Sprix

Eye Pain, Inflammation, corneal refractive surgery + 20 more

Treatment

2 FDA approvals

20 Active Studies for Sprix

Treatment for

Eye Pain

What is Sprix

Ketorolac

The Generic name of this drug

Treatment Summary

Ketorolac is a type of medication used to reduce pain by reducing inflammation. It is available in the form of an oral tablet, injectable, nasal spray, and ophthalmic solution. It can be used to treat a variety of painful conditions, including postoperative pain, arthritis, menstrual disorders, headaches, and back pain. In some cases, it can be used as an alternative to opioids such as morphine and meperidine for pain management.

Toradol

is the brand name

Sprix Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Toradol

Ketorolac

1991

316

Approved as Treatment by the FDA

Ketorolac, also called Toradol, is approved by the FDA for 2 uses like caudal epidural block therapy and induction of Nerve Block .

caudal epidural block therapy

Used to treat caudal epidural block therapy in combination with Bupivacaine

induction of Nerve Block

Used to treat induction of Nerve Block in combination with Bupivacaine

Effectiveness

How Sprix Affects Patients

Ketorolac is a type of non-selective painkiller that blocks two enzymes (COX-1 and COX-2). The COX-1 enzyme is always active and can be found in the platelets, stomach lining, and blood vessel walls. The COX-2 enzyme is only active when inflammation, pain, or fever is present. When COX-1 is blocked, it leads to an increased risk of bleeding and stomach ulcers. The desired effects of the drug like reducing inflammation and pain come from blocking the COX-2 enzyme. Taking ketorolac long-term can lead to serious

How Sprix works in the body

Ketorolac works to reduce pain and inflammation in the body by blocking pathways that produce prostaglandins. Prostaglandins are molecules involved in inflammation and pain, and ketorolac works by stopping the enzymes that create them. The drug is a mixture of two molecules, but the active ingredient is responsible for its pain-relieving and anti-inflammatory effects.

When to interrupt dosage

The measure of Sprix is contingent upon the identified condition, for instance Eye, Macular Edema, Cystoid and Pericarditis Acute. The quantity of dosage is contingent on the approach of delivery (e.g. Tablet - Oral or Ophthalmic) referenced in the table underneath.

Condition

Dosage

Administration

Macular Edema, Cystoid

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Epidural; Infiltration; Intramuscular; Intravenous, Kit, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Injection, solution - Intraocular, Topical, Spray, metered - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic

Miosis disorder

Seasonal Allergic Conjunctivitis

Cataract Surgery

induction of Local Anaesthesia

Ocular Itching

Eye Pain

Intraocular Lens Replacement

Macular Edema, Cystoid

postoperative ocular pain

Pain

caudal epidural block therapy

Macular Edema

Acute Coryza

Pupil

induction of Nerve Block

Pericarditis Acute

Inflammation

corneal refractive surgery

Induced Hyperthermia

Warnings

Sprix has twenty-eight contraindications, thus it should not be administered if any of the conditions outlined in the following table exist.

Sprix Contraindications

Condition

Risk Level

Notes

Heart failure

Do Not Combine

Hyperkalemia

Do Not Combine

Renal Insufficiency

Do Not Combine

Hemorrhagic Disorders

Do Not Combine

Kidney Failure

Do Not Combine

A History of Gastric or Duodenal Ulcers

Do Not Combine

Liver Diseases

Do Not Combine

Major Surgery

Do Not Combine

Pulse Frequency

Do Not Combine

Gastrointestinal Hemorrhage

Do Not Combine

Crohn's Disease

Do Not Combine

suspected cerebrovascular bleeding

Do Not Combine

active Gastrointestinal Bleeding

Do Not Combine

NSAID-Induced Asthma

Do Not Combine

Severe Hepatic Impairment

Do Not Combine

incomplete hemostasis

Do Not Combine

Coronary Artery Bypass Grafting

Do Not Combine

Gastrointestinal Perforation

Do Not Combine

Pulse Frequency

Do Not Combine

Hemorrhage

Do Not Combine

Peptic Ulcer

Do Not Combine

Pulse Frequency

Do Not Combine

Labour

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Third trimester of pregnancy

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Ketorolac may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Ketorolac may interact with Pulse Frequency

There are 20 known major drug interactions with Sprix.

