Silodosin

Enlarged Prostate
Treatment
1 FDA approval
20 Active Studies for Silodosin

What is Silodosin

SilodosinThe Generic name of this drug
Treatment SummarySilodosin is a medication used to treat enlarged prostate in men over the age of 40. It works by binding to certain receptors in the prostate and relaxing the muscles in the lower urinary tract, which reduces pressure in the bladder and improves urinary symptoms. Silodosin is available as an oral capsule under the brand names Rapaflo and Urorec. It has been approved by the FDA, Europe, and Canada.
Rapaflois the brand name
image of different drug pills on a surface
Silodosin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Rapaflo
Silodosin
2009
34

Approved as Treatment by the FDA

Silodosin, also known as Rapaflo, is approved by the FDA for 1 uses including Enlarged Prostate .
Enlarged Prostate

Effectiveness

How Silodosin Affects PatientsSilodosin is a drug that works by blocking a certain type of receptor (alpha-1A) in the body. It is most often used to treat benign prostatic hyperplasia, and has been found to improve urinary flow, and reduce urinary storage and voiding symptoms. In general, it takes two to six hours for the drug to take effect. Silodosin can also cause a certain type of eye reaction during cataract surgery known as intraoperative floppy iris syndrome (IFIS).
How Silodosin works in the bodyBenign prostatic hyperplasia (BPH) is a condition characterized by an enlarged prostate that can cause bladder outlet obstruction and other urinary symptoms. Silodosin is a drug used to treat BPH. It works by blocking certain types of receptors in the prostate, known as alpha-1 adrenoceptors. By blocking these receptors, Silodosin helps relax the smooth muscles of the prostate, improving obstruction and overactivity of the bladder. It also has an effect on the nerves in the bladder, helping to reduce storage symptoms.

When to interrupt dosage

The degree of Silodosin is contingent upon the diagnosed condition. The quantity of dosage also depends upon the delivery process outlined in the table beneath.
Condition
Dosage
Administration
Enlarged Prostate
4.0 mg, , 8.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated

Warnings

Silodosin has seven contraindications, and its utilization should be avoided for the conditions given in the following table.Silodosin Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Silodosin may interact with Pulse Frequency
There are 20 known major drug interactions with Silodosin.
Common Silodosin Drug Interactions
Drug Name
Risk Level
Description
Alfuzosin
Major
Silodosin may increase the hypotensive activities of Alfuzosin.
Aripiprazole lauroxil
Major
Silodosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole lauroxil.
Asenapine
Major
Silodosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Asenapine.
Brexpiprazole
Major
Silodosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Brexpiprazole.
Bucindolol
Major
Silodosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Bucindolol.
Silodosin Toxicity & Overdose RiskThe lowest dose of silodosin that has caused toxicity in rats is 800mg/kg. In clinical trials, the most common side effect of overdose is low blood pressure. If the patient experiences this, they should be put in a lying down position to help restore their blood pressure and heart rate. Additional treatments such as administering fluids intravenously may also be needed. Since silodosin binds strongly to proteins in the blood, dialysis will not be effective.
image of a doctor in a lab doing drug, clinical research

Silodosin Novel Uses: Which Conditions Have a Clinical Trial Featuring Silodosin?

An ongoing investigation of 21 studies is assessing the potential of Silodosin to treat Enlarged Prostate.
Condition
Clinical Trials
Trial Phases
Enlarged Prostate
21 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 3

Silodosin Reviews: What are patients saying about Silodosin?

