Prexxartan

Hypesthesia, Hypesthesia, Hypesthesia + 15 more
Treatment
7 FDA approvals
20 Active Studies for Prexxartan

What is Prexxartan

ValsartanThe Generic name of this drug
Treatment SummaryValsartan is an antihypertensive medication used to reduce high blood pressure. It belongs to a class of drugs called angiotensin II receptor blockers (ARBs) and works by blocking the action of angiotensin II, a hormone that causes the blood vessels to narrow. This leads to lower blood pressure, improved heart function, and reduced risk of heart attack and stroke. Valsartan is also used to treat heart failure, diabetic nephropathy, and other conditions. It was approved by the European Medicines Agency in 1996 and by the US Food and Drug Administration in 1997. Valsartan
Diovanis the brand name
image of different drug pills on a surface
Prexxartan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Diovan
Valsartan
1996
621

Approved as Treatment by the FDA

Valsartan, also known as Diovan, is approved by the FDA for 7 uses such as Hypesthesia and hospitalization due to cardiac failure .
Hypesthesia
Used to treat chronic heart failure with reduced ejection fraction (NYHA Class II-IV) in combination with Sacubitril
hospitalization due to cardiac failure
Used to treat hospitalization due to cardiac failure in combination with Sacubitril
Ventricular Dysfunction, Left
Used to treat Systolic Left Ventricular Dysfunction in combination with Sacubitril
Cardiovascular Mortality
Used to treat Cardiovascular Mortality in combination with Sacubitril
High Blood Pressure
Used to treat Moderate Essential Hypertension in combination with Hydrochlorothiazide
Combined Modality Therapy
Used to treat patients for whom combination therapy is appropriate in combination with Hydrochlorothiazide
Congestive Heart Failure
Used to treat Heart Failure in combination with Sacubitril

Effectiveness

How Prexxartan Affects PatientsValsartan stops the effects of a hormone called angiotensin II which helps regulate blood pressure. In most cases, taking 80mg of valsartan can reduce blood pressure by about 80%. Taking valsartan may cause a slight decrease in aldosterone, but it does not usually have any effect on cholesterol, triglycerides, glucose, or uric acid. In some cases, valsartan may cause low blood pressure, especially in people with heart failure or those taking high doses of diuretics. People with kidney problems may also be more likely to experience a decrease in renal function. Taking vals
How Prexxartan works in the bodyValsartan is a drug that helps control high blood pressure. It works by blocking a receptor in the body, known as the angiotensin receptor 1 (AT1). This stops the body from making a specific hormone called angiotensin II, which can make your blood pressure rise. By blocking this receptor, valsartan helps reduce your blood pressure and protect against heart failure, stroke, and kidney disease. Valsartan is commonly used to manage hypertension, heart failure, and type 2 diabetes-associated nephropathy. It has also been proven to reduce the risk of myocardial infarction

When to interrupt dosage

The suggested measure of Prexxartan is conditional upon the diagnosed condition, including initial treatment, Left Ventricular Failure, Unspecified and Combined Modality Therapy. The amount also fluctuates as per the technique of delivery (e.g. Tablet - Oral or Tablet, film coated) outlined in the below table.
Condition
Dosage
Administration
Left Ventricular Dysfunction
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
initial treatment
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Diabetic Nephropathy
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Type 2 Diabetes
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Left Ventricular Failure, Unspecified
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Cardiovascular Mortality
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Combined Modality Therapy
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypertensive disease
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
multiple antihypertensive drugs likely required
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
High Blood Pressure
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
hospitalization due to cardiac failure
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Ventricular Dysfunction, Left
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
not adequately controlled with monotherapy
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Congestive Heart Failure
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral

Warnings

Prexxartan Contraindications
Condition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
Breast Milk Production
Do Not Combine
Diabetes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Valsartan may interact with Pulse Frequency
There are 20 known major drug interactions with Prexxartan.
Common Prexxartan Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Valsartan.
Amifostine
Major
Valsartan may increase the hypotensive activities of Amifostine.
Cabozantinib
Major
The metabolism of Cabozantinib can be decreased when combined with Valsartan.
Capecitabine
Major
The metabolism of Capecitabine can be decreased when combined with Valsartan.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Valsartan.
Prexxartan Toxicity & Overdose RiskThe amount of valsartan needed to be toxic to rats is greater than 2000mg/kg. Studies have not found any teratogenic effects in pregnant mice, rats, and rabbits when given up to 600mg/kg/day, 10mg/kg/day respectively. However, there have been reports of reduced fetal weight, reduced pup birth weight, decreased pup survival rate, and delays in development when pregnant rats were treated with valsartan at maternally toxic doses of 600mg/kg/day during organogenesis or late gestation and lactation. If pregnancy is detected, valsartan should be discontinued.
image of a doctor in a lab doing drug, clinical research

Prexxartan Novel Uses: Which Conditions Have a Clinical Trial Featuring Prexxartan?

510 active trials are being conducted to assess the potential of Prexxartan in alleviating Type 2 Diabetes, Diabetic Nephropathy and Hypertension.
Condition
Clinical Trials
Trial Phases
initial treatment
0 Actively Recruiting
Combined Modality Therapy
0 Actively Recruiting
Cardiovascular Mortality
0 Actively Recruiting
hospitalization due to cardiac failure
0 Actively Recruiting
not adequately controlled with monotherapy
0 Actively Recruiting
Hypesthesia
8 Actively Recruiting
Not Applicable, Phase 1
Ventricular Dysfunction, Left
1 Actively Recruiting
Phase 2, Phase 3
Hypertensive disease
18 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Hypesthesia
5 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1
High Blood Pressure
0 Actively Recruiting
Type 2 Diabetes
190 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Hypesthesia
4 Actively Recruiting
Not Applicable
Congestive Heart Failure
317 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
multiple antihypertensive drugs likely required
0 Actively Recruiting
Left Ventricular Failure, Unspecified
0 Actively Recruiting
Hypesthesia
0 Actively Recruiting
Left Ventricular Dysfunction
6 Actively Recruiting
Not Applicable, Phase 4

Prexxartan Reviews: What are patients saying about Prexxartan?

