Transrectal vs. Transperineal Biopsy for Prostate Cancer
(ProBE-PC Trial)
Trial Summary
What is the purpose of this trial?
This study evaluates the difference between 2 prostate biopsy methods, transrectal (through the rectal wall) and transperineal (through the skin) needle biopsy. Men who are in need of prostate biopsy due to clinical suspicions of prostate cancer will be randomly assigned (1:1) to either transrectal or transperineal approach. This research study will scientifically determine if one biopsy method is better than the other in reducing complications and improving cancer detection.
Do I need to stop taking my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of this treatment for prostate cancer?
Is prostate biopsy safe for humans?
How does the transperineal biopsy treatment for prostate cancer differ from other treatments?
Transperineal biopsy (TP-Bx) for prostate cancer is unique because it reduces the risk of infection compared to the traditional transrectal biopsy (TR-Bx), as it avoids passing through the rectum. This method also allows for targeted sampling of the prostate, potentially improving cancer detection rates.12459
Research Team
Badar M. Mian, MD
Principal Investigator
Albany Medical College
Eligibility Criteria
Men needing a prostate biopsy due to suspected cancer, who can undergo the procedure without sedation or general anesthesia. They must have access to their rectum (no prior surgery blocking it) and no perineal skin abnormalities like infections.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo either transrectal or transperineal prostate biopsy
Follow-up
Participants are monitored for complications and cancer detection outcomes
Treatment Details
Interventions
- Systematic Transperineal biopsy (TP-Bx)
- Systematic Transrectal biopsy (TR-Bx)
- Targeted Transperineal biopsy (TP-Bx)
- Targeted Transrectal biopsy (TR-Bx)
Systematic Transperineal biopsy (TP-Bx) is already approved in European Union, United States, Canada for the following indications:
- Diagnosis of prostate cancer
- Diagnosis of prostate cancer
- Diagnosis of prostate cancer
Find a Clinic Near You
Who Is Running the Clinical Trial?
Albany Medical College
Lead Sponsor