Piperacillin And Tazobactam

Pyelonephritis, Abdominal Infection, Healthcare-Associated Pneumonia + 2 more

Treatment

2 FDA approvals

3 Active Studies for Piperacillin And Tazobactam

What is Piperacillin And Tazobactam

Tazobactam

The Generic name of this drug

Treatment Summary

Tazobactam is an antibiotic that prevents bacteria from becoming resistant to other antibiotics. It is often combined with Piperacillin or Ceftolozane to treat various bacterial infections. Piperacillin-tazobactam was approved by the FDA in 1994 and Ceftolozane-tazobactam was approved in 2014, providing protection against a wider range of bacterial infections. In 2019, Ceftolozane-tazobactam was also approved for treating hospital-acquired and ventilator-associated bacterial pneumonia, which can be deadly for hospitalized patients.

Zosyn

is the brand name

image of different drug pills on a surface

Piperacillin And Tazobactam Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Zosyn

Tazobactam

1993

153

Approved as Treatment by the FDA

Tazobactam, commonly known as Zosyn, is approved by the FDA for 2 uses including complicated intra-abdominal bacterial infections and Abdominal Infection .

complicated intra-abdominal bacterial infections

Used to treat complicated intra-abdominal bacterial infections in combination with Ceftolozane

Abdominal Infection

Used to treat complicated intra-abdominal bacterial infections in combination with Ceftolozane

Effectiveness

How Piperacillin And Tazobactam Affects Patients

Tazobactam works by stopping bacteria that produce beta-lactamase enzymes from making them resistant to certain antibiotics. This allows other antibiotics to work against infections that would not be treatable otherwise. When combined with other antibiotics, it can be used to treat a variety of serious and life-threatening infections.

How Piperacillin And Tazobactam works in the body

Tazobactam works by stopping beta-lactamase enzymes from breaking down antibiotics like piperacillin and ceftolozane. It does this by forming a covalent bond with the enzymes, which prevents them from degrading the other drugs. This makes these drugs more effective against bacteria that normally produce beta-lactamase enzymes. Tazobactam is most effective against certain groups of beta-lactamases, but can also help inhibit other types. By itself, tazobactam has little to no antibacterial activity, so it is usually used in combination with other antibiotics.

When to interrupt dosage

The recommended dosage of Piperacillin And Tazobactam is contingent upon the identified affliction, including Pneumonia, Bacterial, Urinary tract infection and Nosocomial Pneumonia. The amount likewise modifies as indicated by the technique of delivery (e.g. Injection, powder, lyophilized, for solution or Intravenous) featured in the following table.

Condition

Dosage

Administration

Pyelonephritis

, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral

Abdominal Infection

, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral

Healthcare-Associated Pneumonia

, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral

Urinary tract infection

, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral

Pneumonia, Bacterial

, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral

Warnings

Piperacillin And Tazobactam Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Tazobactam may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Tazobactam may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Tazobactam may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Tazobactam may interact with Pulse Frequency

There are 20 known major drug interactions with Piperacillin And Tazobactam.

Common Piperacillin And Tazobactam Drug Interactions

Drug Name

Risk Level

Description

Didanosine

Minor

The excretion of Didanosine can be decreased when combined with Tazobactam.

Grepafloxacin

Minor

The excretion of Grepafloxacin can be decreased when combined with Tazobactam.

Lamivudine

Minor

The excretion of Lamivudine can be decreased when combined with Tazobactam.

Levofloxacin

Minor

The excretion of Levofloxacin can be decreased when combined with Tazobactam.

Stavudine

Minor

The excretion of Stavudine can be decreased when combined with Tazobactam.

Piperacillin And Tazobactam Toxicity & Overdose Risk

Taking too much piperacillin/tazobactam can cause symptoms such as nausea, vomiting, and diarrhea. It can also cause seizures or uncontrolled muscle movements. There is no specific antidote. Treatment usually involves supportive care and anticonvulsant medications if seizures occur. If the patient has an allergic reaction, they should be given adrenaline, antihistamines, corticosteroids, and oxygen. Hemodialysis can also be used to remove the drug from the bloodstream. Taking high doses of piperacillin/tazobactam can cause kidney damage in critically ill patients, so

image of a doctor in a lab doing drug, clinical research

Piperacillin And Tazobactam Novel Uses: Which Conditions Have a Clinical Trial Featuring Piperacillin And Tazobactam?

11 active clinical trials are presently assessing the potential of Piperacillin and Tazobactam to treat Nosocomial Pneumonia, Pyelonephritis and Abdominal Infections.

Condition

Clinical Trials

Trial Phases

Urinary tract infection

0 Actively Recruiting

Abdominal Infection

0 Actively Recruiting

Healthcare-Associated Pneumonia

0 Actively Recruiting

Pyelonephritis

1 Actively Recruiting

Not Applicable

Pneumonia, Bacterial

2 Actively Recruiting

Not Applicable

Piperacillin And Tazobactam Reviews: What are patients saying about Piperacillin And Tazobactam?

5

Patient Review

8/7/2011

Piperacillin And Tazobactam for Skin Infection

5

Patient Review

8/7/2011

Piperacillin And Tazobactam for Skin Infection

4.7

Patient Review

6/28/2013

Piperacillin And Tazobactam for Complicated Skin Infection

It's wonderful- like magic!

