What is Prochlorperazine Maleate
ProchlorperazineThe Generic name of this drug
Treatment SummaryProchlorperazine, also known as Compazine, is a medication used to treat severe nausea, vomiting, anxiety, and schizophrenia. It works by blocking certain receptors in the brain and depressing the chemoreceptor trigger zone. Prochlorperazine was first developed in the 1950s and approved by the FDA in 1956. Although newer drugs are available, Prochlorperazine is still widely used to treat nausea and vomiting.
Compazineis the brand name
Prochlorperazine Maleate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Compazine
Prochlorperazine
1956
162
Effectiveness
How Prochlorperazine Maleate Affects PatientsProchlorperazine is a drug that works to calm the brain by blocking dopamine receptors. It is also effective in preventing nausea and vomiting, and can have anti-anxiety effects. Compared to other similar drugs, prochlorperazine causes less drowsiness and is less likely to cause low blood pressure or interact with other medications. It can also block certain receptors in the body to help reduce the amount of calcium ion influx.
How Prochlorperazine Maleate works in the bodyThe exact way prochlorperazine works is unknown, but it likely works by blocking the dopamine receptors in the brain. Blocking the dopamine receptors interrupts communication between the brain and the body, reducing nausea and vomiting. Prochlorperazine also blocks serotonin type 3 and dopamine type 2 receptors at the chemoreceptor trigger zone, further reducing nausea and vomiting.
When to interrupt dosage
The prescribed amount of Prochlorperazine Maleate is contingent upon the diagnosed condition, such as Tension Headache, Acute Coryza and Schizophrenia. The quantity of dosage fluctuates, according to the method of delivery noted in the table below.Condition
Dosage
Administration
Tension Headache
10.0 mg, 5.0 mg/mL, 15.0 mg, 2.5 mg, , 5.0 mg, 0.5 mg, 25.0 mg
, Capsule, extended release - Oral, Injection, Syrup - Oral, Tablet, film coated - Oral, Intramuscular; Intravenous, Tablet, coated - Oral, Tablet, film coated, Rectal, Tablet - Oral, Oral, Intramuscular, Solution - Intramuscular; Intravenous, Syrup, Solution, Suppository - Rectal, Tablet, Suppository, Tablet, coated, Injection, solution - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Capsule, extended release, Injection, solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular
Acute Coryza
10.0 mg, 5.0 mg/mL, 15.0 mg, 2.5 mg, , 5.0 mg, 0.5 mg, 25.0 mg
, Capsule, extended release - Oral, Injection, Syrup - Oral, Tablet, film coated - Oral, Intramuscular; Intravenous, Tablet, coated - Oral, Tablet, film coated, Rectal, Tablet - Oral, Oral, Intramuscular, Solution - Intramuscular; Intravenous, Syrup, Solution, Suppository - Rectal, Tablet, Suppository, Tablet, coated, Injection, solution - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Capsule, extended release, Injection, solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular
Schizophrenia
10.0 mg, 5.0 mg/mL, 15.0 mg, 2.5 mg, , 5.0 mg, 0.5 mg, 25.0 mg
, Capsule, extended release - Oral, Injection, Syrup - Oral, Tablet, film coated - Oral, Intramuscular; Intravenous, Tablet, coated - Oral, Tablet, film coated, Rectal, Tablet - Oral, Oral, Intramuscular, Solution - Intramuscular; Intravenous, Syrup, Solution, Suppository - Rectal, Tablet, Suppository, Tablet, coated, Injection, solution - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Capsule, extended release, Injection, solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular
Anxiety
10.0 mg, 5.0 mg/mL, 15.0 mg, 2.5 mg, , 5.0 mg, 0.5 mg, 25.0 mg
, Capsule, extended release - Oral, Injection, Syrup - Oral, Tablet, film coated - Oral, Intramuscular; Intravenous, Tablet, coated - Oral, Tablet, film coated, Rectal, Tablet - Oral, Oral, Intramuscular, Solution - Intramuscular; Intravenous, Syrup, Solution, Suppository - Rectal, Tablet, Suppository, Tablet, coated, Injection, solution - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Capsule, extended release, Injection, solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular
Nausea
10.0 mg, 5.0 mg/mL, 15.0 mg, 2.5 mg, , 5.0 mg, 0.5 mg, 25.0 mg
, Capsule, extended release - Oral, Injection, Syrup - Oral, Tablet, film coated - Oral, Intramuscular; Intravenous, Tablet, coated - Oral, Tablet, film coated, Rectal, Tablet - Oral, Oral, Intramuscular, Solution - Intramuscular; Intravenous, Syrup, Solution, Suppository - Rectal, Tablet, Suppository, Tablet, coated, Injection, solution - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Capsule, extended release, Injection, solution, Liquid, Liquid - Intramuscular; Intravenous, Injection - Intramuscular
Warnings
Prochlorperazine Maleate has five contraindications and must not be employed together with any of the conditions listed in the following table.Prochlorperazine Maleate ContraindicationsCondition
Risk Level
Notes
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Operative Surgery
Do Not Combine
Comatose
Do Not Combine
Toxoplasma Infections
Do Not Combine
Common Prochlorperazine Maleate Drug Interactions
Drug Name
Risk Level
Description
Amisulpride
Major
Prochlorperazine may increase the antipsychotic activities of Amisulpride.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Arsenic trioxide.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Asenapine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Prochlorperazine.
