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What is Plan B One-Step
LevonorgestrelThe Generic name of this drug
Treatment SummaryLevonorgestrel (LNG) is a synthetic hormone used as a form of contraception and hormone therapy. It is sold under the brand name Plan B and can be taken as a single dose emergency contraceptive pill, released from an intrauterine device (IUD), or as a long-term subdermal implant. Levonorgestrel is the most widely used emergency contraceptive and was approved by the FDA in 1982. It is considered highly effective and does not have the estrogenic side effects of older emergency contraceptive regimens.
Triphasil-21is the brand name
Plan B One-Step Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Triphasil-21
Levonorgestrel
1984
243
Approved as Treatment by the FDA
Levonorgestrel, also known as Triphasil-21, is approved by the FDA for 6 uses including Has had at least 1 child and Postmenopausal Osteoporosis .Has had at least 1 child
Postmenopausal Osteoporosis
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
Menopause
Used to treat severe Vasomotor Symptoms Associated With Menopause in combination with Estradiol
moderate Menopausal Vasomotor Symptoms
Used to treat moderate Menopausal Vasomotor Symptoms in combination with Estradiol
Emergency Contraception
Hot flashes
Used to treat Menopause in combination with Estradiol
Effectiveness
How Plan B One-Step Affects PatientsLevonorgestrel is a hormone used as an emergency contraceptive and in certain contraceptives to prevent pregnancy. It works by interfering with ovulation, fertilization, and implantation. If taken as directed within 72 hours of intercourse, it has an 89% success rate. Implantable or intrauterine devices containing levonorgestrel have an over 99% success rate. Additionally, levonorgestrel is sometimes used in hormone therapy to help prevent endometrial cancer caused by estrogen.
How Plan B One-Step works in the bodyLevonorgestrel is a hormone used in oral contraceptives that stops ovulation by slowing the release of gonadotropin-releasing hormone from the hypothalamus. This hormone usually signals for the release of luteinizing hormone, which causes ovulation. Levonorgestrel also thickens cervical mucus, making it hard for sperm to move and survive, and changes the endometrium making it less likely for a fertilized egg to implant. When used with estrogen in hormone therapy, levonorgestrel helps reduce the risk of endometrial cancer.
When to interrupt dosage
The degree of Plan B One-Step is dependent upon the diagnosed condition, including Endometrial Hyperplasia, Emergency Contraception and Hypermenorrhea. The amount of dosage also varies as per the technique of administration featured in the table below.Condition
Dosage
Administration
Hypermenorrhea
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Emergency Contraception
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Hot flashes
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Postmenopausal Osteoporosis
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Endometrial Hyperplasia
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Has had at least 1 child
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
moderate Menopausal Vasomotor Symptoms
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Endometriosis
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Menopause
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Warnings
Plan B One-Step ContraindicationsCondition
Risk Level
Notes
Septic Abortion
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
infected abortions
Do Not Combine
HCG elevated
Do Not Combine
Pelvic Infection
Do Not Combine
Vaginitis
Do Not Combine
Acute Coryza
Do Not Combine
presence or history of breast cancer
Do Not Combine
Uterine Cervicitis
Do Not Combine
Communicable Diseases
Do Not Combine
gonococcal cervical infection
Do Not Combine
Breast Cancer
Do Not Combine
Intrauterine Devices
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
congenital or aquired uterine abnormality
Do Not Combine
Chlamydia Infections
Do Not Combine
Hypersensitivity
Do Not Combine
Emergency Contraception
Do Not Combine
Bacterial Endocarditis
Do Not Combine
lower genital tract infection
Do Not Combine
suspected pregnancy
Do Not Combine
Uterine Cervicitis
Do Not Combine
uterine neoplasia
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
history of progestogen-sensitive breast cancer
Do Not Combine
Cervical Neoplasia
Do Not Combine
Fibroid Tumor
Do Not Combine
Postpartum Endometritis
Do Not Combine
chlamydial cervical infection
Do Not Combine
PAP Test Abnormalities
Do Not Combine
acute liver disease
Do Not Combine
Uterine anomaly distorting uterine cavity
Do Not Combine
Breast Cancer
Do Not Combine
Cervical Dysplasia
Do Not Combine
Thromboembolism
Do Not Combine
Bacterial Vaginosis
Do Not Combine
history of pelvic inflammatory disease
Do Not Combine
Breast
Do Not Combine
Vaginal Bleeding
Do Not Combine
Bacterial Vaginosis
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
gonococcal cervical infection
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Levonorgestrel may interact with Pulse Frequency
Common Plan B One-Step Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Levonorgestrel.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Levonorgestrel.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Levonorgestrel.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Levonorgestrel.