5Patient Review
6/15/2017
Prexxartan for High Blood Pressure
I switched from Atenolol to Losartan, and it's been working great so far. My blood pressure is down to a healthy 175/75.
5Patient Review
11/22/2018
Prexxartan for High Blood Pressure
This is an effective treatment for me.
5Patient Review
11/22/2018
Prexxartan for High Blood Pressure
I found this treatment to be highly effective.
5Patient Review
6/15/2017
Prexxartan for High Blood Pressure
I had to switch from Atenolol to losartan after 20 years, and I'm really happy with the results. My blood pressure is now down to a much healthier level, and I haven't experienced any negative side effects so far.
4.7Patient Review
9/26/2019
Prexxartan for High Blood Pressure
Helps a lot with my chest pain and breathing. I did experience some slight side effects, but it's worth it because this medication literally saved my life.
4.7Patient Review
9/26/2019
Prexxartan for High Blood Pressure
Helps immensely with chest pain and breathing. Will have slight side affects but it's worth it, I promise.
4.3Patient Review
6/23/2020
Prexxartan for High Blood Pressure
I started taking Atorvastatin for my cholesterol at the same time as this treatment, and I've been experiencing some digestive issues like diarrhea and excessive burping. Additionally, my gout has flared up severely.
4.3Patient Review
6/23/2020
Prexxartan for High Blood Pressure
I started taking Atorvastatin for cholesterol at the same time, and now I'm experiencing some really unpleasant side effects like diarrhea and constant burping. On top of that, my gout is flaring up worse than ever.
4Patient Review
11/5/2016
Prexxartan for High Blood Pressure
I just started taking this pill four days ago and my blood pressure has already dropped to 134/82. I've developed a bit of an itchy rash, but it's not been too bad so far. Overall, I'm much happier with this medication than my previous one; that one caused me to have an awful cough and swollen legs. It's hard to know what will work for you when it comes to medicine, since everyone's body is different. Reading reviews can be helpful, but it's important to remember that you don't know the full story of the person writing them.
4Patient Review
12/9/2016
Prexxartan for High Blood Pressure
I'm constantly coughing up mucus and it's really starting to wear me down. I never feel like I'm getting better, and Lisinopril did the same thing to me. My feet are also sore, which may or may not be related to the medication. I'll have to discuss this with my doctor tomorrow.
4Patient Review
3/31/2019
Prexxartan for High Blood Pressure
I've been on this medication for a while now, and it has helped lower my blood pressure. However, I have put on weight even though my diet and activity level haven't changed. Additionally, I seem to have lost my sense of smell.
4Patient Review
12/9/2016
Prexxartan for High Blood Pressure
I'm constantly coughing up mucus and it's really frustrating. I feel like I've had a cold for months now. I might have to switch medications again because this one doesn't seem to be working either.
4Patient Review
3/31/2019
Prexxartan for High Blood Pressure
I've been taking this drug for a while now and it has lowered my blood pressure. However, I have put on some weight even though my diet and physical activity haven't changed. Additionally, I can no longer smell as well as I used to.
4Patient Review
11/5/2016
Prexxartan for High Blood Pressure
I've only been taking this medication for four days, and my blood pressure has already decreased significantly. I have started to experience an itchy rash, but it's not too bad compared to the other side effects of my previous BP medication (coughing and swollen legs). It's hard to know what will work for you without trying it, so I would recommend reading these reviews with a grain of salt.
3.7Patient Review
7/20/2017
Prexxartan for High Blood Pressure
I was able to see results immediately upon taking this medication for my high blood pressure. Unfortunately, I experienced shortness of breath and extreme fatigue as side effects. My doctor just prescribed me a beta blocker, so hopefully that will work better for me.
3.7Patient Review
7/20/2017
Prexxartan for High Blood Pressure
I was able to see immediate results in lowering my blood pressure with this drug. However, I experienced side effects with this drug; shortness of breath & extreme fatigue. My doctor just prescribed me a beta blocker, so hopefully that will work better for me.
3Patient Review
10/15/2020
Prexxartan for High Blood Pressure
I've seen some decent changes in my blood pressure since starting this medication, though my dosage was recently increased. I like that it's easy to work into my schedule.
3Patient Review
10/15/2020
Prexxartan for High Blood Pressure
I've seen some improvement in my blood pressure, although recently my doctor increased the dosage. I appreciate that it's easy to take this medication around my work schedule.
2.3Patient Review
4/17/2018
Prexxartan for High Blood Pressure
This did lower my blood pressure, however, the side effects were way too harsh. They included constipation, hair loss, depression, fatigue, and weight gain. I stuck it out for three months but couldn't handle it anymore.
2.3Patient Review
4/17/2018
Prexxartan for High Blood Pressure
While this did lower my blood pressure, the side effects were really tough to deal with. These included constipation, hair loss, depression, fatigue and weight gain. I gave it a good try for three months but ultimately couldn't continue.
2Patient Review
5/25/2019
Prexxartan for High Blood Pressure
I'm not sure if this drug is compatible with Atenolol 50 mg.
2Patient Review
9/23/2022
Prexxartan for High Blood Pressure
Unfortunately, this drug caused me to quickly become dehydrated and experience a gout attack. I also fainted as a result and ended up in the hospital for three days. If you have CKD or gout, steer clear of this medication!
2Patient Review
9/23/2022
Prexxartan for High Blood Pressure
Unfortunately, this drug caused me a lot of problems. I quickly became dehydrated, had a gout attack, and fainted. As a result, I spent three days in the hospital. If you have any sort of kidney disease or gout, stay away from this medication!
2Patient Review
5/25/2019
Prexxartan for High Blood Pressure
I'm not sure if this drug is compatible with Atenolol 50 mg.
1.7Patient Review
8/6/2019
Prexxartan for High Blood Pressure
After taking this treatment for three weeks, I didn't have enough energy to even walk to my mailbox.
1.7Patient Review
8/6/2019
Prexxartan for High Blood Pressure
After three weeks of using this treatment, I didn't have enough energy to even walk to my mailbox.
1.3Patient Review
10/10/2018
Prexxartan for High Blood Pressure
I first tried Losartan/HCTZ but found it made me lightheaded, constipated, and caused chest pressure. I discontinued use and just took Losartan by itself, but the side effects were even worse. I've now switched to a different medication altogether.
1.3Patient Review
10/10/2018
Prexxartan for High Blood Pressure
I had some pretty unpleasant side effects while taking this medication. Lightheadedness, constipation, and chest pressure were just a few of the problems I experienced.
1Patient Review
10/23/2016
Prexxartan for High Blood Pressure
Losartan has really messed with my body in a lot of negative ways. I've gained a ton of weight, I'm always hungry, and I sweat all the time. Not to mention, this medication hasn't even been effective at keeping my blood pressure stable. I'll be seeing my doctor soon to get off this stuff.
1Patient Review
3/3/2020
Prexxartan for High Blood Pressure
I believe Losartan triggered trigeminal neuralgia. The pain was unbearable - like having root canal work without Lignocaine. It happened within an hour of taking the first dose (quarter of usual dose taken as trial in view of previous side effects, ie 12.5mg -prescribed daily dose 50mg). It also made me feel generally unwell with fatigue.
1Patient Review
10/23/2016
Prexxartan for High Blood Pressure
I've been on Losartan for about a year and have gained 15 pounds while taking it. I always feel hungry and sweat excessively. When I started taking Losartan, my blood pressure was stabilized, but in recent months it has become very erratic. It's clear that this medication is not working and has unfavorable side effects. I don't want to take it any longer and will see my physician next week to find a more acceptable alternative.
1Patient Review
4/10/2017
Prexxartan for High Blood Pressure
I was diagnosed with high blood pressure a few years ago. This medication has been really effective in managing my condition and I haven't had any problems since starting it.
1Patient Review
4/10/2017
Prexxartan for High Blood Pressure
I was diagnosed with high blood pressure a few years ago, and this medication has been essential in keeping my numbers under control.
1Patient Review
3/3/2020
Prexxartan for High Blood Pressure
I believe Losartan caused my trigeminal neuralgia. The pain was unbearable - like having root canal work without Lignocaine. It happened within an hour of taking the first dose (quarter of usual dose taken as trial in view of previous side effects, ie 12.5mg -prescribed daily dose 50mg). It also made me feel generally unwell with fatigue.