Prochlorperazine Maleate Toxicity & Overdose RiskThe toxic dose of prochlorperazine in rats is 750mg/kg, 191mg/kg when administered intraperitoneally, and 320mg/kg when given subcutaneously. Elderly patients with dementia-related psychosis taking antipsychotic medications were found to have an increased risk of death compared to those taking placebos. Prochlorperazine can also cause tardive dyskinesia, a syndrome of potentially irreversible, involuntary movements. Neuroleptic malignant syndrome, a potentially fatal condition, is also associated with prochlorperazine. Symptoms of overdose include dystonic reactions, central nervous system depression, convuls
Prochlorperazine Maleate Novel Uses: Which Conditions Have a Clinical Trial Featuring Prochlorperazine Maleate?
171 active clinical trials are currently underway to assess the effectiveness of Prochlorperazine Maleate in treating Schizophrenia, Acute Coryza and Tension Headache.Condition
Clinical Trials
Trial Phases
Tension Headache
1 Actively Recruiting
Phase 2
Acute Coryza
0 Actively Recruiting
Schizophrenia
183 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Nausea
0 Actively Recruiting
Anxiety
0 Actively Recruiting
Prochlorperazine Maleate Reviews: What are patients saying about Prochlorperazine Maleate?
5Patient Review
6/24/2011 No side effects that I could tell, and it really helped me to relax.
5Patient Review
7/25/2013 I have vertigo and sometimes the attacks are really bad. I get dizzy and sick, and it feels like my head is spinning for hours. Sometimes I have to go to the hospital. This time they gave me this treatment to take home, and it really helped.
5Patient Review
7/25/2013 I have vertigo and this medication has been a huge help in managing my attacks. I don't feel sick for hours anymore and it's really improved my quality of life.
5Patient Review
6/24/2011 I experienced no negative side effects from this treatment, and it helped me to feel more relaxed.
4.7Patient Review
12/29/2011 This treatment has been very effective for me.
4.7Patient Review
12/29/2011 This treatment has been very effective for me.
4.3Patient Review
1/15/2014 I've been struggling with nausea and vomiting for the past three years without any relief. My doctor and I are currently going over all of my tests and repeating them in hopes of finding a cause. Two weeks ago, he prescribed me this medication as a temporary measure, and I'm happy to report that it's working!
4.3Patient Review
1/15/2014 My nausea and vomiting issues have been persistent for the last three years, but my doctor and I are making progress. We're currently retesting everything and this medication has shown good results in the meantime!
4.3Patient Review
10/22/2011 This medication was a godsend. I had been suffering from a gallbladder infection for over a week, to the point where I couldn't keep any food down. After just one dose of this treatment, the nausea completely disappeared.
4.3Patient Review
10/22/2011 This medication was a huge relief. I had been dealing with nausea and vomiting for a week straight before trying this, and one dose completely took away those symptoms.
4Patient Review
12/7/2012 I had been having extreme temporal headaches waking me from sleep. Headaches from an unknown cause. Been seen by 3 different MD's. Finally prescribed to take this 2 10mg 3xdaily. Headaches stopped.
