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What is Osmoprep
Sodium phosphate, dibasicThe Generic name of this drug
Treatment SummarySodium phosphate is a laxative used to help relieve constipation. It works by increasing the amount of fluid in the small intestine, which often causes a bowel movement within 30 minutes to 6 hours.
K Phos Neutralis the brand name
Osmoprep Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
K Phos Neutral
Sodium phosphate, dibasic
1977
15
Approved as Treatment by the FDA
Sodium phosphate, dibasic, also known as K Phos Neutral, is approved by the FDA for 1 uses which include Parenteral Nutrition, Total .Parenteral Nutrition, Total
Effectiveness
How Osmoprep Affects PatientsSodium phosphate is a drug that helps make stools softer, making them easier to pass through the large intestine.
How Osmoprep works in the bodySodium phosphate works by making the inside of the intestine more salty, which in turn causes more water to enter the intestine.
When to interrupt dosage
The suggested dose of Osmoprep is contingent upon the diagnosed condition, such as fluid and electrolyte maintenance therapy, Fluid replacement therapy and Irrigation. Dosage also differs in accordance with the mode of administration (e.g. Liquid or Tablet, coated) featured in the table below.Condition
Dosage
Administration
Parenteral Nutrition, Total
, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Buccal, Spray, Spray - Buccal, Intravenous, Liquid, Kit, Liquid - Buccal, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Irrigation, Solution, Solution - Intravenous, Liquid - Topical, Topical, Tablet, Tablet - Oral, Respiratory (inhalation), Solution - Respiratory (inhalation), Solution - Oral, Liquid - Oral, Rectal, Enema, Enema - Rectal, Tablet, coated, Tablet, coated - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Irrigation, Injection, Injection - Intravenous, Powder, Powder - Oral, Intraocular, Kit; Solution, Kit; Solution - Intraocular, Powder, for solution, Powder, for solution - Intraocular, Intraocular; Irrigation, Kit; Solution - Intraocular; Irrigation
Surgical Procedures
, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Buccal, Spray, Spray - Buccal, Intravenous, Liquid, Kit, Liquid - Buccal, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Irrigation, Solution, Solution - Intravenous, Liquid - Topical, Topical, Tablet, Tablet - Oral, Respiratory (inhalation), Solution - Respiratory (inhalation), Solution - Oral, Liquid - Oral, Rectal, Enema, Enema - Rectal, Tablet, coated, Tablet, coated - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Irrigation, Injection, Injection - Intravenous, Powder, Powder - Oral, Intraocular, Kit; Solution, Kit; Solution - Intraocular, Powder, for solution, Powder, for solution - Intraocular, Intraocular; Irrigation, Kit; Solution - Intraocular; Irrigation
severe constipation
, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Buccal, Spray, Spray - Buccal, Intravenous, Liquid, Kit, Liquid - Buccal, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Irrigation, Solution, Solution - Intravenous, Liquid - Topical, Topical, Tablet, Tablet - Oral, Respiratory (inhalation), Solution - Respiratory (inhalation), Solution - Oral, Liquid - Oral, Rectal, Enema, Enema - Rectal, Tablet, coated, Tablet, coated - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Irrigation, Injection, Injection - Intravenous, Powder, Powder - Oral, Intraocular, Kit; Solution, Kit; Solution - Intraocular, Powder, for solution, Powder, for solution - Intraocular, Intraocular; Irrigation, Kit; Solution - Intraocular; Irrigation
Constipation
, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Buccal, Spray, Spray - Buccal, Intravenous, Liquid, Kit, Liquid - Buccal, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Irrigation, Solution, Solution - Intravenous, Liquid - Topical, Topical, Tablet, Tablet - Oral, Respiratory (inhalation), Solution - Respiratory (inhalation), Solution - Oral, Liquid - Oral, Rectal, Enema, Enema - Rectal, Tablet, coated, Tablet, coated - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Irrigation, Injection, Injection - Intravenous, Powder, Powder - Oral, Intraocular, Kit; Solution, Kit; Solution - Intraocular, Powder, for solution, Powder, for solution - Intraocular, Intraocular; Irrigation, Kit; Solution - Intraocular; Irrigation
Bowel preparation therapy
, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Buccal, Spray, Spray - Buccal, Intravenous, Liquid, Kit, Liquid - Buccal, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Irrigation, Solution, Solution - Intravenous, Liquid - Topical, Topical, Tablet, Tablet - Oral, Respiratory (inhalation), Solution - Respiratory (inhalation), Solution - Oral, Liquid - Oral, Rectal, Enema, Enema - Rectal, Tablet, coated, Tablet, coated - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Irrigation, Injection, Injection - Intravenous, Powder, Powder - Oral, Intraocular, Kit; Solution, Kit; Solution - Intraocular, Powder, for solution, Powder, for solution - Intraocular, Intraocular; Irrigation, Kit; Solution - Intraocular; Irrigation
Colonoscopy
, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Buccal, Spray, Spray - Buccal, Intravenous, Liquid, Kit, Liquid - Buccal, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Irrigation, Solution, Solution - Intravenous, Liquid - Topical, Topical, Tablet, Tablet - Oral, Respiratory (inhalation), Solution - Respiratory (inhalation), Solution - Oral, Liquid - Oral, Rectal, Enema, Enema - Rectal, Tablet, coated, Tablet, coated - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Irrigation, Injection, Injection - Intravenous, Powder, Powder - Oral, Intraocular, Kit; Solution, Kit; Solution - Intraocular, Powder, for solution, Powder, for solution - Intraocular, Intraocular; Irrigation, Kit; Solution - Intraocular; Irrigation
Hypophosphatemia
, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Buccal, Spray, Spray - Buccal, Intravenous, Liquid, Kit, Liquid - Buccal, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Irrigation, Solution, Solution - Intravenous, Liquid - Topical, Topical, Tablet, Tablet - Oral, Respiratory (inhalation), Solution - Respiratory (inhalation), Solution - Oral, Liquid - Oral, Rectal, Enema, Enema - Rectal, Tablet, coated, Tablet, coated - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Irrigation, Injection, Injection - Intravenous, Powder, Powder - Oral, Intraocular, Kit; Solution, Kit; Solution - Intraocular, Powder, for solution, Powder, for solution - Intraocular, Intraocular; Irrigation, Kit; Solution - Intraocular; Irrigation
Warnings
Osmoprep has four contraindications and should not be administered concurrently with the conditions enumerated in the table below.There are 20 known major drug interactions with Osmoprep.Common Osmoprep Drug Interactions
Drug Name
Risk Level
Description
Alloin
Minor
The risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Alloin.