Common Sprix Drug Interactions

Drug Name

Risk Level

Description

Aceclofenac

Major

The risk or severity of adverse effects can be increased when Ketorolac is combined with Aceclofenac.

Acemetacin

Major

The risk or severity of adverse effects can be increased when Ketorolac is combined with Acemetacin.

Acetylsalicylic acid

Major

The risk or severity of adverse effects can be increased when Ketorolac is combined with Acetylsalicylic acid.

Alclofenac

Major

The risk or severity of adverse effects can be increased when Ketorolac is combined with Alclofenac.

Alminoprofen

Major

The risk or severity of adverse effects can be increased when Ketorolac is combined with Alminoprofen.

Sprix Toxicity & Overdose Risk

Taking ketorolac can lead to side effects such as abdominal pain, indigestion, nausea, headaches, and fatigue in up to 39% of patients. An overdose can cause symptoms such as nausea, vomiting, upper abdominal pain, gastrointestinal bleeding, fatigue, and drowsiness. More severe effects such as high blood pressure, kidney damage or failure, hypoventilation, or coma may also occur in rare cases. Pregnant women should avoid ketorolac after 30 weeks gestation since it increases the risk of fetal ductus arteriosus closure. Women who are trying to conceive are also advised not to take ket

image of a doctor in a lab doing drug, clinical research

Sprix Novel Uses: Which Conditions Have a Clinical Trial Featuring Sprix?

188 active trials are being conducted to analyze the potential of Sprix in providing relief from Macular Edema, Cystoid, acute, moderate Pain and for Intraocular Lens Replacement.

Condition

Clinical Trials

Trial Phases

Inflammation

55 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 3, Phase 4

Induced Hyperthermia

0 Actively Recruiting

caudal epidural block therapy

5 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2

Intraocular Lens Replacement

0 Actively Recruiting

Acute Coryza

0 Actively Recruiting

Macular Edema, Cystoid

0 Actively Recruiting

induction of Nerve Block

0 Actively Recruiting

Pupil

0 Actively Recruiting

Local Anaesthesia therapy

0 Actively Recruiting

corneal refractive surgery

0 Actively Recruiting

Seasonal Allergic Conjunctivitis

0 Actively Recruiting

Eye Pain

0 Actively Recruiting

postoperative ocular pain

0 Actively Recruiting

Eye

0 Actively Recruiting

Ocular Itching

0 Actively Recruiting

Pericarditis Acute

1 Actively Recruiting

Phase 2, Phase 3

Miosis disorder

0 Actively Recruiting

Macular Edema, Cystoid

0 Actively Recruiting

Macular Edema

1 Actively Recruiting

Phase 1, Phase 2

Cataract Surgery

3 Actively Recruiting

Not Applicable

Sprix Reviews: What are patients saying about Sprix?

Patient Review

6/19/2020

Sprix for Acute Pain Following an Operation

Despite the burning sensation that comes with this spray, it's an amazing drug. Toradol is a true miracle worker.

Patient Review

5/30/2019

Sprix for Acute Pain Following an Operation

This medication, in conjunction with Percocet, was prescribed to me for managing pain after ankle surgery. I never had to fill the Percocet script because the nasal spray worked so well. My surgeon was amazed at how good I looked just three days post-op.

Patient Review

12/8/2020

Sprix for Severe Pain

I'm so glad that there are non-narcotic pain relievers available that actually work! The downside is that they're quite expensive and not always easy to fill at a pharmacy.