Crizotinib
Major
The metabolism of Crizotinib can be decreased when combined with Levonorgestrel.
Plan B One-Step Toxicity & Overdose RiskThe lowest toxic dose of levonorgestrel in rats has been found to be greater than 5000mg/kg. Symptoms of an overdose may include nausea and bleeding, and there is no antidote. If someone overdoses on levonorgestrel, they should be given supportive care and contact the local poison control center.
Plan B One-Step Novel Uses: Which Conditions Have a Clinical Trial Featuring Plan B One-Step?
99 active experiments are being conducted to evaluate the potential of Plan B One-Step in addressing Postmenopausal Osteoporosis, Women who have had at least one child and Endometrial Hyperplasia.Condition
Clinical Trials
Trial Phases
Endometriosis
32 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 2, Phase 4, Phase 1
Menopause
0 Actively Recruiting
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Has had at least 1 child
0 Actively Recruiting
Emergency Contraception
1 Actively Recruiting
Phase 4
Endometrial Hyperplasia
9 Actively Recruiting
Phase 2, Not Applicable
Hypermenorrhea
0 Actively Recruiting
Postmenopausal Osteoporosis
3 Actively Recruiting
Not Applicable, Phase 4
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Plan B One-Step Reviews: What are patients saying about Plan B One-Step?
5Patient Review
1/7/2013 I took Plan B once and had no side effects. My period was on time after I took this drug. The only negative side effect was the fact that a month after I took plan b my period was ten days so it may mess with your cycle, but then everything will be normal again.
5Patient Review
3/1/2014 I had sex without a condom and took Plan B about an hour later. I was in the middle of my fertile period, so there was a pretty high chance that I could have gotten pregnant. But after taking the pill, I experienced no symptoms whatsoever! I was really worried that it hadn't worked, but sure enough, my period came exactly two weeks later. So this pill is definitely effective!
5Patient Review
2/1/2019 Though it was effective, my period came a week early after taking this pill. The next month it came three weeks late. I took a pregnancy test to be sure, and it turned out negative; however, I would still recommend caution if you're considering this medication.
4.7Patient Review
6/10/2014 I took this medication approximately eighteen hours after unprotected sex. I didn't experience any immediate side effects, but a few days later I had some issues with anxiety and mood swings. It was like being a hormonal thirteen-year-old again. Additionally, I felt fatigue and dizziness. Despite the negative experiences, it did work; I didn't get pregnant. So, all in all, it was worth the fifty dollars and the side effects!
4.7Patient Review
12/5/2014 At first, I had no issues with this medication. However, my period came a few days early (which isn't necessarily a bad thing). But when it did come, the pain was intense. It felt like childbirth all over again. The blood was also bright red. Thankfully, a hot bath provided some relief; however, the pain lasted throughout my entire period (although it did lessen eventually).
4.7Patient Review
5/24/2022 So glad this pill worked for me again! I started bleeding on the 15th day of taking it, which was a bit torturous waiting two weeks, but everything turned out okay in the end.
3.7Patient Review
9/7/2014 I was pleased with how well this worked in terms of preventing pregnancy; however, it threw my hormones out of whack and caused me to gain weight rapidly. Additionally, I developed acne as a result of taking this medication.
2.3Patient Review
7/24/2014 I took Plan B as directed after having unprotected sex. Unfortunately, I was one of the small percentage of women for whom it did not work and I ended up pregnant.
2.3Patient Review
6/20/2016 I got pregnant even though I took the pill within two hours of the condom breaking. Unfortunately, I miscarried later on. The doctor said it might have been because I had morning sickness and a stomach flu at the same time and couldn't eat for almost two weeks.
Patient Q&A Section about plan b one-step
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the difference between Plan B and Plan B One-Step?
"The pill contains a synthetic version of the hormone progestin, which has been used in birth control pills for over 35 years. Plan B One-Step contains a higher dose of this hormone than regular birth control pills."
Answered by AI
What is Plan B One-Step used for?
"Plan B One-Step is a morning-after pill containing the hormone levonorgestrel that can be used after unprotected sex to prevent pregnancy. Plan B One-Step can prevent ovulation, block fertilization, or keep a fertilized egg from implanting in the uterus."
Answered by AI
How effective is the Plan B One-Step?
"Plan B One-Step is most effective when taken within 72 hours of condomless sex or contraceptive failure. It reduces the chance of pregnancy by 89%."
Answered by AI
When should I take Plan B One-Step?
"Take one tablet by mouth as soon as possible after unprotected sex. The sooner it is taken, the more effective it will be. If you vomit within two hours after taking the medication, contact your doctor. You may need to take another dose."
Answered by AI