants. If I stick to one cup of green tea in the morning and no Diet Coke during the day, I can usually make it through the night without having to urinate. Without terasozin, I would get up 2-3 times a night to urinate.
4.3Patient Review
11/10/2015
Terazosin Hydrochloride for Enlarged Prostate with Urination Problems
The capsules are supposed to be 5 mg, but they're only half the size of the former capsules.
4Patient Review
2/8/2020
Terazosin Hydrochloride for Enlarged Prostate with Urination Problems
This medication has helped me to sleep through the night when I previously had to wake up multiple times due to nocturia.
4Patient Review
1/8/2014
Terazosin Hydrochloride for Enlarged Prostate
3.7Patient Review
6/21/2016
Terazosin Hydrochloride for Enlarged Prostate with Urination Problems
I found the sexual side effects quite distressing. I lost the ability to ejaculate, and as a result, also lost the orgasm associated with it. I stopped taking it for that reason - then all the old urinary problems returned. So I'm back on it and have had to accept that lack of sexual fulfillment is now a part of my life.
3.7Patient Review
5/13/2014
Terazosin Hydrochloride for Enlarged Prostate
This treatment is good. It helped me a lot.
3.7Patient Review
11/7/2013
Terazosin Hydrochloride for Enlarged Prostate
3Patient Review
8/6/2016
Terazosin Hydrochloride for Enlarged Prostate with Urination Problems
I had to play around with the dosage a bit before finding one that didn't make me too dizzy and fatigued. I'm urinating much better now, but it is still a bit of a trade-off.
3Patient Review
3/20/2017
Terazosin Hydrochloride for Enlarged Prostate with Urination Problems
The doctor prescribed this for me to help with high blood pressure caused by pain. Unfortunately, it made it difficult to concentrate and my vision got worse. I stopped taking it once the pain subsided, but my eyes are still blurry. Make sure you stay hydrated if you go on this medication.
3Patient Review
7/16/2014
Terazosin Hydrochloride for Enlarged Prostate
Flomax gave me some really unpleasant side effects, so I had to switch to Terazosin. So far it's been working well for my BPH with only minor headaches. It's also a lot cheaper than Flomax, so that's a bonus.
2.7Patient Review
9/12/2016
Terazosin Hydrochloride for High Blood Pressure
I'm a 64 year old woman who has been taking this once per day, and it's helped me a lot without any noticeable side effects. It's also very affordable, which is great.
2.3Patient Review
5/6/2016
Terazosin Hydrochloride for Enlarged Prostate with Urination Problems
Honestly, this was the worst headache I have ever experienced. I couldn't sleep at all, and felt nauseous and dizzy the entire time. My teeth even started hurting really badly. This drug is absolutely intolerable, and I still feel its effects 11 days later. So scary.
2Patient Review
8/29/2018
Terazosin Hydrochloride for Enlarged Prostate with Urination Problems
I had to stop taking this after just a few days because the side effects were so bad. My heart rate would skyrocket and I felt really sick all the time.
1Patient Review
3/24/2017
Terazosin Hydrochloride for Enlarged Prostate with Urination Problems
Though my issues weren't major, this treatment still helped me a lot. I don't have any severe side effects, which is great. My erections aren't perfect but they work well enough, and my blood pressure is as low as it can be without causing problems.
1Patient Review
1/16/2016
Terazosin Hydrochloride for Enlarged Prostate with Urination Problems
This medication definitely helped me with my urinary frequency.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about terazosin hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why do you take terazosin at night?

"Take terazosin at night to avoid problems with dizziness or fainting. The doctor will start with a small dose and gradually increase it."

Answered by AI

What is terazosin hydrochloride used for?

"Terazosin relaxes blood vessels and helps to lower blood pressure. Terazosin is also used to treat benign prostatic hyperplasia (BPH)."

Answered by AI

What is an important side effect of terazosin?

"You may feel dizzy, lightheaded, or faint if you stand up too quickly after lying down. This is more common when you first start or increase your dose of terazosin, or if you stop taking it for a few days and then start again."

Answered by AI

Does terazosin make you pee?

"Terazosin helps to relax the muscles in the prostate and around the bladder opening. This may help to increase the flow of urine, and/or reduce symptoms."

