Piperacillin And Tazobactam
Pyelonephritis, Abdominal Infection, Healthcare-Associated Pneumonia + 2 more
Treatment
2 FDA approvals
2 Active Studies for Piperacillin And Tazobactam
Treatment for
Pyelonephritis
What is Piperacillin And Tazobactam
Tazobactam
The Generic name of this drug
Treatment Summary
Tazobactam is an antibiotic that prevents bacteria from becoming resistant to other antibiotics. It is often combined with Piperacillin or Ceftolozane to treat various bacterial infections. Piperacillin-tazobactam was approved by the FDA in 1994 and Ceftolozane-tazobactam was approved in 2014, providing protection against a wider range of bacterial infections. In 2019, Ceftolozane-tazobactam was also approved for treating hospital-acquired and ventilator-associated bacterial pneumonia, which can be deadly for hospitalized patients.
Zosyn
is the brand name
Piperacillin And Tazobactam Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zosyn
Tazobactam
1993
153
Approved as Treatment by the FDA
Tazobactam, commonly known as Zosyn, is approved by the FDA for 2 uses including complicated intra-abdominal bacterial infections and Abdominal Infection .
complicated intra-abdominal bacterial infections
Used to treat complicated intra-abdominal bacterial infections in combination with Ceftolozane
Abdominal Infection
Used to treat complicated intra-abdominal bacterial infections in combination with Ceftolozane
Effectiveness
How Piperacillin And Tazobactam Affects Patients
Tazobactam works by stopping bacteria that produce beta-lactamase enzymes from making them resistant to certain antibiotics. This allows other antibiotics to work against infections that would not be treatable otherwise. When combined with other antibiotics, it can be used to treat a variety of serious and life-threatening infections.
How Piperacillin And Tazobactam works in the body
Tazobactam works by stopping beta-lactamase enzymes from breaking down antibiotics like piperacillin and ceftolozane. It does this by forming a covalent bond with the enzymes, which prevents them from degrading the other drugs. This makes these drugs more effective against bacteria that normally produce beta-lactamase enzymes. Tazobactam is most effective against certain groups of beta-lactamases, but can also help inhibit other types. By itself, tazobactam has little to no antibacterial activity, so it is usually used in combination with other antibiotics.
When to interrupt dosage
The recommended dosage of Piperacillin And Tazobactam is contingent upon the identified affliction, including Pneumonia, Bacterial, Urinary tract infection and Nosocomial Pneumonia. The amount likewise modifies as indicated by the technique of delivery (e.g. Injection, powder, lyophilized, for solution or Intravenous) featured in the following table.
Condition
Dosage
Administration
Pyelonephritis
, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Abdominal Infection
, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Healthcare-Associated Pneumonia
, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Urinary tract infection
, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Pneumonia, Bacterial
, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Warnings
Piperacillin And Tazobactam Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Tazobactam may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Tazobactam may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Tazobactam may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Tazobactam may interact with Pulse Frequency
There are 20 known major drug interactions with Piperacillin And Tazobactam.
Common Piperacillin And Tazobactam Drug Interactions
Drug Name
Risk Level
Description
Didanosine
Minor
The excretion of Didanosine can be decreased when combined with Tazobactam.
Grepafloxacin
Minor
The excretion of Grepafloxacin can be decreased when combined with Tazobactam.
Lamivudine
Minor
The excretion of Lamivudine can be decreased when combined with Tazobactam.
Levofloxacin
Minor
The excretion of Levofloxacin can be decreased when combined with Tazobactam.
Stavudine
Minor
The excretion of Stavudine can be decreased when combined with Tazobactam.
Piperacillin And Tazobactam Toxicity & Overdose Risk
Taking too much piperacillin/tazobactam can cause symptoms such as nausea, vomiting, and diarrhea. It can also cause seizures or uncontrolled muscle movements. There is no specific antidote. Treatment usually involves supportive care and anticonvulsant medications if seizures occur. If the patient has an allergic reaction, they should be given adrenaline, antihistamines, corticosteroids, and oxygen. Hemodialysis can also be used to remove the drug from the bloodstream. Taking high doses of piperacillin/tazobactam can cause kidney damage in critically ill patients, so
Piperacillin And Tazobactam Novel Uses: Which Conditions Have a Clinical Trial Featuring Piperacillin And Tazobactam?
11 active clinical trials are presently assessing the potential of Piperacillin and Tazobactam to treat Nosocomial Pneumonia, Pyelonephritis and Abdominal Infections.
Condition
Clinical Trials
Trial Phases
Urinary tract infection
0 Actively Recruiting
Abdominal Infection
0 Actively Recruiting
Healthcare-Associated Pneumonia
0 Actively Recruiting
Pyelonephritis
1 Actively Recruiting
Not Applicable
Pneumonia, Bacterial
2 Actively Recruiting
Not Applicable
Piperacillin And Tazobactam Reviews: What are patients saying about Piperacillin And Tazobactam?
5
Patient Review
8/7/2011
Piperacillin And Tazobactam for Skin Infection
5
Patient Review
8/7/2011
Piperacillin And Tazobactam for Skin Infection
4.7
Patient Review
6/28/2013
Piperacillin And Tazobactam for Complicated Skin Infection
4.7
Patient Review
2/18/2010
Piperacillin And Tazobactam for Abscess Within the Abdomen
4.7
Patient Review
6/28/2013
Piperacillin And Tazobactam for Complicated Skin Infection
4.7
Patient Review
2/18/2010
Piperacillin And Tazobactam for Abscess Within the Abdomen
4.3
Patient Review
8/13/2020
Piperacillin And Tazobactam for Blood or Tissue Infection Affecting Whole Body of Newborn
4.3
Patient Review
8/13/2020
Piperacillin And Tazobactam for Blood or Tissue Infection Affecting Whole Body of Newborn
3
Patient Review
1/24/2015
Piperacillin And Tazobactam for Skin Infection
3
Patient Review
1/24/2015
Piperacillin And Tazobactam for Skin Infection
2.3
Patient Review
7/25/2019
Piperacillin And Tazobactam for Skin Infection
2.3
Patient Review
7/25/2019
Piperacillin And Tazobactam for Skin Infection
1.7
Patient Review
1/10/2016
Piperacillin And Tazobactam for Bacterial Pneumonia caused by Haemophilus Influenzae
1.7
Patient Review
1/10/2016
Piperacillin And Tazobactam for Bacterial Pneumonia caused by Haemophilus Influenzae
Patient Q&A Section about piperacillin and tazobactam
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What type of bacteria does piperacillin tazobactam affect?
"Piperacillin/tazobactam is a type of beta-lactam that covers gram-negative organisms, gram-positive organisms, and anaerobic bacterial organisms. P. aeruginosa is a gram-negative bacteria that is resistant to multiple agents."
Answered by AI
What are the side effects of piperacillin?
"The possible side effects of this medication are:
-Swelling, redness, pain, or soreness at the injection site
-Dizziness -Trouble sleeping -Nausea -Vomiting -Diarrhea -Headache
If you experience any of these side effects, please contact your doctor or pharmacist."
Answered by AI
What is piperacillin tazobactam used for?
"Piperacillin and tazobactam combination injection is used to treat bacterial infections in many different parts of the body, including the stomach or bowel, lungs, skin, and female reproductive organs. This medication is scheduled to expire on May 1, 2022."
Answered by AI