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Prochlorperazine Maleate
Schizophrenia, Anxiety, Nausea + 2 more
Treatment
20 Active Studies for Prochlorperazine Maleate
Treatment for
Schizophrenia
What is Prochlorperazine Maleate
ProchlorperazineThe Generic name of this drug
Treatment SummaryProchlorperazine, also known as Compazine, is a medication used to treat severe nausea, vomiting, anxiety, and schizophrenia. It works by blocking certain receptors in the brain and depressing the chemoreceptor trigger zone. Prochlorperazine was first developed in the 1950s and approved by the FDA in 1956. Although newer drugs are available, Prochlorperazine is still widely used to treat nausea and vomiting.
Compazineis the brand name
Prochlorperazine Maleate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Compazine
Prochlorperazine
1956
162
Effectiveness
How Prochlorperazine Maleate Affects PatientsProchlorperazine is a drug that works to calm the brain by blocking dopamine receptors. It is also effective in preventing nausea and vomiting, and can have anti-anxiety effects. Compared to other similar drugs, prochlorperazine causes less drowsiness and is less likely to cause low blood pressure or interact with other medications. It can also block certain receptors in the body to help reduce the amount of calcium ion influx.
How Prochlorperazine Maleate works in the bodyThe exact way prochlorperazine works is unknown, but it likely works by blocking the dopamine receptors in the brain. Blocking the dopamine receptors interrupts communication between the brain and the body, reducing nausea and vomiting. Prochlorperazine also blocks serotonin type 3 and dopamine type 2 receptors at the chemoreceptor trigger zone, further reducing nausea and vomiting.
When to interrupt dosage
The prescribed amount of Prochlorperazine Maleate is contingent upon the diagnosed condition, such as Tension Headache, Acute Coryza and Schizophrenia. The quantity of dosage fluctuates, according to the method of delivery noted in the table below.Condition
Dosage
Administration
Schizophrenia
5.0 mg, , 10.0 mg, 5.0 mg/mL, 0.5 mg, 25.0 mg, 15.0 mg, 2.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Intramuscular, Injection - Intramuscular, Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Syrup, Syrup - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous
Anxiety
5.0 mg, , 10.0 mg, 5.0 mg/mL, 0.5 mg, 25.0 mg, 15.0 mg, 2.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Intramuscular, Injection - Intramuscular, Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Syrup, Syrup - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous
Nausea
5.0 mg, , 10.0 mg, 5.0 mg/mL, 0.5 mg, 25.0 mg, 15.0 mg, 2.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Intramuscular, Injection - Intramuscular, Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Syrup, Syrup - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous
Tension-Type Headache
5.0 mg, , 10.0 mg, 5.0 mg/mL, 0.5 mg, 25.0 mg, 15.0 mg, 2.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Intramuscular, Injection - Intramuscular, Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Syrup, Syrup - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous
Acute Coryza
5.0 mg, , 10.0 mg, 5.0 mg/mL, 0.5 mg, 25.0 mg, 15.0 mg, 2.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Intramuscular, Injection - Intramuscular, Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Syrup, Syrup - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous
Warnings
Prochlorperazine Maleate has five contraindications and must not be employed together with any of the conditions listed in the following table.Prochlorperazine Maleate ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Operative Surgery
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Coma
Do Not Combine
Common Prochlorperazine Maleate Drug Interactions
Drug Name
Risk Level
Description
Amisulpride
Major
Prochlorperazine may increase the antipsychotic activities of Amisulpride.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Arsenic trioxide.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Asenapine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Prochlorperazine.
Prochlorperazine Maleate Toxicity & Overdose RiskThe toxic dose of prochlorperazine in rats is 750mg/kg, 191mg/kg when administered intraperitoneally, and 320mg/kg when given subcutaneously. Elderly patients with dementia-related psychosis taking antipsychotic medications were found to have an increased risk of death compared to those taking placebos. Prochlorperazine can also cause tardive dyskinesia, a syndrome of potentially irreversible, involuntary movements. Neuroleptic malignant syndrome, a potentially fatal condition, is also associated with prochlorperazine. Symptoms of overdose include dystonic reactions, central nervous system depression, convuls
Prochlorperazine Maleate Novel Uses: Which Conditions Have a Clinical Trial Featuring Prochlorperazine Maleate?
171 active clinical trials are currently underway to assess the effectiveness of Prochlorperazine Maleate in treating Schizophrenia, Acute Coryza and Tension Headache.Condition
Clinical Trials
Trial Phases
Schizophrenia
106 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 1, Phase 2
Anxiety
0 Actively Recruiting
Acute Coryza
0 Actively Recruiting
Nausea
0 Actively Recruiting
Tension-Type Headache
2 Actively Recruiting
Not Applicable, Phase 3
Prochlorperazine Maleate Reviews: What are patients saying about Prochlorperazine Maleate?
5Patient Review
6/24/2011 No side effects that I could tell, and it really helped me to relax.
5Patient Review
7/25/2013 I have vertigo and sometimes the attacks are really bad. I get dizzy and sick, and it feels like my head is spinning for hours. Sometimes I have to go to the hospital. This time they gave me this treatment to take home, and it really helped.
5Patient Review
7/25/2013 I have vertigo and this medication has been a huge help in managing my attacks. I don't feel sick for hours anymore and it's really improved my quality of life.
5Patient Review
6/24/2011 I experienced no negative side effects from this treatment, and it helped me to feel more relaxed.
4.7Patient Review
12/29/2011 This treatment has been very effective for me.
Patient Q&A Section about prochlorperazine maleate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is prochlorperazine maleate side effects?
"Dizziness, feeling unsteady, or having trouble keeping your balance can be caused by blurred vision, dry mouth, stuffed nose, headache, nausea, constipation, or difficulty urinating."
Answered by AI
How does prochlorperazine help vertigo?
"Prochlorperazine, or Stemetil, is an anti-sickness drug that helps reduce the impact of abnormal signals from the balance organ. This can help relieve the symptoms of nausea, vomiting, and vertigo associated with Ménière's disease, labyrinthitis, and other inner ear disorders."
Answered by AI
What is prochlorperazine maleate used for?
"Prochlorperazine is an anti-sickness medicine that can help with nausea and vomiting. It is often used to treat morning sickness."
Answered by AI
Is prochlorperazine a sedative?
"Prochlorperazine can act as a sedative, but people usually develop a tolerance to the sedative effects quickly. Prochlorperazine can also help relieve nausea, itching, and the movements of the gastrointestinal tract. Additionally, it has weak antihistamine properties and mild effects on the nervous system."
Answered by AI
Clinical Trials for Prochlorperazine Maleate
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Have you considered Prochlorperazine Maleate clinical trials? We made a collection of clinical trials featuring Prochlorperazine Maleate, we think they might fit your search criteria.Go to Trials
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