Prolixin

Chorea, Depression, Sedation + 4 more
Treatment
1 FDA approval
20 Active Studies for Prolixin

What is Prolixin

FluphenazineThe Generic name of this drug
Treatment SummaryPhenothiazine is an antipsychotic drug that is used to treat mental illnesses such as psychosis. It works in a similar way to chlorpromazine, another type of antipsychotic medicine.
Fluphenazine Hydrochlorideis the brand name
image of different drug pills on a surface
Prolixin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Fluphenazine Hydrochloride
Fluphenazine
1987
181

Approved as Treatment by the FDA

Fluphenazine, also known as Fluphenazine Hydrochloride, is approved by the FDA for 1 uses including Schizophrenia .
Schizophrenia
Helps manage Psychosis

Effectiveness

How Prolixin Affects PatientsFluphenazine is a medication used to treat schizophrenia and other mental disorders. It has not been found to be effective in treating behavior problems in people with intellectual disabilities.
How Prolixin works in the bodyFluphenazine works by blocking receptors in the brain that are related to dopamine. This has the effect of reducing hormones in the hypothalamus and pituitary gland as well as affecting body temperature, alertness, blood pressure, and vomiting.

When to interrupt dosage

The measure of Prolixin is contingent upon the diagnosed disorder, including Schizophrenia, Gilles de la Tourette's Syndrome and Sedation therapy. The amount of dosage is dependent upon the method of application (e.g. Tablet, film coated - Oral or Intramuscular) featured in the table underneath.
Condition
Dosage
Administration
Depression
, 5.0 mg/mL, 0.5 mg/mL, 2.5 mg, 5.0 mg, 10.0 mg, 1.0 mg, 25.0 mg/mL, 2.5 mg/mL, 2.0 mg, 125.0 mg/mL, 100.0 mg/mL
, Oral, Solution, concentrate, Solution, concentrate - Oral, Elixir, Elixir - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Subcutaneous, Tablet, Tablet - Oral, Intramuscular, Injection, solution - Intramuscular, Liquid, Liquid - Intramuscular; Subcutaneous, Liquid - Intramuscular, Solution, Solution - Intramuscular; Subcutaneous, Injection, Injection - Intramuscular; Subcutaneous
Schizophrenia
, 5.0 mg/mL, 0.5 mg/mL, 2.5 mg, 5.0 mg, 10.0 mg, 1.0 mg, 25.0 mg/mL, 2.5 mg/mL, 2.0 mg, 125.0 mg/mL, 100.0 mg/mL
, Oral, Solution, concentrate, Solution, concentrate - Oral, Elixir, Elixir - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Subcutaneous, Tablet, Tablet - Oral, Intramuscular, Injection, solution - Intramuscular, Liquid, Liquid - Intramuscular; Subcutaneous, Liquid - Intramuscular, Solution, Solution - Intramuscular; Subcutaneous, Injection, Injection - Intramuscular; Subcutaneous
Sedation therapy
, 5.0 mg/mL, 0.5 mg/mL, 2.5 mg, 5.0 mg, 10.0 mg, 1.0 mg, 25.0 mg/mL, 2.5 mg/mL, 2.0 mg, 125.0 mg/mL, 100.0 mg/mL
, Oral, Solution, concentrate, Solution, concentrate - Oral, Elixir, Elixir - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Subcutaneous, Tablet, Tablet - Oral, Intramuscular, Injection, solution - Intramuscular, Liquid, Liquid - Intramuscular; Subcutaneous, Liquid - Intramuscular, Solution, Solution - Intramuscular; Subcutaneous, Injection, Injection - Intramuscular; Subcutaneous
Tourette Syndrome
, 5.0 mg/mL, 0.5 mg/mL, 2.5 mg, 5.0 mg, 10.0 mg, 1.0 mg, 25.0 mg/mL, 2.5 mg/mL, 2.0 mg, 125.0 mg/mL, 100.0 mg/mL
, Oral, Solution, concentrate, Solution, concentrate - Oral, Elixir, Elixir - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Subcutaneous, Tablet, Tablet - Oral, Intramuscular, Injection, solution - Intramuscular, Liquid, Liquid - Intramuscular; Subcutaneous, Liquid - Intramuscular, Solution, Solution - Intramuscular; Subcutaneous, Injection, Injection - Intramuscular; Subcutaneous
Chorea
, 5.0 mg/mL, 0.5 mg/mL, 2.5 mg, 5.0 mg, 10.0 mg, 1.0 mg, 25.0 mg/mL, 2.5 mg/mL, 2.0 mg, 125.0 mg/mL, 100.0 mg/mL
, Oral, Solution, concentrate, Solution, concentrate - Oral, Elixir, Elixir - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Subcutaneous, Tablet, Tablet - Oral, Intramuscular, Injection, solution - Intramuscular, Liquid, Liquid - Intramuscular; Subcutaneous, Liquid - Intramuscular, Solution, Solution - Intramuscular; Subcutaneous, Injection, Injection - Intramuscular; Subcutaneous
Sedation
, 5.0 mg/mL, 0.5 mg/mL, 2.5 mg, 5.0 mg, 10.0 mg, 1.0 mg, 25.0 mg/mL, 2.5 mg/mL, 2.0 mg, 125.0 mg/mL, 100.0 mg/mL
, Oral, Solution, concentrate, Solution, concentrate - Oral, Elixir, Elixir - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Subcutaneous, Tablet, Tablet - Oral, Intramuscular, Injection, solution - Intramuscular, Liquid, Liquid - Intramuscular; Subcutaneous, Liquid - Intramuscular, Solution, Solution - Intramuscular; Subcutaneous, Injection, Injection - Intramuscular; Subcutaneous
Huntington Disease
, 5.0 mg/mL, 0.5 mg/mL, 2.5 mg, 5.0 mg, 10.0 mg, 1.0 mg, 25.0 mg/mL, 2.5 mg/mL, 2.0 mg, 125.0 mg/mL, 100.0 mg/mL
, Oral, Solution, concentrate, Solution, concentrate - Oral, Elixir, Elixir - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Subcutaneous, Tablet, Tablet - Oral, Intramuscular, Injection, solution - Intramuscular, Liquid, Liquid - Intramuscular; Subcutaneous, Liquid - Intramuscular, Solution, Solution - Intramuscular; Subcutaneous, Injection, Injection - Intramuscular; Subcutaneous