Patient Review

9/2/2020

Sprix for Severe Lower Back Pain from Kidney Stones

This drug has been a total game-changer for me. I'm now five years sober from opiates, and while it does still burn, the pain relief is well worth it!

4.7

Patient Review

8/7/2018

Sprix for Severe Pain

This drug is really effective at removing pain. I can't take it every day, but when I do use it, it takes away the pain much better than Norco does. The only downside is that inhaling it burns really badly.

4.7

Patient Review

6/15/2020

Sprix for Acute Pain Following an Operation

This provided great pain relief after my outpatient procedure. The nose pain was gone almost instantly. However, it tastes really bad, so make sure you don't inhale it!

3.7

Patient Review

3/26/2020

Sprix for Severe Pain

Sprix is effective in pain relief, but unfortunately leaves the inside of my nose feeling raw and painful. I'm still pretty pleased overall, though.

3.7

Patient Review

12/15/2020

Sprix for Severe Pain

I'm not sure why everyone is complaining about the spray burning so much. Maybe they're not doing it right? You're not supposed to sniff the spray up your nose after you use it; it's supposed to sit in your nostril. If you do that (the correct way) it only burns a little bit for a few seconds. The only problem I had was that it made me sneeze after and caused my nose to run, which probably decreased some of the effectiveness. I did get some pain relief from this though.

3.7

Patient Review

10/30/2020

Sprix for Severe Pain

Sprix was prescribed to me by my doctor and it did help with the pain, though you have to be careful as NSAIDS can lead to other medical conditions. I started getting headaches after taking this medication and was recently diagnosed with bleeding on my brain.

3.7

Patient Review

5/7/2021

Sprix for Severe Pain

Sprix is an amazing medication for menstrual cramps, as it is a strong analgesic. Even though it burns when sprayed (I follow the directions), it's worth it to me to avoid cramps all day.

1.7

Patient Review

2/19/2020

Sprix for Severe Pain

The burning sensation I felt was really intense, like I had just sprayed battery acid into my nose.

1.3

Patient Review

3/17/2020

Sprix for Severe Pain

The burning sensation wasn't too bad, but I became nauseous when the medication ran down my throat.

Patient Review

3/25/2019

Sprix for Acute Pain Following an Operation

Not only was this treatment ineffective, but it also caused a lot of pain when I swallowed it.

Patient Review

12/5/2018

Sprix for Severe Pain

This product didn't work for me at all. Not only did it not stop the pain, but it also caused a burning sensation in my nose and throat that lasted for about 30-40 minutes after each dose. I tried it a third time and ended up with a nosebleed. Overall, this was a very unpleasant experience and I'll be sticking to naproxen from now on.

Patient Review

1/6/2019

Sprix for Severe Pain

This was a terrible experience. The burning sensation was unbearable. I would never take this drug again.

Patient Review

8/16/2019

Sprix for Severe Pain

Unfortunately, this medication did not work at all for my rheumatoid arthritis pain. If anything, it made the pain in my testicles worse.

Patient Review

5/6/2019

Sprix for Severe Pain

Unfortunately, this medication didn't provide the relief I was hoping for. If anything, it made my symptoms worse. Will not be trying again.

Patient Review

3/15/2019

Sprix for Acute Pain Following an Operation

This medication created a burning sensation that was unbearable. Additionally, it gave me really bad allergies and made me feel lightheaded and out of it.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about sprix

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does it take for SPRIX to work?

"Ketorolac nasal spray (Sprix) starts working to relieve pain in as little as 20 to 30 minutes for some people."

Answered by AI

What is SPRIX medication?

"SPRIX should be used for the short-term management (5 days or less) of moderate to moderately severe pain that requires an opioid level of analgesia."

Answered by AI

Does SPRIX make you drowsy?

"You may feel briefly uncomfortable if you use this medication. You may also feel nauseous, dizzy, or tired. If you feel any of these effects for an extended period of time, please tell your doctor."

Answered by AI