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What is Vagistat-1
TioconazoleThe Generic name of this drug
Treatment SummaryTioconazole is a medication used to treat fungal and yeast infections. It comes in topical formulations which can be used to treat common skin infections like ringworm, jock itch, athlete's foot, and sun fungus. Tioconazole works by blocking the production of an important component of the yeast cell membrane, leading to increased permeability and ultimately killing the fungus.
Vagistat-1is the brand name
Vagistat-1 Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Vagistat-1
Tioconazole
1997
32
Effectiveness
How Vagistat-1 Affects PatientsTioconazole is a medication used to fight fungal yeast infections. It kills or stops the growth of fungi like Candida albicans and Torulopsis glabrata. Tioconazole works by blocking the production of substances needed to keep fungi cells alive. It won't work for illnesses caused by bacteria or viruses.
How Vagistat-1 works in the bodyTioconazole works by stopping a specific enzyme from making the molecule ergosterol, which is needed in the cell membrane of yeast. When this molecule isn't present, the yeast cell becomes more permeable. Tioconazole can also have other effects on the yeast, such as inhibiting respiration, blocking the movement of calcium and potassium ions, and preventing the yeast from changing into its fungal form.
When to interrupt dosage
The endorsed dose of Vagistat-1 is contingent upon the acknowledged condition, including Vulvovaginal Candidiasis, cutaneous dermatophyte infection and Infection, Mixed. The quantity of dosage deviates, in accordance with the administration technique (e.g. Ointment - Vaginal or Topical) featured in the table beneath.Condition
Dosage
Administration
superficial Fungal skin infection
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
, Ointment, Ointment - Vaginal, Vaginal, Topical, Ointment - Topical, Suppository, Cream, Suppository - Vaginal, Cream - Topical, Topical; Vaginal, Cream; Ointment, Cream; Ointment - Topical; Vaginal, Cream; Suppository, Cream; Suppository - Topical; Vaginal
Inflammation
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
, Ointment, Ointment - Vaginal, Vaginal, Topical, Ointment - Topical, Suppository, Cream, Suppository - Vaginal, Cream - Topical, Topical; Vaginal, Cream; Ointment, Cream; Ointment - Topical; Vaginal, Cream; Suppository, Cream; Suppository - Topical; Vaginal
Vulvovaginal Candidiasis
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
, Ointment, Ointment - Vaginal, Vaginal, Topical, Ointment - Topical, Suppository, Cream, Suppository - Vaginal, Cream - Topical, Topical; Vaginal, Cream; Ointment, Cream; Ointment - Topical; Vaginal, Cream; Suppository, Cream; Suppository - Topical; Vaginal
Vaginal Candidiasis
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
, Ointment, Ointment - Vaginal, Vaginal, Topical, Ointment - Topical, Suppository, Cream, Suppository - Vaginal, Cream - Topical, Topical; Vaginal, Cream; Ointment, Cream; Ointment - Topical; Vaginal, Cream; Suppository, Cream; Suppository - Topical; Vaginal
Onychomycosis
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
, Ointment, Ointment - Vaginal, Vaginal, Topical, Ointment - Topical, Suppository, Cream, Suppository - Vaginal, Cream - Topical, Topical; Vaginal, Cream; Ointment, Cream; Ointment - Topical; Vaginal, Cream; Suppository, Cream; Suppository - Topical; Vaginal
Cellulitis
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
, Ointment, Ointment - Vaginal, Vaginal, Topical, Ointment - Topical, Suppository, Cream, Suppository - Vaginal, Cream - Topical, Topical; Vaginal, Cream; Ointment, Cream; Ointment - Topical; Vaginal, Cream; Suppository, Cream; Suppository - Topical; Vaginal
cutaneous dermatophyte infection
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
, Ointment, Ointment - Vaginal, Vaginal, Topical, Ointment - Topical, Suppository, Cream, Suppository - Vaginal, Cream - Topical, Topical; Vaginal, Cream; Ointment, Cream; Ointment - Topical; Vaginal, Cream; Suppository, Cream; Suppository - Topical; Vaginal
Infection, Mixed
300.0 mg, , 0.065 mg/mg, 0.3 mg/mg, 6.5 %, 1.0 %, 7.5 %, 0.01 mg/mg
, Ointment, Ointment - Vaginal, Vaginal, Topical, Ointment - Topical, Suppository, Cream, Suppository - Vaginal, Cream - Topical, Topical; Vaginal, Cream; Ointment, Cream; Ointment - Topical; Vaginal, Cream; Suppository, Cream; Suppository - Topical; Vaginal
Warnings
There are 20 known major drug interactions with Vagistat-1.Common Vagistat-1 Drug Interactions
Drug Name
Risk Level
Description
Cariprazine
Major
The metabolism of Cariprazine can be decreased when combined with Tioconazole.
