DASH Diet for High Blood Pressure
(DASH4D Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing a special diet for people with diabetes and different salt levels to see how they affect blood pressure. It focuses on adults with Type 2 diabetes who have moderately high blood pressure. The goal is to find out if healthier food choices and less salt can help lower their blood pressure.
Will I have to stop taking my current medications?
The trial requires that you have a stable dose of certain medications for at least 2 months before joining. Some medications, like potassium supplements over 99 mg/day, short-acting insulin, and certain weight loss drugs, are not allowed. It's best to discuss your specific medications with the trial team.
Is the DASH diet safe for people with high blood pressure?
The DASH diet is generally safe for most people and can be used alongside medication and other lifestyle changes. However, people with chronic kidney or liver disease, heart failure, uncontrolled diabetes, lactose intolerance, or celiac disease should consult their doctor before starting, as they may need to adjust the diet.12345
How is the DASH4D diet treatment different from other treatments for high blood pressure?
The DASH4D diet is unique because it focuses on a specific eating pattern high in fruits, vegetables, and low-fat dairy, which helps lower blood pressure and cholesterol levels without medication. Unlike other treatments that may involve drugs, this diet emphasizes natural food choices to manage high blood pressure.12678
What data supports the effectiveness of the DASH diet treatment for high blood pressure?
The DASH diet has been shown to lower blood pressure and bad cholesterol levels, which are important for heart health. Additionally, a similar diet with low sodium and high potassium was found to enhance the blood pressure-lowering effects of medications, especially in those on certain blood pressure drugs.127910
Who Is on the Research Team?
Lawrence Appel, MD, MPH
Principal Investigator
Johns Hopkins University
Hsin Chieh Yeh, PhD
Principal Investigator
Johns Hopkins University
Scott Pilla, MD, MHS
Principal Investigator
Johns Hopkins University
Elizabeth Selvin, PhD
Principal Investigator
Johns Hopkins University
Are You a Good Fit for This Trial?
Adults with Type 2 Diabetes and blood pressure between 120-159/under 100 mmHg, who can eat on-site meals regularly, have stable weight, no other clinical trials or severe illnesses. Must not be pregnant or planning pregnancy, without significant dietary restrictions that affect adherence.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Feeding Period 1
Participants are fed the DASH4D diet with lower sodium for 5 weeks
Feeding Period 2
Participants are fed the DASH4D diet with higher sodium for 5 weeks
Feeding Period 3
Participants are fed the comparison diet with lower sodium for 5 weeks
Feeding Period 4
Participants are fed the comparison diet with higher sodium for 5 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- comparison diet
- DASH4D diet
- higher sodium
- lower sodium
Find a Clinic Near You
Who Is Running the Clinical Trial?
Johns Hopkins University
Lead Sponsor
Sheikh Khalifa Stroke Institute at Johns Hopkins
Collaborator
University of Colorado - Anschutz Medical Campus
Collaborator
University of Colorado, Denver
Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
Sheikh Khalifa Stroke Institute
Collaborator
Beth Israel Deaconess Medical Center
Collaborator