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What is Plavix
ClopidogrelThe Generic name of this drug
Treatment SummaryClopidogrel is a medication used to reduce the risk of heart attack and stroke in people with non-ST elevated acute coronary syndrome, people with ST-elevated myocardial infarction, and people with recent or established peripheral arterial disease. It is more effective than aspirin at reducing cardiovascular outcomes in people with cardiovascular disease and it provides additional benefits for those who are already taking aspirin. Clopidogrel was approved by the FDA in 1997.
Plavixis the brand name
Plavix Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Plavix
Clopidogrel
1900
178
Approved as Treatment by the FDA
Clopidogrel, commonly known as Plavix, is approved by the FDA for 12 uses including elegible for thrombolytic therapy and Cardiovascular Events .elegible for thrombolytic therapy
Used to treat elegible for thrombolytic therapy in combination with Acetylsalicylic acid
Cardiovascular Events
Peripheral Arterial Disease
atherothrombotic events
Used to treat atherothrombotic events in combination with Acetylsalicylic acid
Myocardial Infarction
Atrial Fibrillation
Unstable Angina Pectoris
Heart Attack
Stroke
Heart Attack
Used to treat Acute Myocardial Infarction (AMI) in combination with Acetylsalicylic acid
prophylaxis of cardiovascular event
Acute Chest Syndrome
Used to treat Acute Coronary Syndrome (ACS) in combination with Acetylsalicylic acid
Effectiveness
How Plavix Affects PatientsClopidogrel is a medication that helps protect against heart attack and stroke. It is usually taken once a day, and the recommended dose is between 75-300mg. This drug has a long lasting effect and a wide range of safe doses.
How Plavix works in the bodyClopidogrel stops platelets from clumping together. It does this by binding to the ADP receptor on platelets, preventing them from receiving signals to form clumps. This binding is irreversible, so the platelets stay blocked from clumping together.
When to interrupt dosage
The prescribed dosage of Plavix is contingent upon the diagnosed state, including Myocardial Infarction, Cardiovascular Events and Heart Attack. The dose may vary as per the method of delivery (e.g. Tablet - Oral or Tablet, film coated - Oral) indicated in the table below.Condition
Dosage
Administration
prophylaxis of cardiovascular event
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Atrial Fibrillation
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
elegible for thrombolytic therapy
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Acute Chest Syndrome
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Heart Attack
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Unstable Angina Pectoris
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Myocardial Infarction
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
atherothrombotic events
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Heart Attack
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Stroke
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Cardiovascular Events
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Peripheral Arterial Disease
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Warnings
Plavix ContraindicationsCondition
Risk Level
Notes
Hemorrhage
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Clopidogrel may interact with Pulse Frequency
Common Plavix Drug Interactions
Drug Name
Risk Level
Description
Abrocitinib
Major
The risk or severity of bleeding and thrombocytopenia can be increased when Clopidogrel is combined with Abrocitinib.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Clopidogrel.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Clopidogrel.
Amodiaquine
Major
The metabolism of Amodiaquine can be decreased when combined with Clopidogrel.
Anastrozole
Major
The metabolism of Anastrozole can be decreased when combined with Clopidogrel.
Plavix Toxicity & Overdose RiskClopidogrel is toxic to mice, rats, and baboons in doses of 1500-3000mg/kg. Symptoms of overdose include vomiting, difficulty breathing, gastrointestinal bleeding, and weakness. Clopidogrel binds to platelets and remains there for 11 days, meaning it cannot be removed from the bloodstream. Platelet transfusions may be used to restore the body's ability to clot if an overdose occurs.
Plavix Novel Uses: Which Conditions Have a Clinical Trial Featuring Plavix?
