Roflumilast

Chronic Obstructive Pulmonary Disease
Treatment
1 FDA approval
20 Active Studies for Roflumilast

What is Roflumilast

RoflumilastThe Generic name of this drug
Treatment SummaryRoflumilast is a medication used to treat exacerbations of chronic obstructive pulmonary disease (COPD). It works by blocking an enzyme called phosphodiesterase-4 (PDE-4) in the lungs. However, this drug may increase the risk of mental health side effects, including suicidal thoughts and behavior.
Dalirespis the brand name
image of different drug pills on a surface
Roflumilast Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Daliresp
Roflumilast
2011
16

Approved as Treatment by the FDA

Roflumilast, otherwise called Daliresp, is approved by the FDA for 1 uses including Chronic Obstructive Pulmonary Disease .
Chronic Obstructive Pulmonary Disease
Helps manage Chronic Obstructive Pulmonary Disease (COPD)

Effectiveness

How Roflumilast Affects PatientsRoflumilast and its active metabolite, roflumilast N-oxide, help increase a type of cellular energy (cyclic adenosine-3′, 5′-monophosphate) in cells affected by the drug. They are very specific for this purpose and don't affect other energy producing molecules.
How Roflumilast works in the bodyRoflumilast is a drug that works by blocking an enzyme in the body called phosphodiesterase-4. This increases levels of a molecule called cyclic AMP, which helps reduce inflammation and modulate the immune system in the lungs.

When to interrupt dosage

The dosage of Roflumilast is contingent upon the diagnosed ailment. The measure likewise varies as indicated by the technique of delivery noted in the table below.
Condition
Dosage
Administration
Chronic Obstructive Pulmonary Disease
, 0.5 mg, 0.25 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral

Warnings

Roflumilast Contraindications
Condition
Risk Level
Notes
Liver
Do Not Combine
There are 20 known major drug interactions with Roflumilast.
Common Roflumilast Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Minor
Roflumilast may increase the immunosuppressive activities of 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Minor
Roflumilast may increase the immunosuppressive activities of 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Minor
Roflumilast may increase the immunosuppressive activities of Abatacept.
Abetimus
Minor
Roflumilast may increase the immunosuppressive activities of Abetimus.
Aclidinium
Minor
Roflumilast may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Roflumilast Toxicity & Overdose RiskThere is no information available on overdosing on roflumilast when taken by mouth. In some cases, patients have experienced headaches, digestive issues, dizziness, racing heart, feeling faint, and low blood pressure at doses of up to 5000 mcg. If an overdose occurs, get medical help right away. It is not likely that hemodialysis will be helpful due to the drug's high protein binding.
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Roflumilast Novel Uses: Which Conditions Have a Clinical Trial Featuring Roflumilast?

98 active studies are currently assessing the possible therapeutic efficacy of Roflumilast in the management of Chronic Obstructive Pulmonary Disease (COPD).
Condition
Clinical Trials
Trial Phases
Chronic Obstructive Pulmonary Disease
99 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4

Roflumilast Reviews: What are patients saying about Roflumilast?

5Patient Review
2/11/2012
Roflumilast for COPD with Chronic Bronchitis
I've had some trouble sleeping, but I've lost a lot of weight, which is great.
2.3Patient Review
4/23/2014
Roflumilast for COPD with Chronic Bronchitis
I haven't seen any difference since starting this pill. Not sure if it's working or not.
1Patient Review
3/20/2012
Roflumilast for COPD with Chronic Bronchitis
I felt awful after taking this medication. I had every symptom of the flu, but much worse. I was completely housebound for two weeks.
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Patient Q&A Section about roflumilast

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of drug is roflumilast?

"Roflumilast belongs to a class of drugs known as phosphodiesterase inhibitors. These drugs work by decreasing inflammation in the lungs."

Answered by AI

Is roflumilast a steroid?

"Roflumilast is a good PDE4 inhibitor to look into as an option to help decreased the amount of steroids patients with COVID-19 need."

Answered by AI

What is the indication of roflumilast?

"This medication is indicated to help reduce exacerbations (worsening of symptoms) in people who have severe COPD associated with chronic bronchitis, and who have a history of exacerbations. It is not a bronchodilator and is not indicated for treating acute bronchospasm."

Answered by AI

How does roflumilast help with COPD?

"Roflumilast is an enzyme inhibitor that specifically targets the inflammation associated with COPD. In addition to reducing inflammatory mediators, it also prevents cell surface Markers from being expressed and halts apoptosis."

Answered by AI

What is roflumilast used for?

"Roflumilast is a medication used to reduce the number of episodes or worsening of symptoms in people with severe chronic obstructive pulmonary disease (COPD). Roflumilast is a class of phosphodiesterase inhibitors."

Answered by AI

What are some of the side effects of roflumilast?

"The following side effects may occur while taking this medication: diarrhea, weight loss, stomach/abdominal pain, nausea, loss of appetite, headache, or dizziness. If you experience any of these side effects, inform your doctor or pharmacist immediately. Keep track of your weight while taking this medication, and let your doctor know if you experience any extreme or unusual weight loss."

Answered by AI

Clinical Trials for Roflumilast

Have you considered Roflumilast clinical trials? We made a collection of clinical trials featuring Roflumilast, we think they might fit your search criteria.
Have you considered Roflumilast clinical trials? We made a collection of clinical trials featuring Roflumilast, we think they might fit your search criteria.
Have you considered Roflumilast clinical trials? We made a collection of clinical trials featuring Roflumilast, we think they might fit your search criteria.
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