Tagamet Hb

Zollinger-Ellison Syndrome, Indigestion, Heartburn + 11 more

Treatment

12 FDA approvals

20 Active Studies for Tagamet Hb

What is Tagamet Hb

Cimetidine

The Generic name of this drug

Treatment Summary

Cimetidine is a type of drug known as a histamine congener. It works by blocking histamine from binding to histamine H2 receptors, which helps reduce the production of stomach acid. Cimetidine can also reduce the production of pepsin and gastrins and inhibit the activity of an enzyme called cytochrome P-450, which may be useful in neoadjuvant therapy.

Cimetidine

is the brand name

image of different drug pills on a surface

Tagamet Hb Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Cimetidine

Cimetidine

1994

91

Approved as Treatment by the FDA

Cimetidine, also known as Cimetidine, is approved by the FDA for 12 uses which include Adenoma and Heartburn .

Adenoma

Helps manage multiple endocrine adenomas

Heartburn

Helps manage Gastro-esophageal Reflux Disease (GERD)

multiple endocrine adenomas

Helps manage multiple endocrine adenomas

benign gastric ulcers

Gastro-esophageal Reflux Disease (GERD)

Helps manage Gastro-esophageal Reflux Disease (GERD)

Zollinger-Ellison Syndrome

Helps manage Zollinger-Ellison Syndrome

Gastric hypersecretion

Helps manage Gastric hypersecretion

active Duodenal ulcer

Systemic Mastocytosis

Helps manage Systemic Mastocytosis

Gastric ulcer

Duodenal Ulcer

Mastocytosis, Systemic

Helps manage Systemic Mastocytosis

Effectiveness

How Tagamet Hb Affects Patients

Cimetidine helps to reduce how much acid the stomach produces, both during the day and at night. It is used to treat digestive issues like stomach or duodenal ulcers, acid reflux, and conditions that cause too much acid to be made in the stomach. Taking cimetidine can also affect how the body processes certain medications, as well as increase the amount of certain bacteria in the stomach.

How Tagamet Hb works in the body

Cimetidine works by blocking the effects of histamine on the stomach. It attaches to a special receptor on the cells in the stomach and prevents histamine from binding. This stops the stomach from producing too much acid, reducing the amount of acid in the stomach and its volume.

When to interrupt dosage

The proposed dosage of Tagamet Hb is contingent upon the diagnosed condition, for instance Acid indigestion, Cystic Fibrosis (CF) and Systemic Mastocytosis. The amount of dosage is also subject to the procedure of delivery (e.g. Liquid or Intramuscular; Intravenous) featured in the following table.

Condition

Dosage

Administration

Heartburn

, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL

Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Liquid - Intramuscular; Intravenous, Intramuscular; Intravenous, Liquid - Intravenous, Intravenous, Solution - Intramuscular; Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Cream, Topical, Cream - Topical, Gel, Gel - Topical

Gastric hypersecretion

, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL

Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Liquid - Intramuscular; Intravenous, Intramuscular; Intravenous, Liquid - Intravenous, Intravenous, Solution - Intramuscular; Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Cream, Topical, Cream - Topical, Gel, Gel - Topical

Zollinger-Ellison Syndrome

, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL

Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Liquid - Intramuscular; Intravenous, Intramuscular; Intravenous, Liquid - Intravenous, Intravenous, Solution - Intramuscular; Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Cream, Topical, Cream - Topical, Gel, Gel - Topical

Indigestion

, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL

Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Liquid - Intramuscular; Intravenous, Intramuscular; Intravenous, Liquid - Intravenous, Intravenous, Solution - Intramuscular; Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Cream, Topical, Cream - Topical, Gel, Gel - Topical

Heartburn

, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL

Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Liquid - Intramuscular; Intravenous, Intramuscular; Intravenous, Liquid - Intravenous, Intravenous, Solution - Intramuscular; Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Cream, Topical, Cream - Topical, Gel, Gel - Topical

