Paromomycin Sulfate
chronic Intestinal amebiasis, Amebic colitis, Hepatic Encephalopathy + 1 more
Treatment
4 FDA approvals
0 Active Studies for Paromomycin Sulfate
Treatment for
chronic Intestinal amebiasis
What is Paromomycin Sulfate
Paromomycin
The Generic name of this drug
Treatment Summary
An oligosaccharide antibiotic is a type of drug made by certain types of bacteria. It is used to treat bacterial infections.
Humatin
is the brand name
Paromomycin Sulfate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Humatin
Paromomycin
1981
9
Approved as Treatment by the FDA
Paromomycin, commonly known as Humatin, is approved by the FDA for 4 uses which include Hepatic coma and Amebic colitis .
Hepatic coma
Amebic colitis
chronic Intestinal amebiasis
Hepatic Encephalopathy
Effectiveness
How Paromomycin Sulfate Affects Patients
Paromomycin is a type of antibiotic created by a type of bacteria called <i>Streptomyces rimosus</i> var. paromomycinus. This antibiotic is effective against a wide range of bacteria, and it works similarly to neomycin.
How Paromomycin Sulfate works in the body
Paromomycin blocks the production of proteins in bacteria by binding to their ribosomal RNA. Ribosomes are the parts of the cell that make proteins, which are essential for a cell to function. Paromomycin binds to the ribosome, which prevents it from making proteins correctly. This eventually causes the bacteria to die.
When to interrupt dosage
The proposed measure of Paromomycin Sulfate is contingent upon the diagnosed affliction, including chronic Intestinal amebiasis, Dientamoeba fragilis infection and Hepatic coma. The dosage can be found in the table below, depending on the procedure of administration (e.g. Oral or Capsule - Oral).
Condition
Dosage
Administration
Amebic colitis
250.0 mg,
, Capsule - Oral, Capsule, Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated
Hepatic Encephalopathy
250.0 mg,
, Capsule - Oral, Capsule, Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated
chronic Intestinal amebiasis
250.0 mg,
, Capsule - Oral, Capsule, Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated
Dientamoebiasis
250.0 mg,
, Capsule - Oral, Capsule, Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated
Warnings
Paromomycin Sulfate Contraindications
Condition
Risk Level
Notes
Intestinal Obstruction
Do Not Combine
There are 20 known major drug interactions with Paromomycin Sulfate.
Common Paromomycin Sulfate Drug Interactions
Drug Name
Risk Level
Description
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Paromomycin is combined with Neomycin.
Tenofovir
Major
Paromomycin may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Paromomycin may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir disoproxil
Major
Paromomycin may increase the nephrotoxic activities of Tenofovir disoproxil.
Vibrio cholerae CVD 103-HgR strain live antigen
Major
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Paromomycin.
Paromomycin Sulfate Novel Uses: Which Conditions Have a Clinical Trial Featuring Paromomycin Sulfate?
There are no active clinical trials at present examining the potential of Paromomycin Sulfate to address Dientamoeba fragilis infection, Amebic colitis and Hepatic coma.
Condition
Clinical Trials
Trial Phases
chronic Intestinal amebiasis
0 Actively Recruiting
Hepatic Encephalopathy
0 Actively Recruiting
Amebic colitis
0 Actively Recruiting
Dientamoebiasis
0 Actively Recruiting
Patient Q&A Section about paromomycin sulfate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How long does paromomycin take to work?
"This medication usually starts working within five days, and can provide relief for conditions other than those listed in these drug information articles."
Answered by AI
What type of antibiotic is paromomycin?
"There are three main types of antibiotics: penicillins, cephalosporins, and tetracyclines. Some examples of each type are phenoxymethylpenicillin, cefaclor, and tetracycline."
Answered by AI
What is paromomycin used to treat?
"Paromomycin is a medication used to treat intestinal amebiasis, a bowel infection caused by a parasite. It is also used, in combination with other medications, to help ease the symptoms of hepatic coma, a complication of liver disease."
Answered by AI
What are the adverse effects of paromomycin?
"These effects include nausea, vomiting, loss of appetite, abdominal cramps, diarrhea, and heartburn. If any of these effects persist or worsen, tell your doctor or pharmacist promptly."
Answered by AI