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What is Renagel
SevelamerThe Generic name of this drug
Treatment SummarySevelamer is a medication used to reduce the levels of phosphate in the blood of people with chronic kidney disease. It is sold under the brand name Renagel and is used to prevent high phosphate levels, which can cause serious health problems.
Renagelis the brand name
Renagel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Renagel
Sevelamer
2006
81
Approved as Treatment by the FDA
Sevelamer, otherwise called Renagel, is approved by the FDA for 2 uses including Hyperphosphataemia and Hemodialysis .Hyperphosphataemia
Helps manage Hyperphosphataemia
Hemodialysis
Helps manage Hemodialysis Treatment
Effectiveness
How Renagel Affects PatientsPeople with end-stage renal disease often have too much phosphorus in their blood, which can lead to calcium buildup in the body (called ectopic calcification). High levels of phosphorus can also cause the parathyroid hormone (PTH) levels to increase, which can cause a bone disease called osteitis fibrosa. To treat hyperphosphatemia, doctors may recommend reducing dietary intake of phosphate, taking drugs to block phosphate absorption, and undergoing dialysis. Sevelamer is a medication that can be taken with meals to reduce serum phosphorus levels. Studies have also shown that sevelamer can lower low-density lipoprotein
How Renagel works in the bodySevelamer stops the body from absorbing too much phosphate from food. This helps keep phosphate levels in the blood from becoming too high.
When to interrupt dosage
The measure of Renagel is contingent upon the determined condition. The measure of dosage fluctuates based on the method of delivery (e.g. Parenteral or Capsule) noted in the table underneath.Condition
Dosage
Administration
Hemodialysis
800.0 mg, , 400.0 mg, 403.0 mg, 1600.0 mg, 2400.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Powder, for suspension, Powder, for suspension - Oral, Tablet, film coated - Parenteral, Parenteral
Hyperphosphataemia
800.0 mg, , 400.0 mg, 403.0 mg, 1600.0 mg, 2400.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Powder, for suspension, Powder, for suspension - Oral, Tablet, film coated - Parenteral, Parenteral
Warnings
There are 20 known major drug interactions with Renagel.Common Renagel Drug Interactions
Drug Name
Risk Level
Description
Mycophenolic acid
Major
The serum concentration of Mycophenolic acid can be decreased when it is combined with Sevelamer.
Raloxifene
Major
Sevelamer can cause a decrease in the absorption of Raloxifene resulting in a reduced serum concentration and potentially a decrease in efficacy.
Technetium Tc-99m oxidronate
Major
Sevelamer may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
(R)-warfarin
Minor
Sevelamer can cause a decrease in the absorption of (R)-warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.
(S)-Warfarin
Minor
Sevelamer can cause a decrease in the absorption of (S)-Warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Renagel Toxicity & Overdose RiskSevelamer has been tested on healthy volunteers at doses of up to 14 grams per day for 8 days with no negative effects. Hemodialysis patients have been given up to 13 grams per day with no reported overdoses. Since sevelamer is not absorbed by the body, there is a low risk of developing systemic toxicity.
Renagel Novel Uses: Which Conditions Have a Clinical Trial Featuring Renagel?
11 active studies are currently evaluating the potential of Renagel in ameliorating Hyperphosphataemia.Condition
Clinical Trials
Trial Phases
Hyperphosphataemia
0 Actively Recruiting
Hemodialysis
11 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 1
Renagel Reviews: What are patients saying about Renagel?
4.7Patient Review
11/21/2009 I've been using Renagel for my dialysis treatments for the past 8 years and it has really helped to control my phosphorus levels. I typically take 5 tablets with each meal that contains protein. I haven't experienced any negative side effects and, although it is quite expensive, I would rather pay for this than risk long-term organ damage from something like Phoslo.
4Patient Review
12/27/2008 I had been taking Renagel to control my high phosphorus levels due to kidney failure, but it was very expensive and ineffective. When the doctors switched me to Phoslo, my phosphorus level dropped to an acceptable level.
3.7Patient Review
6/24/2011 By my doctor's recommendation, I tried this treatment.
3.7Patient Review
6/7/20083.3Patient Review
5/7/20082.7Patient Review
7/5/2009 I find that taking Renagel 800mg constipates me and causes rectal bleeding. I take two tablets after each meal, which can be up to six per day. This results in bright red blood during bowel movements, which is sometimes accompanied by the feeling that I need to have a bowel movement.
2.7Patient Review
11/8/2009 Renagel has been successful in lowering my phosphate levels; however, I am now frequently experiencing heartburn, especially in the morning. It's not a fun way to wake up!
2.3Patient Review
10/4/2009 My husband has been taking this medication for approximately one month to help lower his phosphate level. However, he has frequently experienced nausea and vomiting, as well as changes in taste since starting the medication. He is requesting to go back on Phoslo.
2.3Patient Review
2/21/2011 I'm not a fan of this medication because it seems to have caused constipation.
1.7Patient Review
12/18/2008 This treatment isn't always effective, but seems to work better when used in conjunction with Alumin Hydroxode liquid.
1Patient Review
2/15/2009 This medication has been ineffective in controlling my itch, and if anything, it seems to be getting worse. I've already had to increase the dosage once at the recommendation of my doctor, but it doesn't seem to be helping.
Patient Q&A Section about renagel
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the difference between Renagel and Renvela?
"The next generation of Renagel, called Renvela, is just as effective in controlling serum phosphorus levels in patients with CKD, but has the added benefit of a carbonate buffer."
Answered by AI
What is Renagel used to treat?
"Sevelamer works by binding with phosphate in your intestine so that it is not absorbed into your blood.
Generic name: sevelamer HCL Sevelamer is used to lower high blood phosphorus (phosphate) levels in patients who are on dialysis due to severe kidney disease. Dialysis removes some phosphate from your blood, but it is difficult to remove enough to keep your phosphate levels balanced. Sevelamer works by binding with phosphate in your intestine so that it is not absorbed into your blood."
Answered by AI
Does Renagel cause constipation?
"If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
The following is a brief summary of the drug for the patient or caregiver from First DataBank. SIDE EFFECTS: Headache, diarrhea, stomach upset, nausea, vomiting, cough, gas, or constipation may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly."
Answered by AI
What is Renagel 800 mg used for?
"Renagel is a medication used to help adult kidney failure patients on dialysis to control the levels of phosphate in their blood."
Answered by AI