4Patient Review
12/7/2012 I was getting terrible headaches that would wake me up from sleep. After seeing a few different doctors and trying this medication, my headaches completely stopped.
3.7Patient Review
8/24/2011 This medication was effective at stopping my nausea, but it came with a lot of other unpleasant side effects. I felt cramped and numb all over, and developed a headache and sore throat. I also got very hot and feverish. I stopped taking the medication, but my body still feels tense and tingling. I'm worried something is wrong...
3.7Patient Review
8/24/2011 At first, this medication helped with my nausea caused by dizzy spells. However, I started to experience some very unpleasant side effects like stomach pain, a sore throat, headaches, and fever. I stopped taking the medication but even now my body feels tense and tingling. I'm worried something is wrong...
3Patient Review
2/9/2011 This treatment helped me some days when my anxiety was bad, but other days I still felt overwhelmed. I talked to my doctor about trying a different medication.
3Patient Review
2/9/2011 This medication was sometimes effective for my anxiety, but other times I still felt very overwhelmed. I decided to speak with my doctor about trying a different treatment option.
3Patient Review
10/12/2009 I felt nauseous and threw up a lot while taking this medication.
3Patient Review
10/12/2009 I experienced a lot of nausea and vomiting with this treatment.
2.3Patient Review
7/3/2022 I have Labyrinthitis and vertigo, which causes me to vomit. I was prescribed Stemetil, but it only made me shake uncontrollably. I don't know what's worse: the sickness or the shaking.
2.3Patient Review
12/30/2010 This medication helped to stabilize my mood and anxiety levels.
2.3Patient Review
12/30/2010 I found this treatment to be helpful in terms of mood stabilization and anxiety reduction.
2.3Patient Review
7/3/2022 I was prescribed Stemetil for my vertigo and labyrinthitis, but it only made things worse by giving me the shakes. I don't know what's worse: the sickness or the shaking.
1.7Patient Review
5/16/2009 My sister takes this drug and I'm horrified at the involuntary tongue movements. Her tongue constantly darts in and out of her mouth, making her look like she's crazy. I've talked her into asking her Dr for a different drug.
1.7Patient Review
5/16/2009 My sister takes this drug and I'm horrified at the involuntary tongue movements. Her tongue constantly darts in and out of her mouth, making her look like she's crazy. I've talked her into asking her Dr for a different drug. Her own Dr is the one that took note of the problem and yet did nothing till she asked for a different rx. She's also experienced high anxiety, dizziness and restlessness.
1Patient Review
11/30/2021 My sister was given this medication for dizziness, but she immediately felt confused after taking it. She took a second dose and soon developed schizophrenia, from which she has not yet recovered. This drug has a 73% negative reaction rate; please do your research before taking it.
1Patient Review
11/30/2021 My sister was given this for dizziness, but she immediately felt confused and disoriented after taking it. She took a second dose, and now she's experiencing a full-blown psychosis episode from which she hasn't recovered. I looked into it and found that 73% of people have negative reactions to this drug. Please do your research before taking it.
Patient Q&A Section about prochlorperazine maleate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is prochlorperazine maleate side effects?
"Dizziness, feeling unsteady, or having trouble keeping your balance can be caused by blurred vision, dry mouth, stuffed nose, headache, nausea, constipation, or difficulty urinating."
Answered by AI
How does prochlorperazine help vertigo?
"Prochlorperazine, or Stemetil, is an anti-sickness drug that helps reduce the impact of abnormal signals from the balance organ. This can help relieve the symptoms of nausea, vomiting, and vertigo associated with Ménière's disease, labyrinthitis, and other inner ear disorders."
Answered by AI
What is prochlorperazine maleate used for?
"Prochlorperazine is an anti-sickness medicine that can help with nausea and vomiting. It is often used to treat morning sickness."
Answered by AI
Is prochlorperazine a sedative?
"Prochlorperazine can act as a sedative, but people usually develop a tolerance to the sedative effects quickly. Prochlorperazine can also help relieve nausea, itching, and the movements of the gastrointestinal tract. Additionally, it has weak antihistamine properties and mild effects on the nervous system."
Answered by AI