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What is Spiriva
TiotropiumThe Generic name of this drug
Treatment SummaryTiotropium is a long-acting medication used to help with breathing difficulties caused by chronic obstructive pulmonary disease (COPD) and asthma. It works by relaxing the muscles in the airways, allowing air to flow more freely. Tiotropium is more specific for the type of muscarinic receptors found in the lungs than other similar medications. It was approved by the FDA in 2004.
Spirivais the brand name
Spiriva Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Spiriva
Tiotropium
2004
8
Effectiveness
How Spiriva Affects PatientsTiotropium is an antimuscarinic drug that helps to widen the airways in the lungs and make breathing easier. The effects of this drug can last up to a day, and it is generally considered safe even if taken in higher amounts than recommended.
How Spiriva works in the bodyTiotropium is a drug that relaxes the muscles in the lungs, allowing them to expand and resulting in easier breathing. It works by blocking certain receptors in the lungs, called muscarinic receptors, which are responsible for muscle contraction.
When to interrupt dosage
The suggested dosage of Spiriva is contingent upon the recognized condition, including Chronic Bronchitis, Bronchoconstriction and Acute Bronchitis. The dose also fluctuates according to the technique of delivery (e.g. Respiratory (inhalation) or Spray, metered) as enumerated in the table below.Condition
Dosage
Administration
Acute Bronchitis
0.018 mg, , 0.003124 mg, 0.001562 mg, 0.0025 mg, 0.0025 mg/pump actuation
, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Spray, metered - Respiratory (inhalation), Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation)
Chronic Obstructive Pulmonary Disease
0.018 mg, , 0.003124 mg, 0.001562 mg, 0.0025 mg, 0.0025 mg/pump actuation
, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Spray, metered - Respiratory (inhalation), Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation)
Chronic Obstructive Airway Disease
0.018 mg, , 0.003124 mg, 0.001562 mg, 0.0025 mg, 0.0025 mg/pump actuation
, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Spray, metered - Respiratory (inhalation), Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation)
Asthma
0.018 mg, , 0.003124 mg, 0.001562 mg, 0.0025 mg, 0.0025 mg/pump actuation
, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Spray, metered - Respiratory (inhalation), Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation)
Bronchoconstriction
0.018 mg, , 0.003124 mg, 0.001562 mg, 0.0025 mg, 0.0025 mg/pump actuation
, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Spray, metered - Respiratory (inhalation), Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation)
Chronic Bronchitis
0.018 mg, , 0.003124 mg, 0.001562 mg, 0.0025 mg, 0.0025 mg/pump actuation
, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Spray, metered - Respiratory (inhalation), Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation)
Emphysema
0.018 mg, , 0.003124 mg, 0.001562 mg, 0.0025 mg, 0.0025 mg/pump actuation
, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation), Spray, metered, Spray, metered - Respiratory (inhalation), Oral; Respiratory (inhalation), Capsule - Oral; Respiratory (inhalation)
Warnings
Spiriva has two contraindications and should not be taken in combination with the conditions shown in the table below.Spiriva ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Tiotropium may interact with Pulse Frequency
Not being treated with an inhaled corticosteroid
Do Not Combine
Common Spiriva Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Tiotropium is combined with Aclidinium.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Tiotropium.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Tiotropium is combined with Cimetropium.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Tiotropium.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Tiotropium.
Spiriva Toxicity & Overdose RiskTaking too much tiotropium may cause mental confusion, shaking, abdominal pain, and extreme constipation. However, doses up to 282µg have not been found to cause any anticholinergic effects in a test group of 6 patients. If someone has overdosed on tiotropium, they should stop taking it and receive supportive care.
Spiriva Novel Uses: Which Conditions Have a Clinical Trial Featuring Spiriva?
280 active clinical trials are assessing the potential of Spiriva to alleviate Asthma, Bronchoconstriction and Chronic Obstructive Pulmonary Disease (COPD).Condition
Clinical Trials
Trial Phases
Bronchoconstriction
0 Actively Recruiting
Emphysema
12 Actively Recruiting
Phase 3, Phase 4, Phase 1, Phase 2, Not Applicable
Chronic Obstructive Airway Disease
9 Actively Recruiting
Not Applicable
Acute Bronchitis
12 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 2
Asthma
160 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1, Phase 3
Chronic Obstructive Pulmonary Disease
99 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4
Chronic Bronchitis
5 Actively Recruiting
Not Applicable, Phase 3, Phase 4
Spiriva Reviews: What are patients saying about Spiriva?
5Patient Review
11/22/2016 This medication has helped me a lot with my breathing. Ventolin is still necessary but it's great to have some help. I hope that eventually I won't need the rescue inhaler at all.
5Patient Review
5/27/2020 This drug has been an absolute godsend. I was struggling to do even simple household tasks before, and now I feel like I can live a normal life again.
5Patient Review
7/15/2022 Within just three days of using this medication, I have already noticed a significant difference in my breathing. I used to have to use an inhaler multiple times a day, but now I only need it once in the morning. This has truly been life-changing for me!
5Patient Review
4/30/2019 The last two refills of this prescription have had a very strong soapy taste and smell upon inhalation.
5Patient Review
7/15/2022 I've only been using this medication for a short time, but I'm already noticing significant improvement in my breathing. I used to have to use an inhaler several times throughout the day, but now I can go all day without feeling breathless. This has made a huge difference in my quality of life.
5Patient Review
4/30/2019 The last two Rx refills taste and smell like soap, which is very strange.
5Patient Review
5/27/2020 This drug has been a lifesaver for me. I was struggling to do even basic things around the house, but spiriva has helped me get back to living a normal life.
