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What is Prochlorperazine Edisylate
ProchlorperazineThe Generic name of this drug
Treatment SummaryProchlorperazine, sometimes referred to as Compazine, is a drug used to treat severe nausea and vomiting, and temporary psychosis such as anxiety and schizophrenia. It works by blocking certain receptors in the brain to reduce symptoms. It was first approved by the FDA in 1956, and while newer antiemetic medications are available, Prochlorperazine is still widely used.
Compazineis the brand name
Prochlorperazine Edisylate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Compazine
Prochlorperazine
1956
162
Effectiveness
How Prochlorperazine Edisylate Affects PatientsProchlorperazine is a medicine used to treat certain mental illnesses. It works by blocking certain chemicals in the brain, like dopamine, histamine, and acetylcholine. This can have calming effects and reduce anxiety, but can also cause drowsiness, muscle relaxation, and low blood pressure. Prochlorperazine is generally less sedating than other similar medicines, and it is less likely to increase the effects of other drugs that cause drowsiness. It may also block the P2X7 receptor in human cells, which can help control calcium levels.
How Prochlorperazine Edisylate works in the bodyThe exact way prochlorperazine works is unknown, but it's thought to be linked to its ability to block dopamine receptors in the brain. Blocking these receptors stops them from receiving signals and increases the amount of dopamine in the body. Prochlorperazine is believed to stop nausea and vomiting by blocking serotonin and dopamine receptors in a special area of the brain called the chemoreceptor trigger zone. It also helps inhibit vomiting caused by apomorphine.
When to interrupt dosage
The proposed measure of Prochlorperazine Edisylate is contingent upon the diagnosed malady, including Tension Headache, Acute Coryza and Schizophrenia. The dosage will differ, based on the administration method indicated in the table below.Condition
Dosage
Administration
Schizophrenia
5.0 mg, , 10.0 mg, 5.0 mg/mL, 0.5 mg, 25.0 mg, 15.0 mg, 2.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Intramuscular, Injection - Intramuscular, Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Syrup, Syrup - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous
Anxiety
5.0 mg, , 10.0 mg, 5.0 mg/mL, 0.5 mg, 25.0 mg, 15.0 mg, 2.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Intramuscular, Injection - Intramuscular, Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Syrup, Syrup - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous
Nausea
5.0 mg, , 10.0 mg, 5.0 mg/mL, 0.5 mg, 25.0 mg, 15.0 mg, 2.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Intramuscular, Injection - Intramuscular, Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Syrup, Syrup - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous
Tension Headache
5.0 mg, , 10.0 mg, 5.0 mg/mL, 0.5 mg, 25.0 mg, 15.0 mg, 2.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Intramuscular, Injection - Intramuscular, Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Syrup, Syrup - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous
Acute Coryza
5.0 mg, , 10.0 mg, 5.0 mg/mL, 0.5 mg, 25.0 mg, 15.0 mg, 2.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Intramuscular, Injection - Intramuscular, Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Syrup, Syrup - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous
Warnings
Prochlorperazine Edisylate ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Operative Surgery
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Comatose
Do Not Combine
Common Prochlorperazine Edisylate Drug Interactions
Drug Name
Risk Level
Description
Amisulpride
Major
Prochlorperazine may increase the antipsychotic activities of Amisulpride.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Arsenic trioxide.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Asenapine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Prochlorperazine.
Prochlorperazine Edisylate Toxicity & Overdose RiskThe lowest toxic dose of prochlorperazine in rats is 750mg/kg. Elderly patients taking this medication have an increased risk of death due to heart failure or infection. Prochlorperazine can also increase the risk of developing tardive dyskinesia, a syndrome of involuntary movements, or neuroleptic malignant syndrome, a potentially fatal condition. If someone has overdosed on prochlorperazine, the treatment should be supportive and include medications to reduce symptoms like dystonia, stimulants, and medications to treat agitation or restlessness. Other symptoms of overdose can include seizures, changes in heart rate,
Prochlorperazine Edisylate Novel Uses: Which Conditions Have a Clinical Trial Featuring Prochlorperazine Edisylate?
171 active clinical trials are currently in progress to assess the efficacy of Prochlorperazine Edisylate in treating Schizophrenia, Acute Coryza and Tension Headache.Condition
Clinical Trials
Trial Phases
Acute Coryza
0 Actively Recruiting
Schizophrenia
174 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Nausea
0 Actively Recruiting
Tension Headache
0 Actively Recruiting
Anxiety
0 Actively Recruiting
Prochlorperazine Edisylate Reviews: What are patients saying about Prochlorperazine Edisylate?
5Patient Review
11/14/2009 I've been taking this medication for a long time, but since being diagnosed with MS, it's become clear that it's not good to use for severe nausea. I'm now on Tysabri and Lyrica, which are much better options if you're dealing with MS-induced nausea.
5Patient Review
6/3/2009 I have bipolar type 1 and I've been told that this could cause a different reaction when taken with my oral medication.
5Patient Review
3/27/2009 The pill does help with vomiting, but unfortunately I became immune to its effects after awhile. The nausea persists even now.
5Patient Review
10/3/2009 I was diagnosed with bipolar 1 and my doctor said that I shouldn't use this drug because it would interfere with the medication I take for my illness.
5Patient Review
11/19/2012 I've only taken this medication twice, but it seems to work well in conjunction with Zofran.
4.3Patient Review
7/2/20084Patient Review
8/6/2011 This medication is very effective for nausea, whether it's from migraines or other painkillers. The hardest part is actually getting it down my throat, but once it's there it does its job well!
4Patient Review
10/8/2016 I had a very severe reaction to this medication, to the point where I convulsed and had to be hospitalized. Please be cautious and consult your doctor before taking this drug.
3.3Patient Review
7/24/2010 This treatment is effective for me as I am a cancer patient.
3.3Patient Review
12/9/20071.7Patient Review
2/11/20091Patient Review
12/16/2013 This was my last resort and it finally worked.
1Patient Review
7/2/2008Patient Q&A Section about prochlorperazine edisylate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is prochlorperazine 5mg addictive?
"While prochlorperazine is not typically considered an addictive substance, it is possible to develop a physical dependence on it. Additionally, the medication can be abused."
Answered by AI
What drug class does prochlorperazine belong to?
"Prochlorperazine is a part of a group of medications known as traditional antipsychotics. It helps to reduce unusual brain activity."
Answered by AI
What is prochlorperazine Edisylate used for?
"This medication is used to treat severe nausea and vomiting from certain causes, such as after surgery or cancer treatment. Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery."
Answered by AI
What is the other name for prochlorperazine?
"Prochlorperazine is a medication that goes by the brand names Stemetil and Buccastem. It is used to treat conditions such as nausea, vomiting, and vertigo."
Answered by AI