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What is Rifampin
RifampicinThe Generic name of this drug
Treatment SummaryRifampin is an antibiotic that is derived from Streptomyces mediterranei and is used to treat a wide range of bacterial infections. It works by stopping the bacteria from producing proteins necessary for their survival and multiplication, effectively killing them. Rifampin is effective against both intracellular and extracellular bacteria.
Rifadinis the brand name
Rifampin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Rifadin
Rifampicin
1971
75
Approved as Treatment by the FDA
Rifampicin, otherwise known as Rifadin, is approved by the FDA for 3 uses which include initial phase Tuberculosis and late phase Tuberculosis .initial phase Tuberculosis
Used to treat initial phase Tuberculosis in combination with Isoniazid
late phase Tuberculosis
Used to treat late phase Tuberculosis in combination with Isoniazid
Nasopharynx
Effectiveness
How Rifampin Affects PatientsRifampin is an antibiotic that stops bacteria from producing the proteins they need to survive. It is effective against most types of bacteria, including those that cause tuberculosis, and is usually taken by mouth. It is absorbed quickly and spread throughout the body, including the brain. Rifampin is processed in the liver and then removed from the body in bile. It can also be removed from the body in urine, although no dose adjustments are needed for patients with kidney problems. Because bacteria can become resistant to rifampin, it is only used to treat certain infections.
How Rifampin works in the bodyRifampin works by blocking the production of RNA in cells, which prevents them from functioning and leads to their death.
When to interrupt dosage
The prescribed quantity of Rifampin is contingent upon the diagnosed circumstance, for instance antibacterial therapy, Prosthetic Joint Infections and Nasopharynx. The dosage can be found in the table below, depending on the technique of delivery.Condition
Dosage
Administration
Pruritus
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
Nasopharynx
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
late phase Tuberculosis
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
antibacterial therapy
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
MRSA Infections
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
Prosthetic Joint Infections
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
initial phase Tuberculosis
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
Warnings
Rifampin ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Rifampin Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be increased when combined with Rifampicin.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Rifampicin.
5-androstenedione
Major
The metabolism of 5-androstenedione can be increased when combined with Rifampicin.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be increased when combined with Rifampicin.
7-ethyl-10-hydroxycamptothecin
Major
The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Rifampicin.
Rifampin Toxicity & Overdose RiskThe lethal dose of this drug for rats is 1570 mg/kg. Prolonged exposure could lead to nausea, vomiting, and loss of consciousness.
Rifampin Novel Uses: Which Conditions Have a Clinical Trial Featuring Rifampin?
Five current clinical trials are assessing the potential of Rifampin for managing late phase Tuberculosis, initial phase Tuberculosis and Pruritus.Condition
Clinical Trials
Trial Phases
late phase Tuberculosis
0 Actively Recruiting
Prosthetic Joint Infections
4 Actively Recruiting
Phase 4, Not Applicable
Nasopharynx
0 Actively Recruiting
antibacterial therapy
0 Actively Recruiting
Pruritus
0 Actively Recruiting
MRSA Infections
0 Actively Recruiting
initial phase Tuberculosis
0 Actively Recruiting
Patient Q&A Section about rifampin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why is rifampin used to treat TB?
"Rifampin is a medicine used to treat latent tuberculosis infection (LTBI). It works by killing the tuberculosis bacteria before they wake up and make you sick. Because the bacteria are strong, it can take several months for the medicine to work. Make sure to take Rifampin as often and for as long as your healthcare provider tells you."
Answered by AI
What are the side effects of taking rifampin?
"Symptoms of indigestion may include: heartburn, abdominal pain, loss of appetite, nausea, vomiting, yellowing skin and eyes (jaundice), gas (flatulence), cramps."
Answered by AI
What is the most serious complication of rifampin?
"Liver problems have led to death in up to 1 out of 1000 people.
In some cases, people have had a severe reaction to rifampin, which can be deadly. Symptoms of this reaction may include fever, rash, or swollen glands, as well as problems with organs such as the liver, kidney, blood, heart, muscles, and joints, or lungs. If you have any questions, please speak to your doctor. In some instances, rifampin has been known to cause liver problems, which has resulted in death in up to one in every 1,000 people who take the medication."
Answered by AI
What type of antibiotic is rifampin?
"It is also effective against a number of other strains, including Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis.
Rifampicin is an antibiotic used to treat bacterial infections, including tuberculosis, leprosy, and Legionnaires' disease. It is also effective against other strains, including Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis."
Answered by AI