Duodenal Ulcer

, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL

Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Liquid - Intramuscular; Intravenous, Intramuscular; Intravenous, Liquid - Intravenous, Intravenous, Solution - Intramuscular; Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Cream, Topical, Cream - Topical, Gel, Gel - Topical

NSAID use

, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL

Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Liquid - Intramuscular; Intravenous, Intramuscular; Intravenous, Liquid - Intravenous, Intravenous, Solution - Intramuscular; Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Cream, Topical, Cream - Topical, Gel, Gel - Topical

Adenoma

, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL

Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Liquid - Intramuscular; Intravenous, Intramuscular; Intravenous, Liquid - Intravenous, Intravenous, Solution - Intramuscular; Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Cream, Topical, Cream - Topical, Gel, Gel - Topical

Cystic Fibrosis

, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL

Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Liquid - Intramuscular; Intravenous, Intramuscular; Intravenous, Liquid - Intravenous, Intravenous, Solution - Intramuscular; Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Cream, Topical, Cream - Topical, Gel, Gel - Topical

Gastric ulcer

, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL

Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Liquid - Intramuscular; Intravenous, Intramuscular; Intravenous, Liquid - Intravenous, Intravenous, Solution - Intramuscular; Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Cream, Topical, Cream - Topical, Gel, Gel - Topical

Mastocytosis, Systemic

, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL

Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Liquid - Intramuscular; Intravenous, Intramuscular; Intravenous, Liquid - Intravenous, Intravenous, Solution - Intramuscular; Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Cream, Topical, Cream - Topical, Gel, Gel - Topical

Gastrointestinal Symptoms

, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL

Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Liquid - Intramuscular; Intravenous, Intramuscular; Intravenous, Liquid - Intravenous, Intravenous, Solution - Intramuscular; Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Cream, Topical, Cream - Topical, Gel, Gel - Topical

Duodenum

, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL

Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Liquid - Intramuscular; Intravenous, Intramuscular; Intravenous, Liquid - Intravenous, Intravenous, Solution - Intramuscular; Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Cream, Topical, Cream - Topical, Gel, Gel - Topical

Stomach Ulcer

, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL

Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Liquid - Intramuscular; Intravenous, Intramuscular; Intravenous, Liquid - Intravenous, Intravenous, Solution - Intramuscular; Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Cream, Topical, Cream - Topical, Gel, Gel - Topical

Warnings

Tagamet Hb has one caveat and should not be consumed when encountering any of the conditions detailed in the below table.

Tagamet Hb Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Cimetidine may interact with Pulse Frequency

There are 20 known major drug interactions with Tagamet Hb.

Common Tagamet Hb Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Cimetidine.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Cimetidine.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Cimetidine.

Alpelisib

Major

The metabolism of Alpelisib can be decreased when combined with Cimetidine.

Anagrelide

Major

The metabolism of Anagrelide can be decreased when combined with Cimetidine.

Tagamet Hb Toxicity & Overdose Risk

In the unlikely event of cimetidine overdose, it is essential to make sure the patient can breathe and their heart is functioning normally. Monitor the patient's status and provide treatments that help with their symptoms. If needed, a doctor may decide to do a gastric lavage and give activated charcoal.

image of a doctor in a lab doing drug, clinical research

Tagamet Hb Novel Uses: Which Conditions Have a Clinical Trial Featuring Tagamet Hb?

27 active trials are examining if Tagamet Hb is able to ameliorate Heartburn, Duodenal Ulcer and Duodenal inflammation.

Condition

Clinical Trials

Trial Phases

NSAID use

0 Actively Recruiting

Stomach Ulcer

0 Actively Recruiting

Zollinger-Ellison Syndrome

0 Actively Recruiting

Heartburn

2 Actively Recruiting

Phase 3, Not Applicable

Indigestion

6 Actively Recruiting

Phase 3, Not Applicable, Phase 2

Gastric ulcer

0 Actively Recruiting

Duodenum

0 Actively Recruiting

Duodenal Ulcer

0 Actively Recruiting

Cystic Fibrosis

0 Actively Recruiting

Mastocytosis, Systemic

0 Actively Recruiting

Gastrointestinal Symptoms

2 Actively Recruiting

Not Applicable

Adenoma

0 Actively Recruiting

Heartburn

12 Actively Recruiting

Phase 3, Phase 2, Not Applicable

Gastric hypersecretion

0 Actively Recruiting

Tagamet Hb Reviews: What are patients saying about Tagamet Hb?