245 active trials are currently underway to explore the potential of Plavix in providing relief from Peripheral Arterial Disease, Acute Chest Syndrome and Heart Attack.Condition
Clinical Trials
Trial Phases
elegible for thrombolytic therapy
0 Actively Recruiting
Peripheral Arterial Disease
39 Actively Recruiting
Phase 1, Not Applicable, Phase 3, Phase 2, Early Phase 1
Atrial Fibrillation
146 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Acute Chest Syndrome
1 Actively Recruiting
Not Applicable
Unstable Angina Pectoris
0 Actively Recruiting
Myocardial Infarction
4 Actively Recruiting
Phase 3, Not Applicable, Phase 4
Cardiovascular Events
3 Actively Recruiting
Not Applicable
prophylaxis of cardiovascular event
0 Actively Recruiting
Stroke
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Heart Attack
8 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Heart Attack
8 Actively Recruiting
Not Applicable, Phase 2, Phase 3
atherothrombotic events
0 Actively Recruiting
Plavix Reviews: What are patients saying about Plavix?
5Patient Review
2/17/2016 I took this medication for 14 months before I started bleeding from my large intestine. It was a close call, but I required 3 pints of blood and 2 saline solutions to get back to normal. This drug is very dangerous and it nearly killed me.
5Patient Review
1/3/2017 I began this treatment in December 2015 and have since then lost eyebrows and body hair, as well as experiencing thinning hair that doesn't grow back after waxing.
5Patient Review
3/2/2020 I unfortunately had a very negative reaction to Plavix and developed drug-induced Lupus. I constantly feel flu-like, with chills, fatigue, and general malaise.
5Patient Review
12/15/2020 I don't know what color this is, but it really helped me.
5Patient Review
7/5/2017 I felt really fuzzy and confused after taking this medication, and it didn't feel right.
5Patient Review
12/9/20155Patient Review
5/19/2016 I've been taking Plavix for ten years and it's really helped me.
4.7Patient Review
8/11/2016 I would like to know if anyone has experienced severe heartburn and constipation while taking this medicine. I was on it for a year in 2009 after having a heart attack and 4 stents, but don't remember having any problems. Now the doctor has put me on it because I had a TIA, but I'm experiencing heartburn and constipation.
4.3Patient Review
5/21/2016 This drug has been keeping me alive after three strokes. I have micro vascular disease, and this medication is essential for my survival.
4Patient Review
4/19/2016 This drug unfortunately came with some pretty unpleasant side effects for me, including numbness in my face and a burning feeling in my tongue. The ringing in my ears was also incredibly loud and intrusive.
3.7Patient Review
7/1/2016 I bruise easily and have developed red spots on my arms.
3Patient Review
3/20/2020 I agree with the comment made by "Whats this face". Plavix is a strong blood thinner which, if used for prolonged periods of time, can lead to bleeding in the body. If I were to use it, I would take only 1/2 a tablet each day.
2.7Patient Review
5/23/20151Patient Review
2/11/2019 I've been on Plavix for twenty years now, and it's prevented any further strokes. The only side effects I've experienced are the occasional nosebleed or bruise.
1Patient Review
8/23/2019 Unfortunately, this medication caused a lot of irritation in my bladder and groin area. If I kept taking it, I started to experience stinging and soreness in those areas.
1Patient Review
10/7/20151Patient Review
12/11/2016 The only downside I experienced with this drug was increased bruising. Other than that, it was great!
Patient Q&A Section about plavix
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are Plavix side effects?
"Bleeding that takes a long time to stop, nosebleeds, more frequent bruising, fever, muscle pain, confusion, skin rash, or itching may be signs of a problem."
Answered by AI
Is Plavix a blood thinner?
"Plavix, also known as clopidogrel, is a blood thinner that reduces the risk of blood clots. It was first approved by the FDA in 1997 and is prescribed to people who have a higher risk of cardiovascular problems, such as heart attacks or strokes."
Answered by AI
Is Plavix a blood thinner or antiplatelet?
"Clopidogrel is a medication that prevents your platelets from clumping together. By doing this, it lowers the risk of heart attack since most heart attacks are caused by a clot forming in the vessels supplying your heart."
Answered by AI
Is Plavix a strong blood thinner?
"Plavix, also known as clopidogrel, is a blood thinner that was first approved by the FDA in 1997. It is prescribed to people who have a higher risk of cardiovascular problems, such as heart attacks or strokes, in order to reduce the risk of blood clots."
Answered by AI
What is the drug Plavix used for?
"Clopidogrel is used to prevent heart attacks, strokes, and blood circulation disease in people who have heart disease, a recent heart attack, or a recent stroke."
Answered by AI