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What is Silenor
DoxepinThe Generic name of this drug
Treatment SummaryDoxepin is a medication used to treat depression and anxiety. It belongs to a class of drugs called tricyclic antidepressants, but it does not have the same exact properties as them. Doxepin was first approved by the FDA in 1969 for use as an antidepressant and was later approved in 2010 for the treatment of insomnia. It was developed by Pfizer and is available under the brand name Silenor.
Sinequanis the brand name
Silenor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sinequan
Doxepin
1969
307
Effectiveness
How Silenor Affects PatientsDoxepin is a type of antidepressant that works by decreasing electrical activity in the brain. It can cause antidepressant, sedative, and anticholinergic effects, but at higher doses the anticholinergic and antiadrenergic properties become more prominent. The antidepressant effects of doxepin become noticeable after 2 weeks, while the sedative effects can be seen right away.
How Silenor works in the bodyDoxepin works by blocking histamine receptors, which helps to treat skin conditions. Additionally, it works on the central nervous system to increase the activity of norepinephrine and serotonin, which are neurotransmitters. This increases the activity at the post-synaptic neuron receptor sites. Doxepin also desensitizes serotonin 1A receptors and beta-adrenergic receptors. Lastly, it is thought to increase dopamine activity in the frontal cortex.
When to interrupt dosage
The dosage of Silenor is contingent upon the identified condition, including Depression, Involutional, Mental Disorder, Organic and Insomnia. The measure of dosage is contingent upon the technique of application (e.g. Oral or Tablet - Oral) featured in the table beneath.Condition
Dosage
Administration
Behcet Syndrome
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
psychotic depressive disorder
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Neurotic depression
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Insomnia
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Neuropathic Pain
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Itching
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Generalized Anxiety Disorder
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Lichen simplex chronicus
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Depression
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Depression, Involutional
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Alcoholism
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Warnings
Silenor ContraindicationsCondition
Risk Level
Notes
untreated narrow angle glaucoma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Doxepin may interact with Pulse Frequency
Pulse Frequency
Do Not Combine
Urinary Retention
Do Not Combine
Common Silenor Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
Doxepin may increase the vasopressor activities of 4-Methoxyamphetamine.
Acepromazine
Major
Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Doxepin is combined with Aclidinium.
Alfuzosin
Major
Doxepin may increase the hypotensive activities of Alfuzosin.
Aripiprazole
Major
Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.
Silenor Toxicity & Overdose RiskTaking too much doxepin can cause seizures, irregular heartbeat, unconsciousness, low blood pressure, and depression of the central nervous system. It can also lead to changes in electrocardiogram results and even death. Additionally, doxepin affects fertility in men and women, leading to decreased implantation and litter size, as well as abnormal sperm and reduced sperm motility. There is no evidence that it causes cancer or genetic mutations.
Silenor Novel Uses: Which Conditions Have a Clinical Trial Featuring Silenor?
Currently, 1020 active studies are looking into the potential of Silenor to provide relief from Generalized Anxiety Disorder, Atopic Dermatitis and Bipolar Disorder.Condition
Clinical Trials
Trial Phases
Insomnia
89 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1
Generalized Anxiety Disorder
244 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1, Phase 4
Itching
10 Actively Recruiting
Phase 4, Phase 3, Phase 2, Phase 1
Neurotic depression
0 Actively Recruiting
Depression, Involutional
0 Actively Recruiting
Behcet Syndrome
2 Actively Recruiting
Not Applicable
Alcoholism
7 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Lichen simplex chronicus
0 Actively Recruiting
Depression
693 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4
psychotic depressive disorder
0 Actively Recruiting
Neuropathic Pain
27 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4
Silenor Reviews: What are patients saying about Silenor?
5Patient Review
6/15/2016 I've been using this treatment for two weeks and it's helped me stay asleep through the night. At first I felt groggy during the day, but that has passed. Now I'm really pleased with how well it works.
