Proair Hfa

Hyperkalemia, Acute Bronchitis, Pneumonia + 18 more

Treatment

9 FDA approvals

20 Active Studies for Proair Hfa

Treatment for

Hyperkalemia

What is Proair Hfa

Salbutamol

The Generic name of this drug

Treatment Summary

Salbutamol is a medication used to treat asthma and COPD. It is a selective beta2-adrenergic receptor agonist that is 29 times more effective at targeting the lungs compared to the heart. Salbutamol is a mixture of two different isomers, the R- and S-isomers. The R-isomer is 150 times more effective than the S-isomer, but it is also more expensive. Salbutamol is used to treat acute episodes of bronchospasm, prevent exercise-induced asthma, and treat chronic respiratory disorders like COPD.

Proair HFA

is the brand name

image of different drug pills on a surface

Proair Hfa Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Proair HFA

Salbutamol

1981

314

Approved as Treatment by the FDA

Salbutamol, also known as Proair HFA, is approved by the FDA for 9 uses like prophylaxis of Exercise-induced bronchospasm and prophylaxis of Bronchospasm .

prophylaxis of Exercise-induced bronchospasm

prophylaxis of Bronchospasm

Bronchospasm, Exercise-Induced

Bronchial Spasm

Asthma, Exercise-Induced

Chronic Obstructive Pulmonary Disease

Used to treat Chronic Obstructive Pulmonary Disease (COPD) in combination with Ipratropium

Bronchodilator Agents

Used to treat need of more than one bronchodilator in combination with Ipratropium

Exercise-Induced Bronchospasm

Bronchospasm

Effectiveness

How Proair Hfa Affects Patients

Salbutamol, also known as albuterol, is a drug used to open up the airways and make it easier to breathe. It works by stimulating the beta-1 and beta-2 receptors in the body, causing vasodilation, muscle relaxation, and a faster heartbeat. Although Salbutamol is mostly specific to the beta-2 receptors, it can still affect beta-1 receptors which can cause an increase in insulin and sugar levels in the blood. Salbutamol may also cause a decrease in potassium levels.

How Proair Hfa works in the body

Salbutamol works by activating beta2-adrenergic receptors on airway smooth muscle. This activates a chemical process that relaxes the muscle and lowers the amount of calcium in the cells. This reduces the tension in the muscles, allowing the airways to open up. Salbutamol also prevents the release of mediators from mast cells in the airway. It's usually effective within 5 to 15 minutes and can last up to 6 hours. It has fewer cardiovascular side effects than isoproterenol and produces more respiratory relief.

When to interrupt dosage

The suggested measure of Proair Hfa is contingent upon the diagnosed condition, including Bronchodilator Agents, Emphysema and Wheezing. The quantity of dosage fluctuates in agreement with the technique of delivery featured in the table underneath.

Condition

Dosage

Administration

Bronchial Spasm

2.0 mg/mL, , 2.5 mg/mL, 0.09 mg, 3.0 mg/mL, 2.0 mg, 4.0 mg, 8.0 mg, 0.75 mg/mL, 1.5 mg/mL, 25.0 mg/mL, 0.63 mg/mL, 1.25 mg/mL, 0.108 mg, 5.0 mg/mL, 2.4 mg, 0.045 mg, 3.0 mg, 0.4 mg, 0.2 mg, 0.1 mg, 0.05 %, 0.1 %, 0.2 %, 0.83 mg/mL, 0.12 mg, 4.8 mg, 0.00009 mg/mg, 1.0 mg/mL, 0.1 mg/dose, 0.5 mg/mL, 0.2 mg/pump actuation, 0.097 mg/pump actuation, 0.1 mg/pump actuation, 0.4 mg/mL, 0.25 mg/mL, 0.12 mg/pump actuation

