Promethegan

Anaphylaxis, Catarrh, Acute Bronchitis + 18 more

Treatment

6 FDA approvals

20 Active Studies for Promethegan

What is Promethegan

Promethazine

The Generic name of this drug

Treatment Summary

Promethazine is a medication developed in 1946 in France and is used to treat a range of symptoms including allergies, pain, sedation, nausea, and vomiting. It works by blocking certain receptors in the body and has been approved by the FDA since 1951.

Phenergan

is the brand name

image of different drug pills on a surface

Promethegan Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Phenergan

Promethazine

1951

473

Approved as Treatment by the FDA

Promethazine, otherwise called Phenergan, is approved by the FDA for 6 uses such as Nasal Congestion and Acute Bronchitis .

Nasal Congestion

Used to treat Nasal Congestion in combination with Phenylephrine

Acute Bronchitis

Used to treat Cough in combination with Dextromethorphan

Hypersensitivity

Used to treat Allergic Reaction in combination with Codeine

Anaphylaxis

Catarrh

Used to treat Common Cold in combination with Codeine

upper respiratory symptoms

Used to treat upper respiratory symptoms in combination with Codeine

Effectiveness

How Promethegan Affects Patients

Promethazine is a drug used to reduce pain, induce sedation, and treat allergies. It usually works for 4-6 hours, but can last up to 12 hours. It is important to warn patients about the potential side effects of this drug, which include drowsiness, difficulty breathing, increased risk of seizures, and decreased bone marrow production.

How Promethegan works in the body

Promethazine works by blocking histamine, dopamine, and other receptors in the body. This helps to relieve allergy symptoms, improve sleep, reduce anxiety, and ease nausea and vomiting.

When to interrupt dosage

The quantity of Promethegan is contingent upon the diagnosed ailment, including Hay Fever, Postoperative Pain and Acute Bronchitis. The extent of dosage is dependent on the mode of delivery as specified in the table beneath.

Condition

Dosage

Administration

Hypersensitivity

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Allergic urticaria

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Sedative therapy

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Allergic Conjunctivitis (AC)

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Postoperative Pain

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

upper respiratory symptoms

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Analgesics

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Hay Fever

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Coughing

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Nasal Congestion

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Motion Sickness

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Acute Bronchitis

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Nausea

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Dermographism

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

perioperative nausea and vomiting

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Airsickness

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Rhinitis, Vasomotor

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Anaphylaxis

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Hypersensitivity

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Catarrh

, 12.5 mg, 25.0 mg, 50.0 mg, 6.25 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 0.25 mg, 0.5 mg/mL, 1.0 mg/mL, 0.625 mg/mL, 6.5 mg/mL, 10.0 mg, 2.0 %, 10.0 mg/mL, 28.2 mg/mL, 3.125 mg/mL

Oral, Tablet - Oral, Tablet, , Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Syrup - Oral, Syrup, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous, Intramuscular, Injection - Intramuscular, Liquid, Liquid - Oral, Capsule, Capsule - Oral, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Solution - Oral, Liquid - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Cream, Cream - Topical, Topical

Warnings

Promethegan has six contraindications, and its use should be precluded in the presence of any of the conditions specified in the following table.

Promethegan Contraindications

Condition

Risk Level

Notes

subcutaneous route of administration

Do Not Combine

Asthma

Do Not Combine

Pulse Frequency

Do Not Combine

intra-arterial route of administration

Do Not Combine

Coma

Do Not Combine

lower respiratory tract symptoms

Do Not Combine

There are 20 known major drug interactions with Promethegan.

Common Promethegan Drug Interactions

Drug Name

Risk Level

Description

Acenocoumarol

Major

The metabolism of Acenocoumarol can be decreased when combined with Promethazine.

Aclidinium

Major

The risk or severity of adverse effects can be increased when Promethazine is combined with Aclidinium.

Amisulpride

Major

Promethazine may increase the antipsychotic activities of Amisulpride.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Promethazine.

Azelastine

Major

Promethazine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Promethegan Toxicity & Overdose Risk

The lowest toxic dose of promethazine in rats is 170mg/kg when given intraperitoneally, and 400mg/kg when given subcutaneously. The lowest toxic dose in mice is 160mg/kg intraperitoneally and 240mg/kg subcutaneously, and 255mg/kg orally. Overdosing on promethazine can lead to mild central nervous system and cardiovascular depression, low blood pressure, decreased breathing, loss of consciousness, muscle stiffness, spasms, convulsions, dry mouth, flushing, gastrointestinal symptoms, and fixed, dilated pupils. Treatment for an overdose should include administering activated charcoal

Promethegan Novel Uses: Which Conditions Have a Clinical Trial Featuring Promethegan?

