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What is Sotret
IsotretinoinThe Generic name of this drug
Treatment SummaryIsotretinoin is a derivative of vitamin A used to treat severe acne. It was previously sold under the brand name Accutane, but is no longer available. Isotretinoin has significant risks during pregnancy, which is why it is only available through the iPLEDGE program in the United States. This medication was approved by the FDA in 1982.
Accutaneis the brand name
Sotret Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Accutane
Isotretinoin
1982
78
Effectiveness
How Sotret Affects PatientsThe way isotretinoin works in the body is not well understood.
How Sotret works in the bodyIsotretinoin works in several different ways to reduce acne. It decreases the amount of oil produced in the skin, reducing blockages in the pores and making it harder for bacteria to grow. It also causes cells in the skin to die, and reduces the size of pores. Isotretinoin also makes it harder for bacteria to survive by making the environment less hospitable. It may even boost the immune system and reduce inflammation. Finally, there is evidence that Isotretinoin interacts with FoxO1, which could help explain its other effects.
When to interrupt dosage
The suggested dose of Sotret is dependent upon the declared condition, such as Acne conglobata, Acne Vulgaris and Pregnancy. The measure of dosage is contingent upon the modality of delivery (e.g. Capsule - Oral or Capsule) featured in the table beneath.Condition
Dosage
Administration
Sezary Syndrome
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
refractory Acne vulgaris
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Rosacea
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Acne Vulgaris
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
early Mycosis Fungoides (MF)
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Neuroblastoma (NB)
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Acne Conglobata
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Warnings
Sotret has five contraindications and should not be jointly administered with the conditions enumerated in the following table.Sotret ContraindicationsCondition
Risk Level
Notes
history of basal cell carcinoma
Do Not Combine
Squamous cell carcinoma
Do Not Combine
history of squamous cell
Do Not Combine
family history of basal cell carcinoma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Isotretinoin may interact with Pulse Frequency
Common Sotret Drug Interactions
Drug Name
Risk Level
Description
Clomocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Clomocycline.
Demeclocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Demeclocycline.
Doxycycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Doxycycline.
Eravacycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Eravacycline.
Metacycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Metacycline.
Sotret Toxicity & Overdose RiskSymptoms of an isotretinoin overdose may include vomiting, redness on the face, sores in the mouth, abdominal pain, headache, dizziness, and difficulty with coordination. The lowest dose causing toxic effects for children is 30mg/kg/21W, 24mg/kg/4W in men, and 56mg/kg/8W in women. In animal studies, doses higher than the recommended clinical dose have been linked to an increased risk of tumors of the adrenal gland and testicular atrophy. There is no evidence that isotretinoin affects sperm count or function. Breastfeeding while taking isotretino
Sotret Novel Uses: Which Conditions Have a Clinical Trial Featuring Sotret?
65 active clinical trials are currently examining the potential of Sotret to reduce symptoms of Rosacea, Neuroblastoma (NB) and Acne conglobata.Condition
Clinical Trials
Trial Phases
Acne Vulgaris
0 Actively Recruiting
Acne Conglobata
0 Actively Recruiting
refractory Acne vulgaris
0 Actively Recruiting
early Mycosis Fungoides (MF)
0 Actively Recruiting
Rosacea
8 Actively Recruiting
Not Applicable, Early Phase 1, Phase 2, Phase 4
Sezary Syndrome
18 Actively Recruiting
Phase 2, Phase 1
Neuroblastoma (NB)
1 Actively Recruiting
Early Phase 1
Sotret Reviews: What are patients saying about Sotret?
5Patient Review
2/4/2008 I had tried everything else and this was my last hope. It was a bit of a process to get started (birth control, pregnancy and blood tests, signing into the program...) but it was well worth it. I am in my second month of treatment now and have not had any new acne since my first 2 weeks on the medicine. Furthermore, the redness from my previous acne bumps are beginning to fade.
5Patient Review
12/9/2007 I've now been on this medication for four months, which is one month longer than my doctor said should be necessary. I have seen a significant improvement, but I worry about the other 15% of people who don't see complete results.
5Patient Review
12/19/2007 The treatment I received was great and it finally cured my acne. I was recommended to take a multivitamin supplement without Vitamin A since the Sotret medication is related to Vitamin A and taking the two together can result in potential side effects.
5Patient Review
5/1/2009 I had to stop using this treatment after a month due to the sheer number of side effects I experienced, including but not limited to: constant stomach aches, nausea, and rushes all over my back.
5Patient Review
2/20/2008 I love Solodyn! I started seeing results within the first week, and though there were some headaches early on, they went away after a couple weeks. This is by far the best antibiotic I've tried for my acne.
5Patient Review
9/22/2008 This has been great! I've tried every type of oral medication you could imagine for my face and this is the only one ive seen improvement in. I've only been taking this for less than a month and almost EVERYTHING is gone. Despite the dry lips, peeling skin, and noticable mood changes this is definitely worth it. If nothing has worked for you yet definitely try this, you won't regret it!
5Patient Review
6/2/2008 My 14 year old son became very irritable and aggressive after only taking this medication for two months. It was not worth it to us.
4.3Patient Review
12/10/2008 My son used this medication as directed, and while it did clear up his acne, he developed severe depression that he had not experienced before. Unfortunately, three months later he committed suicide. I am devastated by this turn of events and believe that using this medication was the wrong decision.
4.3Patient Review
12/23/2008 I highly recommend this drug for anyone struggling with acne. It's working really well for me and is much easier than other treatments I've tried in the past. The only downside is that it can cause your skin to dry out, as well as your nose.
3.7Patient Review
11/12/2013 I've been struggling with a skin issue on my face for the last few months. It's red, swollen, and itchy, and no matter what I do, I can't seem to get rid of it. My doctor prescribed Sotret, but even after four months of treatment, there's been no improvement. If anything, it seems to be getting worse. Not sure if I should continue taking this medicine or not.
3.7Patient Review
10/15/2008 My son's acne was much improved while on this medication; however, he had a seizure while taking it. This was the only time he has ever experienced a seizure, and we have not seen any more since taking him off the medication.
3.3Patient Review
11/27/20073Patient Review
10/12/2008 My son started taking this when he was 17. We had tried everything for more than 2 years and nothing worked. But after 6 months on this medication, he was a completely different person. It did wonders for him inside and out. I would tell all parents to try it for their kids' sake, but just be mindful of the potential side effects.
2Patient Review
11/1/2013 I started taking this drug in 2005 to treat my acne. It did improve my skin, but since then I've noticed increased hair loss and thinner hair overall. I also seem to get food poisoning more often than before.
Patient Q&A Section about sotret
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Sotret harmful?
"Sotret can cause severe birth defects or death of a baby if the mother takes this medicine while pregnant."
Answered by AI
Does Sotret reduce acne scars?
"I've been seeing a dermatologist for my acne scars. The doctor prescribed me a medication called Sotret, and I've been taking it for the past 4 months. I've seen great improvements in the condition of my scars, and my face is less oily than it used to be."
Answered by AI
What is Sotret used for?
"Retinoids are a class of medication used to treat severe cystic acne (also known as nodular acne) that has not responded to other treatment options, such as benzoyl peroxide or clindamycin applied to the skin, or tetracycline or minocycline taken orally."
Answered by AI
Is Sotret good for acne?
"Sotret is a drug used to treat severe acne. It is a retinoid, which means it is derived from vitamin A. It is taken in the form of a capsule, and the recommended dosage is two capsules per day, with food."
Answered by AI