Study Summary
This trial will investigate the effect of a physical activity prescription delivered through a mobile app on patient-reported outcomes and cartilage health in individuals 5-10 years post-ACL reconstruction.
- Anterior Cruciate Ligament (ACL) Reconstruction
- Posttraumatic Osteoarthritis
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
1 Primary · 4 Secondary · Reporting Duration: 12 months
Trial Safety
Phase-Based Safety
Awards & Highlights
Trial Design
2 Treatment Groups
Usual Care
1 of 2
Physical Activity Prescription (PARx)
1 of 2
Active Control
Experimental Treatment
196 Total Participants · 2 Treatment Groups
Primary Treatment: PARx · No Placebo Group · N/A
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 21 - 32 · All Participants · 0 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:- Ravalli, Silvia, Paola Castrogiovanni, and Giuseppe Musumeci. 2019. “Exercise as Medicine to Be Prescribed in Osteoarthriti”. World Journal of Orthopedics. Baishideng Publishing Group Inc.. doi:10.5312/wjo.v10.i7.262.
- KRAUS, VIRGINIA B., KYLE SPROW, KENNETH E. POWELL, DAVID BUCHNER, BONNY BLOODGOOD, KATRINA PIERCY, STEPHANIE M. GEORGE, and WILLIAM E. KRAUS. 2019. “Effects of Physical Activity in Knee and Hip Osteoarthritis: A Systematic Umbrella Review”. Medicine & Science in Sports & Exercise. Ovid Technologies (Wolters Kluwer Health). doi:10.1249/mss.0000000000001944.
- Maly, M.R., K.A. Marriott, and J.N. Chopp-Hurley. 2020. “Osteoarthritis Year in Review 2019: Rehabilitation and Outcomes”. Osteoarthritis and Cartilage. Elsevier BV. doi:10.1016/j.joca.2019.11.008.
- Cinque, Mark E., Grant J. Dornan, Jorge Chahla, Gilbert Moatshe, and Robert F. LaPrade. 2017. “High Rates of Osteoarthritis Develop After Anterior Cruciate Ligament Surgery: An Analysis of 4108 Patients”. The American Journal of Sports Medicine. SAGE Publications. doi:10.1177/0363546517730072.
- Evans J, Nielson JL. Anterior Cruciate Ligament Knee Injuries. 2021 Feb 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. PMID: 29763023.
- Pedersen, B. K., and B. Saltin. 2015. “Exercise as Medicine - Evidence for Prescribing Exercise as Therapy in 26 Different Chronic Diseases”. Scandinavian Journal of Medicine & Science in Sports. Wiley. doi:10.1111/sms.12581.
- Maly MR, Marriott KA, Chopp-Hurley JN. Osteoarthritis year in review 2019: rehabilitation and outcomes. Osteoarthritis Cartilage. 2020 Mar;28(3):249-266. doi: 10.1016/j.joca.2019.11.008. Epub 2019 Dec 23.
- Ravalli S, Castrogiovanni P, Musumeci G. Exercise as medicine to be prescribed in osteoarthritis. World J Orthop. 2019 Jul 18;10(7):262-267. doi: 10.5312/wjo.v10.i7.262. eCollection 2019 Jul 18.
- Pedersen BK, Saltin B. Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports. 2015 Dec;25 Suppl 3:1-72. doi: 10.1111/sms.12581.
- 2021. "STABILITY: Physical Activity Intervention at 7 Years Post-Anterior Cruciate Ligament Reconstruction". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05152758.
Frequently Asked Questions
What is the current enrollment count for this clinical research?
"Affirmative. Clinicaltrials.gov reflects that this study, first posted on the 1st of November 2021, is actively searching for participants to enrol in their trial. In total 196 patients will be needed at a solitary medical centre." - Anonymous Online Contributor
Is the research open to individuals of advanced age?
"This research study is specifically targeting participants aged 21 to 32. Persons under 18 years old are limited to only 32 trials, whereas there are 587 for those over 65." - Anonymous Online Contributor
Are there any open enrollment slots for this research project?
"Affirmatively, this clinical trial is actively seeking patients. It was first published on November 1st 2021 and revised most recently the 28th of that same month." - Anonymous Online Contributor
Does my profile meet the requirements to join this experiment?
"To be eligible for this medical experiment, patients should have had a previous anterior cruciate ligament reconstruction and possess ages from 21 to 32. A total of 196 participants are needed for the study's success." - Anonymous Online Contributor