Osmoprep

Constipation, Hypophosphatemia, Parenteral Nutrition, Total + 4 more

Treatment

1 FDA approval

20 Active Studies for Osmoprep

What is Osmoprep

Sodium phosphate, dibasic

The Generic name of this drug

Treatment Summary

Sodium phosphate is a laxative used to help relieve constipation. It works by increasing the amount of fluid in the small intestine, which often causes a bowel movement within 30 minutes to 6 hours.

K Phos Neutral

is the brand name

image of different drug pills on a surface

Osmoprep Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

K Phos Neutral

Sodium phosphate, dibasic

1977

15

Approved as Treatment by the FDA

Sodium phosphate, dibasic, also known as K Phos Neutral, is approved by the FDA for 1 uses which include Parenteral Nutrition, Total .

Parenteral Nutrition, Total

Effectiveness

How Osmoprep Affects Patients

Sodium phosphate is a drug that helps make stools softer, making them easier to pass through the large intestine.

How Osmoprep works in the body

Sodium phosphate works by making the inside of the intestine more salty, which in turn causes more water to enter the intestine.

When to interrupt dosage

The suggested dose of Osmoprep is contingent upon the diagnosed condition, such as fluid and electrolyte maintenance therapy, Fluid replacement therapy and Irrigation. Dosage also differs in accordance with the mode of administration (e.g. Liquid or Tablet, coated) featured in the table below.

Condition

Dosage

Administration

Hypophosphatemia

, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL

, Spray, Intravenous, Kit, Tablet, effervescent, Kit - Intravenous, Tablet, effervescent - Oral, Liquid - Buccal, Spray - Buccal, Irrigation, Irrigant - Irrigation, Irrigant, Buccal, Solution, Liquid, Liquid - Irrigation, Oral, Tablet, Enema, Tablet, coated, Injection, solution - Intravenous, Injection, solution, Solution - Respiratory (inhalation), Respiratory (inhalation), Tablet - Oral, Enema - Rectal, Solution - Irrigation, Rectal, Injection - Intravenous, Injection, Powder, Powder - Oral, Kit; Solution, Powder, for solution - Intraocular, Intraocular, Kit; Solution - Intraocular, Solution - Intravenous, Kit; Solution - Intraocular; Irrigation, Tablet, coated - Oral, Solution - Oral, Powder, for solution, Intraocular; Irrigation, Topical, Liquid - Oral, Liquid - Topical

Parenteral Nutrition, Total

, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL

, Spray, Intravenous, Kit, Tablet, effervescent, Kit - Intravenous, Tablet, effervescent - Oral, Liquid - Buccal, Spray - Buccal, Irrigation, Irrigant - Irrigation, Irrigant, Buccal, Solution, Liquid, Liquid - Irrigation, Oral, Tablet, Enema, Tablet, coated, Injection, solution - Intravenous, Injection, solution, Solution - Respiratory (inhalation), Respiratory (inhalation), Tablet - Oral, Enema - Rectal, Solution - Irrigation, Rectal, Injection - Intravenous, Injection, Powder, Powder - Oral, Kit; Solution, Powder, for solution - Intraocular, Intraocular, Kit; Solution - Intraocular, Solution - Intravenous, Kit; Solution - Intraocular; Irrigation, Tablet, coated - Oral, Solution - Oral, Powder, for solution, Intraocular; Irrigation, Topical, Liquid - Oral, Liquid - Topical

Bowel preparation therapy

, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL

, Spray, Intravenous, Kit, Tablet, effervescent, Kit - Intravenous, Tablet, effervescent - Oral, Liquid - Buccal, Spray - Buccal, Irrigation, Irrigant - Irrigation, Irrigant, Buccal, Solution, Liquid, Liquid - Irrigation, Oral, Tablet, Enema, Tablet, coated, Injection, solution - Intravenous, Injection, solution, Solution - Respiratory (inhalation), Respiratory (inhalation), Tablet - Oral, Enema - Rectal, Solution - Irrigation, Rectal, Injection - Intravenous, Injection, Powder, Powder - Oral, Kit; Solution, Powder, for solution - Intraocular, Intraocular, Kit; Solution - Intraocular, Solution - Intravenous, Kit; Solution - Intraocular; Irrigation, Tablet, coated - Oral, Solution - Oral, Powder, for solution, Intraocular; Irrigation, Topical, Liquid - Oral, Liquid - Topical

