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What is Rifamate
RifampicinThe Generic name of this drug
Treatment SummaryRifampin is an antibiotic created from Streptomyces mediterranei. It can be used to treat a wide range of bacterial infections, including some types of Mycobacterium. Rifampin works by binding to the DNA-dependent RNA polymerase enzyme and stopping the production of RNA. This makes it effective against both intracellular and extracellular bacteria, as it kills both types of organisms.
Rifadinis the brand name
Rifamate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Rifadin
Rifampicin
1971
75
Approved as Treatment by the FDA
Rifampicin, otherwise known as Rifadin, is approved by the FDA for 5 uses which include late phase Tuberculosis and initial phase Tuberculosis .late phase Tuberculosis
Used to treat late phase Tuberculosis in combination with Isoniazid
initial phase Tuberculosis
Used to treat initial phase Tuberculosis in combination with Isoniazid
Nasopharynx
Tuberculosis
Used to treat late phase Tuberculosis in combination with Isoniazid
Latent Tuberculosis
Used to treat initial phase Tuberculosis in combination with Isoniazid
Effectiveness
How Rifamate Affects PatientsRifampin is an antibiotic that prevents bacteria from making the genetic material they need to survive and reproduce. It works on most types of bacteria, including those that cause tuberculosis. It is absorbed quickly when taken by mouth and travels to many areas of the body, including the brain. It is broken down by the liver and then excreted in bile and urine. People with kidney problems do not need to adjust their dose.
How Rifamate works in the bodyRifampin stops cells from making new RNA. This prevents them from replicating and eventually leads to cell death.
When to interrupt dosage
The measure of Rifamate relies upon the determined condition, counting antibacterial therapy, Prosthetic Joint Infections and Nasopharynx. The prescribed dosage shifts, contingent upon the system of dispensation as featured in the table below.Condition
Dosage
Administration
Nasopharynx
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
Latent Tuberculosis
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
Tuberculosis
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
antibacterial therapy
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
Staphylococcal Infections
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
Prosthetic Joint Infections
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
Pruritus
60.0 mg/mL, , 300.0 mg, 120.0 mg, 150.0 mg, 600.0 mg, 450.0 mg
, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Oral, Capsule, Capsule - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, coated - Oral, Capsule, coated, Tablet, Tablet - Oral
Warnings
Rifamate ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Rifamate Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be increased when combined with Rifampicin.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Rifampicin.
5-androstenedione
Major
The metabolism of 5-androstenedione can be increased when combined with Rifampicin.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be increased when combined with Rifampicin.
7-ethyl-10-hydroxycamptothecin
Major
The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Rifampicin.
Rifamate Toxicity & Overdose RiskThe toxic dose of the drug in rats is 1570mg/kg. Long-term exposure can lead to nausea, vomiting, and loss of consciousness.
Rifamate Novel Uses: Which Conditions Have a Clinical Trial Featuring Rifamate?
Presently, 5 active investigations are examining the potential of Rifamate to alleviate late-phase Tuberculosis, initial-phase Tuberculosis and Pruritus.Condition
Clinical Trials
Trial Phases
Tuberculosis
0 Actively Recruiting
Nasopharynx
0 Actively Recruiting
Latent Tuberculosis
0 Actively Recruiting
antibacterial therapy
0 Actively Recruiting
Staphylococcal Infections
0 Actively Recruiting
Prosthetic Joint Infections
2 Actively Recruiting
Phase 4, Not Applicable
Pruritus
0 Actively Recruiting
Patient Q&A Section about rifamate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of isoniazid and rifampin?
"The following are potential side effects of the medication: a change in the color of tears, sweat, saliva, urine, or stools to a red-orange hue; numbness, tingling, or itching; a mild rash; drowsiness, dizziness, or headache; muscle pain or weakness; heartburn, gas, or diarrhea; or mouth pain."
Answered by AI
What is rifampicin and isoniazid?
"Isoniazid belongs to the class of medicines called antituberculous agents, and works by preventing the growth of TB bacteria.
The combination of rifampin and isoniazid is used to treat an infection with tuberculosis (TB) bacteria. Rifampin is an antibiotic that kills or prevents the growth of bacteria. Isoniazid is an antituberculous agent that prevents the growth of TB bacteria."
Answered by AI
How do you take rifampicin and isoniazid?
"The recommended dose of isoniazid, pyrazinamide, and rifampin is one tablet taken with a full glass of water 1 hour before or 2 hours after a meal. After 2 months of using this drug combination, treatment should be continued with rifampin and isoniazid for at least 4 months."
Answered by AI
What is rifampin used to treat?
"Rifampin is used in conjunction with other medications to treat tuberculosis in various parts of the body. It is also used by asymptomatic patients who have meningitis bacteria in their nose or throat, in order to prevent the spread of the infection to others."
Answered by AI
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