Ranolazine

Ventricular Arrhythmia, Chronic Angina
Treatment
1 FDA approval
3 Active Studies for Ranolazine

What is Ranolazine

RanolazineThe Generic name of this drug
Treatment SummaryRanolazine is a medication used to treat chronic angina, a cardiovascular condition that affects millions of people worldwide and causes significant pain and disability. It works differently than other drugs used to treat the same condition and was approved by the FDA in 2006. Ranolazine is well-tolerated and helps to relieve uncomfortable and debilitating angina symptoms.
Ranexais the brand name
image of different drug pills on a surface
Ranolazine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ranexa
Ranolazine
2006
70

Approved as Treatment by the FDA

Ranolazine, also known as Ranexa, is approved by the FDA for 1 uses which include Chronic Angina .
Chronic Angina
Helps manage Chronic Angina

Effectiveness

How Ranolazine Affects PatientsRanolazine is used to reduce chest pain ('angina') and works by blocking a certain type of electric current in the heart (the rapid delayed rectifier potassium current). This electric current is important for the heart's repolarization. Ranolazine does not affect the heart rate, blood pressure, or the strength of the heart's contractions, either at rest or during exercise.
How Ranolazine works in the bodyRanolazine is used to treat angina symptoms like chest pain or pressure, nausea, and dizziness. It works by restoring the balance of sodium and potassium in the heart, which helps it to get enough oxygen and contract and relax properly. Ranolazine also weakly affects calcium channels, making it a mild vasodilator, and blocks some receptors that cause stress on the heart.

When to interrupt dosage

The proposed dose of Ranolazine is contingent upon the diagnosed condition. The amount also fluctuates, in line with the technique of delivery (e.g. Tablet, extended release or Tablet, film coated, extended release) featured in the table beneath.
Condition
Dosage
Administration
Ventricular Arrhythmia
500.0 mg, , 1000.0 mg, 375.0 mg, 750.0 mg
, Tablet, film coated, extended release - Oral, Oral, Tablet, film coated, extended release, Tablet, extended release - Oral, Tablet, extended release, Tablet, Tablet - Oral, Granule - Oral, Granule
Chronic Angina
500.0 mg, , 1000.0 mg, 375.0 mg, 750.0 mg
, Tablet, film coated, extended release - Oral, Oral, Tablet, film coated, extended release, Tablet, extended release - Oral, Tablet, extended release, Tablet, Tablet - Oral, Granule - Oral, Granule

Warnings

Ranolazine Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
clinically significant hepatic impairment
Do Not Combine
There are 20 known major drug interactions with Ranolazine.
Common Ranolazine Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Ranolazine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Ranolazine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Ranolazine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Ranolazine.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Ranolazine is combined with Anagrelide.
Ranolazine Toxicity & Overdose RiskThe toxic dose of ranolazine in rats has been reported to be 980mg/kg. Taking too much of this drug can cause dizziness, nausea, vomiting, double vision, confusion, tingling sensations, and fainting. If someone has overdosed on ranolazine, supportive care should be provided along with an ECG to monitor for any changes in heart rhythm.
image of a doctor in a lab doing drug, clinical research

Ranolazine Novel Uses: Which Conditions Have a Clinical Trial Featuring Ranolazine?

At present, 4 active trials are assessing the potential of Ranolazine to provide relief for Chronic Angina sufferers.
Condition
Clinical Trials
Trial Phases
Chronic Angina
1 Actively Recruiting
Not Applicable
Ventricular Arrhythmia
2 Actively Recruiting
Not Applicable

Ranolazine Reviews: What are patients saying about Ranolazine?

5Patient Review
1/1/2013
Ranolazine for Chronic Stable Angina
I have unstable angina, and this medication has been really effective for me. Just need to make sure I'm getting enough fiber in my diet.
5Patient Review
7/12/2011
Ranolazine for Chronic Stable Angina
I'm feeling more tired and dizzy since I started taking this medication. I'm not sure if it's helping or not, but I didn't have these symptoms before.
4.3Patient Review
4/2/2011
Ranolazine for Chronic Stable Angina
This constipation was really bad. I had trouble even going to the bathroom because it would cause so much chest pain. It took three days of taking colace before things started getting better.
4Patient Review
11/29/2013
Ranolazine for Chronic Stable Angina
I didn't enjoy the effects this treatment had on me. I felt really tired and my teeth hurt. It just made me feel overall sick.
2.7Patient Review
3/24/2011
Ranolazine for Chronic Stable Angina
Used this for my stable angina.
1.7Patient Review
3/14/2011
Ranolazine for Chronic Stable Angina
Unfortunately, this led to severe constipation and an increase in flatulence.
1Patient Review
8/20/2009
Ranolazine for Chronic Stable Angina
This medication caused me severe nausea, dizziness, and extreme blurred vision. I felt very weak after taking it.
1Patient Review
11/30/2011
Ranolazine for Chronic Stable Angina
I'm a type 1 diabetic with stable angina, and this medication has done wonders for relieving the tightness in my chest.
1Patient Review
8/14/2013
Ranolazine for Chronic Stable Angina
Unfortunately, it seems like this medication is triggering my flare-ups. I'm allergic to sulfa drugs, so if that's an ingredient in ranolazine, that would explain the reaction I'm having.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ranolazine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the mechanism of action of ranolazine?

"Ranolazine's main mode of action is to inhibit late INa, preventing sodium from overloading the cell."

Answered by AI

What is the drug ranolazine used for?

"This medicine is used to treat chronic angina by widening blood vessels and decreasing the amount of work your heart has to do."

Answered by AI

Is ranolazine for blood pressure?

"This medication is used to treat chest pain (angina) and high blood pressure (hypertension). The extended-release tablets are only for treating high blood pressure."

Answered by AI

What is the side effect of ranolazine?

"In clinical trials of angina patients, the most common adverse reactions reported were dizziness (6.2%), headache (5.5%), constipation (4.5%), and nausea (4.4%). These reactions were more common in patients taking RANEXA than in those taking a placebo. Dizziness may increase as the dose increases."

Answered by AI

What type of drug is ranolazine?

"Ranolazine is a medication used to treat chronic angina, which is chest pain or pressure that occurs when the heart does not get enough oxygen. Ranolazine is classified as an anti-anginal medication."

Answered by AI

Clinical Trials for Ranolazine