5

Patient Review

2/27/2014

Tagamet Hb for Stomach Ulcer

I've been using Tagamet for decades now, and it's always helped me whenever I have an ulcer flare-up. I find that there are fewer side-effects with this drug than with other medications, which is really important to me because I never know how I will react to a new drug.

5

Patient Review

8/29/2019

Tagamet Hb for Heartburn

Really helped me when I was struggling.

5

Patient Review

9/13/2010

Tagamet Hb for Stomach Ulcer

I felt better within 30 minutes of taking this medication. It's been a lifesaver for my gallbladder issues.

5

Patient Review

6/7/2010

Tagamet Hb for Heartburn

Could taking tagament lead to high liver enzyme levels?

5

Patient Review

7/20/2008

Tagamet Hb for Heartburn

5

Patient Review

9/26/2008

Tagamet Hb for Heartburn

5

Patient Review

9/29/2011

Tagamet Hb for Stress Ulcer Prevention

Tagamet is also useful for people on methadone. It prevents the liver from releasing too much of the drug at one time. I found that by taking it half an hour before and after my dose, I got a much better result. As for the price, you can buy it at Wal-Mart for only $4.88 (07/15/2011). The only downside is that you have to be consistent with it or it will stop working altogether.

4.3

Patient Review

1/10/2009

Tagamet Hb for Heartburn

I found that Tagament worked better than my prescription Aciphex. I experienced fewer side effects, like bloating, with this medication.

4

Patient Review

4/6/2012

Tagamet Hb for Condition in which Stomach Acid is Pushed Into the Esophagus

I'm wondering if my recent high blood pressure readings could be a result of this medication?

4

Patient Review

12/26/2007

Tagamet Hb for Condition in which Stomach Acid is Pushed Into the Esophagus

3.7

Patient Review

10/22/2009

Tagamet Hb for Heartburn

Tagamet works just as well as Nexium for me, but it's much cheaper. I only have heartburn and reflux occasionally now, mostly if I overeat. All in all, this drug is a great GERD treatment option.

3

Patient Review

11/6/2011

Tagamet Hb for Condition in which Stomach Acid is Pushed Into the Esophagus

I've been taking Tagamet for a long time, and it's still the best stomach medication out there in my opinion.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tagamet hb

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Tagamet HB used for?

"This medication is used to treat occasional heartburn that is caused by too much acid in the stomach. It is also used to prevent heartburn and acid indigestion that is caused by certain foods and beverages."

Answered by AI

Is Tagamet and Zantac the same thing?

"Zantac is also used to treat heartburn and other symptoms of GERD. Both Tagamet and Zantac are available as over-the-counter (OTC) and prescription medications.

Tagamet and Zantac are both histamine receptor antagonists used to treat and prevent ulcers. Tagamet is also used to treat conditions that cause the stomach to produce too much acid, and to treat gastroesophageal reflux disease (GERD). Zantac is also used to treat heartburn and other symptoms of GERD. Both Tagamet and Zantac are available as over-the-counter (OTC) and prescription medications."

Answered by AI

Is Tagamet HB over-the-counter?

"Cimetidine is a medication used to treat heartburn and other stomach-acid related issues. It is available via prescription or over-the-counter."

Answered by AI

Why was Tagamet taken off the market?

"The FDA has reported that some medicines may contain high levels of N-Nitrosodimethylamine (NDMA), a substance classified as a 'probable human carcinogen' by the World Health Organization."

Answered by AI

Clinical Trials for Tagamet Hb

Image of University of California, Irvine - UCI Medical Center in Orange, United States.

