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What is Tekturna Hct
HydrochlorothiazideThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a diuretic medication that is commonly used to treat edema (swelling) and high blood pressure. Hydrochlorothiazide is often combined with other medications, such as angiotensin converting enzyme inhibitors or angiotensin II receptor blockers, to treat hypertension more effectively. It was approved by the FDA in 1959 and is still widely prescribed today, although it is becoming less common in favor of other medications.
Esidrixis the brand name
Tekturna Hct Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esidrix
Hydrochlorothiazide
1959
2181
Approved as Treatment by the FDA
Hydrochlorothiazide, also called Esidrix, is approved by the FDA for 22 uses including Stroke and calcium channel blockers .Stroke
Used to treat Cerebrovascular Accident in combination with Losartan
calcium channel blockers
Used to treat calcium channel blockers in combination with Eprosartan
inadequate response to other therapeutic measures
Used to treat inadequate response to other therapeutic measures in combination with Spironolactone
inadequate control of blood pressure with monotherapy
Used to treat inadequate control of blood pressure with monotherapy in combination with Aliskiren
Antepartum magnesium sulfate prophylaxis
Helps manage prophylaxis of preeclampsia
Congestive Heart Failure
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Antihypertensive Treatment
Used to treat Antihypertensive Treatment in combination with Eprosartan
hypokalemia with solo treatment
Used to treat hypokalemia with solo treatment in combination with Triamterene
Bedrest
Used to treat Bedrest in combination with Spironolactone
Cirrhosis
Used to treat Cirrhosis of the Liver in combination with Spironolactone
Diuretics
Used to treat Hypokalemia caused by diuretics in combination with Amiloride
restriction of fluid and sodium
Used to treat restriction of fluid and sodium in combination with Spironolactone
Edema
Helps manage Premenstrual tension with edema
Hypertensive disease
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
blood pressure inadequately controlled with monotherapy
Used to treat blood pressure inadequately controlled with monotherapy in combination with Irbesartan
Sodium retention
Used to treat Sodium retention in combination with Spironolactone
Swollen feet or ankles
Used to treat Edema in combination with Triamterene
Ascites
Used to treat Ascites in combination with Spironolactone
Nephrotic Syndrome
Used to treat Nephrotic Syndrome in combination with Spironolactone
Therapeutic procedure
Used to treat inadequate response to treatment in combination with Spironolactone
Left Ventricular Hypertrophy
Used to treat Left Ventricular Hypertrophy in combination with Losartan
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Losartan
Effectiveness
How Tekturna Hct Affects PatientsHydrochlorothiazide helps the body get rid of extra water in the urine. The amount taken is usually tailored to the individual and can go from 25-100mg. It is important to be aware of if someone has kidney or liver problems as they should take hydrochlorothiazide with caution.
How Tekturna Hct works in the bodyHydrochlorothiazide is transported into cells of the distal convoluted tubule and then to the lumen of the tubule by special proteins. Normally, sodium is reabsorbed into these cells and then pushed into the area around them by a sodium-potassium pump. This creates a difference in concentration that pulls water back into the cells. Hydrochlorothiazide blocks this process by stopping the sodium-chloride transporter from doing its job. This reduces the difference in concentration, so less water is reabsorbed.
When to interrupt dosage
The proposed dosage of Tekturna Hct is contingent upon the diagnosed disorder, including Antepartum magnesium sulfate prophylaxis, blood pressure inadequately managed with monotherapy and antihypertensives. The dosage also varies, in line with the method of delivery (e.g. Tablet, coated - Oral or Oral) as depicted in the table underneath.Condition
Dosage
Administration
inadequate control of blood pressure with monotherapy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrotic Syndrome
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
prophylaxis of calcium nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antepartum magnesium sulfate prophylaxis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
calcium channel blockers
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diabetes Insipidus
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Congestive Heart Failure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
inadequate response to other therapeutic measures
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Bedrest
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Cirrhosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Renal tubular acidosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
restriction of fluid and sodium
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Therapeutic procedure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diuretics
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
blood pressure inadequately controlled with monotherapy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antihypertensive Treatment
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Edema
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Left Ventricular Hypertrophy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Ascites
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Tekturna Hct ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
Common Tekturna Hct Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Fenofibrate
Major
The therapeutic efficacy of Fenofibrate can be decreased when used in combination with Hydrochlorothiazide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Hydroxyzine.
Tekturna Hct Toxicity & Overdose RiskThe highest dose of hydrochlorothiazide that has been found to be toxic in mice and rats is more than 10g/kg. People who overdose on hydrochlorothiazide may experience low potassium, chloride, and sodium levels. Treatment can include fluids, electrolytes, medicines to treat low blood pressure, and oxygen to help with breathing.
Tekturna Hct Novel Uses: Which Conditions Have a Clinical Trial Featuring Tekturna Hct?
