Pravachol

Mortality, Secondary prevention cardiovascular event, Hyperlipoproteinemia Type III + 22 more

Treatment

28 FDA approvals

20 Active Studies for Pravachol

Treatment for

Mortality

What is Pravachol

PravastatinThe Generic name of this drug

Treatment SummaryPravastatin is a drug used to lower cholesterol levels, first approved in the United States in 1991. It is a form of mevastatin and was the second statin to be available in the US. It was developed by Sankyo Co. Ltd. and approved by the FDA in 1991. Pravastatin is made through a fermentation process which involves hydrolyzing the lactone group and using bacteria to add an allylic 6-alcohol group.

Pravacholis the brand name

image of different drug pills on a surface

Pravachol Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Pravachol

Pravastatin

1994

391

Approved as Treatment by the FDA

Pravastatin, otherwise known as Pravachol, is approved by the FDA for 28 uses including Hypertriglyceridemia and Low-Density Lipoproteins .

Hypertriglyceridemia

Low-Density Lipoproteins

Cardiovascular Diseases

Coronary Heart Disease (CHD)

Hyperlipidemia

Helps manage Hyperlipidemias

Coronary Artery Atherosclerosis

Sudden Cardiac Death

Heterozygous Familial Hypercholesterolemia (HeFH)

Low-Density Lipoproteins

Secondary prevention cardiovascular event

elevation of serum triglyceride levels

Dysbetalipoproteinemia

Coronary Heart Disease

cholesterol

Hypercholesterolemia

Stroke

Secondary Prevention

Heart Attack

Transient Ischemic Attack (TIA)

Mortality

High Cholesterol

Helps manage Hyperlipidemias

Coronary Artery Disease

Myocardial Revascularization

Diet

Dyslipidemias

Hyperlipoproteinemia Type III

inadequate response to diet

Acute Coryza

Effectiveness

How Pravachol Affects PatientsPravastatin is a drug used to reduce cholesterol levels. It boosts the production of liver-produced proteins (LDL receptors), which decreases the amount of bad cholesterol (LDL) in the blood. In clinical trials, taking pravastatin decreased total cholesterol by 18%, LDL by 27%, and triglycerides by 6%, while increasing good cholesterol (HDL) by 4%. This can lead to a 24% decrease in the risk of death due to coronary disease. In addition, when taken with a drug called cholestyramine, pravastatin can reduce LDL levels by 50% and slow the progression of athe

How Pravachol works in the bodyPravastatin works by blocking an enzyme in the liver called HMG-CoA reductase. This enzyme helps produce cholesterol in the body, so blocking it reduces cholesterol production. Pravastatin also increases the number of LDL receptors on cells, which helps the body clear LDL cholesterol from the blood. Lastly, it reduces the amount of VLDL produced in the liver, since VLDL is a product of LDL cholesterol.

When to interrupt dosage

The endorsed measure of Pravachol is based on the diagnosed state, for instance, a conventional cholesterol-lowering diet, Hyperlipidemia and augmentation of serum triglyceride levels. The amount of medication varies, contingent upon the delivery method (e.g. Kit; Tablet; Tablet, delayed release - Oral or Kit; Tablet; Tablet, delayed release) featured in the table below.

Condition

Dosage

Administration

Myocardial Revascularization