4.7

Patient Review

2/18/2010

Piperacillin And Tazobactam for Abscess Within the Abdomen

4.7

Patient Review

6/28/2013

Piperacillin And Tazobactam for Complicated Skin Infection

This treatment is wonderful, like magic!

4.7

Patient Review

2/18/2010

Piperacillin And Tazobactam for Abscess Within the Abdomen

4.3

Patient Review

8/13/2020

Piperacillin And Tazobactam for Blood or Tissue Infection Affecting Whole Body of Newborn

This stuff is great!

4.3

Patient Review

8/13/2020

Piperacillin And Tazobactam for Blood or Tissue Infection Affecting Whole Body of Newborn

This stuff is really great!

3

Patient Review

1/24/2015

Piperacillin And Tazobactam for Skin Infection

The patient had issues with watery stools, five times in a 24-hour period. The volume was such that it leaked through adult diapers and underpads.

3

Patient Review

1/24/2015

Piperacillin And Tazobactam for Skin Infection

The patient had five episodes of watery stools in 24 hours. The stool was so voluminous that it leaked into the bed sheets, despite the use of adult diapers and underpads.

2.3

Patient Review

7/25/2019

Piperacillin And Tazobactam for Skin Infection

I unfortunately had an allergic reaction to the medication which made me very uncomfortable. My heart rate spiked and I began sweating profusely. It was a very scary experience.

2.3

Patient Review

7/25/2019

Piperacillin And Tazobactam for Skin Infection

Unfortunately, I had an allergic reaction to this treatment. It was very uncomfortable and sent me into a-fib within one minute. I also experienced itching all over my body, sweating, and difficulty breathing. This lasted for well over an hour and it took me more than two hours to cool down in the emergency room.

1.7

Patient Review

1/10/2016

Piperacillin And Tazobactam for Bacterial Pneumonia caused by Haemophilus Influenzae

I was injected quickly and given a saline drip for 45 minutes each time, over the course of three days. I now have a sore mouth and can't taste anything, six days later.

1.7

Patient Review

1/10/2016

Piperacillin And Tazobactam for Bacterial Pneumonia caused by Haemophilus Influenzae

Injected very quickly and a saline drip followed for 45 minutes each time - over 3 days in hospital. Had a sore mouth and no sense of taste 6 days after treatment.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about piperacillin and tazobactam

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of bacteria does piperacillin tazobactam affect?

"Piperacillin/tazobactam is a type of beta-lactam that covers gram-negative organisms, gram-positive organisms, and anaerobic bacterial organisms. P. aeruginosa is a gram-negative bacteria that is resistant to multiple agents."

Answered by AI

What are the side effects of piperacillin?

"The possible side effects of this medication are:

-Swelling, redness, pain, or soreness at the injection site

-Dizziness -Trouble sleeping -Nausea -Vomiting -Diarrhea -Headache

If you experience any of these side effects, please contact your doctor or pharmacist."

Answered by AI

What is piperacillin tazobactam used for?

"Piperacillin and tazobactam combination injection is used to treat bacterial infections in many different parts of the body, including the stomach or bowel, lungs, skin, and female reproductive organs. This medication is scheduled to expire on May 1, 2022."

Answered by AI

Clinical Trials for Piperacillin And Tazobactam

Image of Ronald Reagan UCLA Medical Center in Los Angeles, United States.

Next Day Clinic for Patient Care

18+
All Sexes
Los Angeles, CA

The Next Day Clinic (NDC) is a quality improvement initiative that will be launched and operated by UCLA Health starting July 22, 2024. Its goals are to improve patient care and safety and to maximize cost effectiveness. The way it does this is by identifying patients in the ED who would normally be admitted for low-acuity conditions, and diverting them to a high-acuity clinic the following day called the NDC. This will help decompress the ED and the hospital, and allow for overall higher quality care. The Health System has partnered with UCLA's Healthcare Value Analytics and Solutions \[UVAS\] group which specializes in these types of program evaluations. The analysis conducted by the study team will be used to directly inform NDC operations, scaling, and future plans.

Recruiting
Has No Placebo

Ronald Reagan UCLA Medical Center

Image of University of Florida in Gainesville, United States.

Standardized Oral Care for Premature Infant Health

12 - 72
All Sexes
Gainesville, FL

Premature very low birth weight (VLBW) infants are susceptible to complications related to infrequent and non-standardized oral care. Although the benefits of frequent standardized oral care are known to reduce oral dybiosis (increased level of potentially pathogenic bacteria) and its associated complications in critically ill adults leading to established evidence-based guidelines, no such information exists for VLBW infants. The proposed study will prospectively follow 40 VLBW infants for 4 weeks following birth. Infants will be randomized into 1 of 2 groups. Standardized oral care will be performed every 3-4 hours (Group 1) and every 12 hours (Group 2). Aim 1 will evaluate the feasibility of frequent standardized oral care, Aim 2 will compare the oral microbiome between groups, and Aim 3 will compare respiratory outcomes including the incidence of ventilator associated pneumonia, bronchopulmonary dysplasia and need for respiratory support between infants receiving standardized oral care every 3-4 hours and every 12 hours. Issues related to recruitment, retention, randomization, acceptance by nursing staff, and treatment fidelity will be examined. Saliva samples will be obtained weekly and analyzed using 16S sequencing, respiratory cultures will be obtained weekly on ventilated infants, and respiratory outcomes will be collected from the medical records.

Waitlist Available
Has No Placebo

University of Florida

Leslie Parker