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What is Pilopine Hs
PilocarpineThe Generic name of this drug
Treatment SummaryPilocarpine is a drug that helps treat glaucoma. It works by increasing the size of the pupil and reducing the pressure in the eye. It is not related to nicotine and works slowly when taken.
Isopto Carpineis the brand name
Pilopine Hs Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Isopto Carpine
Pilocarpine
1974
62
Effectiveness
How Pilopine Hs Affects PatientsPilocarpine is a medication that triggers the release of fluid from glands in the body, like sweat and saliva. When applied directly to the eye, it can cause the pupil to contract. It can also cause some temporary changes in blood pressure, as well as increased activity of the muscles in the intestines, lungs, and urinary and biliary systems. Pilocarpine can also have a strange effect on the heart, causing both a rapid heartbeat and a slow heartbeat in some cases.
How Pilopine Hs works in the bodyPilocarpine is a drug that stimulates certain nerve receptors in the body. When taken as an eye drop, it causes the muscles of the iris and ciliary to contract, leading to increased secretions from the glands.
When to interrupt dosage
The prescribed quantity of Pilopine Hs is contingent upon the diagnosed condition, including Open Angle Glaucoma, Miosis and laser eye surgery. The measure of dosage fluctuates as per the method of administration featured in the table below.Condition
Dosage
Administration
Presbyopia
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Implant, Implant - Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Dry Mouth
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Implant, Implant - Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Radiotherapy
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Implant, Implant - Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Miosis
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Implant, Implant - Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Increased Intra Ocular Pressure (IOP)
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Implant, Implant - Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
laser eye surgery
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Implant, Implant - Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
chronic open-angle glaucoma
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Implant, Implant - Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Ocular Hypertension
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Implant, Implant - Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Open Angle Glaucoma
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Implant, Implant - Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Glaucoma, Closed-Angle
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Implant, Implant - Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Inadequate reduction of intraocular pressure on pilocarpine or beta-blocker monotherapy
, 5.0 mg, 7.5 mg, 10.0 mg/mL, 40.0 mg, 1.0 %, 2.0 %, 4.0 %, 11.0 mg, 0.5 %, 6.0 %, 1.75 %, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg/mL, 17.5 mg/mL, 0.04 mg/mg, 10.0 mg, 0.025 mg/mg, 5.0 mg/mL, 60.0 mg/mL, 12.5 mg/mL
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Conjunctival, Solution / drops, Solution / drops - Conjunctival, Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Implant, Implant - Intraocular, Gel, Gel - Ophthalmic, Suspension, Suspension - Ophthalmic, Kit, Topical, Kit - Ophthalmic, Kit - Topical
Warnings
Pilopine Hs has four contraindications and must not be administered in the presence of the conditions given in the following table.Pilopine Hs ContraindicationsCondition
Risk Level
Notes
Asthma
Do Not Combine
Iritis
Do Not Combine
Miosis disorder
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Pilocarpine may interact with Pulse Frequency
Common Pilopine Hs Drug Interactions
Drug Name
Risk Level
Description
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Pilocarpine.
Antipyrine
Major
The metabolism of Antipyrine can be decreased when combined with Pilocarpine.
Apremilast
Major
The metabolism of Apremilast can be decreased when combined with Pilocarpine.
Arformoterol
Major
The metabolism of Arformoterol can be decreased when combined with Pilocarpine.
Asunaprevir
Major
The metabolism of Asunaprevir can be decreased when combined with Pilocarpine.
Pilopine Hs Novel Uses: Which Conditions Have a Clinical Trial Featuring Pilopine Hs?
Currently, 60 active trials are exploring the potential of Pilopine Hs in ameliorating Dry Mouth, insufficient reduction of intraocular pressure with pilocarpine or beta-blocker monotherapy and Sjögren's Syndrome.Condition
Clinical Trials
Trial Phases
laser eye surgery
0 Actively Recruiting
Open Angle Glaucoma
12 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Miosis
0 Actively Recruiting
Radiotherapy
6 Actively Recruiting
Phase 1, Not Applicable, Phase 3
Ocular Hypertension
22 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
Presbyopia
8 Actively Recruiting
Not Applicable, Phase 4
chronic open-angle glaucoma
0 Actively Recruiting
Increased Intra Ocular Pressure (IOP)
0 Actively Recruiting
Glaucoma, Closed-Angle
0 Actively Recruiting
Dry Mouth
0 Actively Recruiting
Inadequate reduction of intraocular pressure on pilocarpine or beta-blocker monotherapy
0 Actively Recruiting
Pilopine Hs Reviews: What are patients saying about Pilopine Hs?
4.3Patient Review
12/31/2008 Pilopine HS and selective laser treatment have been effective in avoiding surgery for me. I hadn't found anything else that worked as well. There is some discomfort when first using it, but it's worth it to be able to see clearly again.
Patient Q&A Section about pilopine hs
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How does pilocarpine work?
"Pilocarpine is a drug that falls into the category of cholinergic agonists. By working to stimulate certain nerves, pilocarpine increases saliva production which makes it easier to speak and swallow."
Answered by AI
What are the side effects of pilocarpine?
"The following are continuing or severe symptoms that should be discussed with a doctor: chest pain, diarrhea, irregular heartbeat, headache, nausea or vomiting, shortness of breath, stomach cramps or pain, and tiredness or weakness."
Answered by AI
How do you use pilocarpine gel?
"Remove the cap from the tube and place it on a clean surface. Gently pull down the lower eyelid to form a pocket for the gel. Gently squeeze the tube and apply a continuous strip of gel into and along the pocket. The strip of gel should be about a half-inch wide."
Answered by AI
What is pilocarpine gel?
"PILOPINE HS is a gel that contains the drug pilocarpine hydrochloride. It is used to lower intraocular pressure. It may be used together with other drugs that are used to lower intraocular pressure, including beta blockers, carbonic anhydrase inhibitors, sympathomimetics, and hyperosmotic agents."
Answered by AI