5Patient Review
1/4/2020
Silodosin for Enlarged Prostate with Urination Problems
Silodosin has helped me to dramatically reduce the number of times I need to use the restroom at night. It's a vast improvement over Flomax, with none of the associated headaches or stuffy nose. The only " downside" is that it eliminates ejaculation; however, orgasm is still possible and it's much less messy this way!
4.3Patient Review
4/28/2012
Silodosin for Enlarged Prostate
This treatment really helped me with my urine flow. However, I did experience some cognitive impairment and slowness which made it difficult to sustain concentration and focus.
4.3Patient Review
1/9/2013
Silodosin for Enlarged Prostate
I THINK THIS MEDICINE MAKES MY HEARTBEAT STRONGER AND HARDER. I CAN FEEL IT PUMPING IN MY CHEST.
3.7Patient Review
9/29/2012
Silodosin for Enlarged Prostate
I didn't experience the desired effect of this medication. After three doses, there was no seminal fluid. I couldn't find any information about this being a side effect, so I'll be asking for a different drug. Although it did help with my urine flow and sleep patterns.
2.7Patient Review
1/2/2017
Silodosin for Enlarged Prostate with Urination Problems
I had chronic diarrhoea for a while and I eventually realized that this drug was the cause. You're supposed to take it with food, but even then I got occasional cramps.
2.3Patient Review
8/14/2010
Silodosin for Enlarged Prostate
I took one 8mg pill and found it difficult to ejaculate. I also now have pain in my groin area. Not sure where the sperm went, but this was a scary experience. Needless to say, I won't be taking any more of this medication.
2.3Patient Review
4/19/2019
Silodosin for Enlarged Prostate with Urination Problems
Though this treatment is effective, the side effect of fainting caused me to break my C1 vertebrae. I'm lucky that I didn't end up in a wheelchair or worse - dead. My doctor says that even though few people have this side effect, the risk is too much.
2.3Patient Review
4/30/2019
Silodosin for Enlarged Prostate with Urination Problems
I didn't find this effective for my BPH symptoms; the only side effect I experienced was dizziness.
2Patient Review
11/6/2012
Silodosin for Enlarged Prostate
I had improved flow for a few weeks, but then I started to experience dry orgasms and eventually no orgasm. I also had no morning erection and severe constipation. I switched to Flomax and have seen a complete turnaround so far.
1.7Patient Review
5/13/2019
Silodosin for Stones in the Urinary Tract
After having kidney stones removed, my doctor put me on this medication. It did help with urine flow but caused terrible headaches and diarrhea. Once I stopped taking it per my doctor's orders, those problems went away.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about silodosin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of silodosin?

"Anorgasmia is the medical term for regular difficulty reaching orgasm after ample sexual stimulation, causing personal distress. Anorgasmia can be primary, meaning the person has never experienced orgasm, or secondary, meaning they have experienced orgasm in the past, but no longer can. Anorgasmia is much more common in women than men, and is especially common among young adults. The condition can be occasional or persistent, and can be caused by a variety of physical and psychological factors.

Anorgasmia is the medical term for difficulty reaching orgasm after ample sexual stimulation. It can be primary, meaning the person has never experienced orgasm, or secondary, meaning they have experienced orgasm in the past, but no longer can. Anorgasmia is much more common in women than men, and is especially common among young adults. The condition can be occasional or persistent, and can be caused by a variety of physical and psychological factors."

Answered by AI

Is silodosin better than tamsulosin?

"The results showed that silodosin was better than tamsulosin in terms of stone expulsion rate, with 82.4% for silodosin and 61.5% for tamsulosin. The time it took to expel the stones was also significantly lower for silodosin, at 9.4 ± 3.8 vs."

Answered by AI

Does silodosin shrink the prostate?

"This helps to relieve urinary symptoms.

Silodosin is used by men to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia-BPH). It does not shrink the prostate, but it works by relaxing the muscles in the prostate and the bladder. This helps relieve urinary symptoms."

Answered by AI

What is silodosin used for?

"Silodosin is used to treat the signs and symptoms associated with an enlarged prostate, also known as benign prostatic hyperplasia (BPH). BPH is a common issue that can occur in men as they age, and is caused by the prostate gland enlarging and placing pressure on the bladder."

Answered by AI

What is the side effect of silodosin?

"Some common side effects of silodosin may include headaches, diarrhea, abnormal ejaculation, or a stuffy nose and sinus pain."

Answered by AI

Clinical Trials for Silodosin

Have you considered Silodosin clinical trials? We made a collection of clinical trials featuring Silodosin, we think they might fit your search criteria.
Have you considered Silodosin clinical trials? We made a collection of clinical trials featuring Silodosin, we think they might fit your search criteria.
Have you considered Silodosin clinical trials? We made a collection of clinical trials featuring Silodosin, we think they might fit your search criteria.