158 active clinical trials are currently in progress to assess the potential of Tekturna Hct to reduce symptoms of Cirrhosis, Edema and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Antihypertensive Treatment
0 Actively Recruiting
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Renal tubular acidosis
0 Actively Recruiting
Antepartum magnesium sulfate prophylaxis
18 Actively Recruiting
Phase 1, Not Applicable, Phase 3, Early Phase 1, Phase 2, Phase 4
Congestive Heart Failure
23 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Cirrhosis
50 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
inadequate control of blood pressure with monotherapy
0 Actively Recruiting
Ascites
10 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2
Diabetes Insipidus
1 Actively Recruiting
Phase 1
Stroke
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
calcium channel blockers
0 Actively Recruiting
Nephrolithiasis
0 Actively Recruiting
hypokalemia with solo treatment
0 Actively Recruiting
blood pressure inadequately controlled with monotherapy
0 Actively Recruiting
inadequate response to other therapeutic measures
0 Actively Recruiting
Diuretics
0 Actively Recruiting
Bedrest
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Sodium retention
0 Actively Recruiting
Tekturna Hct Reviews: What are patients saying about Tekturna Hct?
5Patient Review
1/25/2012 My blood pressure was out of control, and I had tried many different combinations of medications to try to bring it down. When Tekturna came on the market, my doctor suggested I give it a try. It worked immediately and has been keeping my blood pressure under control ever since. Prior to taking Tekturna, I was taking so much medication that I had no energy. This drug really gave me back my life.
5Patient Review
4/26/2010 I found the higher dosage of this drug to be very effective. However, it also caused me to feel tired and lethargic. After a few weeks on the drug, I had little energy and no sex drive.
5Patient Review
1/26/2011 This medication has drastically reduced my blood pressure readings in just a week and a half. I'm very pleased with the results and would recommend it to others.
5Patient Review
3/10/2011 I had a terrible reaction to this drug. I developed a rash, my skin was swollen and felt like it was sunburned, and I was constantly itch. Do not recommend.
4.7Patient Review
12/3/2010 Tekturna has been a godsend for my blood pressure. In only three months, it's brought my numbers down from 180/98 to 117/67. The only downside is that I've experienced a decrease in libido and an annoying cough.
4Patient Review
1/21/20104Patient Review
2/28/2014 I've been on this medication for over a year and it has done great things for my blood pressure. However, I have since found out that I have kidney stones in both of my kidneys. I've had to have two surgical procedures to break up the larger stones. If you're going to be using this medication, just be sure to see a renal doctor regularly to check your kidney function.
4Patient Review
6/10/2013 The diarrhea is not good for a working person; it is unmanageable when it starts.
3.7Patient Review
1/30/2010 I've been using this medication for a while now and it's helped me a lot. Though I had to reduce the dosage because it was making me really sluggish and incontinent.
3.7Patient Review
1/21/2011 I think this medication overstimulated my bladder. I stopped taking it a few days ago and the feeling has gone away mostly.
3.3Patient Review
12/8/20093Patient Review
1/15/20103Patient Review
1/26/20103Patient Review
2/9/2011 I felt very tired and had a lot of muscle pain, especially in my legs.
3Patient Review
7/10/2010 Norvasc caused me a lot of problems, so my doctor switched me to Tekturna HCT. I'm happy to report that my blood pressure is now at an acceptable level with no side effects.
2.3Patient Review
7/31/2013 Though this medication did lower my blood pressure, the side effects were really not worth it. I had problems with weakness, pain in my feet and knees, and gout that lasted for months. I'm glad to be done with it.
1.7Patient Review
11/14/2012 I'm glad it helped you, but I stopped taking tekturna after two years because I started experiencing a lot of health problems that I later found out were caused by the medication. These included Crohn's disease, low sugar levels, gallbladder removal, and fibromyalgia. So be careful not to take it for too long.
1.3Patient Review
3/23/2010 There's some relief to be found here, but it's not perfect by any means.
Patient Q&A Section about tekturna hct
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Tekturna HCT used for?
"Tekturna HCT is a combination of two drugs used to treat hypertension: an anti-hypertensive and a thiazide diuretic."
Answered by AI
Is Tekturna still on the market?
"The FDA has advised against the use of Tekturna for patients with diabetes who are taking ACE inhibitors or ARBs."
Answered by AI
What is Tekturna prescribed for?
"This medication lowers blood pressure by relaxing blood vessels so blood can flow more easily. It is known as a direct renin inhibitor."
Answered by AI
Is there a generic for Tekturna HCT?
"An authorized generic version of the hypertension medication Tekturna (aliskiren hemifumarate; Noden Pharma) is now available to patients, drug company PDL BioPharma announced. The drug is indicated for use in patients aged 6 years and older."
Answered by AI