5Patient Review
5/12/2016 This was very easy to use, and it worked immediately.
5Patient Review
2/22/2018 I find that if I eat dinner no later than 6:30 PM and then take Silenor at 10:30 PM, I sleep really well. Before taking this medication, I would average 4 to 5 hours of sleep per night; however, now I'm averaging 7.5 hours of sleep per night.
4.7Patient Review
3/14/2016 Before taking Silenor, I was only sleeping for two to four hours per night. This medication doesn't make you fall asleep, but it does help you stay asleep once you do fall asleep. It's been a lifesaver.
4.3Patient Review
9/22/2014 I've been using Ambien for a while now, and unfortunately my body became used to it after a few years. Thankfully, my doctor recommended that I also take Silenor in order to combat this problem. So far it's working great!
4.3Patient Review
10/17/2016 I love how this treatment helps me sleep, but unfortunately I have to be careful not to use it more than a couple nights in a row or else I get a dry mouth.
2.7Patient Review
4/28/2018 This drug helped me sleep at first, but after a few weeks I started experiencing some bad side effects. The worst was memory loss; I would constantly forget things or do something and then completely forget about it. It also made my depression and anxiety much worse. Do not take more than prescribed, as I made this mistake and slept for over 24 hours straight. Would not recommend this drug.
2.3Patient Review
5/9/2015 I have been taking this medication for a week now and it keeps me up all night. I would not recommend it to anyone.
2.3Patient Review
8/29/2016 Unfortunately, this did not help me fall asleep at all. As a result, I've gotten no sleep and feel pretty terrible.
2.3Patient Review
12/21/2014 This medication definitely keeps me awake; however, it also gives me weird and intrusive thoughts. Additionally, I feel like the room temperature is significantly warmer than it actually is.
2Patient Review
7/24/2018 This drug was sometimes effective when I took it to sleep, but not always. At $25 a bottle, it was worth trying. However, now that the price has gone up to $100 for a 30 day supply, it's not worth it anymore.
1.7Patient Review
11/6/2016 I would not recommend this drug to anyone. It caused me severe depression and crying fits, and did nothing to help my insomnia.
1.7Patient Review
11/1/2015 Ambien only helped me sleep for four hours, so I decided to try this treatment. The first night, I woke up after only one hour of sleep. The second night, I took two doses and slept for an extra hour... but that still wasn't enough. This didn't work for me at all.
1.7Patient Review
11/10/2019 PSA - I was prescribed doxepin for insomnia and anxiety. After a lower dose was not effective, my Dr. increased the dose. The first night on the increased dose, I slept drove and was arrested for a DUI. I also had significant memory issues during the several months I was prescribed doxepin and which have persisted. Upon discontinuing doxepin, side effects ceased. Take with EXTREME CAUTION
1.7Patient Review
7/24/2018 I halved the Silenor tablet my doctor prescribed me for insomnia after the first dose made me feel like a zombie the next day. Even halving the dosage leaves me feeling drowsy and barely functional for several hours afterward, so it's not worth it to me.
1Patient Review
10/15/2016 This treatment was ineffective for me and made it harder to function the next day. I wouldn't recommend it to anyone with chronic insomnia.
Patient Q&A Section about silenor
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long does it take for Silenor to kick in?
"After taking doxepin, you should limit your activities to those necessary to prepare for sleep. Doxepin works best when taken 3 hours after a meal and within 30 minutes of bedtime."
Answered by AI
What are the side effects of Silenor?
"trouble sleeping
Drowsiness, dizziness, stuffy nose, sneezing, sore throat, nausea, vomiting, diarrhea, constipation, loss of appetite, and trouble sleeping are all symptoms of the cold."
Answered by AI
Is Silenor a narcotic?
"The manufacturer of Silenor claims that it is a non-abusable option for insomnia relief and is not classified as a controlled substance by the DEA."
Answered by AI