Answered by AI

Clinical Trials for Terazosin Hydrochloride

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
Have you considered Terazosin Hydrochloride clinical trials? We made a collection of clinical trials featuring Terazosin Hydrochloride, we think they might fit your search criteria.Go to Trials
Have you considered Terazosin Hydrochloride clinical trials? We made a collection of clinical trials featuring Terazosin Hydrochloride, we think they might fit your search criteria.Go to Trials
Image of Centre Hospitalier de l'université de Montréal (CHUM) in Montréal, Canada.

Optilume vs Rezum for Enlarged Prostate

18+
Male
Montréal, Canada
Lower urinary symptoms (LUTS) affect older men and their frequency and severity increase with age. According to Berry et al., the histological diagnosis of benign prostatic hyperplasia (BPH) increases from 25% in the group age between 40 to 49 years to 80% in the group age between 70 to 79 years (1). However, this hyperplasia can lead to a bladder outlet obstruction (BOO) secondary to benign prostatic enlargement (BPE), causing storage and voiding symptoms, associated with a considerable impairment of the quality of life (2). Surgical therapy of BPH has continuously evolved in recent years. The current gold standard for the endoscopic treatment of BPH is the transurethral resection of the prostate (TURP). Other innovative techniques were developed including Urolift, transurethral laser enucleation (holmium, thulium) and Aquablation therapy. One of the latest technologies for the management of BPH are Optilume BPH Catheter System (Optilume®, Urotronic Inc, Minneapolis, USA) and Rezum Water Vapor Therapy (Rezum System, Bostocn Scientific, Marlborough, MA). The purpose of the present study is to compare between patient experience, symptom relief and functional improvement when using the Optilume BPH Catheter System (Optilume®, Urotronic Inc, Minneapolis, USA) and Rezum Water Vapor Therapy (Rezum System, Boston Scientific, Marlborough, MA).
Recruiting
Has No Placebo
Centre Hospitalier de l'université de Montréal (CHUM) (+1 Sites)Naeem Bhojani, MD
Image of Wayne Health Mobile Units in Detroit, United States.

Text Message Reminders for High Blood Pressure

18+
All Sexes
Detroit, MI
This project is part of the ACHIEVE GREATER (Addressing Cardiometabolic Health In Populations Through Early PreVEntion in the GREAT LakEs Region) Center (IRB# 100221MP2A), the purpose of which is to improve cardiometabolic health in two uniquely comparable cities: Detroit, Michigan, and Cleveland, Ohio. The ACHIEVE GREATER Center involves separate but related projects that aim to improve cardiometabolic health outcomes through better risk factor control for three chronic conditions that are of tremendous public health importance, (hypertension (HTN), heart failure, and coronary heart disease), all of which contribute significantly to premature death in Detroit and Cleveland. The present study is the prospective observational cohort component of ACHIEVE P1- EPI (Project 1) of the ACHIEVE GREATER Center and serves to characterize the population of patients with blood pressure (BP) levels above normal attending The Wayne Health Mobile Health Unit (MHU) events to better understand key factors (e.g., social determinants of health) that convey information about baseline BP levels and related clinical outcomes (e.g., follow-up clinic visits, BP control, and cardiovascular events).
Recruiting
Has No Placebo
Wayne Health Mobile UnitsSteven J Korzeniewski, PhD
Image of University of Alberta in Edmonton, Canada.

Egg White Powder for High Blood Sugar and High Blood Pressure

18 - 70
All Sexes
Edmonton, Canada
Bioactive peptides derived from food proteins show potential for improving human health. One of such promising peptides is namely IRW made from egg white hydrolysate and composed of three peptides. This is a feasibility study to assess the acute effect of IRW in egg white hydrolysate for the management of high sugar and blood pressure. Participants at high risk of type 2 diabetes (T2D) or having T2D will undergo 4 consecutive treatments of 1 day each (randomly), during which they will consume a standardized breakfast with a smoothie containing different protein powders. Each treatment will be separated by a minimum of 1-week. Participants in the healthy control group will undergo 1 treatment only (one day).
Phase 1
Waitlist Available
University of AlbertaJianping Wu, PhD
Have you considered Terazosin Hydrochloride clinical trials? We made a collection of clinical trials featuring Terazosin Hydrochloride, we think they might fit your search criteria.Go to Trials
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