Prexxartan

Hypesthesia, Hypesthesia, Hypesthesia + 15 more
Treatment
11 FDA approvals
20 Active Studies for Prexxartan

What is Prexxartan

ValsartanThe Generic name of this drug
Treatment SummaryValsartan is an antihypertensive medication used to reduce high blood pressure. It belongs to a class of drugs called angiotensin II receptor blockers (ARBs) and works by blocking the action of angiotensin II, a hormone that causes the blood vessels to narrow. This leads to lower blood pressure, improved heart function, and reduced risk of heart attack and stroke. Valsartan is also used to treat heart failure, diabetic nephropathy, and other conditions. It was approved by the European Medicines Agency in 1996 and by the US Food and Drug Administration in 1997. Valsartan
Diovanis the brand name
image of different drug pills on a surface
Prexxartan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Diovan
Valsartan
1996
621

Approved as Treatment by the FDA

Valsartan, also known as Diovan, is approved by the FDA for 11 uses such as Heart failure and Moderate Essential Hypertension .
Heart failure
Used to treat Heart Failure in combination with Sacubitril
Moderate Essential Hypertension
Used to treat Moderate Essential Hypertension in combination with Hydrochlorothiazide
chronic heart failure with reduced ejection fraction (NYHA Class II-IV)
Used to treat chronic heart failure with reduced ejection fraction (NYHA Class II-IV) in combination with Sacubitril
Heart Failure
Used to treat hospitalization due to cardiac failure in combination with Sacubitril
Systolic Left Ventricular Dysfunction
Used to treat Systolic Left Ventricular Dysfunction in combination with Sacubitril
High Blood Pressure
Used to treat Moderate Essential Hypertension in combination with Hydrochlorothiazide
Combined Modality Therapy
Used to treat patients for whom combination therapy is appropriate in combination with Hydrochlorothiazide
Cardiovascular Mortality
Used to treat Cardiovascular Mortality in combination with Sacubitril
Hypesthesia
Used to treat chronic heart failure with reduced ejection fraction (NYHA Class II-IV) in combination with Sacubitril
Congestive Heart Failure
Used to treat Heart Failure in combination with Sacubitril
Ventricular Dysfunction, Left
Used to treat Systolic Left Ventricular Dysfunction in combination with Sacubitril

Effectiveness

How Prexxartan Affects PatientsValsartan stops the effects of a hormone called angiotensin II which helps regulate blood pressure. In most cases, taking 80mg of valsartan can reduce blood pressure by about 80%. Taking valsartan may cause a slight decrease in aldosterone, but it does not usually have any effect on cholesterol, triglycerides, glucose, or uric acid. In some cases, valsartan may cause low blood pressure, especially in people with heart failure or those taking high doses of diuretics. People with kidney problems may also be more likely to experience a decrease in renal function. Taking vals
How Prexxartan works in the bodyValsartan is a drug that helps control high blood pressure. It works by blocking a receptor in the body, known as the angiotensin receptor 1 (AT1). This stops the body from making a specific hormone called angiotensin II, which can make your blood pressure rise. By blocking this receptor, valsartan helps reduce your blood pressure and protect against heart failure, stroke, and kidney disease. Valsartan is commonly used to manage hypertension, heart failure, and type 2 diabetes-associated nephropathy. It has also been proven to reduce the risk of myocardial infarction

When to interrupt dosage

The suggested measure of Prexxartan is conditional upon the diagnosed condition, including initial treatment, Left Ventricular Failure, Unspecified and Combined Modality Therapy. The amount also fluctuates as per the technique of delivery (e.g. Tablet - Oral or Tablet, film coated) outlined in the below table.
Condition
Dosage
Administration
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Diabetic Nephropathies
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Congestive Heart Failure
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Type 2 Diabetes
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
High Blood Pressure
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Cardiovascular Mortality
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypertensive disease
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Combined Modality Therapy
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
initial treatment
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
multiple antihypertensive drugs likely required
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
not adequately controlled with monotherapy
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Ventricular Dysfunction, Left
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Left Ventricular Failure, Unspecified
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Ventricular Dysfunction, Left
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Heart Failure
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral

