HD-tDCS for Hand Function Improvement

Overseen By Michael Vesia, PhD

Age: 65+

Sex: Any

Trial Phase: Academic

Sponsor: University of Michigan

Must not be taking: Neural receptor drugs, Seizure threshold drugs

Disqualifiers: Seizure, Stroke, Alcohol addiction, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 3

Duration: 1 week

40 Participants Needed

Trial Summary

What is the purpose of this trial?

The purpose of this study is to understand how the brain controls movement and how Non-invasive Brain Stimulation (NIBS) with a technique called High-density transcranial direct current stimulation (HD-tDCS) can alter brain processes to improve behavior. Participants in this study will be randomized to either HD-tDCS with standard intervention or personalized dose-controlled multifocal network-targeted HD-tDCS. The hypothesis is that dexterous hand function will improve after a standard HD-tDCS dose and increase even more after personalized dose-controlled multifocal network-targeted HD-tDCS.

Research Team

Michael Vesia, PhD

Principal Investigator

University of Michigan

Eligibility Criteria

This trial is for healthy individuals interested in how brain stimulation can affect movement control. Participants should be willing to undergo non-invasive brain stimulation and fMRI scans. Specific eligibility criteria are not provided, so generally healthy adults may apply.

Inclusion Criteria

Participants should be English speakers

Participants should be right-handed

Participants should be able to provide written consent prior to admission

Exclusion Criteria

Participants with cochlear hearing implants

Participants with metal anywhere in the head that could increase the risk of serious injury (excluding braces, dental fillings, etc.)

I have been diagnosed with Parkinson's disease or Alzheimer's disease.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either standard HD-tDCS or personalized dose-controlled multifocal network-targeted HD-tDCS in three daily sessions

1 week

3 visits (in-person)

Follow-up

Participants are monitored for changes in precision force-tracking task and reaction time 24 hours after the third session

1 week

Treatment Details

Interventions

• High-density transcranial direct current stimulation (HD-tDCS)
• Multifocal network targeted HD-tDCS

Trial Overview The study tests if High-density transcranial direct current stimulation (HD-tDCS) can improve hand function. It compares standard HD-tDCS with a personalized multifocal version targeting specific brain networks, alongside monitoring with fMRI.

Participant Groups

Group I: Personalized dose-controlled multifocal network-targeted HD-tDCS. Experimental Treatment 2 Interventions

Participants will have three daily sessions.

Group II: HD-tDCS with standard intervention Experimental Treatment 2 Interventions

Participants will have three daily sessions.

Who Is Running the Clinical Trial?

University of Michigan

Lead Sponsor

Trials

1,891

Recruited

6,458,000+

Medical University of South Carolina

Collaborator

Trials

994

Recruited

7,408,000+

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Collaborator

Trials

2,103

Recruited

2,760,000+