Sling-Fiber Preservation vs. Conventional POEM for Achalasia

18+
All Sexes
Orange, CA

Peroral endoscopic myotomy (POEM) is an effective, minimally invasive treatment for achalasia, offering excellent rates of symptom relief. However, a significant drawback is the high incidence of gastroesophageal reflux disease (GERD) following the procedure. One proposed technical modification, the selective preservation of the sling fibers during gastric myotomy (SFP-POEM), may reduce this risk without compromising efficacy as compared to a conventional POEM procedure, which includes myotomy of the sling fibers. In this study, adults with achalasia will be randomly assigned to receive one of the two POEM technical approaches. Researchers will monitor whether preserving sling fibers reduces the rates of reflux esophagitis (classified as Los Angeles Grade B or higher) on follow-up endoscopy. Participants will be followed for up to 1 year after the procedure.

Waitlist Available
Has No Placebo

University of California, Irvine - UCI Medical Center

Jason Samarasena, MD, MBA

Image of Del Sol Research Management, LLC in Tucson, United States.

Linaprazan Glurate vs Lansoprazole for Acid Reflux

18 - 80
All Sexes
Tucson, AZ

The goal of this clinical trial is to find out how well linaprazan glurate can heal erosive esophagitis (EE) caused by gastroesophageal reflux disease (GERD), compared to lansoprazole, a commonly used medication. Researchers will also evaluate whether linaprazan glurate: * Reduces heartburn symptoms more effectively than lansoprazole * Is safe and well tolerated, based on physical exams, blood tests, and vital signs (heart rate, blood pressure, temperature, and breathing rate) * Causes any side effects during treatment * Has different effects depending on how much of the drug is in the blood * Works differently depending on participants' genes Participants must be between 18 to 80 years old and have EE due to GERD confirmed by an endoscopy. Participants cannot join if they have an active Helicobacter pylori (HP) infection or were treated for HP in the past 6 weeks or have taken antibiotics or bismuth-containing drugs in the past 6 weeks. The study is a randomized, double-blind, active comparator-controlled trial lasting up to 4 months. Randomized means that participants are assigned by chance (like flipping a coin) to one of the treatment groups and double-blind means neither the participants nor the study team will know which treatment is given. Participants will be placed into one of three groups (about 167 people in each group): * Linaprazan glurate 50 mg twice a day * Linaprazan glurate 50 mg once a day * Lansoprazole 30 mg once a day Everyone will take 2 tablets and 1 capsule by mouth daily for 8 weeks. Some tablets or capsules will be placebos (look like medicine but contain no active drug). Participants will: * Undergo an endoscopy in the beginning and after 4 weeks of treatment * If healing is not observed, another endoscopy may be done at 8 weeks * During the procedure, doctors will use a thin, flexible tube with a camera to look at the esophagus and take small tissue samples (biopsies) * Have blood and urine tests at clinic visits to check overall health * Receive electrocardiograms (ECGs) to monitor heart function * Complete daily questionnaires on an electronic device about symptoms and experiences

Phase 3
Waitlist Available

Del Sol Research Management, LLC (+24 Sites)

Cinclus Pharma Holding AB

Image of Mayo Clinic in Rochester in Rochester, United States.

High Resolution Gastric Mapping and Gastroduodenal Manometry for Indigestion

18 - 80
All Sexes
Rochester, MN

Dyspepsia is a common problem attributed to gastric sensorimotor dysfunctions ie, delayed, or less frequently rapid gastric emptying (GE), impaired gastric accommodation, and increased gastric sensation. Therapeutic options manage symptoms, and there is no FDA approved medical therapy for dyspepsia. There is a need for better objective understanding of sensorimotor dysfunction in dyspepsia, as well as noninvasive, efficacious, safe, and inexpensive treatments for dyspepsia. The purpose of this research is to identify disturbances and characterize phenotypes in patients with functional dyspepsia, and to assess the correlations between symptoms (during the manometry and in daily life), gastric emptying, electrical activity (BSGM), and pressure activity (manometry).

