Prometrium
Amenorrhea, hormonal imbalance, prophylaxis of recurrent spontaneous preterm birth + 9 more
Treatment
20 Active Studies for Prometrium
Treatment for
Amenorrhea
What is Prometrium
Progesterone
The Generic name of this drug
Treatment Summary
Progesterone is a hormone found naturally in females that helps with fertility and pregnancy. Low levels or an insufficient response to progesterone can cause infertility and pregnancy loss. Progesterone is used in contraception to prevent ovulation and fertilization, as well as other formulations to support pregnancy. It is available in many forms, including capsules, gels, tablets, vaginal inserts, and injections. Progesterone is made from a plant source and is chemically identical to the progesterone found in humans.
Progesterone
is the brand name
Prometrium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Progesterone
Progesterone
1978
124
Effectiveness
How Prometrium Affects Patients
Progesterone is a hormone that can affect the body in different ways depending on the concentration, dosage form, and timing of exposure. Generally, it helps prepare the uterus for a possible pregnancy by changing the inner mucous lining of the uterus from a growing phase to a preparation phase, and by decreasing the elasticity of the cervical mucus. Progesterone capsules mimic the effects of naturally occurring progesterone, and have gestagenic, antiestrogenic, antiandrogenic, and anti-aldosterone effects. The gel preparation also mimics the effects of naturally occurring progesterone, and helps to maintain a
How Prometrium works in the body
Progesterone is a hormone that helps prepare the uterus for pregnancy. It does this by binding to and activating its own receptor, which changes the way certain genes work. Progesterone is also used in some forms of birth control. It helps prevent pregnancy by making it harder for sperm to enter through the cervix, and by stopping the body from releasing an egg each month. When taken correctly, progestin-only birth control is very effective, with a first-year failure rate of less than 1%. However, the typical failure rate is around 5%, due to missed or late doses.
When to interrupt dosage
The advocated dose of Prometrium is contingent upon the specified affliction, such as hormonal imbalance, Female Infertility and Postmenopause. The measure of dosage fluctuates, based on the administration technique outlined in the following table.
Condition
Dosage
Administration
recurrent spontaneous preterm birth
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal
Reproductive Technology
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal
Endometrial Hyperplasia
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal
Amenorrhea
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal
hormonal imbalance
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal
Postmenopause
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal
Hysterectomy
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal
Amenorrhea
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal
Uterine hemorrhage
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal
Vasomotor System
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal
Hot flashes
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal
prophylaxis of recurrent spontaneous preterm birth
50.0 mg, , 50.0 mg/mL, 100.0 mg, 200.0 mg, 0.09 mg/mg, 0.045 mg/mg, 8.0 %, 10.0 mg/mL, 17.0 mg/mL, 0.001 mg/mg, 1.1 mg/hour, 25.0 mg/mL, 1.0 mg/mg, 0.0025 mg/mg
Injection - Intramuscular, Injection, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Capsule - Oral, Capsule, Oral, Gel, Vaginal, Gel - Vaginal, Insert - Vaginal, Insert, Liquid - Intramuscular, Liquid, Solution - Intramuscular, Solution, Oral; Transdermal, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule - Vaginal, Cream - Vaginal, Cream, Cream - Topical, Topical, Solution - Topical, Ring - Vaginal, Ring, Capsule; Spray, metered - Oral; Transdermal, Capsule; Spray, metered, Subcutaneous, Solution - Subcutaneous, Cream - Transdermal, Transdermal
Warnings
Prometrium Contraindications
Condition
Risk Level
Notes
Liver Diseases
Do Not Combine
Thromboembolism
Do Not Combine
suspected pregnancy
Do Not Combine
Pulmonary Embolism
Do Not Combine
Stroke
Do Not Combine
Cerebrovascular accident
Do Not Combine
Thrombophlebitis
Do Not Combine
Breast
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Pulmonary Embolism
Do Not Combine
Pulmonary Embolism
Do Not Combine
Breast Cancer
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Breast
Do Not Combine
Breast
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
suspected pregnancy
Do Not Combine
Thromboembolism
Do Not Combine
Malignant Neoplasms
Do Not Combine
Stroke
Do Not Combine
undiagnosed vaginal bleeding
Do Not Combine
Abortion, Spontaneous
Do Not Combine
Venous Thrombosis
Do Not Combine
Thrombophlebitis
Do Not Combine
Stroke
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Progesterone may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Progesterone may interact with Pulse Frequency
There are 20 known major drug interactions with Prometrium.
Common Prometrium Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Progesterone.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Progesterone.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Progesterone.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Progesterone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Progesterone.
Prometrium Toxicity & Overdose Risk
The toxic dose of progesterone in rats is 327mg/kg. Progesterone should not be used during pregnancy, as it can affect fertility and may increase the risk of certain types of cancer. Progesterone has been found in breast milk, but no adverse effects on babies have been reported. However, in some cases, nursing mothers may experience a decrease in milk production.
Prometrium Novel Uses: Which Conditions Have a Clinical Trial Featuring Prometrium?
56 active clinical trials are underway to assess the potential of Prometrium to provide Gel, Support Assisted Reproductive Techniques (ART) and Facilitate Reproductive Technology.
Condition
Clinical Trials
Trial Phases
Endometrial Hyperplasia
0 Actively Recruiting
Postmenopause
5 Actively Recruiting
Phase 2, Not Applicable
recurrent spontaneous preterm birth
0 Actively Recruiting
Uterine hemorrhage
0 Actively Recruiting
hormonal imbalance
0 Actively Recruiting
Vasomotor System
0 Actively Recruiting
Amenorrhea
0 Actively Recruiting
Hot flashes
19 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Early Phase 1, Phase 3
Reproductive Technology
2 Actively Recruiting
Not Applicable
Amenorrhea
0 Actively Recruiting
prophylaxis of recurrent spontaneous preterm birth
0 Actively Recruiting
Hysterectomy
3 Actively Recruiting
Phase 3, Not Applicable
Prometrium Reviews: What are patients saying about Prometrium?
5
Patient Review
4/19/2016
Prometrium for Prevention of Abnormal Growth in Cells of Uterine Lining
5
Patient Review
1/21/2014
Prometrium for Prevention of Abnormal Growth in Cells of Uterine Lining
2
Patient Review
11/22/2021
Prometrium for Absence of Menstrual Periods in Woman Who Has Had Them
1
Patient Review
3/6/2016
Prometrium for Absence of Menstrual Periods in Woman Who Has Had Them
1
Patient Review
2/29/2020
Prometrium for Prevention of Abnormal Growth in Cells of Uterine Lining
Patient Q&A Section about prometrium
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is Prometrium a HRT?
"Body-Identical HRT is a therapy that involves giving the actual natural human hormones. This type of HRT is one of our safest HRTs."
Answered by AI
Does Prometrium have side effects?
"These are some of the side effects that may occur when taking this medication. If any of them persist or worsen, contact your doctor or pharmacist."
Answered by AI
How does Prometrium make you feel?
"It is best to take progesterone (Prometrium) capsules just before you go to sleep every night as many people feel tired or dizzy from them."
Answered by AI
What is the drug Prometrium used for?
"Prometrium is a brand-name medication for a type of progesterone known as micronized progesterone. Progesterone is a hormone that's produced in the ovaries. Progesterone prepares the lining of the uterus for pregnancy, helping to protect and nourish a growing baby. Progesterone also helps control your menstrual cycle."
Answered by AI