Calcium polycarbophil
Minor
The risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Calcium polycarbophil.
Chlorpropamide
Minor
Sodium phosphate, dibasic may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Frangula purshiana bark
Minor
The risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Frangula purshiana bark.
Konjac mannan
Minor
The risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Konjac mannan.
Osmoprep Toxicity & Overdose RiskIn rats, the toxic dose of sodium phosphate when administered intramuscularly was found to be 250mg/kg, and 8290mg/kg when given orally. High phosphate levels can disrupt other electrolytes in the body and lead to symptoms such as muscle spasms, dehydration, low blood pressure, fast heart rate, high fever, cardiac arrest, and unconsciousness. Smaller patients may be at a higher risk of experiencing phosphate toxicity.
Osmoprep Novel Uses: Which Conditions Have a Clinical Trial Featuring Osmoprep?
54 active clinical trials are currently examining the potential of Osmoprep for Electrolyte replacement, proctoscopy and Irrigation purposes in treating certain diseases.Condition
Clinical Trials
Trial Phases
Bowel preparation therapy
2 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Hypophosphatemia
2 Actively Recruiting
Early Phase 1, Phase 2
Constipation
38 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Early Phase 1
severe constipation
0 Actively Recruiting
Parenteral Nutrition, Total
0 Actively Recruiting
Colonoscopy
4 Actively Recruiting
Not Applicable, Phase 4
Surgical Procedures
0 Actively Recruiting
Osmoprep Reviews: What are patients saying about Osmoprep?
5Patient Review
10/15/2015 I'm glad that this medication comes in pill form now! I couldn't stomach the liquid version.
5Patient Review
2/25/2016 I'm so grateful for these pills! They worked great and were much easier to take than the liquid salt wash.
5Patient Review
3/5/2017 Osmoprep is definitely the best way to go when getting a colonoscopy or endoscopy. The liquid preps make me gag, so this was much easier to use. It's also significantly cheaper than other options on the market.
5Patient Review
11/5/2014 I just started the prep and it's going well so far. I took the first doses at 3, and the final doses at 6 like instructed. They said I could start earlier so I started at 2....I am hoping to be done and able to sleep fairly well. The comments here have been so helpful, thanks.
5Patient Review
9/9/2016 Osmoprep is much easier to use than the traditional drink method, and I experienced no cramping. It did an amazing job of emptying my bowel and I couldn't be happier with the results.
5Patient Review
4/12/2016 The pills were a little hard to swallow but I cut them in half and it was a little better. Overall, prep was no where near as bad as I imagined it would be. Definitely will choose the pill option next time, which hopefully won't be for a while!
5Patient Review
8/4/2016 I never had an issue swallowing a lot of pills so taking the dosage was no problem. This prep was the best money I ever spent on a drug--I could NOT stomach the poisonous tasting meds the doctors prescribe.
5Patient Review
12/5/2016 Osmoprep is my go-to bowel prep. I love how easy it is to use, and I've never had any issues with cramping or vomiting.
5Patient Review
9/4/2015 I wasn't happy with the results of my procedure and had to reschedule.
4.7Patient Review
7/11/20142Patient Review
4/28/2015 After taking the second round of pills, I started vomiting. I was directed to wait a couple of hours and resume the remainder of the pills. I was unable to finish the last 6 pills due to nausea. I had to use a couple of Fleet enemas to finish cleaning out. Following the colonoscopy, I still experienced nauseousness, server diarrhea, and vomiting--something that I've never experienced in the past. Now I'm two weeks after the colonoscopy and I'm still having cramps and diarrhea. So not worth it!!
1.7Patient Review
4/2/2015 I took a lot of pills, but they weren't too hard to swallow. I had no side-effects at all. I drank A LOT of fluids during my prep day and I think that helped - 2 liters water, 2 liter ginger ale, 64 oz apple juice, coffee and tea. Will definitely use this product again.
1.3Patient Review
9/10/2015 Osmoprep is a lifesaver for me because I can't stand the thought of swallowing that other liquid stuff they give you. I just down it with white grape juice and I'm good to go.