Sotret

Sezary Syndrome, Acne Vulgaris, Acne Conglobata + 4 more
Treatment
13 Active Studies for Sotret

What is Sotret

IsotretinoinThe Generic name of this drug
Treatment SummaryIsotretinoin is a derivative of vitamin A used to treat severe acne. It was previously sold under the brand name Accutane, but is no longer available. Isotretinoin has significant risks during pregnancy, which is why it is only available through the iPLEDGE program in the United States. This medication was approved by the FDA in 1982.
Accutaneis the brand name
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Sotret Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Accutane
Isotretinoin
1982
78

Effectiveness

How Sotret Affects PatientsThe way isotretinoin works in the body is not well understood.
How Sotret works in the bodyIsotretinoin works in several different ways to reduce acne. It decreases the amount of oil produced in the skin, reducing blockages in the pores and making it harder for bacteria to grow. It also causes cells in the skin to die, and reduces the size of pores. Isotretinoin also makes it harder for bacteria to survive by making the environment less hospitable. It may even boost the immune system and reduce inflammation. Finally, there is evidence that Isotretinoin interacts with FoxO1, which could help explain its other effects.

When to interrupt dosage

The suggested dose of Sotret is dependent upon the declared condition, such as Acne conglobata, Acne Vulgaris and Pregnancy. The measure of dosage is contingent upon the modality of delivery (e.g. Capsule - Oral or Capsule) featured in the table beneath.
Condition
Dosage
Administration
Sezary Syndrome
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Acne Conglobata
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Rosacea
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Acne Vulgaris
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Neuroblastoma
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Mycosis Fungoides
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Acne Vulgaris
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical

Warnings

Sotret has five contraindications and should not be jointly administered with the conditions enumerated in the following table.Sotret Contraindications
Condition
Risk Level
Notes
Carcinoma, Basal Cell
Do Not Combine
Squamous cell carcinoma
Do Not Combine
history of squamous cell
Do Not Combine
family history of basal cell carcinoma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Isotretinoin may interact with Pulse Frequency
There are 20 known major drug interactions with Sotret.
Common Sotret Drug Interactions
Drug Name
Risk Level
Description
Clomocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Clomocycline.
Demeclocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Demeclocycline.
Doxycycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Doxycycline.
Eravacycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Eravacycline.
Metacycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Metacycline.
Sotret Toxicity & Overdose RiskSymptoms of an isotretinoin overdose may include vomiting, redness on the face, sores in the mouth, abdominal pain, headache, dizziness, and difficulty with coordination. The lowest dose causing toxic effects for children is 30mg/kg/21W, 24mg/kg/4W in men, and 56mg/kg/8W in women. In animal studies, doses higher than the recommended clinical dose have been linked to an increased risk of tumors of the adrenal gland and testicular atrophy. There is no evidence that isotretinoin affects sperm count or function. Breastfeeding while taking isotretino

Sotret Novel Uses: Which Conditions Have a Clinical Trial Featuring Sotret?

65 active clinical trials are currently examining the potential of Sotret to reduce symptoms of Rosacea, Neuroblastoma (NB) and Acne conglobata.
Condition
Clinical Trials
Trial Phases
Mycosis Fungoides
0 Actively Recruiting
Sezary Syndrome
9 Actively Recruiting
Phase 2, Phase 1
Rosacea
4 Actively Recruiting
Not Applicable, Early Phase 1, Phase 2
Acne Vulgaris
0 Actively Recruiting
Acne Conglobata
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Neuroblastoma
0 Actively Recruiting

Sotret Reviews: What are patients saying about Sotret?

5Patient Review
2/4/2008
Sotret for Severe Difficult to Treat Nodular Acne
I had tried everything else and this was my last hope. It was a bit of a process to get started (birth control, pregnancy and blood tests, signing into the program...) but it was well worth it. I am in my second month of treatment now and have not had any new acne since my first 2 weeks on the medicine. Furthermore, the redness from my previous acne bumps are beginning to fade.
5Patient Review
12/9/2007
Sotret for Severe Difficult to Treat Nodular Acne
I've now been on this medication for four months, which is one month longer than my doctor said should be necessary. I have seen a significant improvement, but I worry about the other 15% of people who don't see complete results.
5Patient Review
12/19/2007
Sotret for Severe Difficult to Treat Nodular Acne
The treatment I received was great and it finally cured my acne. I was recommended to take a multivitamin supplement without Vitamin A since the Sotret medication is related to Vitamin A and taking the two together can result in potential side effects.
5Patient Review
5/1/2009
Sotret for Severe Difficult to Treat Nodular Acne
I had to stop using this treatment after a month due to the sheer number of side effects I experienced, including but not limited to: constant stomach aches, nausea, and rushes all over my back.
5Patient Review
2/20/2008
Sotret for Severe Difficult to Treat Nodular Acne
I love Solodyn! I started seeing results within the first week, and though there were some headaches early on, they went away after a couple weeks. This is by far the best antibiotic I've tried for my acne.
View All Reviews
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Patient Q&A Section about sotret

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Sotret harmful?

"Sotret can cause severe birth defects or death of a baby if the mother takes this medicine while pregnant."

Answered by AI

Does Sotret reduce acne scars?

"I've been seeing a dermatologist for my acne scars. The doctor prescribed me a medication called Sotret, and I've been taking it for the past 4 months. I've seen great improvements in the condition of my scars, and my face is less oily than it used to be."

Answered by AI

What is Sotret used for?

"Retinoids are a class of medication used to treat severe cystic acne (also known as nodular acne) that has not responded to other treatment options, such as benzoyl peroxide or clindamycin applied to the skin, or tetracycline or minocycline taken orally."

Answered by AI

Is Sotret good for acne?

"Sotret is a drug used to treat severe acne. It is a retinoid, which means it is derived from vitamin A. It is taken in the form of a capsule, and the recommended dosage is two capsules per day, with food."

Answered by AI

Clinical Trials for Sotret

Have you considered Sotret clinical trials? We made a collection of clinical trials featuring Sotret, we think they might fit your search criteria.
Have you considered Sotret clinical trials? We made a collection of clinical trials featuring Sotret, we think they might fit your search criteria.
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