A total of 131 active studies are investigating the potential of Promethegan to provide Allergy Relief, Sedative Therapy and Hay Fever Relief.

Condition

Clinical Trials

Trial Phases

Anaphylaxis

3 Actively Recruiting

Phase 1, Phase 2

Rhinitis, Vasomotor

1 Actively Recruiting

Not Applicable

Motion Sickness

0 Actively Recruiting

Analgesics

1 Actively Recruiting

Phase 4

Catarrh

0 Actively Recruiting

Nausea

0 Actively Recruiting

Dermographism

0 Actively Recruiting

Acute Bronchitis

8 Actively Recruiting

Phase 4, Not Applicable, Phase 3, Early Phase 1

upper respiratory symptoms

0 Actively Recruiting

Postoperative Pain

20 Actively Recruiting

Phase 4, Phase 2, Phase 1, Phase 3, Not Applicable

Allergic urticaria

0 Actively Recruiting

perioperative nausea and vomiting

0 Actively Recruiting

Sedative therapy

0 Actively Recruiting

Pain management

0 Actively Recruiting

Nasal Congestion

0 Actively Recruiting

Hypersensitivity

1 Actively Recruiting

Phase 4

Allergic Conjunctivitis (AC)

1 Actively Recruiting

Phase 2

Hay Fever

0 Actively Recruiting

Hypersensitivity

0 Actively Recruiting

Airsickness

2 Actively Recruiting

Not Applicable, Phase 3

Promethegan Reviews: What are patients saying about Promethegan?

5

Patient Review

7/30/2015

Promethegan for Feel Like Throwing Up

This medication was extremely effective in getting rid of my nausea, and it worked very quickly. I was already in bed when I took it, as I had a bad colon infection, and it made me very sleepy. That was actually helpful, as I needed to rest at that time. I would highly recommend this medication to others.

5

Patient Review

6/13/2018

Promethegan for Nausea and Vomiting

This drug has been an absolute lifesaver for me during my chemo and radiation treatments. It's helped immensely with anxiety and sleeplessness. As long as you take it as prescribed, it'll work wonders for you.

5

Patient Review

7/1/2020

Promethegan for Nausea and Vomiting

I was prescribed this medication for my anxiety, which caused me a lot of digestive problems. This medicine worked really well for me and helped immensely. However, after 8 years my doctor suddenly said it was dangerous to take long term and took it away from me. He replaced it with Zofran, which is nowhere near as effective. I'm really sad about it.

5

Patient Review

4/12/2019

Promethegan for Nausea and Vomiting

This medication provided relief from my nausea very effectively.

5

Patient Review

2/10/2021

Promethegan for Feel Like Throwing Up

This drug worked well for me in terms of nausea, sleep, and anxiety.

5

Patient Review

6/24/2018

Promethegan for Additional Medications to Treat Pain

This medication is great to use in combination with other treatments.

5

Patient Review

6/3/2015

Promethegan for Nausea and Vomiting

This drug has been excellent for eliminating the nausea I experience during migraines. It's also prevented me from feeling nauseous when using opiates to treat my migraines, which is a huge relief.

5

Patient Review

11/3/2016

Promethegan for Nausea and Vomiting After Surgery

Promethazine is fantastic for nausea. After my surgery, it was a life-saver. Not only does it work quickly, but the calming effect also helped me get some much-needed sleep.

5

Patient Review

7/21/2017

Promethegan for Nausea and Vomiting

This medication was a life-saver for me when I had a severe migraine. Not only did it help with the pain, but also with the nausea that often comes along with migraines.

5

Patient Review

10/17/2015

Promethegan for Nausea and Vomiting

This medication is very effective at treating nausea and vomiting. However, it is important to take it within the first half hour of experiencing these symptoms.

5

Patient Review

7/21/2017

Promethegan for Nausea and Vomiting

I have experienced severe migraines with nausea and vomiting. This medication helped me immensely when it was prescribed for what I thought was a virus, but was actually a migraine. I'm glad that it provided relief almost immediately. It was paired with a pain medication to ease both the pain and the nausea right away, which I appreciated.