Recruiting
Has No Placebo

Mayo Clinic in Rochester

Nicholas R Oblizajek, MD

Have you considered Tagamet Hb clinical trials?

We made a collection of clinical trials featuring Tagamet Hb, we think they might fit your search criteria.
Go to Trials
Image of G. Oppenheimer Center for Neurobiology of Stress and Resilience in Los Angeles, United States.

Biofeedback for Functional Abdominal Bloating

18 - 80
All Sexes
Los Angeles, CA

Background. Abdominal distention is produced by an abnormal somatic postural tone. The authors developed an original biofeedback technique. In a randomized, placebo-controlled trial the authors demonstrated the superiority of biofeedback over placebo for the treatment of abdominal distention. However, the technique is technically complex and unpractical. Aim. To prove the efficacy of a noninstrumental biofeedback technique, transmitted by a standard training program, for the treatment of abdominal distension in different centers. Selection criteria. Episodes of visible abdominal distension. Intervention. Patients will be randomized into biofeedback and placebo groups. Three sessions of either biofeedback or placebo intervention will be performed during the first 3 weeks of the intervention period. Biofeedback: Patients will be taught to control abdominal and thoracic muscular activity by providing instructions using an original video support. In each center one operator will receive a standard training on how to deliver the noninstrumental biofeedback treatment. Patients will be instructed to perform the same exercises before and after breakfast, lunch and dinner during the 4-week intervention period. Placebo: Sham measurements of abdominal and thoracic motion will be performed, and a pill of placebo containing 0.21 g glucose will be administered; patients will be instructed to take a pill of placebo before breakfast, lunch and dinner during the 4-week intervention period.

Recruiting
Paid Trial

G. Oppenheimer Center for Neurobiology of Stress and Resilience (+1 Sites)

Fernando Azpiroz, MD

Image of Cleveland Clinic Center for Abdominal Core Health in Cleveland, United States.

Mesh vs Pledgets for Hernia Repair

18+
All Sexes
Cleveland, OH

The goal of this clinical trial is to compare whether the use of Ovitex mesh provides superior reduction in 2-year recurrence compared to pledgeted suture closure (no mesh) for patients undergoing paraesophageal hernia repair at the Cleveland Clinic. The main questions it aims to answer are: * Determine whether there is a difference in 2-year rates of radiographic recurrence with Ovitex versus pledgeted sutures in paraesophageal hernia repair. * Assess patient quality of life (QOL) after paraesophageal hernia repair with pledgets and mesh. A two-tailed research hypothesis will be used to determine whether there are differences between the two arms

Recruiting
Has No Placebo

Cleveland Clinic Center for Abdominal Core Health

David M Krpata, MD

Image of Memphis VA Medical Center, Memphis, TN in Memphis, United States.

Oral Glutamine for Gulf War Syndrome

18 - 65
All Sexes
Memphis, TN

Many veterans with Gulf War Illness developed chronic gastrointestinal symptoms during their deployment to the Persian Gulf. The pathophysiologic mechanisms of these chronic gastrointestinal symptoms are not well understood but cause significant morbidity in veterans. Our proposed studies will provide an innovative and novel treatment trial for chronic gastrointestinal symptoms in veterans with Gulf War Illness that were deployed into war zones. Given that there are currently no specific treatments for these disorders, and that current symptomatic approaches are far from ideal, proof of principle of our trial would be an extremely important advance as it would not only have a beneficial impact on the health of many thousands of our veterans, but also it would substantially reduce the many negative economic effects of this ailment on the VA Health Care System.

Recruiting
Dietary Supplement

Memphis VA Medical Center, Memphis, TN

QiQi Zhou, MD PhD

Have you considered Tagamet Hb clinical trials?

We made a collection of clinical trials featuring Tagamet Hb, we think they might fit your search criteria.
Go to Trials

Have you considered Tagamet Hb clinical trials?

We made a collection of clinical trials featuring Tagamet Hb, we think they might fit your search criteria.
Go to Trials