, Oral, Syrup, Syrup - Oral, Solution - Respiratory (inhalation), Respiratory (inhalation), Solution, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intrabronchial, Solution - Intrabronchial, Solution - Oral, Aerosol, metered - Oral, Tablet, extended release, Tablet, extended release - Oral, Powder, Powder - Respiratory (inhalation), Liquid, Liquid - Respiratory (inhalation), Liquid - Intravenous, Liquid - Intramuscular, Intramuscular, Capsule - Respiratory (inhalation), Liquid - Oral, Capsule, Spray, metered, Spray, metered - Respiratory (inhalation), Powder, metered, Powder, metered - Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Aerosol, spray - Oral, Aerosol, spray, Spray, Spray - Oral, Aerosol, metered - Intrabronchial, Nasal, Inhalant - Nasal, Inhalant - Oral, Solution - Nasal, Occlusive dressing technique, Syrup - Occlusive dressing technique, Solution - Intravenous, Intravenous, Solution - Intramuscular

prophylaxis of Bronchospasm

Emphysema

Influenza

Bronchitis, Chronic

Asthma, Exercise-Induced

Asthma

Bronchitis

Airway secretion clearance therapy

excess mucus or phlegm

Bronchodilator Agents

Asthma

Respiratory Tract Infections

Bronchodilation

Asthma

Acute Bronchitis

Hyperkalemia

Pneumonia

Bronchospasm, Exercise-Induced

Chronic Obstructive Pulmonary Disease

Warnings

There are 20 known major drug interactions with Proair Hfa.

Common Proair Hfa Drug Interactions

Drug Name

Risk Level

Description

Hydroxyzine

Major

The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Hydroxyzine.

Mobocertinib

Major

The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Mobocertinib.

Ziprasidone

Major

The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Ziprasidone.

1-benzylimidazole

Minor

The risk or severity of hypertension can be increased when Salbutamol is combined with 1-benzylimidazole.

2,5-Dimethoxy-4-ethylamphetamine

Minor

The risk or severity of hypertension can be increased when Salbutamol is combined with 2,5-Dimethoxy-4-ethylamphetamine.

Proair Hfa Toxicity & Overdose Risk

Signs of an overdose on Albuterol include high heart rate, high or low blood pressure, seizures, headache, trembling, muscle cramps, dry mouth, palpitations, nausea, dizziness, tiredness, difficulty sleeping, high blood sugar, low potassium, and acidosis. Pregnant women should use caution when taking Albuterol as there is a risk of birth defects. Nursing mothers should also use caution and talk to their doctor as Albuterol can be passed through breast milk. Albuterol has not been tested in children under 4 years of age. Elderly patients should start with a lower

image of a doctor in a lab doing drug, clinical research

Proair Hfa Novel Uses: Which Conditions Have a Clinical Trial Featuring Proair Hfa?

383 active trials are currently being conducted to ascertain the potential of Proair Hfa to alleviate Respiratory Tract Infections, Asthma and Chronic Obstructive Pulmonary Disease (COPD).

Condition

Clinical Trials

Trial Phases

Bronchospasm, Exercise-Induced

0 Actively Recruiting

Chronic Obstructive Pulmonary Disease

68 Actively Recruiting

Phase 3, Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4

Asthma

78 Actively Recruiting

Phase 1, Phase 4, Early Phase 1, Not Applicable, Phase 2, Phase 3

prophylaxis of Bronchospasm

0 Actively Recruiting

Influenza

24 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Phase 1, Phase 3

Hyperkalemia

4 Actively Recruiting

Phase 3, Not Applicable, Phase 2, Phase 1

Bronchitis, Chronic

0 Actively Recruiting

excess mucus or phlegm

0 Actively Recruiting

Bronchodilator Agents

0 Actively Recruiting

Pneumonia

14 Actively Recruiting

Not Applicable, Early Phase 1, Phase 2, Phase 4

Bronchial Spasm

0 Actively Recruiting

Asthma

1 Actively Recruiting

Phase 2

Airway secretion clearance therapy

0 Actively Recruiting

Respiratory Sounds

4 Actively Recruiting

Phase 2, Phase 3

Asthma

1 Actively Recruiting

Phase 4

Asthma, Exercise-Induced

0 Actively Recruiting

Emphysema

4 Actively Recruiting

Phase 2, Not Applicable

Bronchitis

0 Actively Recruiting

Acute Bronchitis

8 Actively Recruiting

Phase 4, Not Applicable, Phase 3, Early Phase 1

Bronchodilation

0 Actively Recruiting

Proair Hfa Reviews: What are patients saying about Proair Hfa?