5Patient Review
11/22/2016 This medication has already helped me a lot with my breathing problems. I have to use it with my Ventolin inhaler for it to be effective, but if I could just use one inhaler that would be great.
4.7Patient Review
11/29/2017 Despite its high price, this mist has been highly effective in treating my COPD and wheezing.
4.7Patient Review
11/29/2017 Despite the cost, this inhaler has been really helpful for my COPD and wheezing.
3.3Patient Review
4/10/2018 I now have this weird cough, and its like there is something stuck back in the top of my throat.It never really gave me the full nice breaths I was getting on a prior medication. Im off to the drs to try something else.This weird cough is CONSTANT
3.3Patient Review
4/10/2018 I now have a weird cough that feels like there's something stuck in the back of my throat. This medication never really gave me the full, deep breaths that I was getting on a prior medication. I'm off to the doctor's to try something else.
3Patient Review
2/10/2019 I am coughing up more yellow mucus. Also have blurred vision . Last prescription I got has a bad smell and taste . I will take it back to Drug store and hopefully get a refund. It smells like silage and garlic mixed together.I have been using it for 2years with a little improvement in breathing.
3Patient Review
1/7/2017 I have been monitoring my borderline high cholesterol levels all my adult life and have managed, with diet and exercise, to keep it under control. I am 76. I was diagnosed with copd last spring and prescribed Spiriva Resprimat. After two months on this drug all of my cholesterol numbers were elevated. Pulmonary MD says there are no studies to show the relationship, but I'd like to try something else at this point.
3Patient Review
2/10/2019 I have been using this medication for a while now, and while it has helped my breathing somewhat, I recently noticed that the prescription I got had a really bad smell and taste. I'm going to take it back to the store and see if I can get a refund.
3Patient Review
1/7/2017 My cholesterol has always been on the borderline, but I was able to manage it with diet and exercise. However, after being prescribed Spiriva Resprimat for my COPD, all of my cholesterol numbers have gone up. My pulmonary doctor says there's no evidence linking the two, but I'd still like to try a different medication.
2.3Patient Review
5/18/2019 There were at least two empty capsules in my 30-day prescription, which is unacceptable for such an expensive medication. I also couldn't find a contact email address for the manufacturer.
2.3Patient Review
5/18/2019 At least two capsules per 30 day prescription have been empty. Since this medication is expensive, it's not affordable to have empty capsules. I also can't find a contact email address for the manufacturer.
2Patient Review
3/30/2019 Has anyone else experienced their teeth splitting and chunks of enamel breaking off since using this product? I'm curious if it's just me.
2Patient Review
5/10/2020 Since I started taking this medication for my COPD, I have been noticing a heaviness in my chest that I never had before.
2Patient Review
3/30/2019 I'm curious if anyone else is dealing with the same problem I am: my teeth are now splitting and chunks of enamel are cracking.
2Patient Review
5/10/2020 Since I started taking this medication, I have been noticing a heaviness in my chest that I had never experienced before.
1.7Patient Review
9/30/2020 My insurance didn't cover very much of the cost, and I don't think it was worth $341.
1.7Patient Review
7/14/2022 My son and I both tried this treatment for our asthma. We found it to be totally useless and a waste of time. The inhaler device is pretty nifty, though.
1.7Patient Review
9/12/2022 The cartridge is very difficult to use, even after watching the online instructions. I have seen little improvement in my breathing, and given the increase in price, I will be telling my physician that I will no longer be using Spiriva Respimat.
1.7Patient Review
9/13/2022 The design is sleek but it's defective. I contacted the manufacturer and they were unhelpful. Overall, not worth the hassle.
1.7Patient Review
7/14/2022 My son and I both tried this treatment for our asthma. We both found it to be incredibly ineffective and a waste of time. The inhaler device is pretty nifty, though!
1.7Patient Review
9/30/2020 I was disappointed that my insurance didn't cover more of the cost. It seemed expensive to me.
1.7Patient Review
9/12/2022 The cartridge is very difficult to use, even after watching a tutorial. I have also seen little improvement in my breathing. With the recent price increase, I will no longer be using this product.
1.7Patient Review
9/13/2022 The design is sleek but it's defective. I had a lot of trouble setting it up for use, and the manufacturer was unhelpful when I called them.
1.3Patient Review
11/29/2021 I've been using Spiriva for my asthma and COPD per my doctor's orders, but I'm having a lot of trouble with the cartridges. They keep popping out and don't work properly. I contacted the manufacturer about this issue, but they never called me back. Overall, not worth the hassle or money.
1.3Patient Review
11/29/2021 I'm extremely disappointed with Spiriva. It's very difficult to use; the cartridge keeps popping out and it doesn't work. I called the manufacturer about this issue, but they never got back to me. Overall, not worth the cost or aggravation.
1Patient Review
1/13/2021 This inhaler is ineffective more often than not.
1Patient Review
1/13/2021 This inhaler is pretty ineffective.
Patient Q&A Section about spiriva
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the difference between albuterol and Spiriva?
"The drug Spiriva (Tiotropium) makes it easier to breathe. The drug ProAir HFA (albuterol) acts quickly to stop asthma attacks and help you breathe easier. However, ProAir HFA is not used for long-term treatment and prevention of asthma since its effects don't last long."
Answered by AI
Is Spiriva inhaler a steroid?
"SPIRIVA RESPIMAT is a non-steroidal inhaler that has shown to be effective and safe for patients aged 6 and up in clinical trials."
Answered by AI
What inhaler is the same as Spiriva?
"What's an inhaler that works like Spiriva? Tudorza pressair (aclidinium) and Seebri Neohaler (glycopyrrolate) are similar to Spiriva and Incruse Ellipta."
Answered by AI