Warnings

Prexxartan Contraindications
Condition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
Breast Milk Production
Do Not Combine
Diabetes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Valsartan may interact with Pulse Frequency
There are 20 known major drug interactions with Prexxartan.
Common Prexxartan Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Valsartan.
Amifostine
Major
Valsartan may increase the hypotensive activities of Amifostine.
Cabozantinib
Major
The metabolism of Cabozantinib can be decreased when combined with Valsartan.
Capecitabine
Major
The metabolism of Capecitabine can be decreased when combined with Valsartan.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Valsartan.
Prexxartan Toxicity & Overdose RiskThe amount of valsartan needed to be toxic to rats is greater than 2000mg/kg. Studies have not found any teratogenic effects in pregnant mice, rats, and rabbits when given up to 600mg/kg/day, 10mg/kg/day respectively. However, there have been reports of reduced fetal weight, reduced pup birth weight, decreased pup survival rate, and delays in development when pregnant rats were treated with valsartan at maternally toxic doses of 600mg/kg/day during organogenesis or late gestation and lactation. If pregnancy is detected, valsartan should be discontinued.
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Prexxartan Novel Uses: Which Conditions Have a Clinical Trial Featuring Prexxartan?

510 active trials are being conducted to assess the potential of Prexxartan in alleviating Type 2 Diabetes, Diabetic Nephropathy and Hypertension.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
179 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Hypesthesia
7 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1
Diabetic Nephropathies
0 Actively Recruiting
Ventricular Dysfunction, Left
1 Actively Recruiting
Phase 2, Phase 3
High Blood Pressure
4 Actively Recruiting
Not Applicable, Early Phase 1
Congestive Heart Failure
175 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Hypesthesia
2 Actively Recruiting
Not Applicable
Cardiovascular Mortality
0 Actively Recruiting
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Ventricular Dysfunction, Left
0 Actively Recruiting
Combined Modality Therapy
0 Actively Recruiting
Heart Failure
0 Actively Recruiting
Left Ventricular Failure, Unspecified
0 Actively Recruiting
Hypesthesia
0 Actively Recruiting
not adequately controlled with monotherapy
0 Actively Recruiting
Hypesthesia
10 Actively Recruiting
Not Applicable, Phase 1
initial treatment
0 Actively Recruiting
multiple antihypertensive drugs likely required
0 Actively Recruiting

Prexxartan Reviews: What are patients saying about Prexxartan?

5Patient Review
6/15/2017
Prexxartan for High Blood Pressure
I switched from Atenolol to Losartan, and it's been working great so far. My blood pressure is down to a healthy 175/75.
5Patient Review
11/22/2018
Prexxartan for High Blood Pressure
This is an effective treatment for me.
5Patient Review
11/22/2018
Prexxartan for High Blood Pressure
I found this treatment to be highly effective.
5Patient Review
6/15/2017
Prexxartan for High Blood Pressure
I had to switch from Atenolol to losartan after 20 years, and I'm really happy with the results. My blood pressure is now down to a much healthier level, and I haven't experienced any negative side effects so far.
4.7Patient Review
9/26/2019
Prexxartan for High Blood Pressure
Helps a lot with my chest pain and breathing. I did experience some slight side effects, but it's worth it because this medication literally saved my life.
View All Reviews

Patient Q&A Section about prexxartan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can I chew valsartan?

"Do not break, crush, or chew the tablet. You may take this medicine with or without food. If you are also using cholestyramine or colestipol, take these at least 4 hours before or after you take this medicine."

Answered by AI

Why was Prexxartan discontinued?

"A citizen petition was submitted to the FDA requesting that they determine whether or not PREXXARTAN (valsartan) oral solution, 20 mg/5 mL, was withdrawn from sale for reasons of safety or effectiveness. Although the citizen petition did not address the 80 mg/20 mL strength, that strength has also been discontinued."

Answered by AI

What is the Drug valsartan used for?

"UK

The medicine Valsartan is used to treat high blood pressure and heart failure."

Answered by AI

Is there a liquid form of valsartan?

"Prexxartan, which was approved by the FDA in December 2017, is the first oral liquid dosage form of valsartan that has been approved for use in the United States. Valsartan is an angiotensin II receptor blocker (ARB) that is used to treat heart failure, left ventricular dysfunction, and high blood pressure."

Answered by AI

Clinical Trials for Prexxartan

Have you considered Prexxartan clinical trials? We made a collection of clinical trials featuring Prexxartan, we think they might fit your search criteria.
Have you considered Prexxartan clinical trials? We made a collection of clinical trials featuring Prexxartan, we think they might fit your search criteria.
Have you considered Prexxartan clinical trials? We made a collection of clinical trials featuring Prexxartan, we think they might fit your search criteria.
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