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What is Oxytrol
OxybutyninThe Generic name of this drug
Treatment SummaryOxybutynin, also known as Ditropan XL, is a medication used to treat the symptoms of overactive bladder (OAB). It was approved by the FDA in 1975 and is often prescribed as the first line of treatment for OAB. It helps reduce urinary symptoms such as urgency, frequency, and nocturia, which can cause social embarrassment and decrease quality of life. Oxybutynin has been optimized for safety and effectiveness in treating OAB.
Ditropanis the brand name
Oxytrol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ditropan
Oxybutynin
1975
256
Effectiveness
How Oxytrol Affects PatientsOxybutynin helps treat symptoms of overactive bladder, like having to go to the bathroom urgently and often. It does this by blocking a certain type of brain receptors, called muscarinic receptors. People taking oxybutynin may experience swelling of the face, tongue, and throat (angioedema). Other possible side effects include hallucinations, confusion, agitation, drowsiness, and difficulty operating machinery. If any of these side effects occur, the dosage of this drug may need to be adjusted.
How Oxytrol works in the bodyOxybutynin works to relax the bladder by blocking the activity of acetylcholine, a chemical messenger responsible for muscle movement. This reduces muscle spasms and increases the bladder's capacity, allowing you to control when you need to go to the bathroom. The active metabolite of oxybutynin targets muscarinic receptors, which are responsible for controlling muscle movements in the bladder.
When to interrupt dosage
The proposed measure of Oxytrol is contingent upon the identified condition, such as Neurological Disorders, Foley Catheterization and Nocturia. The amount of dosage is subject to the technique of delivery (e.g. Tablet, extended release or Patch) specified in the table beneath.Condition
Dosage
Administration
Nocturia
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Spina Bifida
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Overactive Bladder Syndrome
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Urinary Urgency
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Longterm Indwelling Ureteral Stent
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Detrusor Hyperreflexia
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Neurological Disorders
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Bladder Spasms
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Urinary Urge Incontinence
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
increased frequency of urination
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Foley Catheterization
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Warnings
Oxytrol ContraindicationsCondition
Risk Level
Notes
Urinary Retention
Do Not Combine
uncontrolled narrow-angle glaucoma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Oxybutynin may interact with Pulse Frequency
Gastric Retention
Do Not Combine
Common Oxytrol Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Oxybutynin.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Oxybutynin.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Oxybutynin is combined with Aclidinium.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Oxybutynin.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Oxybutynin.
Oxytrol Toxicity & Overdose RiskThe most toxic dose of oxybutynin in rats is 460mg/kg. Overdosing on oxybutynin may cause symptoms such as confusion, fever, irregular heartbeat, difficulty urinating, difficulty breathing, and paralysis, as well as unconsciousness. If an overdose is suspected, supportive care should be provided and activated charcoal should be administered with a cathartic agent. Two reported cases of overdose involved people taking a 100mg dose of oxybutynin along with alcohol, but the patients recovered after receiving treatment.
Oxytrol Novel Uses: Which Conditions Have a Clinical Trial Featuring Oxytrol?
79 investigations are currently being conducted to assess the potential of Oxytrol for treating Overactive Bladder Syndrome, Foley Catheterization and Neurological Ailments.Condition
Clinical Trials
Trial Phases
Nocturia
6 Actively Recruiting
Phase 4, Not Applicable
Spina Bifida
15 Actively Recruiting
Not Applicable
Overactive Bladder Syndrome
32 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2
increased frequency of urination
2 Actively Recruiting
Phase 4, Not Applicable
Longterm Indwelling Ureteral Stent
0 Actively Recruiting
Urinary Urge Incontinence
15 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Urinary Urgency
3 Actively Recruiting
Phase 4, Phase 1, Not Applicable
Detrusor Hyperreflexia
0 Actively Recruiting
Foley Catheterization
0 Actively Recruiting
Bladder Spasms
1 Actively Recruiting
Phase 1
Neurological Disorders
6 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Oxytrol Reviews: What are patients saying about Oxytrol?
5Patient Review
7/31/2014 We tried this on our granddaughter who was having accidents day and night, and it worked like a charm! We've been using it for over 6 months now with great results.
5Patient Review
2/1/2021 I'm a 63-year-old man who had his prostate removed 10 years ago. Recently, I started feeling the urge to urinate constantly (even though there was no leakage) and the sensation that leakage was occurring. After trying different drugs prescribed by urologists with no success, I looked online for answers and found this product. I've been using it for three months now and am totally satisfied. I believe the low dosage is what works for men. Urologists need to be more open to this treatment option for their male patients.
5Patient Review
7/13/2015 So far, so good! This has helped me a lot in just one week with no adverse effects.
5Patient Review
11/6/2014 I'm really pleased with this patch! It helped me a lot and I didn't have any problems with the adhesive.
4.7Patient Review
2/18/2015 I quickly noticed an improvement in my symptoms after using this treatment. I no longer needed to urinate as frequently and could sleep through the night without interruption. The only downside is that the patch can sometimes come loose, but overall this has been a huge help.
4.3Patient Review
6/6/2015 I found significant relief from using this patch. I was able to extend the time between applications by moving it around on my lower body. It also helped to reduce itching. When removing the patch, be sure to soap up the area.
4Patient Review
1/27/2018 I've been using these patches for a few years now and they're great! I haven't experienced any negative side effects. They definitely help me go less often, except when I'm anxious or something. The only downside is that they're pricey.
2.7Patient Review
7/15/2021 I got a rash from using this patch, as well as blisters around the edge. I also didn't notice any change to my bladder after using it 3 times, so I stopped.
2.3Patient Review
8/21/2014 While this product does help with leakage, I still find myself having to go frequently. Additionally, it's very clingy and hard to remove from the packaging; tape usually falls off after bathing. Finally, it leaves black marks which are difficult to scrub off.
2Patient Review
1/10/2016 I developed a large, red oozing rash that has not gone away after 24 hours. It's still a runny gooey mess. I thought it would dry up after removing the patch (used 2 days) but no such luck. I will call the hotline on Monday when it opens but I am very concerned. Do not use!
1.7Patient Review
1/4/2016 I started using this patch and, after only three days, began to notice blood in my urine. By the fifth day (I was on my second patch), I was having a full-blown period--even though I had just stopped bleeding two days before starting the patch. I also started experiencing dry skin on my face. So, I removed the patch on the sixth day and have continued to bleed heavily since then (it is now the seventh day).
Patient Q&A Section about oxytrol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why is Oxytrol discontinued?
"According to Wilkes (2015), Bayer AG stopped distributing the OTC version of OXY-TDS in early 2015 because sales results were disappointing."
Answered by AI
Can you buy Oxytrol over-the-counter?
"The Oxytrol® skin patch is only available with a doctor's prescription for men, while women can get it without a prescription or over-the-counter (OTC). This product comes in two forms: Patch, Extended Release."
Answered by AI
What is Oxytrol used for?
"Oxybutynin is used to treat an overactive bladder. By relaxing the muscles in the bladder, oxybutynin improves symptoms such as the inability to control urination (incontinence), feeling that one has to urinate (urgency), and having to go to the bathroom often (frequency)."
Answered by AI
How long does it take for Oxytrol to work?
"It takes approximately one week for the medicine in Oxytrol (oxybutynin) patches to build up to steady levels in your system. The patch continuously releases the medication through your skin and into your bloodstream over the course of 3-4 days."
Answered by AI