Colonoscopy

, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL

, Spray, Intravenous, Kit, Tablet, effervescent, Kit - Intravenous, Tablet, effervescent - Oral, Liquid - Buccal, Spray - Buccal, Irrigation, Irrigant - Irrigation, Irrigant, Buccal, Solution, Liquid, Liquid - Irrigation, Oral, Tablet, Enema, Tablet, coated, Injection, solution - Intravenous, Injection, solution, Solution - Respiratory (inhalation), Respiratory (inhalation), Tablet - Oral, Enema - Rectal, Solution - Irrigation, Rectal, Injection - Intravenous, Injection, Powder, Powder - Oral, Kit; Solution, Powder, for solution - Intraocular, Intraocular, Kit; Solution - Intraocular, Solution - Intravenous, Kit; Solution - Intraocular; Irrigation, Tablet, coated - Oral, Solution - Oral, Powder, for solution, Intraocular; Irrigation, Topical, Liquid - Oral, Liquid - Topical

Surgical Procedures

, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL

, Spray, Intravenous, Kit, Tablet, effervescent, Kit - Intravenous, Tablet, effervescent - Oral, Liquid - Buccal, Spray - Buccal, Irrigation, Irrigant - Irrigation, Irrigant, Buccal, Solution, Liquid, Liquid - Irrigation, Oral, Tablet, Enema, Tablet, coated, Injection, solution - Intravenous, Injection, solution, Solution - Respiratory (inhalation), Respiratory (inhalation), Tablet - Oral, Enema - Rectal, Solution - Irrigation, Rectal, Injection - Intravenous, Injection, Powder, Powder - Oral, Kit; Solution, Powder, for solution - Intraocular, Intraocular, Kit; Solution - Intraocular, Solution - Intravenous, Kit; Solution - Intraocular; Irrigation, Tablet, coated - Oral, Solution - Oral, Powder, for solution, Intraocular; Irrigation, Topical, Liquid - Oral, Liquid - Topical

severe constipation

, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL

, Spray, Intravenous, Kit, Tablet, effervescent, Kit - Intravenous, Tablet, effervescent - Oral, Liquid - Buccal, Spray - Buccal, Irrigation, Irrigant - Irrigation, Irrigant, Buccal, Solution, Liquid, Liquid - Irrigation, Oral, Tablet, Enema, Tablet, coated, Injection, solution - Intravenous, Injection, solution, Solution - Respiratory (inhalation), Respiratory (inhalation), Tablet - Oral, Enema - Rectal, Solution - Irrigation, Rectal, Injection - Intravenous, Injection, Powder, Powder - Oral, Kit; Solution, Powder, for solution - Intraocular, Intraocular, Kit; Solution - Intraocular, Solution - Intravenous, Kit; Solution - Intraocular; Irrigation, Tablet, coated - Oral, Solution - Oral, Powder, for solution, Intraocular; Irrigation, Topical, Liquid - Oral, Liquid - Topical

Constipation

, 10.0 mL, 195.0 mg, 0.0875 mg/mL, 398.0 mg, 0.84 %, 852.0 mg, 142.0 mg/mL, 0.034 mL/mL, 0.187 mg/mL, 0.493 mg/mL, 350.0 mg/mL, 70.0 mg/mL, 0.042 %, 180.0 mg/mL, 900.0 mg/mL, 60.0 mg/mL, 4.3 mg/mL, 4.1 mg/mL, 0.01 mg/mg, 0.49 mg/mL, 0.42 mg/mL, 1.242 mg/mL, 0.12 mg/mL, 0.28 mg/mL, 3.05 mg/mL, 7.58 mg/mL, 268.0 mg/mL, 356.9575 mg/mL

, Spray, Intravenous, Kit, Tablet, effervescent, Kit - Intravenous, Tablet, effervescent - Oral, Liquid - Buccal, Spray - Buccal, Irrigation, Irrigant - Irrigation, Irrigant, Buccal, Solution, Liquid, Liquid - Irrigation, Oral, Tablet, Enema, Tablet, coated, Injection, solution - Intravenous, Injection, solution, Solution - Respiratory (inhalation), Respiratory (inhalation), Tablet - Oral, Enema - Rectal, Solution - Irrigation, Rectal, Injection - Intravenous, Injection, Powder, Powder - Oral, Kit; Solution, Powder, for solution - Intraocular, Intraocular, Kit; Solution - Intraocular, Solution - Intravenous, Kit; Solution - Intraocular; Irrigation, Tablet, coated - Oral, Solution - Oral, Powder, for solution, Intraocular; Irrigation, Topical, Liquid - Oral, Liquid - Topical

Warnings

Osmoprep has four contraindications and should not be administered concurrently with the conditions enumerated in the table below.

There are 20 known major drug interactions with Osmoprep.

