Onglyza

Physical Activity, Type 2 Diabetes, Diet + 4 more
Treatment
7 FDA approvals
20 Active Studies for Onglyza

What is Onglyza

SaxagliptinThe Generic name of this drug
Treatment SummarySaxagliptin is an oral medication used to treat diabetes. It works by blocking an enzyme called dipeptidyl peptidase-4 (DPP-4) and was approved by the FDA in 2009.
Onglyzais the brand name
image of different drug pills on a surface
Onglyza Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Onglyza
Saxagliptin
2009
19

Approved as Treatment by the FDA

Saxagliptin, also known as Onglyza, is approved by the FDA for 7 uses which include Type 2 Diabetes Mellitus and Physical Activity .
Type 2 Diabetes Mellitus
Used to treat Type 2 Diabetes Mellitus in combination with Metformin
Physical Activity
Used to treat Exercise in combination with Metformin
Excercise
Used to treat Excercise in combination with Dapagliflozin
Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Metformin
saxagliptin
Used to treat already treated with dapagliflozin and saxagliptin in combination with Dapagliflozin
dapagliflozin
Used to treat inadequate control with dapagliflozin in combination with Dapagliflozin
Diet
Used to treat Diet in combination with Metformin

Effectiveness

How Onglyza Affects PatientsAfter taking saxagliptin, two hormones that help regulate blood sugar (GLP-1 and GIP) increase up to three times the normal level. This drug has fewer side effects than other medications since it is very specific to blocking a certain enzyme (DPP-4). Saxagliptin works for 24 hours, and decreases the hormone glucagon while increasing insulin production from the pancreas. It has been found to be safe and not cause any major changes in heart rhythm.
How Onglyza works in the bodySaxagliptin is a medicine used to treat type 2 diabetes. It works by helping the body produce hormones called incretins, which work to lower blood sugar by making the body consume more sugar and reducing the amount of sugar produced by the liver. Saxagliptin binds to an enzyme called DPP-4, which helps to increase levels of glucagon like peptide 1 in the body. This peptide stops the pancreatic alpha cells from producing too much glucagon, while also increasing the production of insulin from pancreatic beta cells.

When to interrupt dosage

The suggested dosage of Onglyza is contingent upon the diagnosed affliction, including dapagliflozin, Diet and Type 2 Diabetes. The measure of dosage relies upon the technique of delivery specified in the table beneath.
Condition
Dosage
Administration
Physical Activity
2.5 mg, , 5.0 mg
Tablet, film coated, , Oral, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, Tablet - Oral
Type 2 Diabetes
2.5 mg, , 5.0 mg
Tablet, film coated, , Oral, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, Tablet - Oral
Diet
2.5 mg, , 5.0 mg
Tablet, film coated, , Oral, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, Tablet - Oral
saxagliptin
2.5 mg, , 5.0 mg
Tablet, film coated, , Oral, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, Tablet - Oral
inadequate response to other therapeutic measures
2.5 mg, , 5.0 mg
Tablet, film coated, , Oral, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, Tablet - Oral
Excercise
2.5 mg, , 5.0 mg
Tablet, film coated, , Oral, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, Tablet - Oral
dapagliflozin
2.5 mg, , 5.0 mg
Tablet, film coated, , Oral, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, Tablet - Oral

Warnings

There are 20 known major drug interactions with Onglyza.
Common Onglyza Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Saxagliptin.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Saxagliptin.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Saxagliptin.
Carbamazepine
Major
The metabolism of Carbamazepine can be decreased when combined with Saxagliptin.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Saxagliptin.
Onglyza Toxicity & Overdose RiskIn clinical studies, saxagliptin was found to cause side effects in at least 5% of patients, more so than with placebo. These side effects include upper respiratory tract infections, urinary tract infections, and headaches.
image of a doctor in a lab doing drug, clinical research

Onglyza Novel Uses: Which Conditions Have a Clinical Trial Featuring Onglyza?

197 active clinical trials are examining the potential of Onglyza (saxagliptin) for the management of Type 2 Diabetes and its effects on Exercise.
Condition
Clinical Trials
Trial Phases
inadequate response to other therapeutic measures
0 Actively Recruiting
saxagliptin
0 Actively Recruiting
Diet
5 Actively Recruiting
Not Applicable, Phase 1
Type 2 Diabetes
174 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Excercise
1 Actively Recruiting
Not Applicable
dapagliflozin
0 Actively Recruiting
Physical Activity
35 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1

Onglyza Reviews: What are patients saying about Onglyza?

5Patient Review
10/22/2014
Onglyza for Type 2 Diabetes Mellitus
This pill has done amazing things for me. It's completely controlled my blood sugar and I no longer have to use insulin. I do experience some headaches and leg pains, but it's a small price to pay for the benefits I've received.
5Patient Review
4/7/2016
Onglyza for Type 2 Diabetes Mellitus
Not only did my sex drive come back after taking this medication, but my regularity improved as well. My blood sugar levels also normalized. However, it's important to note that diet changes are necessary for this pill to be effective; you can't just keep eating junk food and expect the pill to work its magic.
5Patient Review
9/27/2017
Onglyza for Type 2 Diabetes Mellitus
I've been managing my diabetes for ten years now, and this is by far the best medication I've tried. Thank you!
4.3Patient Review
1/20/2014
Onglyza for Type 2 Diabetes Mellitus
4Patient Review
3/31/2014
Onglyza for Type 2 Diabetes Mellitus
Works great, but my insurance company refused to cover the cost. Now I have to use a different medication (Tradjenta). Good luck to everyone else in this situation!
View All Reviews

Patient Q&A Section about onglyza

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of taking Onglyza?

"You may have a cold if you have a runny or stuffy nose, sore throat, cough, headache, or stomach pain."

Answered by AI

Is Onglyza the same as Januvia?

"The side effects of Januvia include back pain, joint or muscle pain, nausea, diarrhea, or constipation, which are different from the side effects of Onglyza, which include cough. Both Januvia and Onglyza may interact with other anti-diabetic medications."

Answered by AI

What is the difference between Onglyza and metformin?

"Onglyza has the potential to cause heart failure, while other medications with similiar effects do not. It is designed to lower blood sugar levels and is often the first choice medication to control diabetes and lower the risk of death associated with the disease; however, some people may not be able to tolerate potential stomach side effects."

Answered by AI

What is Onglyza used for?

"Saxagliptin works by regulating the levels of insulin your body produces after eating. Saxagliptin is for use in adults with type 2 diabetes. The Saxagliptin and Metformin hydrochloride (HCl) tablets are not for treating type 1 diabetes.

The drug saxagliptin is used in conjunction with a diet and exercise plan to help control high blood sugar levels in adults with type 2 diabetes. High blood sugar can lead to a number of serious health problems, including kidney damage, blindness, nerve damage, loss of limbs, and sexual dysfunction. Saxagliptin helps to regulate the amount of insulin the body produces after eating. It is not, however, effective in treating type 1 diabetes."

Answered by AI

Clinical Trials for Onglyza

Have you considered Onglyza clinical trials? We made a collection of clinical trials featuring Onglyza, we think they might fit your search criteria.
Have you considered Onglyza clinical trials? We made a collection of clinical trials featuring Onglyza, we think they might fit your search criteria.
Have you considered Onglyza clinical trials? We made a collection of clinical trials featuring Onglyza, we think they might fit your search criteria.
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