Tenofovir Disoproxil Fumarate

Antiretroviral Therapy, HIV test negative, HIV Infections + 12 more
Treatment
2 FDA approvals
20 Active Studies for Tenofovir Disoproxil Fumarate

What is Tenofovir Disoproxil Fumarate

EmtricitabineThe Generic name of this drug
Treatment SummaryTenofovir disoproxil fumarate, sold under the brand name Viread, is a medicine used to treat HIV and hepatitis B. It works by interfering with the reproduction of the virus in the body. This drug belongs to a family of antiretroviral medications known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). Tenofovir disoproxil was first approved by the FDA in 2001.
Emtrivais the brand name
image of different drug pills on a surface
Tenofovir Disoproxil Fumarate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Emtriva
Emtricitabine
2003
131

Approved as Treatment by the FDA

Emtricitabine, also called Emtriva, is approved by the FDA for 2 uses including HIV and adults and pediatric patients weighing at least 17 kg .
HIV
Helps manage Human Immunodeficiency Virus Type 1 (HIV-1) Infection
adults and pediatric patients weighing at least 17 kg

Effectiveness

How Tenofovir Disoproxil Fumarate Affects PatientsTenofovir is a drug used to treat HIV-1 and Hepatitis B infections. In laboratory tests, the drug has been shown to be effective against HIV-1 with a 50% effective concentration (EC50) of 0.04 - 8.5 μM. Tenofovir works by preventing viral DNA chain elongation, which stops the virus from replicating. Tenofovir has also been found to have a synergistic effect when taken with other drugs such as nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, and protease inhibitors.
How Tenofovir Disoproxil Fumarate works in the bodyTenofovir is an antiretroviral drug, which works by blocking the enzyme that helps HIV-infected individuals replicate their virus. Tenofovir is first converted to its active form, and then to its active metabolite, tenofovir diphosphate, which stops the virus from replicating by blocking its natural deoxyribonucleotide substrate. In rare cases, HIV-1 isolates can develop a decreased susceptibility to tenofovir, due to a mutation known as K65R.

When to interrupt dosage

The prescribed dosage of Tenofovir Disoproxil Fumarate is contingent upon the diagnosed condition, including Anti-Retroviral Agents, High Risk Patients and Chronic Hepatitis B. The amount of dosage fluctuates as per the method of delivery (e.g. Tablet or Tablet, film coated) listed in the table beneath.
Condition
Dosage
Administration
Antiretroviral Therapy
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV Infections
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV Transmission
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
weight more than 35 kg
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
weight at least 14 kg
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
adults and pediatric patients weighing at least 17 kg
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Anti-Retroviral Agents
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Sexual Behaviour
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
treatment failure
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
weight at least 35 kg
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV test negative
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
not requiring CYP3A inhibitors
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral

Warnings

Tenofovir Disoproxil Fumarate Contraindications
Condition
Risk Level
Notes
HIV
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Emtricitabine may interact with Pulse Frequency
There are 20 known major drug interactions with Tenofovir Disoproxil Fumarate.
Common Tenofovir Disoproxil Fumarate Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Emtricitabine.
Procainamide
Major
The excretion of Procainamide can be decreased when combined with Emtricitabine.
Topotecan
Major
The excretion of Topotecan can be decreased when combined with Emtricitabine.
Cefradine
Minor
The excretion of Cefradine can be decreased when combined with Emtricitabine.
Estrone sulfate
Minor
The excretion of Estrone sulfate can be decreased when combined with Emtricitabine.
Tenofovir Disoproxil Fumarate Toxicity & Overdose RiskBreastfeeding: HIV-1-infected mothers should not breastfeed their infants to prevent postnatal transmission of HIV-1. If a mother is taking tenofovir disoproxil, she should not breastfeed her infant. Carcinogenesis: Long-term studies in mice and rats have found that tenofovir disoproxil fumarate can increase the risk of liver cancer in mice, but no such risk was found in rats. Pregnancy: Tenofovir disoproxil is classified as a pregnancy Category B drug, meaning it
image of a doctor in a lab doing drug, clinical research

Tenofovir Disoproxil Fumarate Novel Uses: Which Conditions Have a Clinical Trial Featuring Tenofovir Disoproxil Fumarate?

