Sevelamer Carbonate

Hyperphosphataemia, Hemodialysis
Treatment
2 FDA approvals
11 Active Studies for Sevelamer Carbonate

What is Sevelamer Carbonate

SevelamerThe Generic name of this drug
Treatment SummarySevelamer is a medication prescribed to help prevent high levels of phosphate in the blood for individuals with chronic kidney disease. It is manufactured by Genzyme and sold under the brand name Renagel.
Renagelis the brand name
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Sevelamer Carbonate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Renagel
Sevelamer
2006
81

Approved as Treatment by the FDA

Sevelamer, otherwise called Renagel, is approved by the FDA for 2 uses including Hyperphosphataemia and Hemodialysis .
Hyperphosphataemia
Helps manage Hyperphosphataemia
Hemodialysis
Helps manage Hemodialysis Treatment

Effectiveness

How Sevelamer Carbonate Affects PatientsPeople with end-stage renal disease often have too much phosphorus in their blood, which can cause calcium to settle in different parts of the body (ectopic calcification). This can also raise levels of a hormone called PTH, which can lead to a bone disease called osteitis fibrosa. To lower phosphorus levels, people can reduce the amount of phosphorus they eat, take a medicine called sevelamer, or use dialysis. Sevelamer taken during meals has been found to lower phosphorus levels and also lower cholesterol levels. It works similarly as a capsule or tablet.
How Sevelamer Carbonate works in the bodySevelamer prevents too much phosphate from entering the bloodstream. It does this by binding to phosphate in the gut and stopping it from being absorbed. This reduces the amount of phosphate in the blood, helping to control levels of parathyroid hormone.

When to interrupt dosage

The suggested dosage of Sevelamer Carbonate is contingent upon the determined condition. The measure of dosage fluctuates, according to the technique of delivery (e.g. Parenteral or Capsule) featured in the following table.
Condition
Dosage
Administration
Hemodialysis
800.0 mg, , 400.0 mg, 403.0 mg, 1600.0 mg, 2400.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Powder, for suspension, Powder, for suspension - Oral, Tablet, film coated - Parenteral, Parenteral
Hyperphosphataemia
800.0 mg, , 400.0 mg, 403.0 mg, 1600.0 mg, 2400.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Powder, for suspension, Powder, for suspension - Oral, Tablet, film coated - Parenteral, Parenteral

Warnings

There are 20 known major drug interactions with Sevelamer Carbonate.
Common Sevelamer Carbonate Drug Interactions
Drug Name
Risk Level
Description
Mycophenolic acid
Major
The serum concentration of Mycophenolic acid can be decreased when it is combined with Sevelamer.
Raloxifene
Major
Sevelamer can cause a decrease in the absorption of Raloxifene resulting in a reduced serum concentration and potentially a decrease in efficacy.
Technetium Tc-99m oxidronate
Major
Sevelamer may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
(R)-warfarin
Minor
Sevelamer can cause a decrease in the absorption of (R)-warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.
(S)-Warfarin
Minor
Sevelamer can cause a decrease in the absorption of (S)-Warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sevelamer Carbonate Toxicity & Overdose RiskSevelamer has been tested on healthy volunteers in doses up to 14 grams per day for eight days and no adverse side effects were reported. Patients receiving hemodialysis have been given up to 13 grams per day with no reported overdoses. Since sevelamer is not absorbed, it is unlikely to cause any systemic toxicity.
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Sevelamer Carbonate Novel Uses: Which Conditions Have a Clinical Trial Featuring Sevelamer Carbonate?

11 active clinical trials are presently analyzing the potential of Sevelamer Carbonate to address Hyperphosphataemia.
Condition
Clinical Trials
Trial Phases
Hyperphosphataemia
0 Actively Recruiting
Hemodialysis
11 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 1

Sevelamer Carbonate Reviews: What are patients saying about Sevelamer Carbonate?

1Patient Review
3/28/2011
Sevelamer Carbonate for Renal Osteodystrophy with Hyperphosphatemia
I had a really unfortunate reaction to this treatment and would not recommend it to others.
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Patient Q&A Section about sevelamer carbonate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What drug class is sevelamer carbonate?

"Renvela is a prescription medicine used to treat the symptoms of Serum Phosphorus Regulation in patients with chronic kidney disease (CKD) who are on dialysis. Renvela may be used alone or with other medications. Renvela belongs to a class of drugs called PO4 Scavengers."

Answered by AI

What are the side effects of sevelamer?

"You may experience headaches, diarrhea, stomach upsets, nausea, vomiting, coughing, gas, or constipation. If you experience any of these effects for an extended period of time, talk to your doctor or pharmacist."

Answered by AI

What is sevelamer carbonate taken for?

"This medicine is only available with a doctor's prescription and is used to treat hyperphosphatemia (too much phosphate in the blood) in patients with chronic kidney disease who are on dialysis."

Answered by AI

When should you take sevelamer?

"Sevelamer is available as a tablet or powder for suspension, which is generally taken three times a day with meals."

Answered by AI

Clinical Trials for Sevelamer Carbonate

Have you considered Sevelamer Carbonate clinical trials? We made a collection of clinical trials featuring Sevelamer Carbonate, we think they might fit your search criteria.
Have you considered Sevelamer Carbonate clinical trials? We made a collection of clinical trials featuring Sevelamer Carbonate, we think they might fit your search criteria.