5

Patient Review

11/3/2016

Promethegan for Nausea and Vomiting After Surgery

After surgery for kidney stones, I was prescribed promethazine. Once it kicks in, it's great for nausea and has a calming effect that helps me sleep. This is by far the best drug for nausea that I've tried.

5

Patient Review

6/13/2018

Promethegan for Nausea and Vomiting

This drug has been a life saver for me! Take the prescription correctly and it’ll work very well for you

5

Patient Review

6/16/2016

Promethegan for Nausea and Vomiting

This medicine is really effective against nausea, and it has a calming effect too. It's been a total game changer for me and my mother.

5

Patient Review

7/30/2015

Promethegan for Feel Like Throwing Up

This medication was given to me for extreme nausea while taking an antibiotic. It worked very quickly in getting rid of the nausea. I was already in bed as a result of a very bad colon infection and the pill did make me very sleepy. That helped me to get the rest I was needing at that time. I would highly recommend this medication.

5

Patient Review

7/1/2020

Promethegan for Nausea and Vomiting

I was really struggling with anxiety-induced nausea before this medication. It worked great for me for eight years, and then my doctor suddenly said it wasn't safe for long-term use. Zofran is an inferior substitute in my opinion.

5

Patient Review

6/3/2015

Promethegan for Nausea and Vomiting

This drug has been excellent for eliminating nausea due to migraine and preventing nausea due to opiate use when treating migraine.

5

Patient Review

7/21/2017

Promethegan for Nausea and Vomiting

This medication quickly and effectively alleviated my migraines, which I had originally thought were caused by a virus. Paired with another pain medication, it eased both the headache and the nausea immediately.

5

Patient Review

6/13/2018

Promethegan for Nausea and Vomiting

If you follow the instructions, this drug will be very effective in treating your anxiety and sleeplessness. It's been a life-saver for me during my chemotherapy and radiation treatment.

5

Patient Review

11/3/2016

Promethegan for Nausea and Vomiting After Surgery

Promethazine is an excellent drug for nausea. It can take a little while to kick in, but once it does it's very effective and has a calming effect that helps me sleep.

5

Patient Review

7/30/2015

Promethegan for Feel Like Throwing Up

This medication was incredibly effective at getting rid of my nausea, and fast. I was already in bed when I took it, as I had a really bad colon infection, and it made me very sleepy. That was actually helpful, as I needed to rest. I would highly recommend this medication to anyone else experiencing similar issues.

5

Patient Review

2/10/2021

Promethegan for Feel Like Throwing Up

Perfect for nausea, sleep and anxiety.

5

Patient Review

4/12/2019

Promethegan for Nausea and Vomiting

I found this to be an effective treatment against nausea.

5

Patient Review

10/17/2015

Promethegan for Nausea and Vomiting

This medication is very effective against nausea and vomiting, as long as it's taken within the first 30 minutes of symptoms.

5

Patient Review

11/3/2016

Promethegan for Nausea and Vomiting After Surgery

After surgery, I was prescribed promethazine for nausea. It works great to calm my stomach and help me sleep. This is a wonderful drug for anyone experiencing nausea.

5

Patient Review

6/13/2018

Promethegan for Nausea and Vomiting

This drug has been an absolute godsend for me. Not only does it help with the anxiety and sleeplessness brought on by chemo/radiation, but it actually makes the treatment more bearable.

5

Patient Review

6/16/2016

Promethegan for Nausea and Vomiting

This medicine is highly effective for nausea and has a calming effect. This pill is a miracle for me and my mother.

5

Patient Review

6/24/2018

Promethegan for Additional Medications to Treat Pain

This medication is great to use in combination with other treatments.

5

Patient Review

7/30/2015

Promethegan for Feel Like Throwing Up

This medication was very effective in quelling my nausea. I was also pleased that it made me drowsy, as I needed to sleep a lot due to a bad infection.

5

Patient Review

6/3/2015

Promethegan for Nausea and Vomiting

This drug has been excellent for eliminating nausea due to migraine and preventing nausea due to opiate use when treating migraine.

5

Patient Review

7/1/2020

Promethegan for Nausea and Vomiting

I was really struggling with anxiety and this medication helped me so much. I don't understand why my doctor took it away after eight years, saying it's suddenly dangerous for long-term use? Zofran is nowhere near as good.

5

Patient Review

6/16/2016

Promethegan for Nausea and Vomiting

This medicine is great for nausea and has a calming effect too. It's been a lifesaver for me and my mom.