Currently, 46 active trials are evaluating the potential of Tenofovir Disoproxil Fumarate to replace current antiretroviral regimens for adult patients with virologically suppressed HIV-1 RNA (<50 copies/mL) at the start of therapy, as well as for the treatment of Chronic Hepatitis B and HIV (Human Immunodeficiency Virus).
Condition
Clinical Trials
Trial Phases
treatment failure
0 Actively Recruiting
HIV Transmission
0 Actively Recruiting
HIV
0 Actively Recruiting
Anti-Retroviral Agents
0 Actively Recruiting
HIV Infections
0 Actively Recruiting
HIV test negative
0 Actively Recruiting
adults and pediatric patients weighing at least 17 kg
0 Actively Recruiting
Antiretroviral Therapy
2 Actively Recruiting
Phase 3, Phase 1
HIV
39 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
HIV
146 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
not requiring CYP3A inhibitors
0 Actively Recruiting
weight more than 35 kg
0 Actively Recruiting
weight at least 35 kg
0 Actively Recruiting
weight at least 14 kg
0 Actively Recruiting
Sexual Behaviour
18 Actively Recruiting
Phase 2, Not Applicable, Phase 4

Tenofovir Disoproxil Fumarate Reviews: What are patients saying about Tenofovir Disoproxil Fumarate?

5Patient Review
6/17/2008
Tenofovir Disoproxil Fumarate for HIV
I've been taking this medication in conjunction with other treatments and it's working really well for me. I didn't have any negative side effects, except for some temporary withdrawal symptoms when I first started taking it, but overall it's a great medication that's helped my cells stay undetectable.
4.7Patient Review
2/1/2012
Tenofovir Disoproxil Fumarate for Chronic Hepatitis B
I stopped taking this medication for a while and when I started again, I had itchiness all over my body. After taking it for three months though, I feel much better now and the itching has gone away.
4.3Patient Review
8/30/2013
Tenofovir Disoproxil Fumarate for Chronic Hepatitis B
I've been taking this medication for six months and my viral load is now undetectable. I'm pleased with this outcome, though my doctor wants me to keep taking the drug and getting tested periodically.
4Patient Review
8/27/2011
Tenofovir Disoproxil Fumarate for Chronic Hepatitis B
This treatment has kept my virus load at a chronic level of below 500iu. In fact, it lowered to 50iu after just six months. And as of now, my current viral load is <20ui.
4Patient Review
4/28/2015
Tenofovir Disoproxil Fumarate for Chronic Hepatitis B
I've gained weight, gotten chronic headaches, and struggled with insomnia since starting this medication, but it has normalized my liver enzymes.
3Patient Review
6/22/2012
Tenofovir Disoproxil Fumarate for Chronic Hepatitis B
I've been on this medication for five weeks to treat a viral infection. I'm not seeing the results I want yet, but I'm hopeful that with more time it will be effective.
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Patient Q&A Section about tenofovir disoproxil fumarate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

When is the best time to take tenofovir disoproxil fumarate?

"You should take tenofovir tablets with a meal or a snack. (However, if you have been prescribed the combination brand Atripla®, these tablets should be taken when your stomach is empty, which means taking them one hour before any food or waiting until two hours afterwards.)"

Answered by AI

Can tenofovir cure hepatitis B?

"Although Tenofovir cannot cure hepatitis b, it might help to prevent further complications such as cirrhosis of the liver or liver cancer. Additionally, it may prevent the spread of the virus to others. However, there are no generic drugs available for this medication."

Answered by AI

What are the side effects of taking tenofovir?

"The side effects of the medication include diarrhea, headache, depression, rash, itching, fever, difficulty falling asleep or staying asleep, and gas."

Answered by AI

What is tenofovir disoproxil fumarate used for?

"Emtricitabine; Tenofovir Disoproxil Fumarate helps manage HIV infection by limiting the spread of the virus in the body. It can also be used for Prep (pre-exposure prophylaxis) to lower the risk of getting HIV through sex."

Answered by AI

Clinical Trials for Tenofovir Disoproxil Fumarate

Have you considered Tenofovir Disoproxil Fumarate clinical trials? We made a collection of clinical trials featuring Tenofovir Disoproxil Fumarate, we think they might fit your search criteria.
Have you considered Tenofovir Disoproxil Fumarate clinical trials? We made a collection of clinical trials featuring Tenofovir Disoproxil Fumarate, we think they might fit your search criteria.
Have you considered Tenofovir Disoproxil Fumarate clinical trials? We made a collection of clinical trials featuring Tenofovir Disoproxil Fumarate, we think they might fit your search criteria.