Silenor

Insomnia, Neurotic depression, Depression + 8 more
Treatment
20 Active Studies for Silenor

What is Silenor

DoxepinThe Generic name of this drug
Treatment SummaryDoxepin is a medication used to treat depression and anxiety. It belongs to a class of drugs called tricyclic antidepressants, but it does not have the same exact properties as them. Doxepin was first approved by the FDA in 1969 for use as an antidepressant and was later approved in 2010 for the treatment of insomnia. It was developed by Pfizer and is available under the brand name Silenor.
Sinequanis the brand name
image of different drug pills on a surface
Silenor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sinequan
Doxepin
1969
307

Effectiveness

How Silenor Affects PatientsDoxepin is a type of antidepressant that works by decreasing electrical activity in the brain. It can cause antidepressant, sedative, and anticholinergic effects, but at higher doses the anticholinergic and antiadrenergic properties become more prominent. The antidepressant effects of doxepin become noticeable after 2 weeks, while the sedative effects can be seen right away.
How Silenor works in the bodyDoxepin works by blocking histamine receptors, which helps to treat skin conditions. Additionally, it works on the central nervous system to increase the activity of norepinephrine and serotonin, which are neurotransmitters. This increases the activity at the post-synaptic neuron receptor sites. Doxepin also desensitizes serotonin 1A receptors and beta-adrenergic receptors. Lastly, it is thought to increase dopamine activity in the frontal cortex.

When to interrupt dosage

The dosage of Silenor is contingent upon the identified condition, including Depression, Involutional, Mental Disorder, Organic and Insomnia. The measure of dosage is contingent upon the technique of application (e.g. Oral or Tablet - Oral) featured in the table beneath.
Condition
Dosage
Administration
Insomnia
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Neurotic depression
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Depression
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Generalized Anxiety Disorder
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Neuropathic Pain
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Itching
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Depressive Disorder, Major
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Behcet Syndrome
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Alcoholism
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Depressive Disorder, Major
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Neurodermatitis
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated

Warnings

Silenor Contraindications
Condition
Risk Level
Notes
untreated narrow angle glaucoma
Do Not Combine
Pulse Frequency
Do Not Combine
Urinary Retention
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Doxepin may interact with Pulse Frequency
There are 20 known major drug interactions with Silenor.
Common Silenor Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
Doxepin may increase the vasopressor activities of 4-Methoxyamphetamine.
Acepromazine
Major
Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Doxepin is combined with Aclidinium.
Alfuzosin
Major
Doxepin may increase the hypotensive activities of Alfuzosin.
Aripiprazole
Major
Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.
Silenor Toxicity & Overdose RiskTaking too much doxepin can cause seizures, irregular heartbeat, unconsciousness, low blood pressure, and depression of the central nervous system. It can also lead to changes in electrocardiogram results and even death. Additionally, doxepin affects fertility in men and women, leading to decreased implantation and litter size, as well as abnormal sperm and reduced sperm motility. There is no evidence that it causes cancer or genetic mutations.

Silenor Novel Uses: Which Conditions Have a Clinical Trial Featuring Silenor?

Currently, 1020 active studies are looking into the potential of Silenor to provide relief from Generalized Anxiety Disorder, Atopic Dermatitis and Bipolar Disorder.
Condition
Clinical Trials
Trial Phases
Insomnia
1 Actively Recruiting
Not Applicable
Generalized Anxiety Disorder
206 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Early Phase 1, Phase 4, Phase 1
Depression
337 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3
Alcoholism
6 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Neurotic depression
0 Actively Recruiting
Depressive Disorder, Major
205 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3
Itching
3 Actively Recruiting
Phase 2, Phase 3, Not Applicable
Behcet Syndrome
1 Actively Recruiting
Not Applicable
Neuropathic Pain
5 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Neurodermatitis
0 Actively Recruiting
Depressive Disorder, Major
0 Actively Recruiting

Silenor Reviews: What are patients saying about Silenor?

5Patient Review
6/15/2016
Silenor for Chronic Trouble Sleeping
I've been using this treatment for two weeks and it's helped me stay asleep through the night. At first I felt groggy during the day, but that has passed. Now I'm really pleased with how well it works.
5Patient Review
5/12/2016
Silenor for Chronic Trouble Sleeping
This was very easy to use, and it worked immediately.
5Patient Review
2/22/2018
Silenor for Chronic Trouble Sleeping
I find that if I eat dinner no later than 6:30 PM and then take Silenor at 10:30 PM, I sleep really well. Before taking this medication, I would average 4 to 5 hours of sleep per night; however, now I'm averaging 7.5 hours of sleep per night.
4.7Patient Review
3/14/2016
Silenor for Chronic Trouble Sleeping
Before taking Silenor, I was only sleeping for two to four hours per night. This medication doesn't make you fall asleep, but it does help you stay asleep once you do fall asleep. It's been a lifesaver.
4.3Patient Review
9/22/2014
Silenor for Chronic Trouble Sleeping
I've been using Ambien for a while now, and unfortunately my body became used to it after a few years. Thankfully, my doctor recommended that I also take Silenor in order to combat this problem. So far it's working great!
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about silenor

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does it take for Silenor to kick in?

"After taking doxepin, you should limit your activities to those necessary to prepare for sleep. Doxepin works best when taken 3 hours after a meal and within 30 minutes of bedtime."

Answered by AI

What are the side effects of Silenor?

"trouble sleeping

Drowsiness, dizziness, stuffy nose, sneezing, sore throat, nausea, vomiting, diarrhea, constipation, loss of appetite, and trouble sleeping are all symptoms of the cold."

Answered by AI

Is Silenor a narcotic?

"The manufacturer of Silenor claims that it is a non-abusable option for insomnia relief and is not classified as a controlled substance by the DEA."

Answered by AI

Is Silenor a good sleeping pill?

"Doxepin is a medication used to treat insomnia. It is in a class of medications called tricyclic antidepressants. Doxepin works by slowing activity in the brain to allow sleep."

Answered by AI

Clinical Trials for Silenor

Have you considered Silenor clinical trials? We made a collection of clinical trials featuring Silenor, we think they might fit your search criteria.
Have you considered Silenor clinical trials? We made a collection of clinical trials featuring Silenor, we think they might fit your search criteria.
Have you considered Silenor clinical trials? We made a collection of clinical trials featuring Silenor, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top