Patient Q&A Section about prexxartan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can I chew valsartan?

"Do not break, crush, or chew the tablet. You may take this medicine with or without food. If you are also using cholestyramine or colestipol, take these at least 4 hours before or after you take this medicine."

Answered by AI

Why was Prexxartan discontinued?

"A citizen petition was submitted to the FDA requesting that they determine whether or not PREXXARTAN (valsartan) oral solution, 20 mg/5 mL, was withdrawn from sale for reasons of safety or effectiveness. Although the citizen petition did not address the 80 mg/20 mL strength, that strength has also been discontinued."

Answered by AI

What is the Drug valsartan used for?

"UK

The medicine Valsartan is used to treat high blood pressure and heart failure."

Answered by AI

Is there a liquid form of valsartan?

"Prexxartan, which was approved by the FDA in December 2017, is the first oral liquid dosage form of valsartan that has been approved for use in the United States. Valsartan is an angiotensin II receptor blocker (ARB) that is used to treat heart failure, left ventricular dysfunction, and high blood pressure."

Answered by AI

Clinical Trials for Prexxartan

Have you considered Prexxartan clinical trials? We made a collection of clinical trials featuring Prexxartan, we think they might fit your search criteria.
Have you considered Prexxartan clinical trials? We made a collection of clinical trials featuring Prexxartan, we think they might fit your search criteria.
Have you considered Prexxartan clinical trials? We made a collection of clinical trials featuring Prexxartan, we think they might fit your search criteria.