Common Osmoprep Drug Interactions

Drug Name

Risk Level

Description

Alloin

Minor

The risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Alloin.

Calcium polycarbophil

Minor

The risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Calcium polycarbophil.

Chlorpropamide

Minor

Sodium phosphate, dibasic may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.

Frangula purshiana bark

Minor

The risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Frangula purshiana bark.

Konjac mannan

Minor

The risk or severity of adverse effects can be increased when Sodium phosphate, dibasic is combined with Konjac mannan.

Osmoprep Toxicity & Overdose Risk

In rats, the toxic dose of sodium phosphate when administered intramuscularly was found to be 250mg/kg, and 8290mg/kg when given orally. High phosphate levels can disrupt other electrolytes in the body and lead to symptoms such as muscle spasms, dehydration, low blood pressure, fast heart rate, high fever, cardiac arrest, and unconsciousness. Smaller patients may be at a higher risk of experiencing phosphate toxicity.

image of a doctor in a lab doing drug, clinical research

Osmoprep Novel Uses: Which Conditions Have a Clinical Trial Featuring Osmoprep?

54 active clinical trials are currently examining the potential of Osmoprep for Electrolyte replacement, proctoscopy and Irrigation purposes in treating certain diseases.

Condition

Clinical Trials

Trial Phases

severe constipation

0 Actively Recruiting

Bowel preparation therapy

1 Actively Recruiting

Phase 1, Phase 2

Colonoscopy

3 Actively Recruiting

Not Applicable

Constipation

16 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Phase 3

Surgical Procedures

0 Actively Recruiting

Hypophosphatemia

1 Actively Recruiting

Phase 2

Parenteral Nutrition, Total

0 Actively Recruiting

Osmoprep Reviews: What are patients saying about Osmoprep?

5

Patient Review

10/15/2015

Osmoprep for Emptying of the Bowel

I'm glad that this medication comes in pill form now! I couldn't stomach the liquid version.

5

Patient Review

2/25/2016

Osmoprep for Emptying of the Bowel

I'm so grateful for these pills! They worked great and were much easier to take than the liquid salt wash.

5

Patient Review

3/5/2017

Osmoprep for Emptying of the Bowel

Osmoprep is definitely the best way to go when getting a colonoscopy or endoscopy. The liquid preps make me gag, so this was much easier to use. It's also significantly cheaper than other options on the market.

5

Patient Review

11/5/2014

Osmoprep for Emptying of the Bowel

I just started the prep and it's going well so far. I took the first doses at 3, and the final doses at 6 like instructed. They said I could start earlier so I started at 2....I am hoping to be done and able to sleep fairly well. The comments here have been so helpful, thanks.

5

Patient Review

9/9/2016

Osmoprep for Emptying of the Bowel

Osmoprep is much easier to use than the traditional drink method, and I experienced no cramping. It did an amazing job of emptying my bowel and I couldn't be happier with the results.

5

Patient Review

4/12/2016

Osmoprep for Emptying of the Bowel

The pills were a little hard to swallow but I cut them in half and it was a little better. Overall, prep was no where near as bad as I imagined it would be. Definitely will choose the pill option next time, which hopefully won't be for a while!

5

Patient Review

8/4/2016

Osmoprep for Emptying of the Bowel

I never had an issue swallowing a lot of pills so taking the dosage was no problem. This prep was the best money I ever spent on a drug--I could NOT stomach the poisonous tasting meds the doctors prescribe.

5

Patient Review

12/5/2016

Osmoprep for Emptying of the Bowel

Osmoprep is my go-to bowel prep. I love how easy it is to use, and I've never had any issues with cramping or vomiting.

5

Patient Review

9/4/2015

Osmoprep for Emptying of the Bowel

I wasn't happy with the results of my procedure and had to reschedule.

4.7

Patient Review

7/11/2014

Osmoprep for Emptying of the Bowel

2

Patient Review

4/28/2015

Osmoprep for Emptying of the Bowel

After taking the second round of pills, I started vomiting. I was directed to wait a couple of hours and resume the remainder of the pills. I was unable to finish the last 6 pills due to nausea. I had to use a couple of Fleet enemas to finish cleaning out. Following the colonoscopy, I still experienced nauseousness, server diarrhea, and vomiting--something that I've never experienced in the past. Now I'm two weeks after the colonoscopy and I'm still having cramps and diarrhea. So not worth it!!

1.7

Patient Review

4/2/2015

Osmoprep for Emptying of the Bowel

I took a lot of pills, but they weren't too hard to swallow. I had no side-effects at all. I drank A LOT of fluids during my prep day and I think that helped - 2 liters water, 2 liter ginger ale, 64 oz apple juice, coffee and tea. Will definitely use this product again.