Patient Review

7/27/2022

Proair Hfa for Asthma

I have seen people complain about only getting 40 good puffs out of this before it clogs. My friend suggested that I rinse the applicator under running hot water, let it air dry overnight, and shake it at least 20 times before using. This has worked really well for me and I haven't had any issues since.

Patient Review

4/17/2017

Proair Hfa for Asthma

Works really quickly for me, which is a lifesaver given my asthma.

4.3

Patient Review

12/1/2017

Proair Hfa for Chronic Obstructive Lung Disease

I've been using this since March 2017 to help manage my breathing. So far, it's been effective in helping me avoid triggering an attack.

Patient Review

12/16/2017

Proair Hfa for Asthma

This inhaler didn't work very well for my severe asthma and it's extremely expensive.

1.7

Patient Review

6/10/2019

Proair Hfa for Asthma

This inhaler is effective when it works, but only for about 60 puffs. After that, the spray nozzle gets clogged and it's effectively useless. As someone with asthma, this is not a very comforting feeling.

Patient Review

8/31/2017

Proair Hfa for Asthma

In my 40 years of experience with asthma, I have found PROAIR to be the worst inhaler on the market. VENTOLIN is much more effective in my opinion. It seems like the decision to stop production of the other inhalers was made by people who don't suffer from asthma and don't understand how important a good inhaler can be.

Patient Review

1/25/2017

Proair Hfa for Bronchitis

I sought out medical attention for my cough at an urgent care, and they prescribed me this inhaler. Unfortunately, it did nothing to improve my condition over the course of four or five days. If you're considering this medication, I would recommend looking elsewhere – Symbicort worked much better for me.

Patient Review

4/29/2018

Proair Hfa for Chronic Obstructive Lung Disease

My husband needed to start using an inhaler and Ventolin worked great for him, but then his doctor prescribed Proventil and our insurance gave us ProAir. The pump was faulty from the beginning; I never experienced this issue when I had asthma years ago. It's a waste of money and it's dangerous--this should be taken off the market.

Patient Review

11/29/2017

Proair Hfa for Asthma Attack

Do not bother with this inhaler. It actually makes your breathing worse by using a powder instead of liquid. I've had to go to the ER twice now because Walgreens won't give me Proventil, which is what my doctor prescribed in the first place.

Patient Review

1/9/2019

Proair Hfa for Asthma

The propulsion system is way too weak on this product. I often can't tell if I'm actually receiving the medication or not. It's very scary not knowing whether or not the invisible mist is working, but my insurance won't pay for anything else. If you can, try to get a different prescription from your doctor.

Patient Review

5/18/2021

Proair Hfa for Asthma

The new design for this inhaler is really not good. You just have to huff it, and there's no indicator if you're actually getting any medicine. I'm worried that if I have a real asthma attack, I won't be able to get the right dosage because of how hard you have to puff. Avoid this new model altogether and stick with the old one.

Patient Review

2/12/2017

Proair Hfa for Asthma Attack

This medication didn't do much for me, and actually made my symptoms worse.

Patient Review

8/4/2020

Proair Hfa for Asthma Attack

I have both asthma and RA, which makes using my hands difficult. Proair is very hard for me to use; I can't open the lid or compress the canister, so it doesn't help me during an asthma attack. It's also more expensive than other inhalers that actually work.

Patient Review

9/5/2018

Proair Hfa for Asthma

This product has not worked for me at all, and the delivery system has failed on three separate occasions. I've had to get replacements from my pharmacy, but it's been an expensive process.

Patient Review

2/9/2017

Proair Hfa for Chronic Obstructive Lung Disease

I think this drug is dangerous and not at all effective. My pharmacist told me that the doctors who prescribe proair receive a "thank you" payment of $25 from the pharmaceutical company. I find this unethical and will be asking my doctor to switch my prescription next week.