Eliglustat
Major
The metabolism of Eliglustat can be decreased when combined with Tioconazole.
Entrectinib
Major
The metabolism of Entrectinib can be decreased when combined with Tioconazole.
Fentanyl
Major
The metabolism of Fentanyl can be decreased when combined with Tioconazole.
Infigratinib
Major
The metabolism of Infigratinib can be decreased when combined with Tioconazole.
Vagistat-1 Toxicity & Overdose RiskOverdosing on the drug can cause redness, stinging, blistering, swelling, itching, hives, burning, and general skin irritation, as well as cramps.
Vagistat-1 Novel Uses: Which Conditions Have a Clinical Trial Featuring Vagistat-1?
191 separate studies are currently being conducted to explore Vagistat-1's potential to mitigate cutaneous dermatophyte infection, superficial Fungal skin infection and Communicable Diseases.Condition
Clinical Trials
Trial Phases
Inflammation
171 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Onychomycosis
4 Actively Recruiting
Phase 2, Not Applicable, Phase 1
Vulvovaginal Candidiasis
0 Actively Recruiting
cutaneous dermatophyte infection
0 Actively Recruiting
Vaginal Candidiasis
0 Actively Recruiting
Infection, Mixed
0 Actively Recruiting
superficial Fungal skin infection
0 Actively Recruiting
Cellulitis
0 Actively Recruiting
Vagistat-1 Reviews: What are patients saying about Vagistat-1?
5Patient Review
4/28/2014 This was much more effective than Monistat, and the itching wasn't nearly as bad.
5Patient Review
2/7/2022 This treatment completely knocked out all of my symptoms overnight! I woke up feeling normal again. Some people might be more sensitive to this product, but it worked great for me even though I'm usually quite sensitive.
4.3Patient Review
4/13/2022 I'm only a couple hours into using this, but so far it's been much better than Monistat in terms of burning and itching.
3.3Patient Review
9/3/2022 I'm trying this brand for the first time and chose the Vagistat 1 because I wanted to avoid leakage for more than a week. After insertion, I felt burning which is something I expected. It's not too bad though. So far, so good. I'll update my review once I know more about what's going on.
2.7Patient Review
4/25/2022 The burning and pain was unbearable. My vulva was so swollen, it hurt to walk. I have chronic infections, so I'm used to calling and getting fluconazole. Since it was a Sunday, I decided to try this treatment instead. Big mistake.
2.3Patient Review
12/5/2019 My condition only deteriorated after using this treatment.
1.7Patient Review
10/14/2014 The burning and swelling is really bad. My yeast infection wasn't that serious to begin with, but now it's ten times worse. Has anyone else experienced this? And if so, what did you do to make the swelling go down? Or has it gone away on its own eventually?
1.7Patient Review
4/7/2014 I found this site helpful, thank you. I used Vagistate 1 a few hours ago and now I'm experiencing burning on my vulva, swelling, and redness. I went to the med clinic and they told me I have a bladder infection and am also having a bad reaction to the Vagistate 1. Let's hope the ice or bath ideas work because this is severe.
1Patient Review
3/24/2013 I'm really surprised this product is still on the market. The burning, itching, and swelling were almost immediate and unbearable. I had to get in the bathtub and wash most of it off. Benadryl also helped with the swelling. I definitely recommend monistat-3 instead.
1Patient Review
10/16/2021 I would not recommend this treatment to anyone. It made my very mild yeast infection much worse. I'm still in pain 12 hours later. Get Monistat 3 day or 7 day instead.
1Patient Review
2/2/2022 I took this medication and saw zero relief. In fact, I'm now in more pain than before, with added burning, itching, and swelling. Do not bother using this product.
1Patient Review
10/2/2022 Do not bother with this medication! I put it on 12 hours ago and the burning, swelling, and pain is unbearable. I've never had such a horrible experience with any yeast infection medication.
Patient Q&A Section about vagistat-1
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How effective is vagistat?
"Vagistat-1 has an average rating of 6.5 from 18 ratings for the treatment of Vaginal Yeast infection. 50% reported a positive experience, while 22% reported a negative experience."
Answered by AI
How long does vagistat-1 take to work?
"If you use the one-day treatment, you should start seeing some improvement in your symptoms within a day. However, it may take up to a week for your symptoms to completely go away."
Answered by AI
Are vagistat and MONISTAT the same?
"Vagisil will help relieve itching, but it does not contain an antifungal to help the source of the infection. There is a product called Vagistat, from the manufacturers of Vagisil, which contains miconazole in an internal and external cream and is similar to Monistat 3."
Answered by AI
Does vagistat cure yeast infection?
"This drug is used to treat vaginal yeast infections. Miconazole decreases vaginal irritation, itching, and discharge that may happen with this condition. This drug is an azole antifungal. It works by preventing the growth of yeast (fungus) that causes the infection."
Answered by AI