5

Patient Review

6/3/2015

Promethegan for Nausea and Vomiting

This has been an effective drug for me in terms of eliminating migraine-induced nausea as well as preventing nausea when using opiates to treat migraines.

5

Patient Review

10/17/2015

Promethegan for Nausea and Vomiting

This medication is very effective at treating nausea and vomiting. Just be sure to take it within the first 30 minutes of feeling those symptoms.

5

Patient Review

6/24/2018

Promethegan for Additional Medications to Treat Pain

This medication is great to use in combination with other treatments.

5

Patient Review

2/10/2021

Promethegan for Feel Like Throwing Up

Perfect for nausea, sleep and anxiety.

5

Patient Review

10/17/2015

Promethegan for Nausea and Vomiting

This medication was very helpful in curbing my nausea and vomiting. Just make sure to take it within thirty minutes of when you start feeling those symptoms.

5

Patient Review

6/16/2016

Promethegan for Nausea and Vomiting

This medicine is both effective and calming, which makes it perfect for nausea. It's a real lifesaver for me and my mom.

5

Patient Review

6/24/2018

Promethegan for Additional Medications to Treat Pain

This medication is great to use in combination with others.

5

Patient Review

4/12/2019

Promethegan for Nausea and Vomiting

This medication provided quick and effective relief from nausea.

5

Patient Review

7/1/2020

Promethegan for Nausea and Vomiting

This medication was really effective for my anxiety. I'm so disappointed that my doctor took it away after eight years, saying it's suddenly dangerous for long-term use. Zofran is nowhere near as good.

5

Patient Review

2/10/2021

Promethegan for Feel Like Throwing Up

Perfect for nausea, sleep and anxiety.

5

Patient Review

4/12/2019

Promethegan for Nausea and Vomiting

This medication worked well for me and relieved my nausea.

5

Patient Review

7/21/2017

Promethegan for Nausea and Vomiting

I have experienced severe migraine headaches with nausea and vomiting. This medication helped me so much when it was prescribed for what I thought was a virus but was actually a severe migraine. I was so glad that it helped me right away. It was paired with a pain medication to ease both the pain and the nausea right away.

4.7

Patient Review

8/3/2014

Promethegan for Nausea and Vomiting After Surgery

This has been effective in preventing nausea when used alongside the narcotic Tromadol. I tried taking Hydrocodine in the past and couldn't tolerate it because of extreme nausea. I did get constipation, but the Tromadol also causes that.

4.7

Patient Review

8/27/2019

Promethegan for Feel Like Throwing Up

Being nauseous is one of the worst feelings and if I vomit from it just once, it's downhill from there. The headache this treatment can bring is quite bad, but I'd rather have an awful headache than be awfully nauseous and vomiting.

4.7

Patient Review

8/3/2014

Promethegan for Nausea and Vomiting After Surgery

This medication has been very effective in preventing nausea, especially when used in conjunction with the narcotic Tromadol. I've tried taking Hydrocodine in the past but couldn't tolerate it because of how nauseous it made me.

4.7

Patient Review

8/27/2019

Promethegan for Feel Like Throwing Up

Being nauseous is one of the worst feelings for me, and if I vomit just once it's a downhill spiral from there. This medication can make you drowsy but that's not a big set back for me. The headache it brings is quite bad, but I'd rather have an awful headache then being awfully nauseous and vomiting.

4.7

Patient Review

2/17/2015

Promethegan for Nausea and Vomiting

An important thing to remember is that this drug also comes in suppository form! This can be incredibly helpful because it works quickly and you don't have to worry about losing it when you vomit.

4.7

Patient Review

8/3/2014

Promethegan for Nausea and Vomiting After Surgery

This has been very helpful in preventing nausea when taken with Tromadol. I've tried Hydrocodine in the past but couldn't tolerate it because of how badly it made me feel.

4.7

Patient Review

2/17/2015

Promethegan for Nausea and Vomiting

The suppository option for this drug is great because it works extremely fast and you don't have to worry about losing it when vomiting.

4.7

Patient Review

8/27/2019

Promethegan for Feel Like Throwing Up

Nausea is one of the worst feelings, in my opinion. If I vomit just once, it's hard to stop and I feel even worse. This medication can make you drowsy, but that's not a big deal to me. The headache it brings is quite bad, but it's still better than nausea and vomiting.

