Relistor

Palliative Treatment, Pain, Opioid-Induced Constipation
Treatment
5 FDA approvals
1 Active Study for Relistor

What is Relistor

MethylnaltrexoneThe Generic name of this drug
Treatment SummaryMethylnaltrexone is a medication used to treat constipation caused by opioid use without affecting the pain-relieving effects of the opioid. It is also known to inhibit the CYP2D6 enzyme. The drug was approved by the FDA in 2008.
Relistoris the brand name
Relistor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Relistor
Methylnaltrexone
2008
8

Approved as Treatment by the FDA

Methylnaltrexone, also known as Relistor, is approved by the FDA for 5 uses like Chronic Noncancer Pain and Opioid Induced Constipation (OIC) .
Chronic Noncancer Pain
Opioid Induced Constipation (OIC)
Pain
Palliative Treatment
Opioid-Induced Constipation

Effectiveness

How Relistor Affects PatientsOpioids slow down the digestion process in the body. In a study, those who took remifentanil experienced no change in their pupil size, while those who took naloxone experienced a change in the size of their pupils over the course of the study.
How Relistor works in the bodyMethylnaltrexone is a medication that works on the gastrointestinal tract to reduce the slowing of digestion caused by opioid medications. It does this without entering the brain, so it will not affect pain relief or cause any withdrawal symptoms.

When to interrupt dosage

The suggested measure of Relistor is contingent upon the diagnosed condition, including Opioid-Induced Constipation, Pain and Palliative Care. The amount of dosage is outlined in the table beneath, depending on the method of administration.
Condition
Dosage
Administration
Palliative Treatment
, 8.0 mg, 12.0 mg, 120.0 mg/mL, 80.0 mg/mL, 150.0 mg, 20.0 mg/mL
, Subcutaneous, Solution, Solution - Subcutaneous, Injection, solution - Subcutaneous, Injection, solution, Oral, Tablet, Tablet - Oral, Kit
Pain
, 8.0 mg, 12.0 mg, 120.0 mg/mL, 80.0 mg/mL, 150.0 mg, 20.0 mg/mL
, Subcutaneous, Solution, Solution - Subcutaneous, Injection, solution - Subcutaneous, Injection, solution, Oral, Tablet, Tablet - Oral, Kit
Opioid-Induced Constipation
, 8.0 mg, 12.0 mg, 120.0 mg/mL, 80.0 mg/mL, 150.0 mg, 20.0 mg/mL
, Subcutaneous, Solution, Solution - Subcutaneous, Injection, solution - Subcutaneous, Injection, solution, Oral, Tablet, Tablet - Oral, Kit

Warnings

Relistor has four contraindications. It should not be combined with any of the conditions indicated in the following table.Relistor Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
recurrent obstruction
Do Not Combine
Gastrointestinal obstruction
Do Not Combine
suspected gastrointestinal obstruction
Do Not Combine
There are 20 known major drug interactions with Relistor.
Common Relistor Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Minor
Methylnaltrexone may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Methylnaltrexone may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Methylnaltrexone may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Almasilate
Minor
Methylnaltrexone may decrease the excretion rate of Almasilate which could result in a higher serum level.
Ancestim
Minor
Methylnaltrexone may decrease the excretion rate of Ancestim which could result in a higher serum level.
Relistor Toxicity & Overdose RiskMethylnaltrexone bromide is toxic at 50mg/kg in primates and may cause low blood pressure if the plasma levels exceed 1400ng/mL. Common side effects include abdominal pain, excessive gas, nausea, dizziness, diarrhea, and excessive sweating.
image of a doctor in a lab doing drug, clinical research

Relistor Novel Uses: Which Conditions Have a Clinical Trial Featuring Relistor?

19 current clinical trials are investigating the potential of Relistor to alleviate symptoms of Opioid-Induced Constipation, Pain and Palliative Care.
Condition
Clinical Trials
Trial Phases
Pain
0 Actively Recruiting
Palliative Treatment
1 Actively Recruiting
Not Applicable
Opioid-Induced Constipation
0 Actively Recruiting

Relistor Reviews: What are patients saying about Relistor?

3.3Patient Review
1/10/2020
Relistor for Opiate Pain Medication causing Severe Constipation
This treatment was effective for me for about six months, but now it doesn't seem to do anything.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about relistor

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of Relistor?

"Stomach pain, gas, bloating, mild nausea or diarrhea, headache, muscle spasms, dizziness, tremors, feeling anxious, runny nose, or chills, sweating, or hot flashes."

Answered by AI

How often do you take Relistor?

"This medication should be taken on an empty stomach, as directed by your doctor, at least 30 minutes before your first meal of the day. The dosage is based on your medical condition and response to treatment. You should continue using your usual medications for constipation, if your doctor tells you to."

Answered by AI

What is Relistor used for?

"RELISTOR can be used to treat constipation in adults that is caused by certain prescription pain medicines."

Answered by AI

How quickly does Relistor work?

"Relistor (methylnaltrexone bromide) is a medication that can work quickly to produce a bowel movement. After taking a dose of Relistor (methylnaltrexone bromide) in the form of a tablet or injection, you may have a bowel movement within 4 hours."

Answered by AI

Clinical Trials for Relistor

Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top