Warnings

Prolixin has seven contraindications, so it should not be taken in cases of the conditions specified in the following table.Prolixin Contraindications
Condition
Risk Level
Notes
Brain Injuries
Do Not Combine
Disease
Do Not Combine
Liver Damage
Do Not Combine
Mental Depression
Do Not Combine
Hypnotics
Do Not Combine
Brain Injuries
Do Not Combine
Coma
Do Not Combine
There are 20 known major drug interactions with Prolixin.
Common Prolixin Drug Interactions
Drug Name
Risk Level
Description
Amisulpride
Major
Fluphenazine may increase the antipsychotic activities of Amisulpride.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Fluphenazine.
Azelastine
Major
Fluphenazine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Dacomitinib
Major
The metabolism of Dacomitinib can be decreased when combined with Fluphenazine.
Deutetrabenazine
Major
The risk or severity of adverse effects can be increased when Fluphenazine is combined with Deutetrabenazine.
image of a doctor in a lab doing drug, clinical research

Prolixin Novel Uses: Which Conditions Have a Clinical Trial Featuring Prolixin?

640 active studies are examining the potential of Prolixin in providing relief for Huntington Disease, Sedation therapy and Chorea.
Condition
Clinical Trials
Trial Phases
Sedation therapy
0 Actively Recruiting
Sedation
2 Actively Recruiting
Not Applicable, Phase 1
Tourette Syndrome
0 Actively Recruiting
Depression
335 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3
Huntington Disease
5 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Chorea
0 Actively Recruiting
Schizophrenia
33 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4

Prolixin Reviews: What are patients saying about Prolixin?

5Patient Review
11/6/2013
Prolixin for Mental Disorder with Loss of Normal Personality & Reality
I haven't had any problems since I started this treatment.
4.3Patient Review
12/13/2008
Prolixin for Schizophrenia
3.3Patient Review
7/6/2009
Prolixin for Schizophrenia
My son is on the prolixin injection and he says it's making him depressed. He's 17 years old and was diagnosed with paranoid schizophrenia. He believes that he doesn't need this medication.
1Patient Review
9/3/2009
Prolixin for Mental Disorder with Loss of Normal Personality & Reality
I was given Prolixin injections a few years ago, and I told the doctor that I was having bad side effects. He gave me another injection anyway, and I had a seizure and then things got worse. I ended up being paralyzed for several months and had to learn how to walk and talk again. When the institution realized they couldn't take care of me, they placed me in an old folks home where I didn't receive any therapy. I had to do it all on my own, which was really tough since I was only about 37 at the time - by far the youngest person in the home.
1Patient Review
5/23/2009
Prolixin for Mental Disorder with Loss of Normal Personality & Reality
I was pleased to find that this medication stopped the voices I was hearing. However, now I am struggling with side effects like an inability to sit still and constant pacing. If anyone else has experienced this, please let me know how you coped or what alleviated the symptoms. Thank you!

Patient Q&A Section about prolixin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the drug prolixin used for?

"Fluphenazine is a medication that treats schizophrenia. It works by rebalancing the levels of dopamine in the brain, which improves thinking, mood, and behavior."

Answered by AI

What is the side effects of prolixin?

"The following side effects may occur: drowsiness, lethargy, dizziness, lightheadedness, nausea, loss of appetite, sweating, dry mouth, blurred vision, headache, and constipation. If any of these effects persist or worsen, tell your doctor or pharmacist."

Answered by AI

Is prolixin still used today?

"This medication is only available in generic form since the brand name Prolixin has been discontinued."

Answered by AI

Is prolixin the same as Haldol?

"Prolixin is less likely to cause weight gain or sedation, but may cause movement disorders. It can help stabilize mood in people with schizophrenia or psychosis."

Answered by AI

Clinical Trials for Prolixin

Have you considered Prolixin clinical trials? We made a collection of clinical trials featuring Prolixin, we think they might fit your search criteria.
Have you considered Prolixin clinical trials? We made a collection of clinical trials featuring Prolixin, we think they might fit your search criteria.
Have you considered Prolixin clinical trials? We made a collection of clinical trials featuring Prolixin, we think they might fit your search criteria.
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