4.7

Patient Review

8/18/2015

Promethegan for Nausea and Vomiting

This medication usually does wonders for me.

4.7

Patient Review

8/3/2014

Promethegan for Nausea and Vomiting After Surgery

I've found this to be an effective method of preventing nausea when taking the narcotic Tromadol. In the past, I tried taking Hydrocodine but couldn't tolerate it because of how nauseous it made me. With this treatment, I did get constipation--but that's also a side effect of Tromadol.

4.7

Patient Review

2/17/2015

Promethegan for Nausea and Vomiting

The suppository option for this drug is great because it works quickly and you don't have to worry about losing it when vomiting.

4.7

Patient Review

8/27/2019

Promethegan for Feel Like Throwing Up

For me, being nauseous is one of the absolute worst feelings. And if I vomit once, it's downhill from there because I can't stop. It can make you drowsy but that's not a big set back for me. The headache it brings is quite bad, but I'd rather have an awful headache then being awfully nauseous and vomiting.

4.7

Patient Review

8/18/2015

Promethegan for Nausea and Vomiting

This medication usually does wonders for me.

4.7

Patient Review

2/17/2015

Promethegan for Nausea and Vomiting

The suppository option for this drug is great because it works quickly and you don't have to worry about losing it when vomiting.

4.7

Patient Review

8/18/2015

Promethegan for Nausea and Vomiting

This medication usually does wonders for me.

4.7

Patient Review

8/18/2015

Promethegan for Nausea and Vomiting

This medication usually does wonders for me.

4.3

Patient Review

12/13/2014

Promethegan for Nausea and Vomiting

This medication was very effective at treating my nausea. However, it made me extremely drowsy and I slept for 14 hours straight. The next day I felt groggy and had a dull headache. I suspect that the dosage was too high for my small frame (I weigh 116 pounds). If you have sleep apnea, I would not recommend taking this medication as it could make your condition worse.

4.3

Patient Review

9/11/2019

Promethegan for Nausea and Vomiting

This medication has helped me a lot with my nausea. I do get tired if I take it and am sensitive to medications, so be warned. That said, it's also been great for insomnia!

4.3

Patient Review

12/13/2014

Promethegan for Nausea and Vomiting

This medication was effective for my nausea; however, the dosage given made me feel excessively tired and groggy the next day. I would recommend that smaller doses be given to women of a smaller stature. Additionally, if you suspect you have sleep apnea, do not take this medication as it will exacerbate the problem.

4.3

Patient Review

12/13/2014

Promethegan for Nausea and Vomiting

This medication was very effective in treating my nausea. However, it made me excessively tired and I felt groggy the next day. I also suspect that it exacerbated my sleep apnea symptoms. If you are considering this medication, be sure to speak with your doctor about a smaller dose if you have any concerns.

4.3

Patient Review

9/11/2019

Promethegan for Nausea and Vomiting

This treatment has really helped with my nausea. I do find that if I'm sensitive to medication, it can make me tired; but that's actually been a plus since it helps with my insomnia too.

4.3

Patient Review

12/13/2014

Promethegan for Nausea and Vomiting

I was prescribed 25 mg. for nausea and it worked wonders, though I slept for 14 hours straight. The next day I felt groggy and had a headache, so I would recommend either asking for a smaller dosage or being prepared to feel out of sorts the following day.

4.3

Patient Review

9/11/2019

Promethegan for Nausea and Vomiting

This medication has really helped with my nausea. However, if you're sensitive to medications, be aware that you may feel tired after taking this medicine. It also helps with my insomnia, which is a plus.

4.3

Patient Review

9/11/2019

Promethegan for Nausea and Vomiting

This medication has helped a lot with my nausea. I do get tired if I take it and am sensitive to medications, but that also helps me fall asleep so it's not all bad.

4

Patient Review

8/8/2021

Promethegan for Nausea and Vomiting

This medication can make me drowsy, however it effectively prevents vomiting and helps me keep food down.

4

Patient Review

5/23/2014

Promethegan for Nausea and Vomiting

I have been hospitalized over a dozen times for vomiting and diarrhea, but this medication always does the trick.

4

Patient Review

5/23/2014

Promethegan for Nausea and Vomiting

I've been hospitalized over a dozen times for vomiting and diarrhea, but this medication really does the trick for me.

4

Patient Review

8/8/2021

Promethegan for Nausea and Vomiting

Although it makes me drowsy, this treatment is effective for reducing vomiting and helping me keep food down.

