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Chemotherapy + Stem Cell Transplant for Lymphoma
Study Summary
This trial is studying the side effects of giving high-dose chemotherapy drugs and a stem cell transplant to treat patients with HIV-associated lymphoma.
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Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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- I do not have an ongoing bacterial or fungal infection.I haven't had any AIDS-related infections in the past year, except for treatable conditions like Mycobacterium Avium, oral thrush, or herpes.I am mostly able to care for myself.You have mental or emotional conditions that make it difficult for you to follow the study requirements.I have had severe bladder inflammation from past chemotherapy.I have had cancer before, but it was either skin cancer treated successfully or cervical changes, depending on my doctor's advice.I am on a preventive treatment for a specific type of pneumonia due to low immune cells.I cannot take AZT for at least 2 months after my transplant.My heart pumps well and I don't have heart failure or irregular heartbeat.I have severe, uncontrollable diarrhea causing serious health issues.I currently have an active CMV infection affecting my eyes or other organs.I do not have AIDS-related conditions that increase risk for transplant complications.I had a relapse of a specific type of pneumonia in the last year.My spinal fluid test was negative for cancer cells within the last 30 days after treatment.I was HIV positive when or before my lymphoma was diagnosed.My bone marrow involvement is less than 10% before stem cell collection.I am a woman who can have children and my pregnancy test is negative.I am on HIV medication and meet the specific viral load requirements.I have Hepatitis B or C but no signs of severe liver damage, pending further tests.My lymphoma is confirmed to be of a specific aggressive type, not including L&H lymphocyte predominant.My kidney function tests are within normal limits.My cancer can be measured by scans or physically, and is not in complete remission.
- Group 1: Treatment (high-dose chemotherapy, anti-HIV therapy)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What are common applications of a pharmacological examination?
"Pharmacological interventions are frequently prescribed for lymphoma, but may also have positive results when treating acute lymphoblastic leukemia (ALL), glioblastomas and brain stem gliomas."
Does this pharmacological investigation have the endorsement of the FDA?
"The pharmacological study is still in its earliest stages, so it was awarded a score of 1 due to the lack of data available on safety and efficacy."
What other investigations have transpired related to pharmacological research?
"Of the 999 live clinical trials currently evaluating pharmacological interventions, 204 are at Phase 3. Though Philadelphia is a major hub for this research, there are 36320 sites globally dedicated to these studies."
What is the enrollment size for this research project?
"Unfortunately, this research is not currently seeking volunteers. The study was initially posted on May 10th 2000 and last updated on February 17th 2022. If you are interested in alternative trials, there are 1,718 studies actively recruiting participants with lymphoma and 999 clinical investigations requiring volunteers for pharmacological evaluation."
Does your research offer opportunities for me to get involved?
"To be considered for inclusion in this medical trial, applicants must lie within the 10 to 60 year old range and have lymphoma. Only 25 individuals can partake in the study upon its completion."
Would someone who is 25 years old or older be able to become part of this experiment?
"The parameters for joining this clinical trial demand that participants be between 10 and 60 years old. There are 637 trials available for minors, and 2323 trials meant specifically for seniors."
Are participants being recruited at this time for the trial?
"As per the data hosted on clinicaltrials.gov, this specific trial is not currently recruiting patients; it was initially posted in May 2000 and last updated in February 2022. Conversely, a total of 2717 other trials are looking for participants at present."
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