1.3

Patient Review

9/10/2015

Osmoprep for Emptying of the Bowel

Osmoprep is a lifesaver for me because I can't stand the thought of swallowing that other liquid stuff they give you. I just down it with white grape juice and I'm good to go.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about osmoprep

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Osmoprep

Have you considered Osmoprep clinical trials?

We made a collection of clinical trials featuring Osmoprep, we think they might fit your search criteria.
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Kiwifruit Extract for Constipation in Children

4 - 17
All Sexes
Hamilton, Canada

The goal of this pilot feasibility randomized controlled trial is to determine whether Actazin (kiwifruit extract) is a feasible and effective alternative to polyethylene glycol 3350 (PEG 3350) for maintenance therapy in children with functional constipation (FC). This study will include children aged 4 to 17 years who meet the Rome IV criteria for functional constipation. The main questions it aims to answer are: 1. Is it feasible to conduct a definitive, multi-centre trial comparing Actazin to PEG 3350 in children with FC? 2. What are the within-group differences in clinical outcomes such as stool frequency, abdominal pain, and laxative use over a 4-week period? Researchers will compare chewable Actazin tablets with placebo PEG 3350 powder to PEG 3350 powder with placebo Actazin tablets to see if Actazin is a viable non-pharmacologic natural health product alternative for treating FC. Participants will: Undergo an initial bowel cleanout using PEG 3350 and bisacodyl. Following, they will be randomized to one of two groups: 1. Actazin chewable tablets (titrate to effect: 600-2400 mg/day) + placebo PEG 3350 2. PEG 3350 (dose based on age and titratable to effect) + placebo Actazin chewable tablets Participants will take the assigned intervention daily for 4 weeks and complete a daily bowel diary recording stool frequency, consistency (Bristol Stool Scale), abdominal pain, and laxative use. They will have weekly follow-ups via phone or electronic survey to assess adherence, medication use, and adverse events. Additionally, a bi-weekly follow-up will be conducted for an additional 8 weeks to track longer-term outcomes. Outcomes: Primary feasibility outcomes include consent rate, adherence to allocated intervention, and 4-week follow-up completion rate. Secondary clinical outcomes include resolution of FC (Rome IV criteria), weekly stool frequency, abdominal pain episodes, use of rescue laxatives, and treatment palatability. This study is being conducted at McMaster Children's Hospital and is funded by the Hamilton Academic Health Sciences Organization (HAHSO). Data collection will be managed using the Lumedi™ platform, and safety will be overseen by a Data Safety Monitoring Board (DSMB).

Phase 2 & 3
Waitlist Available

Hamilton Health Sciences

Elyanne Ratcliffe, MD

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Pelvic Health Rehabilitation for Breast and Gynecologic Cancer

18+
Female
Edmonton, Canada

The GYVE study aims at testing an online program (eModule) to help people who have had breast or gynecologic cancer and are experiencing pelvic health issues like urinary incontinence and pain during sex. These cancers and their treatments can cause significant pelvic health problems, affecting daily life and quality of life. Physiotherapy can help, but access is often limited due to costs and other barriers. The study will involve 20 participants from Quebec and Edmonton, who will take part in a 12-week program with weekly online group sessions led by a physiotherapist. Topics include pelvic floor muscle training, use of vaginal moisturizers, hydration, diet, and pain management. Led by experts in cancer rehabilitation and pelvic health, the study aims to provide valuable information on the feasibility and effectiveness of the eModule, potentially leading to broader implementation to help more people with lived experience of cancer.

Recruiting
Has No Placebo

University of Alberta (+1 Sites)

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AI-Assisted Colonoscopy for Polyp Detection

18+
All Sexes
Chicago, IL

Based on prior studies, trainee and practicing gastroenterologists miss pre-cancerous polyps (adenomas and serrated polyps) during colonoscopy. The use of computer-aided detection (CADe) systems, a form of artificial intelligence (AI) has been shown to help identify colorectal lesions for practicing gastroenterologists. However, less is known how AI impacts polyp detection for trainees. The investigators are conducting a tandem colonoscopy study wherein a portion of the colon is examined first by the trainee and then the attending physician. For each procedure, randomization will occur which will determine whether or not the trainee will utilize AI for their examination of the colon. At the end of the study, the investigators will determine whether AI helps trainees miss fewer polyps during colonoscopy. The investigators will also conduct interviews with trainees to understand how AI impacts colonoscopy training.

Recruiting
Has No Placebo

Northwestern Memorial Hospital

Rajesh Keswani, MD

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