Osmoprep

Constipation, Hypophosphatemia, Parenteral Nutrition, Total + 4 more
Treatment
1 FDA approval
20 Active Studies for Osmoprep

What is Osmoprep

Sodium phosphate, dibasicThe Generic name of this drug
Treatment SummarySodium phosphate is a laxative used to help relieve constipation. It works by increasing the amount of fluid in the small intestine, which often causes a bowel movement within 30 minutes to 6 hours.
K Phos Neutralis the brand name
image of different drug pills on a surface
Osmoprep Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
K Phos Neutral
Sodium phosphate, dibasic
1977
15

Approved as Treatment by the FDA

Sodium phosphate, dibasic, also known as K Phos Neutral, is approved by the FDA for 1 uses which include Parenteral Nutrition, Total .
Parenteral Nutrition, Total

Effectiveness

How Osmoprep Affects PatientsSodium phosphate is a drug that helps make stools softer, making them easier to pass through the large intestine.
How Osmoprep works in the bodySodium phosphate works by making the inside of the intestine more salty, which in turn causes more water to enter the intestine.

When to interrupt dosage

The suggested dose of Osmoprep is contingent upon the diagnosed condition, such as fluid and electrolyte maintenance therapy, Fluid replacement therapy and Irrigation. Dosage also differs in accordance with the mode of administration (e.g. Liquid or Tablet, coated) featured in the table below.
Condition
Dosage
Administration
Hypophosphatemia
, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Buccal, Spray, Spray - Buccal, Intravenous, Liquid, Kit, Liquid - Buccal, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Irrigation, Solution, Solution - Intravenous, Liquid - Topical, Topical, Tablet, Tablet - Oral, Respiratory (inhalation), Solution - Respiratory (inhalation), Solution - Oral, Liquid - Oral, Rectal, Enema, Enema - Rectal, Tablet, coated, Tablet, coated - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Irrigation, Injection, Injection - Intravenous, Powder, Powder - Oral, Intraocular, Kit; Solution, Kit; Solution - Intraocular, Powder, for solution, Powder, for solution - Intraocular, Intraocular; Irrigation, Kit; Solution - Intraocular; Irrigation
Parenteral Nutrition, Total
, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Buccal, Spray, Spray - Buccal, Intravenous, Liquid, Kit, Liquid - Buccal, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Irrigation, Solution, Solution - Intravenous, Liquid - Topical, Topical, Tablet, Tablet - Oral, Respiratory (inhalation), Solution - Respiratory (inhalation), Solution - Oral, Liquid - Oral, Rectal, Enema, Enema - Rectal, Tablet, coated, Tablet, coated - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Irrigation, Injection, Injection - Intravenous, Powder, Powder - Oral, Intraocular, Kit; Solution, Kit; Solution - Intraocular, Powder, for solution, Powder, for solution - Intraocular, Intraocular; Irrigation, Kit; Solution - Intraocular; Irrigation
Bowel preparation therapy
, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Buccal, Spray, Spray - Buccal, Intravenous, Liquid, Kit, Liquid - Buccal, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Irrigation, Solution, Solution - Intravenous, Liquid - Topical, Topical, Tablet, Tablet - Oral, Respiratory (inhalation), Solution - Respiratory (inhalation), Solution - Oral, Liquid - Oral, Rectal, Enema, Enema - Rectal, Tablet, coated, Tablet, coated - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Irrigation, Injection, Injection - Intravenous, Powder, Powder - Oral, Intraocular, Kit; Solution, Kit; Solution - Intraocular, Powder, for solution, Powder, for solution - Intraocular, Intraocular; Irrigation, Kit; Solution - Intraocular; Irrigation
Colonoscopy
, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Buccal, Spray, Spray - Buccal, Intravenous, Liquid, Kit, Liquid - Buccal, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Irrigation, Solution, Solution - Intravenous, Liquid - Topical, Topical, Tablet, Tablet - Oral, Respiratory (inhalation), Solution - Respiratory (inhalation), Solution - Oral, Liquid - Oral, Rectal, Enema, Enema - Rectal, Tablet, coated, Tablet, coated - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Irrigation, Injection, Injection - Intravenous, Powder, Powder - Oral, Intraocular, Kit; Solution, Kit; Solution - Intraocular, Powder, for solution, Powder, for solution - Intraocular, Intraocular; Irrigation, Kit; Solution - Intraocular; Irrigation
Surgical Procedures
, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Buccal, Spray, Spray - Buccal, Intravenous, Liquid, Kit, Liquid - Buccal, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Irrigation, Solution, Solution - Intravenous, Liquid - Topical, Topical, Tablet, Tablet - Oral, Respiratory (inhalation), Solution - Respiratory (inhalation), Solution - Oral, Liquid - Oral, Rectal, Enema, Enema - Rectal, Tablet, coated, Tablet, coated - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Irrigation, Injection, Injection - Intravenous, Powder, Powder - Oral, Intraocular, Kit; Solution, Kit; Solution - Intraocular, Powder, for solution, Powder, for solution - Intraocular, Intraocular; Irrigation, Kit; Solution - Intraocular; Irrigation
severe constipation
, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Buccal, Spray, Spray - Buccal, Intravenous, Liquid, Kit, Liquid - Buccal, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Irrigation, Solution, Solution - Intravenous, Liquid - Topical, Topical, Tablet, Tablet - Oral, Respiratory (inhalation), Solution - Respiratory (inhalation), Solution - Oral, Liquid - Oral, Rectal, Enema, Enema - Rectal, Tablet, coated, Tablet, coated - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Irrigation, Injection, Injection - Intravenous, Powder, Powder - Oral, Intraocular, Kit; Solution, Kit; Solution - Intraocular, Powder, for solution, Powder, for solution - Intraocular, Intraocular; Irrigation, Kit; Solution - Intraocular; Irrigation
Constipation
, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL
, Irrigation, Irrigant, Irrigant - Irrigation, Buccal, Spray, Spray - Buccal, Intravenous, Liquid, Kit, Liquid - Buccal, Kit - Intravenous, Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Irrigation, Solution, Solution - Intravenous, Liquid - Topical, Topical, Tablet, Tablet - Oral, Respiratory (inhalation), Solution - Respiratory (inhalation), Solution - Oral, Liquid - Oral, Rectal, Enema, Enema - Rectal, Tablet, coated, Tablet, coated - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Irrigation, Injection, Injection - Intravenous, Powder, Powder - Oral, Intraocular, Kit; Solution, Kit; Solution - Intraocular, Powder, for solution, Powder, for solution - Intraocular, Intraocular; Irrigation, Kit; Solution - Intraocular; Irrigation