Patient Review

9/7/2022

Proair Hfa for Asthma Attack

I was very disappointed with this product. It spits instead of making a mist, and I saw no relief from my asthma symptoms.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about proair hfa

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many times a day can I use my ProAir inhaler?

"The bronchodilator inhalers should be used 4-6 times a day since the medication works for 4-6 hours after inhaling it."

Answered by AI

Is ProAir inhaler a steroid?

"Proair is a medication used to treat and prevent wheezing and shortness of breath caused by asthma. Proair is a bronchodilator, and Symbicort is a combination of a steroid and a long-acting bronchodilator."

Answered by AI

Is ProAir HFA the same as albuterol?

"The generic version of ProAir HFA is called albuterol sulfate. It is an exact copy of the active drug in ProAir HFA and is just as safe and effective."

Answered by AI

What is ProAir HFA inhaler used for?

"Albuterol belongs to a class of drugs known as bronchodilators.

Albuterol sulfate is a generic drug that is used to prevent and treat wheezing and shortness of breath caused by breathing problems such as asthma and chronic obstructive pulmonary disease. Albuterol is also used to prevent asthma that is brought on by exercise. bronchodilators."

Answered by AI

Clinical Trials for Proair Hfa

Image of Children's of Alabama in Birmingham, United States.

Antibiotic Duration for Infections in Children

60 - 17

All Sexes

Birmingham, AL

Infections like pneumonia, skin and soft tissue infection (also called SSTI or cellulitis), and urinary tract infections (UTI) are some of the most common reasons children get admitted to the hospital. All three of these conditions require antibiotics for treatment. Although antibiotics are needed to treat the infection and help children feel better, taking them longer than needed can negatively impact children and their families. Negative impacts include things like the burdens of taking more medications and medication side effects. There are guidelines (instructions) from expert medical organizations that suggest the number of days children need antibiotics, but they give a wide range (between 5 and 14 days). Unfortunately, these guidelines are not based on high-quality studies. National data suggests that doctors often choose on the higher end of this range when writing prescriptions for children in the hospital. Our three caregiver co-investigators, other parents of hospitalized children, doctors, other care providers, and researchers, all believe that additional study is needed to determine the best length of antibiotic treatment that weighs both the benefits and harms of antibiotics. The goal of our study is to understand if 5 total days of antibiotic treatment compared to 10 total days of antibiotic treatment is better for children who have been in the hospital for pneumonia, SSTI, or UTI. We will study this question through a randomized control trial. In other words, half of the children will receive 5-days of antibiotics and the other half will receive 10-days of antibiotics. Children in this study (and their caregivers) will not know how many days of antibiotics they will receive to cure their infection because some children will take a placebo (or a pill without antibiotics in it). Only the pharmacy will know if a child is getting antibiotic or placebo (for days 6-10 of treatment). During the first phase of the trial (feasibility phase), 4 hospitals will enroll children in the study. We plan on enrolling 50 patients during this phase. We are starting with just 4 hospitals, so our study team can create and update our study plans if needed. We will closely review information about how many patients and families agree to participate, and if they have any trouble completing any part of the study. We will also interview families to understand the choice to participate in the study, the choice not to participate in the study, and what it is like to be in the study. During the second study phase, we will enroll 1150 more patients across all 11 hospitals. Families will complete short, daily surveys until the 15th day after they started antibiotics, then a larger survey at day 15, at day 20, and at day 30. These surveys will ask about the child's symptoms and recovery from their illness, how the antibiotics are making them feel, and if they had to go back to their doctor, emergency room, or hospital. The answers to these questions will be combined to measure how well the child did, balancing feeling better and having bad effects from the antibiotics. We will use mathematical tests to determine which antibiotic duration is better for treating these illnesses. We will complete other mathematical tests to see if all children should receive the same length of antibiotics or if certain children should be prescribed shorter courses and others longer courses.

Phase 4

Waitlist Available

Drug

Children's of Alabama (+9 Sites)

Sunitha V Kaiser, MD, MSc