4

Patient Review

5/23/2014

Promethegan for Nausea and Vomiting

I have been hospitalized more than a dozen times due to vomiting and diarrhea. This medication really helps me out.

4

Patient Review

8/8/2021

Promethegan for Nausea and Vomiting

This medication makes me drowsy, but it has been effective in curbing my vomiting and helping me keep food down.

4

Patient Review

5/23/2014

Promethegan for Nausea and Vomiting

I have been hospitalized over a dozen times for vomiting and diarrhea, but this medication really does the trick for me.

4

Patient Review

8/8/2021

Promethegan for Nausea and Vomiting

Though it leaves me feeling pretty drowsy, this medication helps with my vomiting and lets me keep food down.

1

Patient Review

8/26/2015

Promethegan for Nausea and Vomiting

I would use extreme caution before taking this drug, especially if you are also taking other medication. I ended up in the ER with a number of serious side effects that could have been life-threatening. This is not a drug to be used long-term.

1

Patient Review

8/26/2015

Promethegan for Nausea and Vomiting

I would use extreme caution before mixing this drug with any others. I had to go to the ER as a result of serious side effects that could have been deadly. Do not use this for long term treatment.

1

Patient Review

8/26/2015

Promethegan for Nausea and Vomiting

I would use extreme caution before taking this drug, especially if you are already on other medication. I landed in the ER with numerous life-threatening side effects. This is not a drug to be taken lightly or for long periods of time.

1

Patient Review

8/26/2015

Promethegan for Nausea and Vomiting

I would use extreme caution before taking this drug, as it landed me in the ER with a number of serious side effects. Do not use this medication long-term.

Patient Q&A Section about promethegan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Promethegan the same as promethazine?

"Promethazine should not be used in children younger than 2 years because it may causeslowed or shallow breathing, which could be fatal."

Answered by AI

What is Promethegan used for?

"Promethazine is an anti-nausea medication that is also used to treat allergy symptoms. It works by preventing the release of a chemical called histamine in the body."

Answered by AI

How long after promethazine suppository Can I poop?

"For best results from this medicine, use it at around the same time every day.

After using this medication, stay lying down for a few minutes and don't have a bowel movement for at least an hour so the drug can be absorbed. The suppository is only for rectal use. To get the best results from this medicine, use it at around the same time every day."

Answered by AI

What is promethazine 25mg suppositories used for?

"This medication prevents and treats the symptoms of an allergic reaction by blocking histamine, a substance that is released by the body during an allergic reaction. In addition, this medication may help you relax, go to sleep, and relieve nausea, vomiting, or pain before or after procedures."

Answered by AI

Clinical Trials for Promethegan

Image of University Center for Ambulatory Surgery in Somerset, United States.

Infusion Pump for Postoperative Pain

18+
All Sexes
Somerset, NJ

This study will be a pragmatic, prospective cluster randomized trial, where clusters will formed based on sequential 2 week time increments across the study recruitment period.. Patients 18 years or older undergoing ACL reconstruction, open shoulder labrum or rotator cuff surgery, arthroscopic rotator cuff repair, proximal or distal patellar realignment surgery, open knee arthrotomy cases (i.e. inside out meniscus repair, osteochondral allograft transplantation (OCA), meniscal allograft transplantation (MAT)) at University Center for Ambulatory Surgery, LLC (UOA) will be reviewed for eligibility. Once identified, potential study subjects will be asked whether they are interested in participating in the project. If the patient agrees, the subject will be given the informed consent to read and sign. Objectives: The primary objective is to compare the effectiveness of postoperative infusion pain pump versus preoperative nerve block in reducing visual analog pain scores/numerical pain rating scale (VAS/NPRS) in the postoperative period. The second objective is to evaluate the requirement of narcotic and non-narcotic analgesic medications between the two groups. Hypotheses: Use of continuous infusion pain pump or single shot peripheral block will result in similar post-operative pain control after outpatient sports medicine surgical cases.

Phase 4
Recruiting

University Center for Ambulatory Surgery

Image of Cedars-Sinai Medical Center Otolaryngology Clinics in Los Angeles, United States.

