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Oral Antibiotics for Prosthetic Joint Infections
Study Summary
This trial is testing whether a 7-day course of an oral, prophylactic antibiotic can reduce the incidence of periprosthetic joint infection and wound complications following primary total hip and knee arthroplasty in a high-risk patient population.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Media Library
- I am having or have had a hip or knee replacement redone.I am allergic to certain antibiotics listed in the treatment plan.I have had a partial joint replacement.I have had clostridium difficile colitis in the past.I will have a hip or knee replacement within the next 12 weeks.I am having or have had both hips or knees replaced at the same time.I have had surgery that was not planned in advance.I am scheduled for a first-time hip or knee replacement surgery.I have had a partial knee replacement.I am at high risk for joint infections due to one or more health issues.
- Group 1: Additional Antibiotic Group
- Group 2: Control Group - No Additional Antibiotic
- Drug Has Already Been Approved - The FDA has already approved this drug, and is just seeking more data.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
To what bacterial infections is Group A antibiotic typically prescribed?
"Group A - antibiotic is typically utilised to combat severe acne flare-ups, but can also prove efficacious against certain bacterial infections such as trachoma and Klebsiella."
What assessment has been conducted to review the safety of Group A antibiotics for human use?
"Extensive clinical data supports the safety of Group A - antibiotic group, so it was awarded a score 3."
What are the current venues in which this experiment is being conducted?
"Currently, 4 medical sites are enrolling individuals for this trial. These locations include Morgantown, Iowa City and Rochester as well as other nearby spots. It is best to select a clinic close by in order to minimize travelling needs while taking part in the study."
Does this experiment accept participants aged 55 and above?
"This trial has established the age range of 18 to 99 as its criteria for eligibility. For those below 18, there are 154 trials available and 919 studies for individuals above 65 years old."
Would I be eligible to join the experiment?
"This medical study seeks to recruit 956 individuals aged 18-99, who are undergoing elective primary total hip or knee arthroplasty. Applicants should also meet these additional criteria: BMI over 35kg/m^2, diagnosis of diabetes mellitus, actively using tobacco products, chronic kidney disease (eGFR lower than 60 mL/min/1.73 m2), nasal colonization by MRSA and MSSA bacteria; autoimmune or inflammatory illnesses."
How many participants are currently selected for this research program?
"That is accurate. Per information hosted on clinicaltrials.gov, this medical trial first appeared on June 11th 2020 and was recently updated December 27 2021. The study necessitates 956 participants recruited from 4 distinct sites in order to be completed successfully."
What other investigations have been performed with Group A - antibiotic cohort?
"Group A - antibiotic group has been the subject of 192 completed trials since its original study at The Univeristy Hospital in 2010, with 51 active studies being conducted primarily out of Morgantown, West virginia."
Are there any opportunities for people to join the research project at this time?
"Affirmative, the info hosted on clinicaltrials.gov reveals that this medical study is currently seeking volunteers. This trial was first published on June 11th 2020 and recently updated December 27th 2021; it requires 956 patients from 4 distinct sites to participate."
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