Warnings

Osmoprep has four contraindications and should not be administered concurrently with the conditions enumerated in the table below.There are 20 known major drug interactions with Osmoprep.
Common Osmoprep Drug Interactions
Drug Name
Risk Level
Description
Alloin
Minor
The risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Alloin.
Calcium polycarbophil
Minor
The risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Calcium polycarbophil.
Chlorpropamide
Minor
Sodium phosphate, dibasic may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Frangula purshiana bark
Minor
The risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Frangula purshiana bark.
Konjac mannan
Minor
The risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Konjac mannan.
Osmoprep Toxicity & Overdose RiskIn rats, the toxic dose of sodium phosphate when administered intramuscularly was found to be 250mg/kg, and 8290mg/kg when given orally. High phosphate levels can disrupt other electrolytes in the body and lead to symptoms such as muscle spasms, dehydration, low blood pressure, fast heart rate, high fever, cardiac arrest, and unconsciousness. Smaller patients may be at a higher risk of experiencing phosphate toxicity.
image of a doctor in a lab doing drug, clinical research

Osmoprep Novel Uses: Which Conditions Have a Clinical Trial Featuring Osmoprep?

54 active clinical trials are currently examining the potential of Osmoprep for Electrolyte replacement, proctoscopy and Irrigation purposes in treating certain diseases.
Condition
Clinical Trials
Trial Phases
severe constipation
0 Actively Recruiting
Bowel preparation therapy
1 Actively Recruiting
Phase 1, Phase 2
Colonoscopy
2 Actively Recruiting
Not Applicable
Constipation
16 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3
Surgical Procedures
0 Actively Recruiting
Hypophosphatemia
1 Actively Recruiting
Phase 2
Parenteral Nutrition, Total
0 Actively Recruiting

Osmoprep Reviews: What are patients saying about Osmoprep?

5Patient Review
10/15/2015
Osmoprep for Emptying of the Bowel
I'm glad that this medication comes in pill form now! I couldn't stomach the liquid version.
5Patient Review
2/25/2016
Osmoprep for Emptying of the Bowel
I'm so grateful for these pills! They worked great and were much easier to take than the liquid salt wash.
5Patient Review
3/5/2017
Osmoprep for Emptying of the Bowel
Osmoprep is definitely the best way to go when getting a colonoscopy or endoscopy. The liquid preps make me gag, so this was much easier to use. It's also significantly cheaper than other options on the market.
5Patient Review
11/5/2014
Osmoprep for Emptying of the Bowel
I just started the prep and it's going well so far. I took the first doses at 3, and the final doses at 6 like instructed. They said I could start earlier so I started at 2....I am hoping to be done and able to sleep fairly well. The comments here have been so helpful, thanks.
5Patient Review
9/9/2016
Osmoprep for Emptying of the Bowel
Osmoprep is much easier to use than the traditional drink method, and I experienced no cramping. It did an amazing job of emptying my bowel and I couldn't be happier with the results.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about osmoprep

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Osmoprep

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Have you considered Osmoprep clinical trials? We made a collection of clinical trials featuring Osmoprep, we think they might fit your search criteria.
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