Ozempic

Caloric Restriction, at least one weight-related comorbid condition, Obesity + 6 more
Treatment
6 FDA approvals
20 Active Studies for Ozempic

What is Ozempic

SemaglutideThe Generic name of this drug
Treatment SummarySemaglutide is a medication used to treat type 2 diabetes. It works by stimulating insulin production and reducing blood sugar levels. It is available in two forms: injections that are given once a week and tablets that are taken once a day. Clinical trials have shown that semaglutide can lower the levels of glycosylated hemoglobin (HbA1c) and reduce body weight. In 2021, semaglutide was approved by the FDA and Health Canada for use in adults with general obesity or overweight who have at least one weight-related condition. This makes semaglutide the first drug
Ozempicis the brand name
image of different drug pills on a surface
Ozempic Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ozempic
Semaglutide
2017
19

Approved as Treatment by the FDA

Semaglutide, commonly known as Ozempic, is approved by the FDA for 6 uses including Type 2 Diabetes Mellitus and Cardiovascular Events .
Type 2 Diabetes Mellitus
Cardiovascular Events
Type 2 Diabetes
Cardiovascular Diseases
Physical Activity
Used in combination with other therapies
Diet
Used in combination with other therapies

Effectiveness

How Ozempic Affects PatientsSemaglutide helps to reduce levels of HbA1c, blood pressure, and body weight. It does this by increasing insulin production and decreasing the amount of glucagon in the body. It also lowers triglycerides and VLDL cholesterol, which can help improve cardiovascular health. There is a risk of developing medullary thyroid cell cancer, pancreatitis, and dehydration while taking semaglutide. It is important to stay hydrated and seek medical attention right away if experiencing abdominal pain. Additionally, this drug may affect how other drugs taken orally are absorbed, so it's important to monitor for both positive and negative
How Ozempic works in the bodySemaglutide helps to keep blood sugar levels in check by stimulating the pancreas to produce insulin. It also slows down the digestion of food and reduces the amount of glucagon released after meals. Semaglutide binds to the GLP-1 receptor in the body, activating several processes that lower blood sugar. Additionally, semaglutide may reduce the progression of atherosclerosis, a type of heart disease, by decreasing inflammation and gut permeability. Finally, semaglutide can also lead to weight loss through its effects on appetite and food cravings.

When to interrupt dosage

The dosage of Ozempic is contingent upon the diagnosed issue, such as Type 2 Diabetes, at least one weight-related comorbid condition and reduced-calorie diet. The sum of medication also fluctuates in accordance with the technique of delivery (e.g. Solution - Subcutaneous or Subcutaneous) specified in the table beneath.
Condition
Dosage
Administration
Obesity
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
Physical Activity
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
Type 2 Diabetes
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
Diet
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
Chronic Weight Management therapy
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
Cardiovascular Diseases
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
Caloric Restriction
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
at least one weight-related comorbid condition
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
Cardiovascular Events
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension

Warnings

Ozempic Contraindications
Condition
Risk Level
Notes
Multiple Endocrine Neoplasia
Do Not Combine
Thyroid Neoplasms
Do Not Combine
Medullary carcinoma of thyroid
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Semaglutide may interact with Pulse Frequency
There are 20 known major drug interactions with Ozempic.
Common Ozempic Drug Interactions
Drug Name
Risk Level
Description
Acetohexamide
Moderate
Semaglutide may increase the hypoglycemic activities of Acetohexamide.
Carbutamide
Moderate
Semaglutide may increase the hypoglycemic activities of Carbutamide.
Chlorpropamide
Moderate
Semaglutide may increase the hypoglycemic activities of Chlorpropamide.
Englitazone
Moderate
The risk or severity of hypoglycemia can be increased when Semaglutide is combined with Englitazone.
Fluconazole
Moderate
The risk or severity of hypoglycemia can be increased when Semaglutide is combined with Fluconazole.
Ozempic Toxicity & Overdose RiskSome people have overdosed on Semaglutide and experienced nausea as the primary symptom. All those who have overdosed have recovered fully with the help of medical care. It can take up to one week for Semaglutide to leave the body, so observation and treatment may be necessary for a while. There is no specific antidote for an overdose on this drug.
image of a doctor in a lab doing drug, clinical research

Ozempic Novel Uses: Which Conditions Have a Clinical Trial Featuring Ozempic?

196 active studies are currently underway to assess the effectiveness of Ozempic in treating Disease, Weight-Related Comorbidities and BMI >27 kg/m2.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
174 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Physical Activity
35 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1
Cardiovascular Diseases
0 Actively Recruiting
Cardiovascular Events
4 Actively Recruiting
Not Applicable
at least one weight-related comorbid condition
0 Actively Recruiting
Chronic Weight Management therapy
0 Actively Recruiting
Caloric Restriction
0 Actively Recruiting
Obesity
0 Actively Recruiting
Diet
5 Actively Recruiting
Not Applicable, Phase 1

Ozempic Reviews: What are patients saying about Ozempic?

5Patient Review
10/16/2022
Ozempic for Weight Loss Management for Overweight Person with BMI 27 to 29 and Weight-Related Comorbidity
I've been on this medication for four months now. I definitely noticed a change in my cravings; I used to love greasy foods, but now they don't appeal to me at all. I'm down 31 pounds since starting the medication, and I don't feel the need to snack constantly like I used to.
5Patient Review
10/29/2022
Ozempic for Weight Loss Management for an Obese Person
I've lost 35lbs since starting this treatment in July. The side effects were unpleasant at first, but they've gone away now and I'm really happy with the results. It's important to drink lots of water when you're on this medication, and to be patient as your body adjusts to it. The constipation was the hardest part for me, but it eventually went away.
5Patient Review
11/4/2022
Ozempic for Type 2 Diabetes Mellitus
This is the best medication I've ever been on. In just four months, it's helped me lower my A1C from 11 to 7. Plus, I haven't experienced any negative side effects.
4.3Patient Review
10/21/2022
Ozempic for Type 2 Diabetes Mellitus
Just feeling sick... otherwise this treatment is working well.
3Patient Review
11/8/2022
Ozempic for Weight Loss Management for an Obese Person
I get very nauseous from this medication, to the point of vomiting. The taste is incredibly unpleasant as well.
View All Reviews
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Patient Q&A Section about ozempic

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What exactly does Ozempic do?

"Ozempic, when used with diet and exercise, has been shown to improve blood sugar in adults with type 2 diabetes. In adults with type 2 diabetes and known heart disease, Ozempic reduces the risk of major cardiovascular events such as stroke, heart attack, or death."

Answered by AI

Is Ozempic for weight loss?

"Ozempic is a medication for adults with type 2 diabetes. It is not a weight-loss drug. Ozempic, combined with diet and exercise, may improve blood sugar."

Answered by AI

What are the most common side effects of Ozempic?

"These are some of the side effects that may occur when using semaglutide. If you experience any of these effects, tell your doctor or pharmacist."

Answered by AI

What are the dangers of Ozempic?

"The pancreas can become inflamed, which is called pancreatitis. This can cause changes in vision, low blood sugar (hypoglycemia), kidney problems (kidney failure), serious allergic reactions, and gallbladder problems."

Answered by AI

Clinical Trials for Ozempic

Have you considered Ozempic clinical trials? We made a collection of clinical trials featuring Ozempic, we think they might fit your search criteria.
Have you considered Ozempic clinical trials? We made a collection of clinical trials featuring Ozempic, we think they might fit your search criteria.
Have you considered Ozempic clinical trials? We made a collection of clinical trials featuring Ozempic, we think they might fit your search criteria.
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