Lavender Aromatherapy for Anxiety and Pain During Otolaryngologic Procedures

18+
All Sexes
Los Angeles, CA

The purpose of this study is to evaluate the efficacy of lavender aromatherapy in adult patients undergoing awake otolaryngologic procedures in the outpatient clinic setting. The main questions it aims to answer are: * Does lavender aromatherapy help reduce anxiety and/or pain, and improve patient comfort during awake otolaryngologic procedures in the clinic? * Do patients subjectively find aromatherapy relaxing and/or beneficial during the procedure? Researchers will compare lavender aromatherapy to placebo (an odorless liquid) to see if lavender aromatherapy helps improve patient comfort during their awake procedure Participants will: * Have their scheduled procedure performed with lavender aromatherapy or placebo during the duration of the procedure * Take a short, less than 1 minute questionnaire both before and after the procedure, describing their levels of anxiety, pain and subjective impressions of the aromatherapy

Recruiting
Paid Trial

Cedars-Sinai Medical Center Otolaryngology Clinics

Ankona Ghosh, MD

Have you considered Promethegan clinical trials?

We made a collection of clinical trials featuring Promethegan, we think they might fit your search criteria.
Go to Trials

Have you considered Promethegan clinical trials?

We made a collection of clinical trials featuring Promethegan, we think they might fit your search criteria.
Go to Trials
Image of Thomas Jefferson University in Philadelphia, United States.

Physical Therapy for Ventral Hernia

18 - 75
All Sexes
Philadelphia, PA

The goal of this clinical trial is to evaluate the efficacy, safety, and cost-effectiveness of a tailored physical therapy (PT) intervention targeting Abdominal Core Health components in patients recovering from ventral hernia repair. The study focuses on patients aged 18-75 diagnosed with a ventral transverse hernia between 4 cm and 10 cm, scheduled for elective Ventral Hernia Repair (VHR). The main questions it aims to answer are: * Will tailored PT significantly improve abdominal core strength, biomechanical stability, and functional mobility compared to usual care at 3-months post-surgery? * Will tailored PT lead to higher patient-reported quality of life and satisfaction scores, with a lower incidence of post-operative complications such as bowel obstruction and pelvic floor dysfunction over a 1-year follow-up? * Will tailored PT result in decreased healthcare utilization, leading to overall cost savings or neutrality compared to usual care over the first year after VHR? Researchers will compare the tailored physical therapy group to a usual care group to see if the tailored intervention leads to significant improvements in clinical efficacy, patient outcomes, and cost-effectiveness. Participants will: * Be randomly assigned to either the Usual Care Group or the PT Group. * If in the Usual Care Group, receive standard post-operative instructions for 12 weeks, including guidance on binder use, safe lifting, and gradual return to activities. * If in the PT Group, receive foundational post-operative instructions for the first 2 weeks (similar to usual care). Undergo 6 structured and individualized PT sessions over 10 weeks if in the PT Group, with progression based on Oswestry Disability Index (ODI) and Pelvic Floor Distress Inventory-20 (PFDI-20) scores, including Symptom Modulation, Movement Control, Functional Optimization, or Impairment-Based interventions. Participants undergo data collection at 2 weeks, 12 weeks, and 1 year post-operation, including imaging, functional mobility tests, pain scales, patient-reported outcomes, physical measurements, and tracking of complications and healthcare utilization. Participate in semi-structured interviews after the 12-week assessment to provide qualitative insights into their experiences and perceived barriers/facilitators.

Waitlist Available
Has No Placebo

Thomas Jefferson University

Christopher Keating

Image of Rutgers School of Dental Medicine in Newark, United States.

Temporo-masseteric Nerve Block for Postoperative Pain

18+
All Sexes
Newark, NJ

The proposed design is a triple-blind, placebo-controlled randomized prospective phase II trial to assess the feasibility of employing the Temporo-masseteric Nerve Block (TMNB) injection to decrease jaw muscle pain, overall pain, improve mouth opening and minimize pain medication consumption. 80 participants undergoing lower third molar removal under sedation will be enrolled. Those who develop significant jaw muscle pain on the following day will be randomized to receive either the TMNB injection or a placebo. Daily ecological momentary assessments (EMAs) will be collected reflecting elements of patient experience for all participants. On Day 8, participants return for an end-of-study evaluation and return their unused pain medications. Up to 40 participants who are randomized to receive TMNB/placebo will be recruited to participate in a qualitative interview regarding their experience.

Phase 2
Waitlist Available

Rutgers School of Dental Medicine

Have you considered Promethegan clinical trials?

We made a collection of clinical trials featuring Promethegan, we think they might fit your search criteria.
Go to Trials