Pilopine Hs
Presbyopia, Miosis, laser eye surgery + 8 more
Treatment
20 Active Studies for Pilopine Hs
Treatment for
Presbyopia
What is Pilopine Hs
Pilocarpine
The Generic name of this drug
Treatment Summary
Pilocarpine is a drug that helps treat glaucoma. It works by increasing the size of the pupil and reducing the pressure in the eye. It is not related to nicotine and works slowly when taken.
Isopto Carpine
is the brand name
Pilopine Hs Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Isopto Carpine
Pilocarpine
1974
62
Effectiveness
How Pilopine Hs Affects Patients
Pilocarpine is a medication that triggers the release of fluid from glands in the body, like sweat and saliva. When applied directly to the eye, it can cause the pupil to contract. It can also cause some temporary changes in blood pressure, as well as increased activity of the muscles in the intestines, lungs, and urinary and biliary systems. Pilocarpine can also have a strange effect on the heart, causing both a rapid heartbeat and a slow heartbeat in some cases.
How Pilopine Hs works in the body
Pilocarpine is a drug that stimulates certain nerve receptors in the body. When taken as an eye drop, it causes the muscles of the iris and ciliary to contract, leading to increased secretions from the glands.
When to interrupt dosage
The prescribed quantity of Pilopine Hs is contingent upon the diagnosed condition, including Open Angle Glaucoma, Miosis and laser eye surgery. The measure of dosage fluctuates as per the method of administration featured in the table below.
Condition
Dosage
Administration
Presbyopia
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Implant, Implant - Intraocular, Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Miosis
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Implant, Implant - Intraocular, Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
laser eye surgery
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Implant, Implant - Intraocular, Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Glaucoma, Open-Angle
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Implant, Implant - Intraocular, Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Radiotherapy
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Implant, Implant - Intraocular, Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Glaucoma
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Implant, Implant - Intraocular, Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Xerostomia
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Implant, Implant - Intraocular, Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Open Angle Glaucoma
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Implant, Implant - Intraocular, Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Ocular Hypertension
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Implant, Implant - Intraocular, Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Glaucoma, Angle-Closure
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Implant, Implant - Intraocular, Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Glaucoma
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Implant, Implant - Intraocular, Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Warnings
Pilopine Hs has four contraindications and must not be administered in the presence of the conditions given in the following table.
Pilopine Hs Contraindications
Condition
Risk Level
Notes
Asthma
Do Not Combine
Iritis
Do Not Combine
Miosis disorder
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Pilocarpine may interact with Pulse Frequency
There are 20 known major drug interactions with Pilopine Hs.
Common Pilopine Hs Drug Interactions
Drug Name
Risk Level
Description
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Pilocarpine.
Antipyrine
Major
The metabolism of Antipyrine can be decreased when combined with Pilocarpine.
Apremilast
Major
The metabolism of Apremilast can be decreased when combined with Pilocarpine.
Arformoterol
Major
The metabolism of Arformoterol can be decreased when combined with Pilocarpine.
Asunaprevir
Major
The metabolism of Asunaprevir can be decreased when combined with Pilocarpine.
Pilopine Hs Novel Uses: Which Conditions Have a Clinical Trial Featuring Pilopine Hs?
Currently, 60 active trials are exploring the potential of Pilopine Hs in ameliorating Dry Mouth, insufficient reduction of intraocular pressure with pilocarpine or beta-blocker monotherapy and Sjögren's Syndrome.
Condition
Clinical Trials
Trial Phases
Presbyopia
8 Actively Recruiting
Not Applicable, Phase 3
Glaucoma
0 Actively Recruiting
Glaucoma, Open-Angle
0 Actively Recruiting
Miosis
0 Actively Recruiting
Glaucoma, Angle-Closure
0 Actively Recruiting
Open Angle Glaucoma
10 Actively Recruiting
Phase 3, Not Applicable, Phase 4
Xerostomia
0 Actively Recruiting
laser eye surgery
0 Actively Recruiting
Glaucoma
0 Actively Recruiting
Ocular Hypertension
10 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4
Radiotherapy
7 Actively Recruiting
Phase 1, Not Applicable, Phase 3, Phase 2
Pilopine Hs Reviews: What are patients saying about Pilopine Hs?
4.3
Patient Review
12/31/2008
Pilopine Hs for Increased Pressure in Eyes
Patient Q&A Section about pilopine hs
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How does pilocarpine work?
"Pilocarpine is a drug that falls into the category of cholinergic agonists. By working to stimulate certain nerves, pilocarpine increases saliva production which makes it easier to speak and swallow."
Answered by AI
What are the side effects of pilocarpine?
"The following are continuing or severe symptoms that should be discussed with a doctor: chest pain, diarrhea, irregular heartbeat, headache, nausea or vomiting, shortness of breath, stomach cramps or pain, and tiredness or weakness."
Answered by AI
How do you use pilocarpine gel?
"Remove the cap from the tube and place it on a clean surface. Gently pull down the lower eyelid to form a pocket for the gel. Gently squeeze the tube and apply a continuous strip of gel into and along the pocket. The strip of gel should be about a half-inch wide."
Answered by AI
What is pilocarpine gel?
"PILOPINE HS is a gel that contains the drug pilocarpine hydrochloride. It is used to lower intraocular pressure. It may be used together with other drugs that are used to lower intraocular pressure, including beta blockers, carbonic anhydrase inhibitors, sympathomimetics, and hyperosmotic agents."
Answered by AI